Medicine and Health Sciences Commons^™

Models Of School Breakfast Program Implementation In Western Australia And The Implications For Supporting Disadvantaged Students, Susan M. Hill, Matthew F. Byrne, Elizabeth Wenden, Amanda Devine, Margaret Miller, Henrietta Quinlan, Donna Cross, Judy Eastham, Miranda Chester

Research outputs 2022 to 2026

A substantial body of literature points to the educational and social benefits of school breakfast programs. Most high-income countries provide free or subsidized school breakfasts to support disadvantaged children. Australia does not have a nationally-funded school meal program. Instead, charitable organizations offer school breakfast programs on a voluntary basis, often with funding support from state/territory governments. Decisions about participating in a school breakfast program (SBP), which students to support, and the degree of integration with other strategies to support disadvantaged students are made at the school level. This large-scale, multi-year study examined models of SBP implementation in Western Australian (WA) …

Woman-Centred Ethics: A Feminist Participatory Action Research [Journal Article], Kate Buchanan, Sadie Geraghty, Lisa Whitehead, Elizabeth Newnham

Research outputs 2022 to 2026

Introduction: Contemporary ethical issues in the maternity system are nuanced, complex and layered. Medicalisation and the reported rise in incidence of mistreatment and birth trauma, has been described as unethical. Some authors suggest bioethical principles are limited in terms of guiding everyday care of pregnancy and birth. There is currently no known published research which explores what birthing people say is ethical. Aims: This study sought to explore women's experience of maternity care from an ethical perspective. Method: A Feminist Participatory Action Research (FPAR) was conducted over three years, in two phases. A Community Action Research Group (CARG) was formed …

Risk Factors Associated With 30-Day Unplanned Hospital Readmission For Patients With Mental Illness, Huaqiong Zhou, Irene Ngune, Matthew A. Albrecht, Phillip R. Della

Research outputs 2022 to 2026

Unplanned hospital readmission rate is up to 43 % in mental health settings, which is higher than in general health settings. Unplanned readmissions delay the recovery of patients with mental illness and add financial burden on families and healthcare services. There have been efforts to reduce readmissions with a particular interest in identifying patients at higher readmission risk after index admission; however, the results have been inconsistent. This systematic review synthesized risk factors associated with 30-day unplanned hospital readmissions for patients with mental illness. Eleven electronic databases were searched from 2010 to 30 September 2021 using key terms of 'mental …

Geospatiotemporal And Causal Inferential Study Of European Epidemiological Patterns Of Cannabis- And Substance-Related Congenital Orofacial Anomalies, Albert Stuart Reece, Gary Kenneth Hulse

Research outputs 2022 to 2026

Introduction:

Since high rates of congenital anomalies (CAs), including facial CAs (FCAs), causally attributed to antenatal and community cannabis use have been reported in several recent series, it was of interest to examine this subject in detail in Europe.

Methods:

CA data were taken from the EUROCAT database. Drug exposure data were downloaded from the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). Income was taken from the World Bank’s online sources.

Results:

On the bivariate maps of both orofacial clefts and holoprosencephaly against resin, the Δ9-tetrahydrocannabinol concentration rates of both covariates increased together in France, Bulgaria, and the …

An Examination Of Primary Health Care Nursing Service Evaluation Using The Donabedian Model: A Systematic Review, Kylie Mccullough, Lesley Andrew, Angela Genoni, Melissa Dunham, Lisa Whitehead, Davina Porock

Research outputs 2022 to 2026

Nurses are key to the delivery of global primary health care services. However, there appears to be a lack of evaluation of primary health care nursing delivery models in the published literature. This evaluation is vital to the improvement of patient experiences, national and global health outcomes, and the justification of future investment in primary health care nursing services. The purpose of this review was to explore and analyze the literature that reports on the evaluation of primary health care nursing services, to ascertain the nature and utility of these evaluation methods, and identify opportunities for future research in this …

Epigenetic Regulation Of Corneal Epithelial Differentiation By Tet2, Yuzuru Sasamoto, Siyuan Wu, Catherine A. A. Lee, Jason Y. Jiang, Bruce R. Ksander, Markus H. Frank, Natasha Y. Frank

Research outputs 2022 to 2026

Epigenetic DNA modification by 5-hydroxymethylcytosine (5hmC), generated by the Ten-eleven translocation (TET) dioxygenases, regulates diverse biological functions in many organ tissues, including the mammalian eye. For example, 5hmC has been shown to be involved in epigenetic regulation of retinal gene expression. However, a functional role of 5hmC in corneal differentiation has not been investigated to date. Here, we examined 5hmC and TET function in the human cornea. We found 5hmC highly expressed in MUC16-positive terminally differentiated cells that also co-expressed the 5hmC-generating enzyme TET2. TET2 knockdown (KD) in cultured corneal epithelial cells led to significant reductions of 5hmC peak distributions …

Corticospinal And Intracortical Responses From Both Motor Cortices Following Unilateral Concentric Versus Eccentric Contractions, Onno Van Der Groen, Christopher Latella, Kazunori Nosaka, Dylan Edwards, Wei Peng Teo, Janet L. Taylor

Research outputs 2022 to 2026

Cross-education is the phenomenon where training of one limb can cause neuromuscular adaptations in the opposite untrained limb. This effect has been reported to be greater after eccentric (ECC) than concentric (CON) strength training; however, the underpinning neurophysiological mechanisms remain unclear. Thus, we compared responses to transcranial magnetic stimulation (TMS) in both motor cortices following single sessions of unilateral ECC and CON exercise of the elbow flexors. Fourteen healthy adults performed three sets of 10 ECC and CON right elbow flexor contractions at 75 % of respective maximum on separate days. Elbow flexor maximal voluntary isometric contraction (MVIC) torques were …

Effect Of Deferoxamine On Post-Transfusion Iron, Inflammation, And In Vitro Microbial Growth In A Canine Hemorrhagic Shock Model: A Randomized Controlled Blinded Pilot Study, Melissa A. Claus, Lisa Smart, Anthea L. Raisis, Claire R. Sharp, Sam Abraham, Joel P. A. Gummer, Martin K. Mead, Damian L. Bradley, Rachel Van Swelm, Erwin T. G. Wiegerinck, Edward Litton

Research outputs 2022 to 2026

Red blood cell (RBC) transfusion is associated with recipient inflammation and infection, which may be triggered by excessive circulating iron. Iron chelation following transfusion may reduce these risks. The aim of this study was to evaluate the effect of deferoxamine on circulating iron and inflammation biomarkers over time and in vitro growth of Escherichia coli (E. coli) following RBC transfusion in dogs with atraumatic hemorrhage. Anesthetized dogs were subject to atraumatic hemorrhage and transfusion of RBCs, then randomized to receive either deferoxamine or saline placebo of equivalent volume (n = 10 per group) in a blinded fashion. Blood was sampled …

Calling An Ambulance For Non-Emergency Medical Situations: Results Of A Cross-Sectional Online Survey From An Australian Nationally Representative Sample, Brennen Mills, Michella Hill, Alecka Miles, Erin Smith, Eben Afrifa-Yamoah, David Reid, Shane Rogers, Moira Sim

Research outputs 2022 to 2026

Objective

To investigate the Australian general public's perception of appropriate medical scenarios that warrants a call to an emergency ambulance.

Methods

An online survey asked participants to identify the likely medical treatment pathway they would take for 17 hypothetical medical scenarios. The number and type of non-emergency scenarios (n = 8) participants incorrectly suggested were appropriate to place a call for an emergency ambulance were calculated. Participants included Australian residents (aged >18 years) who had never worked as an Australian registered medical doctor, nurse or paramedic.

Results

From a sample of 5264 participants, 40% suggested calling an emergency ambulance …

Measures Of Carotid Atherosclerosis And Fall-Related Hospitalization Risk: The Perth Longitudinal Study Of Ageing Women, Abadi K. Gebre, Marc Sim, Jack Dalla Via, Alexander J. Rodríguez, Jonathan M. Hodgson, Catherine P. Bondonno, Peter L. Thompson, Richard L. Prince, Joshua R. Lewis

Research outputs 2022 to 2026

Background and aims: We and others have identified links between cardiovascular conditions and poor musculoskeletal health. However, the relationship between measures of carotid atherosclerosis such as focal carotid plaque and common carotid intima media thickness (CCA-IMT) and falls remains understudied. This study examined the association between measures of carotid atherosclerosis and fall-related hospitalization over 11.5 years in community dwelling older women. Methods and results: 1116 older women recruited in 1998 to a five-year randomized controlled trial to examine the effect of calcium supplementation in preventing fracture and who had undertaken B-mode ultrasound in 2001 (three years after the baseline clinical …

Genetic Association And Causal Inference Between Lung Function And Venous Thromboembolism, Qiaoyun Zhang, Xiaoyu Zhang, Jie Zhang, Mengyang Jiang, Yiqiang Zhang, Deqiang Zheng, Lijuan Wu, Wei Wang, Baoguo Wang, Youxin Wang

Research outputs 2022 to 2026

Background: Previous studies have indicated that lower lung function is related to a higher risk of venous thromboembolism (VTE). However, causal inferences may be affected by confounders, coheritability or reverse causality. We aimed to explore the causal association between lung function and VTE. Methods: Summary data from public genome-wide association studies (GWAS) for lung function and VTE were obtained from published meta-analysis studies and the FinnGen consortium, respectively. Independent genetic variables significantly related to exposure were filtered as proxy instruments. We adopted linkage disequilibrium score regression (LDSC) and two-sample Mendelian randomization (MR) analyses to infer the genetic backgrounds and causal …

What We Don't Need To Prove But Need To Do In Multidisciplinary Treatment And Care In Huntington's Disease: A Position Paper, Alzbeta Mühlbӓck, Marleen Van Walsem, Martha Nance, Astri Arnesen, Kirsty Page, Alexandra Fisher, Manon Van Kampen, Angela Nuzzi, Roy Limpert, Hanne Ludt Fossmo, Travis Cruickshank, Ruth Veenhuizen

Research outputs 2022 to 2026

Background: Huntington’s disease is a complex neurodegenerative hereditary disease with symptoms in all domains of a person’s functioning. It begins after a healthy start in life and leads through the relentless progression over many years to complete care dependency and finally death. To date, the disease is incurable. The long progressive complex nature of the disease demands multiple disciplines for treatment and care of patient and family. These health care providers need inter- and multidisciplinary collaboration to persevere and be efficacious in this devastating disease trajectory. Discussion: The position paper outlines current knowledge and experience alongside the experience and consensus …

Early Visual Alterations In Individuals At-Risk Of Alzheimer’S Disease: A Multidisciplinary Approach, Inés López-Cuenca, Alberto Nebreda, Alejandra García-Colomo, Elena Salobrar-García, Jaisalmer De Frutos-Lucas, Ricardo Bruña, Ana I. Ramírez, Federico Ramirez-Toraño, Juan J. Salazar, Ana Barabash, Pedro Gil, Fernando Maestú, José M. Ramírez, Rosa De Hoz

Research outputs 2022 to 2026

Background: The earliest pathological features of Alzheimer’s disease (AD) appear decades before the clinical symptoms. The pathology affects the brain and the eye, leading to retinal structural changes and functional visual alterations. Healthy individuals at high risk of developing AD present alterations in these ophthalmological measures, as well as in resting-state electrophysiological activity. However, it is unknown whether the ophthalmological alterations are related to the visual-related electrophysiological activity. Elucidating this relationship is paramount to understand the mechanisms underlying the early deterioration of the system and an important step in assessing the suitability of these measures as early biomarkers of disease. …

Temporal Relationship Between Atherogenic Dyslipidemia And Inflammation And Their Joint Cumulative Effect On Type 2 Diabetes Onset: A Longitudinal Cohort Study, Yulong Lan, Guanzhi Chen, Dan Wu, Xiong Ding, Zegui Huang, Xianxuan Wang, Lois Balmer, Xingang Li, Manshu Song, Wei Wang, Shouling Wu, Youren Chen

Research outputs 2022 to 2026

Background: Concurrent atherogenic dyslipidemia and elevated inflammation are commonly observed in overt hyperglycemia and have long been proposed to contribute to diabetogenesis. However, the temporal relationship between them and the effect of their cumulative co-exposure on future incident type 2 diabetes (T2D) remains unclear. Methods: Longitudinal analysis of data on 52,224 participants from a real-world, prospective cohort study (Kailuan Study) was performed to address the temporal relationship between high-sensitivity C-reactive protein (hsCRP) and the atherogenic index of plasma (AIP, calculated as triglyceride/high-density lipoprotein) in an approximately 4-year exposure period (2006/2007 to 2010/2011). After excluding 8824 participants with known diabetes, 43,360 …

Review Of Alcohol And Drug Treatment For Aboriginal And Torres Strait Islander Peoples, Marguerite Tracy, Bradley Freeburn, Kylie Lee, Julie Woods, Kate Conigrave

Journal of the Australian Indigenous HealthInfoNet

This review provides an overview of treatments for problem alcohol and other drug (AOD) use for Aboriginal and Torres Strait Islander people. It includes information on the available research and discusses core principles for providing treatment. The review outlines how effective mainstream treatment approaches can be adapted to be more suitable for Aboriginal and Torres Strait Islander ways of being or worldview. It also highlights that services, such as those offered by Aboriginal community controlled health organisations are in a unique position to offer culturally secure treatment approaches. The barriers to accessing treatment are discussed as well as recommendations for …

Approaches To Clinical Guideline Development In Healthcare: A Scoping Review And Document Analysis, Annemarie De Leo, Dianne Bloxsome, Sara Bayes

Research outputs 2022 to 2026

Background: Over the past decade, an industry has emerged around Clinical Practice Guideline (CPG) development in healthcare, which has increased pressure on guideline-producing organisations to develop CPGs at an accelerated rate. These are intended to improve the quality of care provided to patients while containing healthcare costs and reducing variability in clinical practice. However, this has inadvertently led to discrepancies in CPG recommendations between health organisations, also challenging healthcare providers who rely on these for decision-making and to inform clinical care. From a global perspective, although some countries have initiated national protocols regarding developing, appraising and implementing high-quality CPGs, there …

Adherence To A Mediterranean Diet For 6 Months Improves The Dietary Inflammatory Index In A Western Population: Results From The Medley Study, Jessie S. Clark, Kathryn A. Dyer, Courtney R. Davis, Nitin Shivappa, James R. Hébert, Richard Woodman, Jonathan M. Hodgson, Karen J. Murphy

Research outputs 2022 to 2026

Increasing evidence supports that a higher dietary inflammatory index (DII®) score is associated with inflammation and cardiovascular disease (CVD) risk, events, and mortality. This randomized trial sought to determine if a change to a Mediterranean diet resulted in a reduction in the DII score, and then it evaluated the relationship between the DII and cardiometabolic outcomes following the administration of a traditional Mediterranean diet in older Australian adults. A total of 152 Australian adults (mean age 71 ± 5 years) was randomly allocated either a MedDiet (n = 80) or to continue their habitual diet (HabDiet) (n = 72) for …

Checkpoint Inhibitor Immune-Related Adverse Events: A Focused Review On Autoantibodies And B Cells As Biomarkers, Advancements And Future Possibilities, John Taylor, Aesha Gandhi, Elin Gray, Pauline Zaenker

Research outputs 2022 to 2026

The use of immune checkpoint inhibitors (ICIs) has evolved rapidly with unprecedented treatment benefits being obtained for cancer patients, including improved patient survival. However, over half of the patients experience immune related adverse events (irAEs) or toxicities, which can be fatal, affect the quality of life of patients and potentially cause treatment interruption or cessation. Complications from these toxicities can also cause long term irreversible organ damage and other chronic health conditions. Toxicities can occur in various organ systems, with common observations in the skin, rheumatologic, gastrointestinal, hepatic, endocrine system and the lungs. These are not only challenging to manage …

Higher Dietary Vitamin K Intake Is Associated With Better Physical Function And Lower Long-Term Injurious Falls Risk In Community-Dwelling Older Women, Marc Sim, C. Smith, Nicky P. Bondonno, Simone Radavelli-Bagatini, Lauren C. Blekkenhorst, Jack Dalla Via, R. Mccormick, K. Zhu, Jonathan M. Hodgson, R. L. Prince, Joshua R. Lewis

Research outputs 2022 to 2026

Background: In recent years, a potential beneficial role of Vitamin K in neuromuscular function has been recognised. However, the optimal dietary intake of Vitamin K to support muscle function in the context of falls prevention remains unknown. Objective: To examine the relationship of dietary Vitamin K1 and K2 with muscle function and long-term injurious fall-related hospitalisations in older women. Design: Cohort study. Participants: 1347 community-dwelling older Australian women ≥ 70 years. Measurements: A new Australian Vitamin K nutrient database, supplemented with published data, was used to calculate Vitamin K1 and K2 intake from a validated food frequency questionnaire at baseline …

The Role Of Adaptive Goal Processes In Mental Wellbeing In Chronic Pain, Tara Swindells, Joanne Iddon, Joanne M. Dickson

Research outputs 2022 to 2026

Chronic pain, experienced as pain persisting for three months or longer, is associated with risk of poor mental health and disability. Research has implicated adaptive goal processes as important to mental wellbeing in a range of populations. However, research has rarely assessed these mechanisms in relation to pain characteristics and mental wellbeing in chronic pain populations. This study aimed to examine the potentially mediating roles of goal flexibility and goal tenacity in the relationships between pain intensity and pain interference and mental wellbeing among individuals with chronic pain. Community members who self-identified as experiencing non-cancer chronic pain (N = 315) …

Editorial: What Does Not Kill You Makes You Stronger: Interactions Between Environmental Stresses And Microbial Virulence, Liang Wang, Ling-Jun Zhan, Michael J. Wise

Research outputs 2022 to 2026

The intriguing sit-and-wait hypothesis predicts that “virulence should be positively correlated with durability in the external environment because high durability reduces the dependence of transmission on host mobility” (Walther and Ewald, 2004) (Figure 1). Since the hypothesis was first proposed in the late 20th century (Ewald, 1983), both theoretical and computational studies have been reporting the relationships between environmental durability and microbial virulence (Sundberg et al., 2014; Wang et al., 2017, 2018, 2019a,b, 2020; Rafaluk-Mohr, 2019; Li et al., 2021) [...].

Identification Of Tp53 Mutations In Circulating Tumour Dna In High Grade Serous Ovarian Carcinoma Using Next Generation Sequencing Technologies, Leslie Calapre, Tindaro Giardina, Aaron B. Beasley, Anna L. Reid, Colin Stewart, Benhur Amanuel, Tarek M. Meniawy, Elin S. Gray

Research outputs 2022 to 2026

Plasma circulating tumour DNA (ctDNA) has been suggested to be a viable biomarker of response to treatment in patients with high grade serous ovarian carcinoma (HGSOC). TP53 mutations are present in more than 90 % of HGSOCs but somatic variants are distributed across all exonic regions of the gene, requiring next generation sequencing (NGS) technologies for mutational analysis. In this study, we compared the suitability of the Accel (Swift) and Oncomine (ThermoFisher) panels for identification of TP53 mutations in ctDNA of HGSOC patients (N = 10). Only 6 patients (60 %) were found to have TP53 mutations using the ACCEL …

Experience, Training Preferences, And Fighting Style Are Differentially Related To Measures Of Body Composition, Strength, And Power In Male Brazilian Jiu Jitsu Athletes - A Pilot Study, Christian G. Almeda, Gerald T. Mangine, Zackary H. Green, Yuri Feito, Duncan N. French

Research outputs 2022 to 2026

To examine relationships between Brazilian Jiu Jitsu (BJJ) descriptors (belt rank, experience, gi preference, and fighting style), resistance training (RT) experience, and measures of body composition, strength (maximal handgrip, 3-5-repetition maximum [RM] in barbell glute bridge [GB], prone bench row [PBR], and bench press [BP]), and velocity (GB, PBR, and BP at 7 kg and 30 – 60 % 1-RM), 13 experienced (4.3 ± 3.4 years) BJJ athletes were recruited for this cross-sectional, pilot study. Significant (p < 0.05) Kendall’s tau and Bayesian relationships were seen between belt rank and body fat percentage (τ = − 0.53, BF₁₀ = 6.5), BJJ experience and body fat percentage (τ = − 0.44 to − 0.66, BF₁₀ = 2.6 – 30.8) and …

Ifi27 Transcription Is An Early Predictor For Covid-19 Outcomes, A Multi-Cohort Observational Study, Maryam Shojaei, Amir Shamshirian, James Monkman, Laura Grice, Minh Tran, Chin Wee Tan, Siok Min Teo, Gustavo Rodrigues Rossi, Timothy R. Mcculloch, Marek Nalos, Maedeh Raei, Alireza Razavi, Roya Ghasemian, Mobina Gheibi, Fatemeh Roozbeh, Peter D. Sly, Kirsten M. Spann, Keng Yih Chew, Yanshan Zhu, Yao Xia, Timothy J. Wells, Alexandra Cristina Senegaglia, Carmen Lúcia Kuniyoshi, Claudio Luciano Franck, Anna Flavia Ribeiro Dos Santos, Lucia De Noronha, Sepideh Motamen, Reza Valadan, Omolbanin Amjadi, Rajan Gogna, Esha Madan, Reza Alizadeh-Navaei, Liliana Lamperti, Felipe Zuñiga, Estefania Nova-Lamperti, Gonzalo Labarca, Ben Knippenberg, Velma Herwanto, Ya Wang, Amy Phu, Tracy Chew, Timothy Kwan, Karan Kim, Sally Teoh, Tiana M. Pelaia, Win Sen Kuan, Yvette Jee, Jon Iredell, Ken O’Byrne, John F. Fraser, Melissa J. Davis, Gabrielle T. Belz, Majid E. Warkiani, Carlos Salomon Gallo, Fernando Souza-Fonseca-Guimaraes, Quan Nguyen, Anthony Mclean, Arutha Kulasinghe, Kirsty R. Short, Benjamin Tang

Research outputs 2022 to 2026

Purpose:

Robust biomarkers that predict disease outcomes amongst COVID-19 patients are necessary for both patient triage and resource prioritisation. Numerous candidate biomarkers have been proposed for COVID-19. However, at present, there is no consensus on the best diagnostic approach to predict outcomes in infected patients. Moreover, it is not clear whether such tools would apply to other potentially pandemic pathogens and therefore of use as stockpile for future pandemic preparedness.

Methods:

We conducted a multi-cohort observational study to investigate the biology and the prognostic role of interferon alpha-inducible protein 27 (IFI27) in COVID-19 patients.

Results:

We show that IFI27 is …

Population Genomics Of Australian Indigenous Mesorhizobium Reveals Diverse Nonsymbiotic Genospecies Capable Of Nitrogen-Fixing Symbioses Following Horizontal Gene Transfer, Elena Colombi, Yvette Hill, Rose Lines, John T. Sullivan, Maclean G. Kohlmeier, Claus T. Christophersen, Clive W. Ronson, Jason J. Terpolilli, Joshua P. Ramsay

Research outputs 2022 to 2026

Mesorhizobia are soil bacteria that establish nitrogen-fixing symbioses with various legumes. Novel symbiotic mesorhizobia frequently evolve following horizontal transfer of symbiosis-gene-carrying integrative and conjugative elements (ICESyms) to indigenous mesorhizobia in soils. Evolved symbionts exhibit a wide range in symbiotic effectiveness, with some fixing nitrogen poorly or not at all. Little is known about the genetic diversity and symbiotic potential of indigenous soil mesorhizobia prior to ICESym acquisition. Here we sequenced genomes of 144 Mesorhizobium spp. strains cultured directly from cultivated and uncultivated Australian soils. Of these, 126 lacked symbiosis genes. The only isolated symbiotic strains were either exotic strains used …

Adaptive Goal Processes And Underlying Motives That Sustain Mental Wellbeing And New Year Exercise Resolutions, Joanne M. Dickson, Amelia Hart, Caitlin Fox-Harding, Christopher D. Huntley

Research outputs 2022 to 2026

Exercise resolutions are the most common goals people set each New Year. However, research has rarely examined adaptive goal processes and motives that may maintain wellbeing and resolution pursuit. We therefore investigated if (1) personal goal flexibility and tenacity maintain mental wellbeing and adherence to New Year exercise resolutions and if (2) underlying intrinsic and extrinsic motives maintain wellbeing and sustained exercise resolution adherence. A community sample (N = 297) completed an online longitudinal study. At baseline, participants listed their most important exercise-related New Year resolution. Participants then completed measures to assess goal flexibility and tenacity, resolution motives, and mental …

Advancement In Human Face Prediction Using Dna, Aamer Alshehhi, Aliya Almarzooqi, Khadija Alhammadi, Naoufel Werghi, Guan Kwang Tay, Habiba Alsafar

Research outputs 2022 to 2026

The rapid improvements in identifying the genetic factors contributing to facial morphology have enabled the early identification of craniofacial syndromes. Similarly, this technology can be vital in forensic cases involving human identification from biological traces or human remains, especially when reference samples are not available in the deoxyribose nucleic acid (DNA) database. This review summarizes the currently used methods for predicting human phenotypes such as age, ancestry, pigmentation, and facial features based on genetic variations. To identify the facial features affected by DNA, various two-dimensional (2D)- and three-dimensional (3D)-scanning techniques and analysis tools are reviewed. A comparison between the scanning …

Novel Insights Into Potential Cannabis-Related Cancerogenesis From Recent Key Whole Epigenome Screen Of Cannabis Dependence And Withdrawal: Epidemiological Commentary And Explication Of Schrott Et Al., Albert Stuart Reece, Gary Kenneth Hulse

Research outputs 2022 to 2026

Whilst the cannabis-cancer link has been traditionally described as controversial recent whole nation and whole continent studies have demonstrated that well documented laboratory-based multimodal cannabinoid genotoxicity is indeed reflected in numerous cancer types in larger epidemiological series. A recent longitudinal human sperm epigenome-wide DNA methylation screen in both cannabis dependence and cannabis withdrawal has revealed remarkable insights into the manner in which widespread perturbations of DNA methylation may lead to cancerogenic changes in both the exposed and subsequent generations as a result of both cannabis exposure and withdrawal. These results therefore powerfully strengthen and further robustify the causal nature of …

Sex Differences In Skeletal Muscle Fiber Types: A Meta-Analysis, James L. Nuzzo

Research outputs 2022 to 2026

Biopsies have been acquired from living men and women to determine proportions of Type I (slow-twitch) and II (fast-twitch) skeletal muscle fibers since the 1970s. Sex differences have been assumed but the literature has not been submitted to meta-analysis. Here, the aim was to generate effect sizes of sex differences in muscle fiber cross-sectional areas, distribution percentages, and area percentages. Data from 2875 men and 2452 women, who participated in 110 studies, were analyzed. Myofibrillar adenosine triphosphatase histochemistry was used in 71.8% of studies to classify fibers as Type I, II, IIA, and/or IIX; immunohistochemistry, immunofluorescence, or sodium dodecyl sulfate-polyacrylamide …

Timing Is Everything, But Does It Really Matter? Impact Of 8-Weeks Morning Versus Evening Iron Supplementation In Ballet And Contemporary Dancers, Caitlin Attwell, Alannah Mckay, Marc Sim, Cory Dugan, Joanna Nicholas, Luke Hopper, Peter Peeling

Research outputs 2022 to 2026

The effectiveness of a morning versus evening oral iron supplement strategy to increase iron stores was explored. Ballet and contemporary dancers with serum ferritin (sFer) < 50 g/L (n = 14), were supplemented daily with 105 mg elemental oral iron in either the morning (FeAM) or evening (FePM) for 8 weeks. A control group (n = 6) with sFer > 50 g/L were given no supplement over the same period. Dancers’ sFer were measured at baseline and post-intervention. Assessment of daily training load, dietary intake, and menstruation were made. A significant interaction (p < 0.001) showed the within group sFer change over the 8-week intervention in FeAM (+25.9 ± 10.5 g/L) and FePM, (+22.3 ± 13.6 g/L) was significantly different to CON (−30.17 ± 28.7 g/L; both p = 0.001). This change was not different between FeAM and FePM (p = 0.778). sFer levels within FeAM and FePM significantly increased over the 8-weeks; however, they significantly decreased in the CON group (all p < 0.05). Post-intervention sFer levels were no longer different between the three groups (p > 0.05). Training load, dietary intake, and number of menstrual cycles incurred were similar between FeAM and FePM (p > 0.05). Oral iron supplementation in either the morning or evening appears equally effective in increasing sFer levels in dancers with sub-optimal iron status.