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Articles 1531 - 1560 of 4977

Full-Text Articles in Medicine and Health Sciences

The Influence Of Baseline Sleep On Exercise-Induced Cognitive Change In Cognitively Unimpaired Older Adults: A Randomised Clinical Trial, Kelsey R. Sewell, Stephanie R. Rainey-Smith, Jeremiah Peiffer, Hamid R. Sohrabi, James Doecke, Natalie J. Frost, Shaun J. Markovic, Kirk Erickson, Belinda M. Brown Oct 2023

The Influence Of Baseline Sleep On Exercise-Induced Cognitive Change In Cognitively Unimpaired Older Adults: A Randomised Clinical Trial, Kelsey R. Sewell, Stephanie R. Rainey-Smith, Jeremiah Peiffer, Hamid R. Sohrabi, James Doecke, Natalie J. Frost, Shaun J. Markovic, Kirk Erickson, Belinda M. Brown

Research outputs 2022 to 2026

Objectives: Observational studies consistently demonstrate that physical activity is associated with elevated cognitive function, however, there remains significant heterogeneity in cognitive outcomes from randomized exercise interventions. Individual variation in sleep behaviours may be a source of variability in the effectiveness of exercise-induced cognitive change, however this has not yet been investigated. The current study aimed to (1) investigate the influence of a 6-month exercise intervention on sleep, assessed pre- and post-intervention and, (2) investigate whether baseline sleep measures moderate exercise-induced cognitive changes. Methods: We utilised data from the Intense Physical Activity and Cognition (IPAC) study (n = 89), a 6-month …

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Chromosomal Aberrations In Pediatric Patients With Moderate/Severe Developmental Delay/Intellectual Disability With Abundant Phenotypic Heterogeneities: A Single-Center Study, Dan Wu, Yi Wu, Yulong Lan, Shaocong Lan, Zhiwei Zhong, Duo Li, Zexin Zheng, Hongwu Wang, Lian Ma Oct 2023

Chromosomal Aberrations In Pediatric Patients With Moderate/Severe Developmental Delay/Intellectual Disability With Abundant Phenotypic Heterogeneities: A Single-Center Study, Dan Wu, Yi Wu, Yulong Lan, Shaocong Lan, Zhiwei Zhong, Duo Li, Zexin Zheng, Hongwu Wang, Lian Ma

Research outputs 2022 to 2026

Background: This study aimed to examine the clinical usefulness of chromosome microarray (CMA) for selective implementation in patients with unexplained moderate or severe developmental delay/intellectual disability (DD/ID) and/or combined with different dysphonic features in the Han Chinese population. Methods: We retrospectively analyzed data on 122 pediatric patients with unexplained isolated moderate/severe DD/ID with or without autism spectrum disorders, epilepsy, dystonia, and congenital abnormalities from a single-center neurorehabilitation clinic in southern China. Results: A total of 46 probands (37.7%) had abnormal CMA results among the 122 study patients. With the exclusion of aneuploidies, uniparental disomies, and multiple homozygotes, 37 patients harbored …

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Elearning Improves Allied Health Professionals' Knowledge And Confidence To Manage Medically Unexplained Chronic Fatigue States: A Randomized Controlled Trial, Matthew D. Jones, Sally M. Casson, Benjamin K. Barry, Sophie H. Li, Trinidad Valenzuela, Joanne Cassar, Camillo Lamanna, Andrew R. Lloyd, Carolina X. Sandler Oct 2023

Elearning Improves Allied Health Professionals' Knowledge And Confidence To Manage Medically Unexplained Chronic Fatigue States: A Randomized Controlled Trial, Matthew D. Jones, Sally M. Casson, Benjamin K. Barry, Sophie H. Li, Trinidad Valenzuela, Joanne Cassar, Camillo Lamanna, Andrew R. Lloyd, Carolina X. Sandler

Research outputs 2022 to 2026

Objectives: To evaluate the impact of eLearning by allied health professionals on improving the knowledge and confidence to manage people with medically unexplained chronic fatigue states (FS). Methods: Using a parallel randomized controlled trial design, participants were randomized 1:1 to a 4-week eLearning or wait-list control group. Knowledge and self-reported confidence in clinical skills to implement a therapeutic intervention for patients with FS were assessed at baseline, post-intervention and follow-up. Secondary outcomes (adherence and satisfaction with online education, knowledge retention) were also assessed. Data was analyzed using intention-to-treat. Results: There were 239 participants were randomized (eLearning n = 119, control …

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Spontaneous Collapse As A Prognostic Marker For Human Blastocysts: A Systematic Review And Meta-Analysis, Kate Bickendorf, Fang Qi, Kelli Peirce, Jay Natalwala, Vincent Chapple, Yanhe Liu Oct 2023

Spontaneous Collapse As A Prognostic Marker For Human Blastocysts: A Systematic Review And Meta-Analysis, Kate Bickendorf, Fang Qi, Kelli Peirce, Jay Natalwala, Vincent Chapple, Yanhe Liu

Research outputs 2022 to 2026

STUDY QUESTION: Is spontaneous collapse (SC) by human blastocysts a prognostic factor in IVF treatment? SUMMARY ANSWER: SC in human blastocyst is associated with reduced euploid embryo and pregnancy rates. WHAT IS KNOWN ALREADY: SC of the human blastocyst is a phenomenon that was revealed relatively recently following the clinical application of time-lapse monitoring in IVF laboratories. The ploidy and clinical prognosis of affected blastocysts are still poorly understood, with inconsistent reports. Systematic reviews and meta-analyses on this topic are currently absent in the literature but its potential as a marker of embryo viability holds great clinical value. In this …

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“I Believe…” - Graduating Midwifery Students’ Midwifery Philosophies And Intentions For Their Graduate Year: A Longitudinal Descriptive Study, Kate Dawson, Heather Wallace, Sara Bayes Oct 2023

“I Believe…” - Graduating Midwifery Students’ Midwifery Philosophies And Intentions For Their Graduate Year: A Longitudinal Descriptive Study, Kate Dawson, Heather Wallace, Sara Bayes

Research outputs 2022 to 2026

Objective: Midwifery graduates may experience transition shock that makes them question their fit for their workplace and the profession and in extreme cases, may lead to them leaving. Understanding graduate midwives’ worldviews, job intentions and work experiences is important to inform retention strategies. Factors such as having a strong professional identity and experiencing strong job satisfaction are important for midwife retention. Conversely, stress, trauma and work-life imbalances are examples of factors that lead to attrition from midwifery. Transition shock experienced by some graduates can exacerbate these factors if not managed effectively. This study aimed to identify causes and impact of …

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Nurses’ Perceptions Of Using Volunteer Support In Health Care Settings: A Systematic Scoping Review, Kate Crookes, Rosemary Saunders, Vivien Kemp, Olivia Gallagher, Manonita Ghosh, Caroline Bulsara, Karen Gullick, Bev O'Connell Sep 2023

Nurses’ Perceptions Of Using Volunteer Support In Health Care Settings: A Systematic Scoping Review, Kate Crookes, Rosemary Saunders, Vivien Kemp, Olivia Gallagher, Manonita Ghosh, Caroline Bulsara, Karen Gullick, Bev O'Connell

Research outputs 2022 to 2026

Aims: To understand nurses’ perceptions of volunteer support in health care settings. Background: Increasingly, volunteers provide specialised support to health care service users, requiring volunteers and nurses to work closely together. However, little is known about nurses’ perceptions of volunteer support. Methods: A scoping review was conducted following the PRISMA-ScR checklist. A mixed-methods convergent integrative approach was taken guided by the JBI framework. Quantitative data were transformed into qualitative data for synthesis and descriptive thematic analysis. Six databases were searched (CINHAL+, EMBASE, PubMed, Scopus, PsycInfo, ProQuest Health and Medical Collection) on 24 January 2022 using terms related to nurses, perceptions, …

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Protocol For Isolating Human Bcam-Positive Corneal Progenitor Cells By Flow Cytometry And Cell Sorting, Yuzuru Sasamoto, Philip C. Yeung, Johnathan Tran, Markus H. Frank, Natasha Y. Frank Sep 2023

Protocol For Isolating Human Bcam-Positive Corneal Progenitor Cells By Flow Cytometry And Cell Sorting, Yuzuru Sasamoto, Philip C. Yeung, Johnathan Tran, Markus H. Frank, Natasha Y. Frank

Research outputs 2022 to 2026

BCAM-positive basal limbal epithelial cells are an early transit-amplifying cell population (TAC) capable of holoclone formation and corneal epithelial differentiation. Here, we present a protocol for isolating BCAM-positive cells from human donor corneas by flow cytometry and cell sorting. We describe steps for cell dissection and dissociation, antibody staining, and flow cytometry. We then detail procedures for culturing the purified BCAM-positive and BCAM-negative cells for holoclone and cell sheet formation assays to study the factors that regulate corneal regeneration. For complete details on the use and execution of this protocol, please refer to Sasamoto et al.1

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Velocity-Based Training—A Critical Review, Stuart Guppy, Kristina Kendall, G. Gregory Haff Sep 2023

Velocity-Based Training—A Critical Review, Stuart Guppy, Kristina Kendall, G. Gregory Haff

Research outputs 2022 to 2026

Velocity-based training (VBT) is an increasingly popular programming strategy used by strength and conditioning professionals to develop their athlete's ability to express force rapidly. To implement the varying forms of VBT effectively within their training regimes, strength and conditioning professionals need to understand the strengths and weaknesses of strategies, such as predicting 1 repetition maximum using the load-velocity profile, modulating training loads using the load-velocity profile, and controlling training volume using the magnitude of velocity-loss. The aim of this review was to highlight these strengths and weaknesses and then provide practical examples of when each programming strategy may be most …

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Mapping Between Cognitive Theories And Psycho-Physiological Models Of Attention System Performance, Oliver A. Guidetti, Craig P. Speelman, Peter Bouhlas Sep 2023

Mapping Between Cognitive Theories And Psycho-Physiological Models Of Attention System Performance, Oliver A. Guidetti, Craig P. Speelman, Peter Bouhlas

Research outputs 2022 to 2026

Declines in the capacity to sustain attention to repetitive, monotonous tasks is a phenomenon known as vigilance decrement (Endsley M, Kiris E. The out-of-the-loop performance problem and level of control in automation. 1995. Hum Factors. 37:32-64). This review compares cognitive theories with psycho-physiological models of vigilance decrement, and a gap is identified in mapping between the 2. That is, theories of vigilance decrement refer to "cognitive" resources; by contrast, psychophysiological models of the cerebral systems associated with attention explain performance functions according to neurochemical resources. A map does not currently exist in the literature that bridges the gap between cognitive …

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A Socioecological Description Of The Influencing Factors To Midwives’ Management Of Preeclampsia In A Ghanaian Tertiary Hospital, Isabella Garti, Michelle Gray, Angela Bromley, Benjamin Tan Sep 2023

A Socioecological Description Of The Influencing Factors To Midwives’ Management Of Preeclampsia In A Ghanaian Tertiary Hospital, Isabella Garti, Michelle Gray, Angela Bromley, Benjamin Tan

Research outputs 2022 to 2026

Introduction: In low-resource settings, midwives are the first contact for women with preeclampsia and lead the coordination of care. Unfavourable preeclampsia outcomes create a burden for women, families, and the health system. It is therefore important to understand the unique context of midwives’ practice and the complex factors that influence the delivery of maternal healthcare. Aim: This qualitative study explored the perspectives of key stakeholders in a tertiary hospital in Ghana regarding the facilitators and barriers influencing midwives’ provision of preeclampsia care using a socioecological model. Methods: Semi-structured interviews were conducted with 42 participants comprising senior managers (n = 7) …

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The Predictive Validity Of Individualised Load–Velocity Relationships For Predicting 1rm: A Systematic Review And Individual Participant Data Meta-Analysis, Leon Greig, Rodrigo R. Aspe, Andy Hall, Paul Comfort, Kay Cooper, Paul A. Swinton Sep 2023

The Predictive Validity Of Individualised Load–Velocity Relationships For Predicting 1rm: A Systematic Review And Individual Participant Data Meta-Analysis, Leon Greig, Rodrigo R. Aspe, Andy Hall, Paul Comfort, Kay Cooper, Paul A. Swinton

Research outputs 2022 to 2026

Background: Load–velocity relationships are commonly used to estimate one-repetition maximums (1RMs). Proponents suggest these estimates can be obtained at high frequencies and assist with manipulating loads according to session-by-session fluctuations. Given their increasing popularity and development of associated technologies, a range of load–velocity approaches have been investigated. Objective: This systematic review and individual participant data (IPD) meta-analysis sought to quantify the predictive validity of individualised load–velocity relationships for the purposes of 1RM prediction. Methods: In September 2022, a search of MEDLINE, SPORTDiscus, Web of Science and Scopus was conducted for published research, with Google Scholar, CORE and British Ethos also …

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Electric Field Navigated 1-Hz Rtms For Poststroke Motor Recovery: The E-Fit Randomized Controlled Trial, Dylan J. Edwards, Charles Liu, Kari Dunning, Felipe Fregni, Jarmo Laine, Benjamin E. Leiby, Lynn M. Rogers, Richard L. Harvey Sep 2023

Electric Field Navigated 1-Hz Rtms For Poststroke Motor Recovery: The E-Fit Randomized Controlled Trial, Dylan J. Edwards, Charles Liu, Kari Dunning, Felipe Fregni, Jarmo Laine, Benjamin E. Leiby, Lynn M. Rogers, Richard L. Harvey

Research outputs 2022 to 2026

BACKGROUND: To determine if low-frequency repetitive transcranial magnetic stimulation targeting the primary motor cortex contralateral (M1CL) to the affected corticospinal tract in patients with hemiparetic stroke augments intensive training-related clinical improvement; an extension of the NICHE trial (Navigated Inhibitory rTMS to Contralesional Hemisphere Trial) using an alternative sham coil. METHODS: The present E-FIT trial (Electric Field Navigated 1Hz rTMS for Post-stroke Motor Recovery Trial) included 5 of 12 NICHE trial outpatient US rehabilitation centers. The stimulation protocol remained identical (1 Hz repetitive transcranial magnetic stimulation, M1CL, preceding 60-minute therapy, 18 sessions/6 wks; parallel arm randomized clinical trial). The sham coil …

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Hla Class I Associations With The Severity Of Covid-19 Disease In The United Arab Emirates, Guan K. Tay, Halima Alnaqbi, Sarah Chehadeh, Braulio Peramo, Farah Mustafa, Tahir A. Rizvi, Bassam H. Mahboub, Maimunah Uddin, Nawal Alkaabi, Eman Alefishat, Herbert F. Jelinek, Habiba Alsafar Sep 2023

Hla Class I Associations With The Severity Of Covid-19 Disease In The United Arab Emirates, Guan K. Tay, Halima Alnaqbi, Sarah Chehadeh, Braulio Peramo, Farah Mustafa, Tahir A. Rizvi, Bassam H. Mahboub, Maimunah Uddin, Nawal Alkaabi, Eman Alefishat, Herbert F. Jelinek, Habiba Alsafar

Research outputs 2022 to 2026

SARS-CoV-2 appears to induce diverse innate and adaptive immune responses, resulting in different clinical manifestations of COVID-19. Due to their function in presenting viral peptides and initiating the adaptive immune response, certain Human Leucocyte Antigen (HLA) alleles may influence the susceptibility to severe SARS-CoV-2 infection. In this study, 92 COVID-19 patients from 15 different nationalities, with mild (n = 30), moderate (n = 35), and severe (n = 27) SARS-CoV-2 infection, living in the United Arab Emirates (UAE) were genotyped for the Class I HLA -A, -C, and -B alleles using next-generation sequencing (NGS) between the period of May 2020 …

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Artificial Intelligence In Cardiology: An Australian Perspective, Biyanka Jaltotage, Abdul R. Ihdayhid, Nick S. R. Lan, Faraz Pathan, Sanjay Patel, Clare Arnott, Gemma Figtree, Leonard Kritharides, Syed M. S. Islam, Clara K. Chow, James M. Rankin, Stephen J. Nicholls, Girish Dwivedi Aug 2023

Artificial Intelligence In Cardiology: An Australian Perspective, Biyanka Jaltotage, Abdul R. Ihdayhid, Nick S. R. Lan, Faraz Pathan, Sanjay Patel, Clare Arnott, Gemma Figtree, Leonard Kritharides, Syed M. S. Islam, Clara K. Chow, James M. Rankin, Stephen J. Nicholls, Girish Dwivedi

Research outputs 2022 to 2026

Significant advances have been made in artificial intelligence technology in recent years. Many health care applications have been investigated to assist clinicians and the technology is close to being integrated into routine clinical practice. The high prevalence of cardiac disease in Australia places overwhelming demands on the existing health care system, challenging its capacity to provide quality patient care. Artificial intelligence has emerged as a promising solution. This discussion paper provides an Australian perspective on the current state of artificial intelligence in cardiology, including the benefits and challenges of implementation. This paper highlights some current artificial intelligence applications in cardiology, …

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Performance Of Urinary Phenyl-Γ-Valerolactones As Biomarkers Of Dietary Flavan-3-Ol Exposure, Benjamin H. Parmenter, Sujata Shinde, Kevin Croft, Kevin Murray, Catherine P. Bondonno, Angela Genoni, Claus T. Christophersen, Keren Bindon, Colin Kay, Pedro Mena, Daniele Del Rio, Jonathan M. Hodgson, Nicola P. Bondonno Aug 2023

Performance Of Urinary Phenyl-Γ-Valerolactones As Biomarkers Of Dietary Flavan-3-Ol Exposure, Benjamin H. Parmenter, Sujata Shinde, Kevin Croft, Kevin Murray, Catherine P. Bondonno, Angela Genoni, Claus T. Christophersen, Keren Bindon, Colin Kay, Pedro Mena, Daniele Del Rio, Jonathan M. Hodgson, Nicola P. Bondonno

Research outputs 2022 to 2026

Background: Phenyl- -valerolactones (PVLs) have been identified as biomarkers of dietary flavan-3-ol exposure, although their utility requires further characterization. Objectives: We investigated the performance of a range of PVLs as biomarkers indicative of flavan-3-ol intake. Methods: We report the results of 2 companion studies: a 5-way randomized crossover trial (RCT) and an observational cross-sectional study. In the RCT (World Health Organization, Universal Trial Number: U1111-1236-7988), 16 healthy participants consumed flavan-3-ol–rich interventions (of apple, cocoa, black tea, green tea, or water [control]) for 1 d each. First morning void samples and 24-h urine samples were collected with diet standardized throughout. For …

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Abdominal Aortic Calcification, Bone Mineral Density And Fractures: A Systematic Review And Meta-Analysis Of Observational Studies, Abadi K. Gebre, Joshua R. Lewis, Kevin Leow, Pawel Szulc, David Scott, Peter R. Ebeling, Marc Sim, Germaine Wong, Wai H. Lim, John T. Schousboe, Douglas P. Kiel, Richard L. Prince, Alexander J. Rodriguez Aug 2023

Abdominal Aortic Calcification, Bone Mineral Density And Fractures: A Systematic Review And Meta-Analysis Of Observational Studies, Abadi K. Gebre, Joshua R. Lewis, Kevin Leow, Pawel Szulc, David Scott, Peter R. Ebeling, Marc Sim, Germaine Wong, Wai H. Lim, John T. Schousboe, Douglas P. Kiel, Richard L. Prince, Alexander J. Rodriguez

Research outputs 2022 to 2026

Background: Abdominal aortic calcification (AAC) has been inconsistently associated with skeletal health. We aimed to investigate the association of AAC with bone mineral density (BMD) and fracture risk by pooling the findings of observational studies. Methods: MEDLINE, EMBASE, Web of Science, and Google Scholar were searched (August 2021). All clinical studies that assessed the association between AAC and BMD or fracture were included. AAC was categorized into any/advanced (all higher reported groups) versus no/less advanced (lowest reported group). Pooled standardized mean differences (SMDs) and risk ratios (RRs) with 95% confidence intervals (CI) were determined for BMD and fracture, respectively, using …

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First-Line, Fixed-Duration Nivolumab Plus Ipilimumab Followed By Nivolumab In Clinically Diverse Patient Populations With Unresectable Stage Iii Or Iv Melanoma: Checkmate 401, Reinhard Dummer, Pippa Corrie, Ralf Gutzmer, Tarek M. Meniawy, Michele Del Vecchio, Céleste Lebbé, Michele Guida, Caroline Dutriaux, Brigitte Dreno, Nicolas Meyer, Pier F. Ferrucci, Stéphane Dalle, Muhammad A. Khattak, Jean-Jacques Grob, Karen Briscoe, James Larkin, Sandrine Mansard, Thierry Lesimple, Massimo Guidoboni, Silvia Sabatini, Erika Richtig, Rudolf Herbst, Maurice Lobo, Margarita Askelson, Paolo A. Ascierto, Michele Maio Aug 2023

First-Line, Fixed-Duration Nivolumab Plus Ipilimumab Followed By Nivolumab In Clinically Diverse Patient Populations With Unresectable Stage Iii Or Iv Melanoma: Checkmate 401, Reinhard Dummer, Pippa Corrie, Ralf Gutzmer, Tarek M. Meniawy, Michele Del Vecchio, Céleste Lebbé, Michele Guida, Caroline Dutriaux, Brigitte Dreno, Nicolas Meyer, Pier F. Ferrucci, Stéphane Dalle, Muhammad A. Khattak, Jean-Jacques Grob, Karen Briscoe, James Larkin, Sandrine Mansard, Thierry Lesimple, Massimo Guidoboni, Silvia Sabatini, Erika Richtig, Rudolf Herbst, Maurice Lobo, Margarita Askelson, Paolo A. Ascierto, Michele Maio

Research outputs 2022 to 2026

PURPOSE: To address the paucity of data in patients with historically poor outcomes, we conducted the single-arm phase IIIb CheckMate 401 study to evaluate the safety and efficacy of nivolumab plus ipilimumab followed by nivolumab monotherapy in clinically diverse patient populations with advanced melanoma. METHODS: Treatment-naive patients with unresectable stage III-IV melanoma received nivolumab 1 mg/kg plus ipilimumab 3 mg/kg once every 3 weeks (four doses) followed by nivolumab 3 mg/kg (240 mg following a protocol amendment) once every 2 weeks for ≤ 24 months. The primary end point was the incidence of grade 3-5 select treatment-related adverse events (TRAEs). …

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Revolutionising Health Care: Exploring The Latest Advances In Medical Sciences, Gehendra Mahara, Cuihong Tian, Xiaojia Xu, Wei Wang Aug 2023

Revolutionising Health Care: Exploring The Latest Advances In Medical Sciences, Gehendra Mahara, Cuihong Tian, Xiaojia Xu, Wei Wang

Research outputs 2022 to 2026

Recent years have seen a revolution in the domain of medical science, with ground-breaking discoveries changing health care as we once knew it [1]. These advances have considerably improved disease diagnosis, treatment, and management, improving patient outcomes and quality of life [2–5]. . . .

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Lung Volume Reduction For Emphysema Using One-Way Endobronchial Valves: An Australian Cohort, Calvin Sidhu, Nicholas Wilsmore, Narinder Shargill, Kanishka Rangamuwa Aug 2023

Lung Volume Reduction For Emphysema Using One-Way Endobronchial Valves: An Australian Cohort, Calvin Sidhu, Nicholas Wilsmore, Narinder Shargill, Kanishka Rangamuwa

Research outputs 2022 to 2026

Emphysema can be associated with gas trapping and hyperinflation, which negatively impacts on quality of life, life expectancy, and functional capacity. Lung volume reduction (LVR) surgery can reduce gas trapping and improve mortality in select patients but carries a high risk of major complications. Bronchoscopic techniques for LVR using one-way endobronchial valves (EBV) have become an established efficacious alternative to surgery. A bi-center retrospective cohort study was conducted on patients with severe emphysema who underwent endoscopic lung volume reduction (ELVR) using Pulmonx Zephyr EBVs. Symptomatic patients with gas-trapping and hyperinflation on lung function testing were selected. Target-lobe selection was based …

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Nurses’ Education, Knowledge And Perceptions Of Peripheral Intravenous Catheter Management: A Web-Based, Cross-Sectional Survey, Debbie Massey, Marie Cooke, Gillian Ray-Barruel, Nicole Marsh, Amanda J. Ullman, Alison Craswell, Marianne Wallis Aug 2023

Nurses’ Education, Knowledge And Perceptions Of Peripheral Intravenous Catheter Management: A Web-Based, Cross-Sectional Survey, Debbie Massey, Marie Cooke, Gillian Ray-Barruel, Nicole Marsh, Amanda J. Ullman, Alison Craswell, Marianne Wallis

Research outputs 2022 to 2026

Background: Peripheral intravenous catheters (PIVCs) are the most used invasive medical device. Unfortunately, PIVCs fail for a variety of reasons and failure often results in serious adverse events leading to patient discomfort, infection, delays in treatment, increased healthcare costs, and even death. In Australia, qualified nurses assess, manage, and remove a PIVC as part of their clinical role. To date, no study has described the current state of knowledge and confidence (self-efficacy) about PIVCs from the perspectives of qualified nurses working in Australian hospital settings. Aims: To describe the current state of knowledge and confidence (self-efficacy) about PIVC management from …

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Positron Emission Tomography And Magnetic Resonance Imaging Methods And Datasets Within The Dominantly Inherited Alzheimer Network (Dian), Nicole S. Mckay, Brian A. Gordon, Russ C. Hornbeck, Aylin Dincer, Shaney Flores, Sarah J. Keefe, Nelly Joseph-Mathurin, Clifford R. Jack, Robert Koeppe, Peter R. Millar, Beau M. Ances, Charles D. Chen, Alisha Daniels, Diana A. Hobbs, Kelley Jackson, Deborah Koudelis, Parinaz Massoumzadeh, Austin Mccullough, Michael L. Nickels, Farzaneh Rahmani, Laura Swisher, Qing Wang, Ricardo F. Allegri, Sarah B. Berman, Adam M. Brickman, William S. Brooks, David M. Cash, Jasmeer P. Chhatwal, Gregory S. Day, Martin R. Farlow, Christian La Fougère, Nick C. Fox, Michael Fulham, Bernardino Ghetti, Neill Graff-Radford, Takeshi Ikeuchi, William Klunk, Jae-Hong Lee, Johannes Levin, Ralph Martins, Colin L. Masters, Jonathan Mcconathy, Hiroshi Mori, James M. Noble, Gerald Reischl, Christopher Rowe, Stephen Salloway, Raquel Sanchez-Valle, Peter R. Schofield, Hiroyuki Shimada, Mikio Shoji, Yi Su, Kazushi Suzuki, Jonathan Vöglein, Igor Yakushev, Carlos Cruchaga, Jason Hassenstab, Celeste Karch, Eric Mcdade, Richard J. Perrin, Chengjie Xiong, John C. Morris, Randall J. Bateman, Tammie L. S. Benzinger, Dominantly Inherited Alzheimer Network Aug 2023

Positron Emission Tomography And Magnetic Resonance Imaging Methods And Datasets Within The Dominantly Inherited Alzheimer Network (Dian), Nicole S. Mckay, Brian A. Gordon, Russ C. Hornbeck, Aylin Dincer, Shaney Flores, Sarah J. Keefe, Nelly Joseph-Mathurin, Clifford R. Jack, Robert Koeppe, Peter R. Millar, Beau M. Ances, Charles D. Chen, Alisha Daniels, Diana A. Hobbs, Kelley Jackson, Deborah Koudelis, Parinaz Massoumzadeh, Austin Mccullough, Michael L. Nickels, Farzaneh Rahmani, Laura Swisher, Qing Wang, Ricardo F. Allegri, Sarah B. Berman, Adam M. Brickman, William S. Brooks, David M. Cash, Jasmeer P. Chhatwal, Gregory S. Day, Martin R. Farlow, Christian La Fougère, Nick C. Fox, Michael Fulham, Bernardino Ghetti, Neill Graff-Radford, Takeshi Ikeuchi, William Klunk, Jae-Hong Lee, Johannes Levin, Ralph Martins, Colin L. Masters, Jonathan Mcconathy, Hiroshi Mori, James M. Noble, Gerald Reischl, Christopher Rowe, Stephen Salloway, Raquel Sanchez-Valle, Peter R. Schofield, Hiroyuki Shimada, Mikio Shoji, Yi Su, Kazushi Suzuki, Jonathan Vöglein, Igor Yakushev, Carlos Cruchaga, Jason Hassenstab, Celeste Karch, Eric Mcdade, Richard J. Perrin, Chengjie Xiong, John C. Morris, Randall J. Bateman, Tammie L. S. Benzinger, Dominantly Inherited Alzheimer Network

Research outputs 2022 to 2026

The Dominantly Inherited Alzheimer Network (DIAN) is an international collaboration studying autosomal dominant Alzheimer disease (ADAD). ADAD arises from mutations occurring in three genes. Offspring from ADAD families have a 50% chance of inheriting their familial mutation, so non-carrier siblings can be recruited for comparisons in case–control studies. The age of onset in ADAD is highly predictable within families, allowing researchers to estimate an individual’s point in the disease trajectory. These characteristics allow candidate AD biomarker measurements to be reliably mapped during the preclinical phase. Although ADAD represents a small proportion of AD cases, understanding neuroimaging-based changes that occur during …

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Exploring Assessment Policies For Clinical Practice: A Scoping Review Of The Literature, Lynda J. Hughes, Amy N. B. Johnston, Jacqueline H. Byrne, Debbie Massey Aug 2023

Exploring Assessment Policies For Clinical Practice: A Scoping Review Of The Literature, Lynda J. Hughes, Amy N. B. Johnston, Jacqueline H. Byrne, Debbie Massey

Research outputs 2022 to 2026

Background: Assessment of pre-registration nursing students in clinical practice is an essential process, ensuring students who graduate meet standards for practice and competently and safely care for patients under their care. However, such assessment remains challenging for individuals and organisations. Aim: We aimed to investigate what is known about the application of clinical placement assessment policies guiding pre-registration nursing programmes. Methods: Arskey and O'Malley’s five-stage method for scoping reviews was employed. Health and education databases were searched in July 2020 and December 2021. Identified papers were screened. The Joanna Briggs Institute's critical appraisal tools were used to appraise the quality …

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Proposed Quality Indicators And Recommended Standard Reporting Items In Performance Of Ebus Bronchoscopy: An Official World Association For Bronchology And Interventional Pulmonology Expert Panel Consensus Statement, Daniel P. Steinfort, Matthew Evison, Ashleigh Witt, Georgios Tsaknis, Fayez Kheir, David Manners, Karan Madan, Calvin Sidhu, Alberto Fantin, Daniel A. Korevaar, Erik H. F. M. Van Der Heijden, The Wabip Taskforce On Quality Indicators In Ebus Bronchoscopy Aug 2023

Proposed Quality Indicators And Recommended Standard Reporting Items In Performance Of Ebus Bronchoscopy: An Official World Association For Bronchology And Interventional Pulmonology Expert Panel Consensus Statement, Daniel P. Steinfort, Matthew Evison, Ashleigh Witt, Georgios Tsaknis, Fayez Kheir, David Manners, Karan Madan, Calvin Sidhu, Alberto Fantin, Daniel A. Korevaar, Erik H. F. M. Van Der Heijden, The Wabip Taskforce On Quality Indicators In Ebus Bronchoscopy

Research outputs 2022 to 2026

Background: Since their introduction, both linear and radial endobronchial ultrasound (EBUS) have become an integral component of the practice of Pulmonology and Thoracic Oncology. The quality of health care can be measured by comparing the performance of an individual or a health service with an ideal threshold or benchmark. The taskforce sought to evaluate quality indicators in EBUS bronchoscopy based on clinical relevance/importance and on the basis that observed significant variation in outcomes indicates potential for improvement in health care outcomes. Methods: A comprehensive literature review informed the composition of a comprehensive list of candidate quality indicators in EBUS. A …

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Interactions Between Mediterranean Diet Supplemented With Dairy Foods And The Gut Microbiota Influence Cardiovascular Health In An Australian Population, Jocelyn M. Choo, Karen J. Murphy, Alexandra T. Wade, Yanan Wang, Ella L. Bracci, Courtney R. Davis, Kathryn A. Dyer, Richard J. Woodman, Jonathan M. Hodgson, Geraint B. Rogers Aug 2023

Interactions Between Mediterranean Diet Supplemented With Dairy Foods And The Gut Microbiota Influence Cardiovascular Health In An Australian Population, Jocelyn M. Choo, Karen J. Murphy, Alexandra T. Wade, Yanan Wang, Ella L. Bracci, Courtney R. Davis, Kathryn A. Dyer, Richard J. Woodman, Jonathan M. Hodgson, Geraint B. Rogers

Research outputs 2022 to 2026

The impact of a Mediterranean diet on the intestinal microbiome has been linked to its health benefits. We aim to evaluate the effects of a Mediterranean diet supplemented with dairy foods on the gut microbiome in Australians at risk of cardiovascular disease. In a randomised controlled cross-over study, 34 adults with a systolic blood pressure ≥120 mmHg and with risk factors for cardiovascular disease were randomly allocated to a Mediterranean diet with 3–4 daily serves of dairy foods (Australian recommended daily intake (RDI) of 1000–1300 mg per day (MedDairy)) or a low-fat (LFD) control diet. Between each 8-week diet, participants …

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Cerebrospinal Fluid Proteomics Define The Natural History Of Autosomal Dominant Alzheimer’S Disease, Erik C. B. Johnson, Shijia Bian, Rafi U. Haque, E. Kathleen Carter, Caroline M. Watson, Brian A. Gordon, Lingyan Ping, Duc M. Duong, Michael P. Epstein, Eric Mcdade, Nicolas R. Barthélemy, Celeste M. Karch, Chengjie Xiong, Carlos Cruchaga, Richard J. Perrin, Aliza P. Wingo, Thomas S. Wingo, Jasmeer P. Chhatwal, Gregory S. Day, James M. Noble, Sarah B. Berman, Ralph Martins, Neill R. Graff-Radford, Peter R. Schofield, Takeshi Ikeuchi, Hiroshi Mori, Johannes Levin, Martin Farlow, James J. Lah, Christian Haass, Mathias Jucker, John C. Morris, Tammie L. S. Benzinger, Blaine R. Roberts, Randall J. Bateman, Anne M. Fagan, Nicholas T. Seyfried, Allan I. Levey, Dominantly Inherited Alzheimer Network Aug 2023

Cerebrospinal Fluid Proteomics Define The Natural History Of Autosomal Dominant Alzheimer’S Disease, Erik C. B. Johnson, Shijia Bian, Rafi U. Haque, E. Kathleen Carter, Caroline M. Watson, Brian A. Gordon, Lingyan Ping, Duc M. Duong, Michael P. Epstein, Eric Mcdade, Nicolas R. Barthélemy, Celeste M. Karch, Chengjie Xiong, Carlos Cruchaga, Richard J. Perrin, Aliza P. Wingo, Thomas S. Wingo, Jasmeer P. Chhatwal, Gregory S. Day, James M. Noble, Sarah B. Berman, Ralph Martins, Neill R. Graff-Radford, Peter R. Schofield, Takeshi Ikeuchi, Hiroshi Mori, Johannes Levin, Martin Farlow, James J. Lah, Christian Haass, Mathias Jucker, John C. Morris, Tammie L. S. Benzinger, Blaine R. Roberts, Randall J. Bateman, Anne M. Fagan, Nicholas T. Seyfried, Allan I. Levey, Dominantly Inherited Alzheimer Network

Research outputs 2022 to 2026

Alzheimer’s disease (AD) pathology develops many years before the onset of cognitive symptoms. Two pathological processes—aggregation of the amyloid- (A ) peptide into plaques and the microtubule protein tau into neurofibrillary tangles (NFTs)—are hallmarks of the disease. However, other pathological brain processes are thought to be key disease mediators of A plaque and NFT pathology. How these additional pathologies evolve over the course of the disease is currently unknown. Here we show that proteomic measurements in autosomal dominant AD cerebrospinal fluid (CSF) linked to brain protein coexpression can be used to characterize the evolution of AD pathology over a timescale …

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Does Gender And Cultural Diversity Matter For Sustainability In Healthcare? Evidence From Global Organizations, Kylie De Klerk, Favil Singh Aug 2023

Does Gender And Cultural Diversity Matter For Sustainability In Healthcare? Evidence From Global Organizations, Kylie De Klerk, Favil Singh

Research outputs 2022 to 2026

Global healthcare organizations are fundamental in addressing the healthcare needs of local and global communities. This highly regulated sector means it is under constant scrutiny for health, safety, and ethical compliance risks by federal regulatory bodies. Despite higher monitoring, an increasing number of healthcare companies receive fines for their irresponsible practices, manifesting significant questions about their corporate governance and sustainability practices. Against this backdrop, this study examines the relationship between boardroom diversity on the sustainability performance of companies operating in healthcare. Utilizing a global sample of publicly listed healthcare companies, using panel regression data and the system-GMM estimator accounting for …

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Contrast Detection Is Enhanced By Deterministic, High-Frequency Transcranial Alternating Current Stimulation With Triangle And Sine Waveform, Weronika Potok, Onno Van Der Groen, Sahana Sivachelvam, Marc Bächinger, Flavio Fröhlich, Laszlo B. Kish, Nicole Wenderoth Aug 2023

Contrast Detection Is Enhanced By Deterministic, High-Frequency Transcranial Alternating Current Stimulation With Triangle And Sine Waveform, Weronika Potok, Onno Van Der Groen, Sahana Sivachelvam, Marc Bächinger, Flavio Fröhlich, Laszlo B. Kish, Nicole Wenderoth

Research outputs 2022 to 2026

Stochastic resonance (SR) describes a phenomenon where an additive noise (stochastic carrier-wave) enhances the signal transmission in a nonlinear system. In the nervous system, nonlinear properties are present from the level of single ion channels all the way to perception and appear to support the emergence of SR. For example, SR has been repeatedly demonstrated for visual detection tasks, also by adding noise directly to cortical areas via transcranial random noise stimulation (tRNS). When dealing with nonlinear physical systems, it has been suggested that resonance can be induced not only by adding stochastic signals (i.e., noise) but also by adding …

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Sideffect Gameplan: Development Of An Alcohol And Other Drug Serious Game For High School Students Using A Systematic And Iterative User-Centred Game Development Framework, Joanna Nicholas, Brennen Mills, Sara Hansen, Stephen J. Bright, Joseph Scott, Imogen Ridout, Jess Watson, Heather Boyd, Luke Brook, Luke Hopper Aug 2023

Sideffect Gameplan: Development Of An Alcohol And Other Drug Serious Game For High School Students Using A Systematic And Iterative User-Centred Game Development Framework, Joanna Nicholas, Brennen Mills, Sara Hansen, Stephen J. Bright, Joseph Scott, Imogen Ridout, Jess Watson, Heather Boyd, Luke Brook, Luke Hopper

Research outputs 2022 to 2026

Serious games have shown to be effective in improving motivation to learn, knowledge and retention, thus are being increasingly used for alcohol and other drug (AOD) education. This paper outlines the development of an online AOD serious game for in-class use by Australian secondary school teachers for students in Years 9–10. Adapted from Edwards et al. (2018), the seven-step systematic and iterative user-centred development framework included: (1) Forming an expert multidisciplinary design team, (2) Defining the problem and establishing user preferences, (3) Incorporating the evidence base, (4) Serious game design, (5) Incorporating behavioural and psychological theory, (6) Developing a logic …

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Sleep Health Of Young Adults In Western Australia And Associations With Physical And Mental Health: A Population-Level Cross-Sectional Study, Alexandra P. Metse, Peter Eastwood, Melissa Ree, Adrian Lopresti, Joseph J. Scott, Jenny Bowman Aug 2023

Sleep Health Of Young Adults In Western Australia And Associations With Physical And Mental Health: A Population-Level Cross-Sectional Study, Alexandra P. Metse, Peter Eastwood, Melissa Ree, Adrian Lopresti, Joseph J. Scott, Jenny Bowman

Research outputs 2022 to 2026

OBJECTIVES: This article aims to report on the sleep health characteristics of a population-level sample of young Australian adults and examine associations with measures of physical and mental health. METHODS: A cross-sectional study using data from the Raine Study. Data from participants (n = 1234) born into the study (Generation 2) at the 22-year follow-up were used, including data from a self-report questionnaire and polysomnography. RESULTS: The highest prevalence of suboptimal sleep health was seen on measures of sleep duration (30%), onset latency (18%), satisfaction (25%) and regularity (60%). Dissatisfaction with sleep (physical health: =0.08; mental health: =0.34) and impaired …

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Prevalence, Knowledge, And Lifestyle-Associated Risk Factors Of Dyslipidemia Among Ghanaian Type-2 Diabetes Mellitus Patients In Rural And Urban Areas: A Multicenter Cross-Sectional Study, Wina I.O. Boadu, Enoch O. Anto, Joseph Frimpong, Felix Ntiful, Emmanuel E. Korsah, Ezekiel Ansah, Valentine C.K.T. Tamakloe, Afia Agyapomaa, Stephen Opoku, Ebenezer Senu, Michael Nyantakyi, Albright Etwi-Mensah, Emmanuel Acheampong, Kwame O. Boadu, Emmanuel Timmy Donkoh, Christian Obirikorang Aug 2023

Prevalence, Knowledge, And Lifestyle-Associated Risk Factors Of Dyslipidemia Among Ghanaian Type-2 Diabetes Mellitus Patients In Rural And Urban Areas: A Multicenter Cross-Sectional Study, Wina I.O. Boadu, Enoch O. Anto, Joseph Frimpong, Felix Ntiful, Emmanuel E. Korsah, Ezekiel Ansah, Valentine C.K.T. Tamakloe, Afia Agyapomaa, Stephen Opoku, Ebenezer Senu, Michael Nyantakyi, Albright Etwi-Mensah, Emmanuel Acheampong, Kwame O. Boadu, Emmanuel Timmy Donkoh, Christian Obirikorang

Research outputs 2022 to 2026

Background and Aims: Dyslipidemia in diabetes mellitus has been linked to unhealthy lifestyle and bad eating habits. However, this association has not been well studied among rural and urban Ghanaian populations. In this study, we determined the prevalence, knowledge, and lifestyle-associated risk factors of dyslipidemia among Ghanaian type-2 diabetes mellitus (T2DM) patients in rural and urban areas. Methods: This comparative multicentre-cross-sectional study recruited 228 T2DM outpatients attending the St. Michael Hospital, Pramso (rural) and Kumasi South Regional Hospital (urban), Ghana for routine check-ups. Self-structured questionnaire was used to collect sociodemographic, knowledge, and lifestyle characteristics. Fasting blood samples were taken to …

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