Medicine and Health Sciences Commons^™

The Caregiving Role Influences Suboptimal Health Status And Psychological Symptoms In Unpaid Carers, Monique Garcia, Zheng Guo, Yulu Zheng, Zhiyuan Wu, Ethan Visser, Lois Balmer, Wei Wang

Research outputs 2022 to 2026

Background: Suboptimal Health Status (SHS) is the physical state between health and disease. This study aimed to fill in the knowledge gap by investigating the prevalence of SHS and psychological symptoms among unpaid carers and to identify SHS-risk factors from the perspective of predictive, preventive and personalised medicine (PPPM). Methods: A cross-sectional study was conducted among 368 participants who were enrolled from Australia, including 203 unpaid carers as cases and 165 individuals from the general population as controls. SHS scores were measured using SHSQ-25 (Suboptimal Health Status Questionnaire-25), whilst psychological symptoms were measured by DASS-21 (Depression, Anxiety and Stress Scale-21). …

The Influence Of Culture On The Health Beliefs And Health Behaviours Of Older Vietnam-Born Australians Living With Chronic Disease, Thi Ngoc Minh Nguyen, Rosemary Saunders, Gordana Dermody, Lisa Whitehead

Research outputs 2022 to 2026

Aim: To explore the health beliefs and health behaviours of older Vietnam-born people living with chronic disease in Western Australia. Design: This study was designed as a focused ethnography guided by the interpretative research paradigm and Leininger's Theory of Culture Care. Methods: Data were collected through participant observation and interviews undertaken at participants' homes in Western Australia over 7 months in 2019. Data were analysed using Wolcott's approach for transferring qualitative data, comprising three phases: description, thematic analysis and interpretation. Results: This study included 12 participants. The health perspectives and practices of older Vietnam-born Australians significantly reflected the traditional Vietnamese …

Utilisation Of Simulation-Based Learning To Decrease Student Anxiety And Increase Readiness For Clinical Placements For Speech-Language Pathology Students, Teresa Petrich, Brennen Mills, Abigail Lewis, Sara Hansen, Emily Brogan, Natalie Ciccone

Research outputs 2022 to 2026

Purpose: To investigate the use of two versions of a simulation-based learning experience (SBLE) to decrease speech-language pathology (SLP) students’ anxiety and increase their confidence and sense of preparedness for clinical placements. Method: Two cohorts of third-year SLP students (n = 33) participated in a mixed-methods study with each cohort completing one version of the SBLE. Participants completed pre- and post-program quantitative ratings of anxiety, confidence, and preparedness for clinical placements and participated in focus groups. Three clinical educators also provided qualitative data in debriefs and interviews. Result: Significant decreases in student ratings of anxiety, and increases in confidence and …

Using Image-Reflections To Support Undergraduate Students’ Relational Employability: A Practitioner Reflection, Ruth M. Wallace, Sally-Anne Doherty, Elizabeth Cook

Research outputs 2022 to 2026

This practitioner reflection explores our integration of the Relational Employability Framework within the Health Research Project capstone unit of a Bachelor of Health Science degree. To address the historically low quality of student reflections, we incorporated image-based reflective activities to improve engagement and depth. These activities encouraged students to use visual media to examine their developing relational employability. We developed and implemented a series of tutorial activities designed to scaffold this process, aiming to foster deeper reflective practice and highlight its importance for career development and employability. Our reflections indicate that, while grades did not significantly increase, students showed enhanced …

Alzheimer's Disease Genetic Risk And Changes In Brain Atrophy And White Matter Hyperintensities In Cognitively Unimpaired Adults, Anja Soldan, Jiangxia Wang, Corinne Pettigrew, Christos Davatzikos, Guray Erus, Timothy J. Hohman, Logan Dumitrescu, Murat Bilgel, Susan M. Resnick, Leonardo A. Rivera-Rivera, Rebecca Langhough, Sterling C. Johnson, Tammie Benzinger, John C. Morris, Simon M. Laws, Jurgen Fripp, Colin L. Masters, Marilyn S. Albert

Research outputs 2022 to 2026

Reduced brain volumes and more prominent white matter hyperintensities on MRI scans are commonly observed among older adults without cognitive impairment. However, it remains unclear whether rates of change in these measures among cognitively normal adults differ as a function of genetic risk for late-onset Alzheimer's disease, including APOE- ε4, APOE-ε2 and Alzheimer's disease polygenic risk scores (AD-PRS), and whether these relationships are influenced by other variables. This longitudinal study examined the trajectories of regional brain volumes and white matter hyperintensities in relationship to APOE genotypes (N = 1541) and AD-PRS (N = 1093) in a harmonized dataset of middle-aged …

Envisaging A Thriving Future: The Integration Of Positive Psychology Into Brief Psychotherapy And Family Therapy Practice, Richard Lakeman

Research outputs 2022 to 2026

This paper delves into the pragmatic integration of positive psychology, particularly Seligman's PERMA model, and brief psychotherapy to foster a vision of a thriving future for clients. Despite the entrenched tribalism within psychotherapy that often resists the incorporation of new techniques, a deliberate and flexible approach to integration, rooted in congruence with theoretical frameworks, can overcome these barriers. Positive psychology dovetails neatly with the goals of family therapy by highlighting strengths and resilience. The PERMA model—encompassing Positive emotions, Engagement, Relationships, Meaning and Accomplishment—captures the essence of a flourishing life. While primarily applied in non-clinical settings, its potential to enhance wellbeing …

Exploration Of Alzheimer's Disease-Related Gene Expression Following High-Intensity And Moderate-Intensity Exercise Interventions, Kieran J. Marston, Jaisalmer De Frutos-Lucas, Tenielle Porter, Lidija Milicic, Michael Vacher, Kelsey R. Sewell, Jeremiah J. Peiffer, Simon M. Laws, Belinda M. Brown

Research outputs 2022 to 2026

Objectives: There are currently 29 genome regions that demonstrate associations with Alzheimer's disease (AD) risk. Regular physical exercise can promote systemic change in gene expression and may modify the risk of cognitive decline and AD. This study is a secondary analysis of a randomised controlled trial and examines the effect of a six-month exercise intervention versus control on AD-related gene expression. Design: Single-site parallel pilot randomised controlled trial. Methods: 91 cognitively unimpaired older adults were enrolled in the Intense Physical Activity and Cognition (IPAC) study. Participants were randomised into one of three groups: high-intensity exercise, moderate-intensity exercise, or inactive control …

Exploring The Health Benefits Of Raw White Garlic Consumption In Humans: A Mini Review, Rebeka Fejes, Catherine P. Bondonno, Simone Radavelli-Bagatini, Tilman Kühn, Karl Heinz Wagner

Research outputs 2022 to 2026

Introduction: Raw white garlic, a fundamental food in both culinary and medicinal practices globally, has gained attention for its potential health benefits. Despite widespread use, clinical research has predominantly focused on aged black garlic or garlic extracts, leaving raw white garlic consumption in humans underexplored. This mini review aims to summarize the evidence from clinical and observational studies on the health effects of raw white garlic consumption. Methods: A search in PubMed and Scopus databases was conducted to identify clinical and observational studies on raw white garlic consumption. Twelve clinical trials and 10 observational studies meeting the predefined inclusion criteria …

How Does The Proportion Of Child-Specific Content Of Pre-Registration Nursing Programmes In Higher Education Institutions Impact Upon Newly Qualified Registered Nurses’ Perceptions Of Preparedness To Care For Children, Young People, And Their Families? A Narrative Review Protocol, Matthew C. Carey, Danielle Edge, Julie Blamires, Mandie Foster, Sarah Neill

Research outputs 2022 to 2026

This paper presents a narrative review protocol to explore how the proportion of child-specific content of pre-registration programmes in universities impact upon newly qualified nurses’ perceptions of preparedness to care for children, young people (CYP), and their families. The preparation and education to become a nurse who cares for children and young people differs from country to country. Providers of pre-registration nurse education offer routes into nursing from diploma to degree and in some countries post-graduate routes. The United Kingdom offers pre-registration programmes leading to qualifying as a children’s nurse whereas programmes in countries such as the USA and Canada …

Lessons Learned: Drive-Through Covid-19 Clinic Testing During An Adaptive Epidemic Response And A Point-Of-Care Test Assessment Of A Computer-Read Rapid Lateral Flow Immunoassay With Fluorescence-Based Detection, Leah Rankine-Wilson, Teresa Oncken, Irshan Basrewan, Courtney Jeffery, Todd M. Pryce, Rebecca Wake, Aus A.L. Molan, T. F. Paton, Tim J.J. Inglis

Research outputs 2022 to 2026

Background. The COVID-19 pandemic demonstrated a need for robust SARS-CoV-2 test evaluation infrastructure to underpin biosecurity and protect the population during a pandemic health emergency. Gap statement. The first generation of rapid antigen tests was less accurate than molecular methods due to their inherent sensitivity and specificity shortfalls, compounded by the consequences of self-testing. This created a need for more accurate point-of-care SARS-CoV-2 detection methods. Aim. Here we present the lessons-learned during the COVID-19 emergency response in Western Australia including the detailed set-up, evaluation and operation of rapid antigen test in a state-run drive-through sample collection service during the COVID-19 …

Out-Of-Hospital Birth Training, Experience And Confidence Of Australian Rural Volunteer Ambulance Officers, Michella G. Hill, Belinda Flanagan, Sara Hansen, Luke Hopper, Brennen Mills

Research outputs 2022 to 2026

Introduction: Unplanned out-of-hospital births represent less outs have a high risk of life-threatening complications, which are than 1% of ambulance requests for assistance. However, these call- particularly complex in rural or remote settings with limited accessibility to specialist care support. Many community hospitals Four themes emerged from analysis: (1) Lack of education and no longer provide obstetrics care, so birth parents must travel to exposure to birth resulted in low confidence. Most participants larger regional or metropolitan hospitals for assistance. Increased reported significant anxiety attending obstetric call-outs, and travel time may increase the risk of unplanned out-of-hospital explained under-utilisation of …

Prevalence Of Disordered Eating And Its Relationship With Rapid Weight Loss Amongst Male And Female Combat Sport Competitors: A Prospective Study, Colin S. Doherty, Lauren V. Fortington, Oliver R. Barley

Research outputs 2022 to 2026

Objectives:

To compare prevalence and change scores of disordered eating (DE) in combat sport athletes by sex and explore the potential relationship between rapid weight loss (RWL) and DE scores.

Design:

Prospective study based on 24 events (September 2022–2023).

Methods:

A body mass (BM) questionnaire was completed at ~ 1 day post-competition providing pre-competition BM data for − 7 days, − 24 h, and weigh-in. The Athletic Disordered Eating (ADE) online questionnaire was completed at ~ 7 and ~ 28 days post-competition, providing overall DE and four subscale scores (food and energy control, bingeing, body control, and body discontent).

Results: …

Self-Efficacy And Home Dialysis: An Integrative Review, Nicola A. D'Souza, Ma'en Zaid Abu-Qamar, Lisa Whitehead

Research outputs 2022 to 2026

Background: Enhancing patient confidence in their ability (self-efficacy) is vital to ensure people are equipped to maintain home dialysis protocols. Bandura's social cognitive theory provided a framework for understanding the role of self-efficacy in patients managing home dialysis. Objectives: To identify self-reported levels of self-efficacy, the measurements used to assess self-efficacy and the effectiveness of interventions to enhance self-efficacy in patients undergoing home dialysis. Design: An integrative review approach was employed using Whittemore and Knafl's methodology. Methods: A comprehensive search was conducted to identify literature on self-efficacy in patients managing home dialysis. Searches were conducted in CINAHL, MEDLINE, Embase and …

The Delta Concept Does Not Effectively Normalise Exercise Responses To Exhaustive Interval Training, Arthur Henrique Bossi, Wouter Timmerman, Diana Cole, Louis Passfield, James Hopker

Research outputs 2022 to 2026

Objectives: This study was designed to quantify inter- and intra-individual variability in performance, physiological, and perceptual responses to high-intensity interval training prescribed using the percentage of delta (%Δ) method, in which the gas exchange threshold and maximal oxygen uptake (V̇O2max) are taken into account to normalise relative exercise intensity. Design: Repeated-measures, within-subjects design with mixed-effects modelling. Methods: Eighteen male and four female cyclists (age: 36 ± 12 years, height: 178 ± 10 cm, body mass: 75.2 ± 13.7 kg, V̇O2max: 51.6 ± 5.3 ml·kg−1·min−1) undertook an incremental test to exhaustion to determine the gas exchange threshold and V̇O2max as prescription …

Associations Between Flavonoid Intake And Subclinical Atherosclerosis: The Mesa, Nicola P. Bondonno, Benjamin H. Parmenter, Kevin Murray, Catherine P. Bondonno, Lauren C. Blekkenhorst, Alexis C. Wood, Wendy S. Post, Matthew Allison, Michael H. Criqui, Joshua R. Lewis, Jonathan M. Hodgson

Research outputs 2022 to 2026

Background: Flavonoids may play a role in mitigating atherosclerotic cardiovascular diseases, with evidence suggesting effects may differ between vascular beds. Studies examining associations with subclinical markers of atherosclerosis between subpopulations with different underlying risks of atherosclerosis are lacking. METHODS: Among 5599 participants from the MESA (Multi-Ethnic Study of Atherosclerosis), associations between dietary flavonoid intakes (estimated from a food frequency questionnaire) and subclinical measures of atherosclerosis (ankle-brachial index, carotid plaques and intima-media thickness, and coronary artery calcification) were examined using repeated measures models. Exposures and outcomes were measured at exam 1 (2000-2002) and exam 5 (2010-2011). Stratified analyses and interaction terms …

Physical And Psychological Factors Related To Injury, Illness And Tactical Performance In Law Enforcement Recruits: A Systematic Review, Myles Murphy, Nicole Merrick, Gill Cowen, Vanessa Sutton, Garth Allen, Nicolas H. Hart, Andrea B. Mosler

Research outputs 2022 to 2026

Objective: There are inconsistent reports of factors relating to injury, illness and tactical performance in law enforcement recruits. Our objectives were to: (1) report physical and psychological risk factors and protective factors for injury and illness and (2) report physical and psychological risk factors and protective factors for tactical performance success. Design: Systematic epidemiological review.

Methods: Searches of six databases were conducted on 13 December 2022. We included cohorts that assessed physical and psychological factors for injury, illness and tactical performance success. Study quality was assessed using the Joanna Briggs Institute Quality Assessment Checklist for Prevalence Studies and certainty assessed …

White Lies And Safety Nets: The Perceptions Of Nurses On The Use Of Early Warning Systems And The Development Of Higher-Order Thinking Skills, Deb Massey, Tracy Flenady, Amy Louise Byrne, Justine Connor, Danielle Le Lagadec

Research outputs 2022 to 2026

Background: Algorithmic tools such as early warning systems (EWSs) have been embedded into clinical practice globally to facilitate the early recognition of patient deterioration and to guide the escalation of care. Concerns have been raised that the mandated use of these EWS tools may impact the development of nurses' higher-order thinking. However, the relationship between EWS tools and the development of higher-order thinking is poorly understood.

Objectives: This paper provides the qualitative results of a larger study that sought to explore the impact of EWS tools on the development of nurses' higher-order thinking. The objective of this component of the …

Preparing The Future Public Health Workforce: Fostering Global Citizenship Through The Relational Employability Framework - Insights From Two Case Studies, Elizabeth Cook, Sally-Anne Doherty, Ruth M. Wallace

Research outputs 2022 to 2026

A well-prepared public health workforce is essential for reducing disease burdens and improving population health, necessitating an education that addresses global and complex challenges. This paper explores the integration of the Relational Employability Framework in public health education as a tool to foster critical reflection and cultivate global citizenship among students and graduates. Global citizenship encompasses the social, political, environmental and economic actions of globally conscious individuals and communities, recognising that individuals operate within diverse local and global networks. Relational employability expands traditional notions of graduate employability, incorporating not only foundational career development and human interactions but also connections with …

A Flavonoid-Rich Diet Is Associated With Lower Risk And Improved Imaging Biomarkers Of Nonalcoholic Fatty Liver Disease: A Prospective Cohort Study, William Bell, Amy Jennings, Alysha S. Thompson, Nicola P. Bondonno, Anna Tresserra-Rimbau, Tilman Kühn, Aedín Cassidy

Research outputs 2022 to 2026

Background: Mechanistic studies and short-term randomized trials suggest higher intakes of dietary flavonoids may protect against nonalcoholic fatty liver disease (NAFLD).

Objectives: We aimed to perform the first population-based study with long-term follow-up on flavonoid consumption, incident NAFLD, and validated NAFLD biomarkers.

Methods: In a prospective study, we assessed the associations between flavonoid intake based on ≥2 24-h dietary assessments and NAFLD risk among 121,064 adults aged 40–69 y by multivariable Cox regression analyses. We further assessed the associations between flavonoid intake and magnetic resonance imaging-derived liver fat (a subset of n = 11,435) and liver-corrected T1 values (cT1; a …

A Systematic Review And Network Meta-Analysis On The Effectiveness Of Exercise-Based Interventions For Reducing The Injury Incidence In Youth Team-Sport Players. Part 1: An Analysis By Classical Training Components, Francisco Javier Robles-Palazón, Desirée Blázquez-Rincón, Alejandro López-Valenciano, Paul Comfort, José Antonio López-López, Francisco Ayala

Research outputs 2022 to 2026

Objectives: The primary purposes were (a) to estimate the pooled effects of injury prevention programs (IPPs) on reducing overall and some specific body regions (lower extremity, thigh, knee, and ankle) injury incidence rates (IIRs) and (b) to compare the effects of single- and multi-component IPPs on mitigating injury risk in youth team sport athletes. A secondary objective was to explore the individual effects of different components on these IIRs. Materials and methods: Searches were performed up to 15 January 2024 in PubMed, Web of Science, SPORTDiscus, and Cochrane Library. Eligible criteria were: exercise-based interventions evaluated against a control group, overall …

Classification Of Vaginal Cleanliness Grades Through Surface-Enhanced Raman Spectral Analysis Via The Deep-Learning Variational Autoencoder: Long Short-Term Memory Model, Jia Wei Tang, Xin Ru Wen, Hui Min Chen, Jie Chen, Kun Hui Hong, Quan Yuan, Muhammad Usman, Liang Wang

Research outputs 2022 to 2026

In this study, it is aimed to establish a novel method based on a deep-learning-guided surface-enhanced Raman spectroscopy (SERS) technique to achieve rapid and accurate classification of vaginal cleanliness levels. We proposed a variational autoencoder (VAE) approach to enhance spectral quality, coupled with a deep learning algorithm long short-term memory (LSTM) neural network to analyze SERS spectra produced by vaginal secretions. The performance of various machine learning (ML) algorithms is assessed using multiple evaluation metrics. Finally, the reliability of the optimal model is tested using blind test data (N = 10/group for each cleanliness level). The data quality of the …

Longitudinal Associations Between Exercise And Biomarkers In Autosomal Dominant Alzheimer's Disease, Kelsey R. Sewell, James D. Doecke, Chengjie Xiong, Tammie Benzinger, Colin L. Masters, Christoph Laske, Mathias Jucker, Francisco Lopera, Brian A. Gordon, Jorge Llibre-Guerra, Johannes Levin, Edward D. Huey, Jason Hassenstab, Peter R. Schofield, Gregory S. Day, Nick C. Fox, Jasmeer Chhatwal, Laura Ibanez, Jee Hoon Roh, Richard Perrin, Jae Hong Lee, Ralph N. Martins, Stephanie Rainey-Smith, Samantha L. Gardener, Hamid R. Sohrabi, Belinda Brown

Research outputs 2022 to 2026

INTRODUCTION: We investigated longitudinal associations between self-reported exercise and Alzheimer's disease (AD)-related biomarkers in individuals with autosomal dominant AD (ADAD) mutations. METHODS: Participants were 308 ADAD mutation carriers aged 39.7 ± 10.8 years from the Dominantly Inherited Alzheimer's Network. Weekly exercise volume was measured via questionnaire and associations with brain volume (magnetic resonance imaging), cerebrospinal fluid biomarkers, and brain amyloid beta (Aβ) measured by positron emission tomography were investigated. RESULTS: Greater volume of weekly exercise at baseline was associated with slower accumulation of brain Aβ at preclinical disease stages β = –0.16 [–0.23 to –0.08], and a slower decline in …

Nurse Knowledge, Attitudes, And Barriers To Pressure Injuries: A Cross-Sectional Study In An Australian Metropolitan Teaching Hospital, Linda Coventry, Amanda Towell-Barnard, Joelle Winderbaum, Nicole Walsh, Mark Jenkins, Dimitri Beeckman

Research outputs 2022 to 2026

Background: Pressure injuries are associated with significant clinical complications with negative effects on the patient's emotional, psychological, social and physical wellbeing. However, in Australia little is known about the knowledge and attitudes of nurses towards hospital-acquired pressure injuries.

Objective: To determine nurse knowledge and attitudes towards hospital-acquired pressure injuries and to identify barriers towards prevention.

Methods: A cross-sectional study following the STROBE statement was conducted between May to July in 2017. All nurses at a major metropolitan teaching hospital in Western Australia were invited to participate. Nurse knowledge and attitude to pressure injury were assessed using validated Pressure Ulcer Knowledge …

Optimizing Cardiac Resynchronization Therapy In Heart Failure Patients With Prolonged Qrs Duration: Insights Into Electrical And Mechanical Dyssynchrony, Zhisheng Chen, Lois Balmer, Xuerui Tan

Research outputs 2022 to 2026

Heart failure (HF) represents a critical stage of cardiac disease, associated with high morbidity and mortality. Cardiac resynchronization therapy (CRT) has become a pivotal treatment for HF patients with prolonged QRS duration. This therapy employs a biventricular pacing system to correct cardiac electromechanical dyssynchrony, thereby improving cardiac function, symptoms, and prognosis. Numerous clinical trials have consistently highlighted the benefits of CRT in this subgroup, leading to its unanimous recommendation in clinical practice guidelines. However, a significant proportion of patients do not achieve an adequate therapeutic response, despite adherence to these guidelines. As CRT treats patients by correcting cardiac electromechanical dyssynchrony, …

Optimizing Resistance Training For Sprint And Endurance Athletes: Balancing Positive And Negative Adaptations, Bas Van Hooren, Per Aagaard, Anthony J. Blazevich

Research outputs 2022 to 2026

Resistance training (RT) triggers diverse morphological and physiological adaptations that are broadly considered beneficial for performance enhancement as well as injury risk reduction. Some athletes and coaches therefore engage in, or prescribe, substantial amounts of RT under the assumption that continued increments in maximal strength capacity and/or muscle mass will lead to improved sports performance. In contrast, others employ minimal or no RT under the assumption that RT may impair endurance or sprint performances. However, the morphological and physiological adaptations by which RT might impair physical performance, the likelihood of these being evoked, and the training program specifications that might …

Plant But Not Animal Sourced Nitrate Intake Is Associated With Lower Dementia-Related Mortality In The Australian Diabetes, Obesity, And Lifestyle Study, Anjana Rajendra, Nicola P. Bondonno, Liezhou Zhong, Simone Radavelli-Bagatini, Kevin Murray, Stephanie R. Rainey-Smith, Samantha L. Gardener, Lauren C. Blekkenhorst, Dianna J. Magliano, Jonathan E. Shaw, Robin M. Daly, Kaarin J. Anstey, Joshua R. Lewis, Jonathan M. Hodgson, Catherine P. Bondonno

Research outputs 2022 to 2026

Introduction: Dietary nitrate is potentially beneficial for cardiovascular, cerebrovascular, and nervous systems due to its role as a nitric oxide (NO) precursor. Increased nitrate intake improves cardiovascular health and therefore could protect against dementia, given the cardiovascular-dementia link. Objective: To investigate the association between source-dependent nitrate intake and dementia-related mortality. As individuals with diabetes are at higher risk of dementia, a secondary aim was to investigate if the associations between nitrate and dementia varied by diabetes mellitus (DM) and pre-diabetes status. Methods: This study involved 9,149 participants aged ≥25 years from the well-characterised Australian Diabetes, Obesity, and Lifestyle (AusDiab) Study …

Reliability Of Time-Motion Analysis In Striking Combat Sports, L. Rohner, C. R. Abbiss, W. Poon, O. R. Barley

Research outputs 2022 to 2026

Introduction: Time-motion analysis (TMA) is a noninvasive performance analysis technique used in various sports to provide broad insights into the technical, tactical, and physiological demands of competitions by quantifying the mode, frequency, and duration of discrete activities. Objectives: This study aimed to assess the intra- and inter-observer reliability of activities in full-contact kickboxing athletes determined using TMA. Equipment and methods: A total of 29 bouts from the World Association of Kickboxing Organizations World Championships 2019, involving 58 male athletes, were analyzed by two expert analysts in a randomised order to determine the number of actions performed (i.e., punches, kicks, significant …

The Australian Frailty Network: Development Of A Consumer-Focussed National Response To Frailty, Natasha Reid, Adrienne Young, Loretta Baldassar, Anja Christoffersen, Tracy Comans, Simon Conroy, Christopher Etherton-Beer, Jason Ferris, Maria Fiatarone Singh, Sarah Fox, Emily H. Gordon, Manonita Ghosh, Chandana Guha, Sarah Hilmer, Lisa Kouladjian O’Donnell, Benignus Logan, Kristiana Ludlow, Michelle Miller, Mark Morgan, Alison Mudge, John Muscedere, Donna Reidlinger, Kenneth Rockwood, Rosemary Saunders, David Ward, Paul Yates

Research outputs 2022 to 2026

Frailty is an important concept in the care of older adults. Over the past two decades, significant advances have been made in measuring frailty. While it is now well-recognised that frailty status is an important determinant of outcomes from medical illnesses or surgical interventions, frailty measurement is not currently routinely integrated into clinical practice. In the community setting, it is uncommon for general practitioners to deliver frailty-optimised care. In hospitals, there is substantial variability in how people living with frailty are managed. This variability is notable between and even within disciplines. Furthermore, gains from understanding frailty mechanisms and risk factors …

The European Association For Predictive, Preventive And Personalized Medicine (Epma) World Congress 2024: Pioneering The Intersection Of Tourism And Health Science, Fangli Hu, Jun Wen

Research outputs 2022 to 2026

No abstract provided.

Rapid Analysis Of N-Nitrosamines In Urine Using Ultra High-Pressure Liquid Chromatography-Mass Spectrometry, S. Shinde, K. D. Croft, J. M. Hodgson, C. P. Bondonno

Research outputs 2022 to 2026

N-Nitrosamines, carcinogenic compounds present in dietary and environmental sources and formed endogenously, are believed to be linked with the presence of nitrate and nitrite, both within dietary sources and after intake. To fully evaluate this potential threat to human health, an accurate analytical method to measure N-nitrosamines in biological matrices is necessary. We report a simple, fast, selective mass spectrometry method to detect N-nitrosamines in human urine. Analysis of seven N-nitrosamines, N-nitrosodimethylamine (NDMA), N-nitrosomethylethylamine (NMEA), N-nitrosodiethylamine (NDEA), N-nitrosopiperdine (NPIP), N-nitrosopyrrolidine (NPYR), N-nitrosodi-N-propylamine (NDPA) and N-nitrosodi-N-butylamine (NDBA) in urine was quantitated using Ultra High-Pressure Liquid Chromatography-tandem Mass spectrometry (UHPLC-MS/MS). A Sorbent …