Medicine and Health Sciences Commons^™

Point Of View On Outcome Prediction Models In Post-Stroke Motor Recovery, Onno Van Der Groen, Manonita Ghosh, Richard Norman, Amy Kuceyeski, Ceren Tozlu, Teresa J. Kimberley, David J. Lin, Laurel J. Buxbaum, Gert Kwakkel, Steven C. Cramer, Dylan J. Edwards

Research outputs 2022 to 2026

Stroke is a leading cause of disability worldwide which can cause significant and persistent upper limb (UL) impairment. It is difficult to predict UL motor recovery after stroke and to forecast the expected outcomes of rehabilitation interventions during the acute and subacute phases when using clinical data alone. Accurate prediction of response to treatment could allow for more timely and targeted interventions, thereby improving recovery, resource allocation, and reducing the economic impact of post-stroke disability. Initial motor impairment is currently the strongest predictor of post-stroke motor recovery. Despite significant progress, current prediction models could be refined with additional predictors, and …

Powerlifting Participation And Engagement Across All Ages: A Retrospective, Longitudinal, Population Analysis With Comparison To Community Strength Norms, Daniel J. Van Den Hoek, Alistair Mallard, Joel M. Garrett, Patrick L. Beaumont, Robert J. Howells, Jemima G. Spathis, Joshua Pearson, Christopher Latella

Research outputs 2022 to 2026

Background: In Australia, one-third of people ≥ 15 years perform regular resistance training and 90% of those do not meet current health guidelines. All age groups should engage in regular resistance exercise, to maintain strength and function. Objectives: To identify trends in powerlifting competition participation in Australia by sex and age group from 1968 to 2022, and to compare the strength of powerlifting competitors to population age- and sex-based normative values. Method: The number of unique participants and total competition entries for each year were analysed using Australian powerlifting competition data. Subdomains of age and sex were investigated, and mean …

Resistance Exercise Minimal Dose Strategies For Increasing Muscle Strength In The General Population: An Overview, James L. Nuzzo, Matheus Daros Pinto, Benjamin J. C. Kirk, Kazunori Nosaka

Research outputs 2022 to 2026

Many individuals do not participate in resistance exercise, with perceived lack of time being a key barrier. Minimal dose strategies, which generally reduce weekly exercise volumes to less than recommended guidelines, might improve muscle strength with minimal time investment. However, minimal dose strategies and their effects on muscle strength are still unclear. Here our aims are to define and characterize minimal dose resistance exercise strategies and summarize their effects on muscle strength in individuals who are not currently engaged in resistance exercise. The minimal dose strategies overviewed were: “Weekend Warrior,” single-set resistance exercise, resistance exercise “snacking,” practicing the strength test, …

The Association Between Plasma Igg N-Glycosylation And Neonatal Hypoxic–Ischemic Encephalopathy: A Case-Control Study, Liangao Wang, Xinxia Lu, Meng Wang, Xuezhen Zhao, Peirui Li, Haitao Zhang, Qingtang Meng, Yujing Zhang, Yingjie Wang, Wei Wang, Long Ji, Haifeng Hou, Dong Li

Research outputs 2022 to 2026

Introduction: Hypoxic-ischemic encephalopathy (HIE) is one of severe neonatal brain injuries, resulting from inflammation and the immune response after perinatal hypoxia and ischemia. IgG N-glycosylation plays a crucial role in various inflammatory diseases through mediating the balance between anti-inflammatory and pro-inflammatory responses. This study aimed to explore the effect of IgG N-glycosylation on the development of HIE. Methods: This case-control study included 53 HIE patients and 57 control neonates. An ultrahigh-performance liquid chromatography (UPLC) method was used to determine the features of the plasma IgG N-glycans, by which 24 initial glycan peaks (GPs) were quantified. Multivariate logistic regression was used …

Application Of Genomics And Epigenetics In Disease And Syndrome Classification, Yanqi Dang, Wei Wang, Aiping Lyu, Lisheng Wang, Guang Ji

Research outputs 2022 to 2026

No abstract provided.

Can The Cross-Education Of Strength Attenuate The Impact Of Detraining After A Period Of Strength Training? A Quasi-Randomized Trial, Grant S. Rowe, Anthony J. Blazevich, Janet L. Taylor, Timothy Pulverenti, G. Gregory Haff

Research outputs 2022 to 2026

Purpose: Unilateral strength training may attenuate the decline in muscle strength and size in homologous, contralateral muscles. This study aimed to determine whether the cross-education of strength could specifically attenuate the effects of detraining immediately after a short (prehabilitation-type) period of strength training. Methods: Twenty-six strength-trained participants were assigned to either four weeks of unilateral strength training of the stronger arm (UNI) or detraining (Detrain). Motor evoked potential (MEP) and cortical silent period (cSP) responses, muscle cross-sectional area (CSAFlexor; peripheral quantitative computed tomography) and maximal strength, rate of force development (RFD) and muscle activation (EMG) were examined in both elbow …

Enablers And Barriers Of Online Mindfulness-Based Interventions For Informal Carers: A Mixed-Methods Systematic Review, Charunya Amilani Kumarihami Rambukwella Abeysinghe Mudiyanselage, Beverley Ewens, Aisling Smyth, Joanne Dickson, Seng Giap Marcus Ang

Research outputs 2022 to 2026

Objectives: Informal carers are an integral part of any health care system. However, provision of informal care is associated with caregiver burden and decreased wellbeing. Mindfulness programs can reduce caregiving burden and improve wellbeing among informal carers, but they face challenges when participating in face-to-face programs. Studies have explored the effects of online delivery of mindfulness programs for informal carers. However, the enablers and barriers for participation are not well understood. This review aimed to synthesise the evidence and provide a comprehensive understanding of the enablers and barriers to participation in online mindfulness programs among this population. Methods: A mixed-methods …

Evaluating The Association Between Effort-Reward Imbalance And Suboptimal Health Status Among Hospital Nurses: A Cross-Sectional Study Evaluating The Association Between Effort-Reward Imbalance And Suboptimal Health Status Among Hospital Nurses: A Cross-Sectional Study, Leilei Yu, Weiting Liu, Jingzheng Wang, Ziyao Jin, Ruoyu Meng, Zhiyuan Wu, Yuanyuan Zheng, Zheng Guo

Research outputs 2022 to 2026

Objectives: Occupational stress is a common complaint in nurses, who perceived more sense of effort-reward imbalance (ERI). Suboptimal health status (SHS) is a state between health and disease. However, the correlation between ERI and SHS is unclear. Therefore, the aim of this study was to examine the prevalence of SHS and ERI and evaluate the relationship between ERI and SHS in clinical nurses by a cross-sectional study. Material and Methods: The current cross-sectional study was conducted through an online survey at Dongping People's Hospital in China. A total of 633 completed surveys were received. Effort-reward imbalance was measured by subscales …

Glycan Clock Of Ageing—Analytical Precision And Time-Dependent Inter- And I-Individual Variability, Borna Rapčan, Manshu Song, Azra Frkatović-Hodžić, Tea Pribić, Jakov Vuk, Anđelo Beletić, Maja Hanić, Julija Jurić, Petra Tominac, Josip Milas, Vedrana Ivić, Sven Viland, Sara Bonet, Branko Šego, Marija Heffer, Wei Wang, Michael P. Snyder, Gordan Lauc

Research outputs 2022 to 2026

Ageing is a complex biological process with variations among individuals, leading to the development of ageing clocks to estimate biological age. Glycans, particularly in immunoglobulin G (IgG), have emerged as potential biomarkers of ageing, with changes in glycosylation patterns correlating with chronological age. For precision analysis, three different plasma pools were analysed over 26 days in tetraplicates, 312 samples in total. In short-term variability analysis, two cohorts were analysed: AstraZeneca MFO cohort of 26 healthy individuals (median age 20) and a cohort of 70 premenopausal Chinese women (median age 22.5) cohort monitored over 3 months. Long-term variability analysis involved two …

Higher Plant-Derived Nitrate Intake Is Associated With Lower Odds Of Frailty In A Cross-Sectional Study Of Community-Dwelling Older Women, Eleanor Hayes, Elsa Dent, Oliver M. Shannon, Lie Zhou Zhong, Trent Bozanich, Lauren C. Blekkenhorst, Kun Zhu, Catherine P. Bondonno, Mario Siervo, Emiel O. Hoogendijk, Jonathan M. Hodgson, Richard L. Prince, Joshua R. Lewis, Marc Sim

Research outputs 2022 to 2026

Purpose: Dietary nitrate intake is inversely related to numerous contributors towards frailty, including cardiovascular disease and poor physical function. Whether these findings extend to frailty remain unknown. We investigated if habitual nitrate intake, derived from plants or animal-based foods, was cross-sectionally associated with frailty in women. Methods: Community-dwelling older Australian women (n = 1390, mean age 75.1 ± 2.7 years) completed a validated semi-quantitative food frequency questionnaire (FFQ). Nitrate concentrations in food were obtained from international nitrate databases. We adopted the Rockwood frailty index (FI) of cumulative deficits comprising 33 variables across multiple health domains (scored 0 to 1), which …

Maternal Health Considerations: Highlighting And Advancing Opportunities For Improved Maternal Health, Caitlin Fox-Harding

Research outputs 2022 to 2026

The special collection on Maternal Health Considerations offers a comprehensive exploration of critical issues surrounding maternal well-being across diverse contexts and disciplines. Recognising that maternal health extends beyond the physiological realm, this collection delves into the multifaceted dimensions of maternal well-being, including physical, mental, and socio-ecological factors. The collection comprises a series of interdisciplinary studies that investigate various facets of maternal health, from conception to postpartum stages. It addresses the complex interplay between biological, psychological, and socio-cultural determinants that influence maternal health outcomes. By adopting a holistic approach, the contributors shed light on the interconnectedness of maternal well-being. Key themes …

Source-Specific Nitrate Intake And All-Cause Mortality In The Danish Diet, Cancer, And Health Study, Nicola P. Bondonno, Pratik Pokharel, Catherine P. Bondonno, Dorit W. Erichsen, Liezhou Zhong, Jörg Schullehner, Kirsten Frederiksen, Cecilie Kyrø, Peter Fjeldstad Hendriksen, Jonathan M. Hodgson, Frederik Dalgaard, Lauren C. Blekkenhorst, Ole Raaschou-Nielsen, Torben Sigsgaard, Christina C. Dahm, Anne Tjønneland, Anja Olsen

Research outputs 2022 to 2026

Introduction: Nitrate and nitrite are naturally occurring in both plant- and animal-sourced foods, are used as additives in the processing of meat, and are found in water. There is growing evidence that they exhibit a spectrum of health effects, depending on the dietary source. The aim of the study was to examine source-dependent associations between dietary intakes of nitrate/nitrite and both all-cause and cause-specific mortality. Methods: In 52,247 participants of the Danish Diet, Cancer and Health Study, associations between source-dependent nitrate and nitrite intakes––calculated using comprehensive food composition and national drinking water quality monitoring databases––and all-cause, cardiovascular disease (CVD)-related, and …

The Experience Of Occupational Therapists And Physiotherapists Using A Prototype, Evidence-Informed Online Knowledge Translation Resource To Learn About Patient-Defined, Personally-Meaningful Chronic Pain Rehabilitation, Katrina J. Liddiard, Annette J. Raynor, Cary A. Brown

Research outputs 2022 to 2026

Purpose: Chronic pain is a complex biopsychosocial experience, and rehabilitation helps people to manage pain, and restore valued life roles. Evidence suggests that more positive outcomes occur when clients perceive their rehabilitation to be meaningful. People with chronic pain describe rehabilitation as personally-meaningful when they develop a genuine connection with a credible therapist who they see as a guiding partner, and when rehabilitation holds personal value, is self-defined, and relevant to their sense of self-identity. This paper presents a qualitative study of therapists’ experience using an e-learning package on patient-defined, personally-meaningful rehabilitation. Methods: A qualitative descriptive design was used to …

Weathering The Storm: Diagnosis And Treatment Of A Life-Threatening Disseminated Nocardia Otitidiscaviarum Infection, Li Yan Zhang, Liang Wang, Zeeshan Umar, Yuan Hong Huang, Bing Gu

Research outputs 2022 to 2026

Nocardiosis demonstrates a temporal categorization that includes acute, subacute, and chronic stages alongside distinct typical localizations such as pulmonary, cutaneous, and disseminated forms. Disseminated nocardiosis, commonly caused by Nocardia asteroides, N. brasiliensis, and N. farcinica, continues to result in substantial morbidity and mortality. Herein, we report a life-threatening disseminated nocardiosis caused by Nocardia otitidiscaviarum in a patient with minimal change disease. This study emphasizes the difficulty in the diagnosis and treatment of unknown infections in clinical settings and highlights the important role played by laboratories in solving infectious diseases caused by rare pathogens.

A Comprehensive Multi-Omics Analysis Reveals Unique Signatures To Predict Alzheimer’S Disease, Michael Vacher, Rodrigo Canovas, Simon M. Laws, James D. Doecke

Research outputs 2022 to 2026

Background: Complex disorders, such as Alzheimer’s disease (AD), result from the combined influence of multiple biological and environmental factors. The integration of high-throughput data from multiple omics platforms can provide system overviews, improving our understanding of complex biological processes underlying human disease. In this study, integrated data from four omics platforms were used to characterise biological signatures of AD. Method: The study cohort consists of 455 participants (Control:148, Cases:307) from the Religious Orders Study and Memory and Aging Project (ROSMAP). Genotype (SNP), methylation (CpG), RNA and proteomics data were collected, quality-controlled and pre-processed (SNP = 130; CpG = 83; RNA …

A Cross-Cultural Study Of The Montreal Cognitive Assessment For People With Hearing Impairment, Stacey Theocharous, Greg Savage, Anna Pavlina Charalambous, Mathieu Côté, Renaud David, Kathleen Gallant, Catherine Helmer, Robert Laforce, Iracema Leroi, Ralph N. Martins, Ziad Nasreddine, Antonis Politis, David Reeves, Gregor Russell, Marie Josée Sirois, Hamid R. Sohrabi, Chyrssoula Thodi, Christiane Völter, Wai Kent Yeung, Piers Dawes

Research outputs 2022 to 2026

Background: Cognitive screening tools enable the detection of cognitive impairment, facilitate timely intervention, inform clinical care, and allow long-term planning. The Montreal Cognitive Assessment for people with hearing impairment (MoCA-H) was developed as a reliable cognitive screening tool for people with hearing loss. Using the same methodology across four languages, this study examined whether cultural or linguistic factors affect the performance of the MoCA-H. Methods: The current study investigated the performance of the MoCA-H across English, German, French, and Greek language groups (n = 385) controlling for demographic factors known to affect the performance of the MoCA-H. Results: In a …

Cross-Sectional Survey Of Staff And Family Perspectives On The Use Of Cctv In Australian Residential Aged Care, Davina Porock, Caroline Vafeas, Mandy Towell-Barnard, Laura Emery, Gemma Doleman, Janine Alan

Research outputs 2022 to 2026

Objective: To describe staff and family members' opinions about closed-circuit television (CCTV) in communal and private areas of residential aged care facilities (RACF), and to investigate how this relates to perceptions of care quality. Methods: A cross-sectional survey was developed to capture perceptions of CCTV's influence on care quality, and acceptable locations for CCTV placement. Data were recorded as ordinal-scale and open responses. Non-parametric tests of association were conducted. Results: The survey was completed by 81 staff and 74 family members. Both staff and family were satisfied with care quality and safety, irrespective of CCTV use. More family members were …

Enhancing Breast Cancer Treatment: Mesoporous Dopamine Nanoparticles In Synergy With Chrysin For Photothermal Therapy, Jing Zhu, Heng Zhang, Haomiao Lan, Bing Bi, Xianfeng Peng, Dandan Li, Haili Wang, Ke Zhu, Fuqiang Shao, Minggang Yin

Research outputs 2022 to 2026

Introduction: Breast cancer is one of the most prevalent cancers, primarily affecting women. Among its subtypes, estrogen receptor-positive (ER+) breast cancer is particularly common. Inhibiting estrogen's effects is crucial for treating ER+ breast cancer, but current therapies often have significant side effects and limitations. Chrysin, a natural flavonoid, has shown potential in reducing estrogen receptor expression, but its poor water solubility hampers clinical application. This study explores the use of mesoporous dopamine nanoparticles (mPDA) to enhance the delivery and efficacy of Chrysin, combined with photothermal therapy (PTT), for breast cancer treatment. Methods: Chrysin-loaded mPDA nanoparticles (Chrysin@mPDA) were synthesized and characterized …

Estimating Cardiorespiratory Fitness In Older Adults Using The International Physical Activity Questionnaire, Kelsey R. Sewell, Jeremiah J. Peiffer, Shaun J. Markovic, Belinda M. Brown

Research outputs 2022 to 2026

Introduction:

Non-exercise estimates of cardiorespiratory fitness hold great utility for epidemiological research and clinical practice. Older adults may yield the greatest benefit from fitness estimates due to limited capacity to undergo strenuous maximal exercise testing, however, few of the previously developed non-exercise equations are suitable for use in older adults. Thus, the current study developed a non-exercise equation for estimating cardiorespiratory fitness in older adults derived from the widely used International Physical Activity Questionnaire (IPAQ).

Methods:

This study was a secondary analysis of baseline data from a randomized controlled trial. Participants were community-dwelling, cognitively unimpaired older adults aged 60–80 years …

Experiences Of The Change Process During Emotion Focused Group Therapy, Jason M. Sharbanee, Kirra Rauchelle, Marina Nelson, Eyal Gringart

Research outputs 2022 to 2026

Emotion Focused Group Therapy has demonstrated preliminary efficacy for multiple syndromes. The groups involve individual chair-work in the context of the group, followed by interpersonal processing of the aroused emotions. So far there has been limited investigation of the mechanisms of change, including participants’ experiences of the change process. This study aimed to qualitatively examine participants’ experiences of the change process during Emotion Focused Group Therapy. Sixteen participants were interviewed about their experiences of the change process during the therapy group. The interview was structured to move from overarching reflections on the process of change, to specific experiences of their …

Impact On Help-Seeking Behaviours Of A Campaign Perceived To Decrease Stigma And Increase Openness Around Mental Health, Robert J. Donovan, Catherine F. Drane, Ziggi I. Santini, Geoffrey Jalleh

Research outputs 2022 to 2026

Issue Addressed: There is considerable evidence that public stigma around mental illness inhibits help-seeking for mental health problems. Hence there have been many interventions and campaigns designed to reduce stigma around mental illness. However, as far as could be ascertained, none of these stigma reduction interventions has reported any substantial impact of reducing stigma on people's mental health help-seeking behaviours. The aim of this paper is to report on the impact of the Act-Belong-Commit positive mental health promotion Campaign on help-seeking via increasing perceived openness around mental health and reducing perceived stigma around mental illness. Methods: State-wide computer assisted telephone …

Intersectoral Collaboration For Supporting The Health And Wellbeing Of Aboriginal Families And Children In Out-Of-Home Care: Perspectives From Western Australian Aboriginal Community Controlled Health Organisations, Sasha Moodie, Jocelyn Jones, Richard Chenhall, Robyn Williams, Cathy Garlett, Alison Gibberd, Melissa O’Donnell, Dan Mcaullay, Bridgette Mcnamara, Sandra Eades

Research outputs 2022 to 2026

Introduction: Western Australia has one of the highest rates of Aboriginal children entering out-of-home care in Australia. Kinship care is the preferred culturally safe out-of-home care option for Aboriginal children, yet all jurisdictions, including Western Australia, are far from meeting best-practice national standards. Intersectoral collaboration is a key primary healthcare principle and internationally recognized for improving health systems and outcomes. This paper presents findings from a qualitative research project investigating Aboriginal primary healthcare workers’ experiences of intersectoral collaboration challenges and strengthening opportunities. Methods: Constructivist grounded theory guided this research involving 55 semi-structured interviews and four focus group discussions with Aboriginal …

It's Day To Day Problems: Experiences Of People With Aphasia Who Live Alone, Deborah Hersh, Clare Williamson, Emily Brogan, Mandy Stanley

Research outputs 2022 to 2026

Purpose: Living alone is increasing and associated with health and social risks. Aphasia compounds these risks but there is little research on how living alone interacts with aphasia. This study is a preliminary exploration of this issue. Method: Five people with aphasia who lived alone participated in two supported semi-structured interviews, with the second interview including sharing an artefact that held significance for living alone with aphasia. Interviews were recorded, transcribed verbatim, and analysed through reflexive thematic analysis. Result: Four themes encompassed meaning-making about living alone with aphasia: relationships and reliance on others; risk, vulnerability, and uncertainty; loneliness and time …

Motoneuron Persistent Inward Current Contribution To Increased Torque Responses To Wide-Pulse High-Frequency Neuromuscular Electrical Stimulation, Timothée Popesco, Lucas Bet Da Rosa Orssatto, François Hug, Anthony John Blazevich, Gabriel Siqueira Trajano, Nicolas Place

Research outputs 2022 to 2026

Purpose: To assess the effect of a remote handgrip contraction during wide-pulse high-frequency (WPHF) neuromuscular electrical stimulation (NMES) on the magnitude of extra torque, progressive increase in torque during stimulation, and estimates of the persistent inward current (PIC) contribution to motoneuron firing in the plantar flexors. Methods: Ten participants performed triangular shaped contractions to 20% of maximal plantar flexion torque before and after WPHF NMES with and without a handgrip contraction, and control conditions. Extra torque, the relative difference between the initial and final torque during stimulation, and sustained electromyographic (EMG) activity were assessed. High-density EMG was recorded during triangular …

Nursing/Midwifery Students' Perceptions Of Caring Pedagogy And Online Learning During The Covid-19 Pandemic, Rikki Jones, Debra Jackson, Kylie Rice, Murray Fisher, Pauline Callega, Martin Hopkins, Caryn West, Pauletta Irwin, Shirley Mcgough, Lauretta Luck, Felicity Walker, Nicola Whiteing, Kim Usher

Research outputs 2022 to 2026

Aim: This study aimed to gain a better understanding of nursing/midwifery students' perspectives on a pedagogy of caring and online learning during the COVID-19 pandemic. In addition, it aimed to determine if the COVID-19 pandemic impacted students' perceptions and experience of online learning and students' desire to enter the nursing/midwifery workforce. Design: Mixed methods. Methods: A multi-centre cross-sectional survey of Australian nursing and midwifery students was undertaken to explore students’ experience of learning during the COVID-19 pandemic. Results: There are several key findings from this study that may be relevant for the future delivery of undergraduate health education, students transitioning …

Psychedelic Trip Sitting, Dosages And Intensities: Supplementing Clinical Studies With Anecdotal Reports, Liam B. Engel, Sascha Thal, Stephen J. Bright, Mitchell Low

Research outputs 2022 to 2026

Background and aims: Online communities provide insights into psychedelic consumption, assisting in identification of trends, informing both harm reduction provisions and clinical research. This study extracts forum data on psychedelic substances, dosages, and administration routes, categorising and analysing self-reported consumption to inform care services and guide clinical work with psychedelics. Methods: Posts (n = 660) from online psychedelic forums (The Shroomery and DMT Nexus) on 'trip sitting' were analysed. Using a Delphi-style expert panel review facilitated by LE, we created drug weight and intensity charts (threshold, light, common, strong and heavy dosages) for psychedelics discussed in these posts. The psychedelic …

Pulmonary Embolism Response Teams. A Description Of The First 36-Month Australian Experience, Bapti Roy, Jin Gun Cho, Luke Baker, Liza Thomas, Jennifer Curnow, John J. Harvey, Paul Geenty, Ashoke Banerjee, Kevin Lai, Mauro Vicaretti, Odette Erksine, Jane Li, Rafid Alasady, Vanessa Wong, Jian E. Tai, Caitlin Thirunavukarasu, Imran Haque, Jimmy Chien

Research outputs 2022 to 2026

Background: High/intermediate-risk pulmonary embolism (PE) confers increased risk of cardiovascular morbidity and mortality. International guidelines recommend the formation of a PE response team (PERT) for PE management because of the complexity of risk stratification and emerging treatment options. However, there are currently no available Australian data regarding outcomes of PE managed through a PERT. Aims: To analyse the clinical and outcome data of patients from an Australian centre with high/intermediate-risk PE requiring PERT-guided management. Methods: We performed a retrospective observational study of 75 consecutive patients with high/intermediate-risk PE who had PERT involvement, between August 2018 and July 2021. We recorded …

Recovery From Sport-Induced Muscle Damage In Relation To Match-Intervals In Major Events, Kazunori Nosaka, Trevor C. Chen

Research outputs 2022 to 2026

Muscle damage could affect the next match performance in sports when the time to recover from a previous match is shorter. We examined the interval between matches in nine team sports (e.g., soccer, rugby, field hockey, basketball, volleyball, baseball) and two racket sports (badminton, tennis) in World Cups held in 2022-2023, 2020 Tokyo Olympic Games and Gland Slam in 2023. We then performed narrative review using three electronic databases (PubMed, Scopus, Google Scholar) to get information about muscle damage and recovery in the 11 sports, and discussed whether the intervals in the events would be enough for athletes. We found …

Resting Heart Rate And Risk Of Dementia: A Mendelian Randomization Study In The International Genomics Of Alzheimer’S Project And Uk Biobank, Xingxing Chen, Yi Zheng, Jun Wang, Blake Yue, Xian Zhang, Kenta Nakai, Lijing L. Yan

Research outputs 2022 to 2026

Background: Observational studies have demonstrated that a higher resting heart rate (RHR) is associated with an increased risk of dementia. However, it is not clear whether the association is causal. This study aimed to determine the causal effects of higher genetically predicted RHR on the risk of dementia. Methods: We performed a two-sample Mendelian randomization analysis to investigate the causal effect of higher genetically predicted RHR on Alzheimer’s disease (AD) using summary statistics from genome-wide association studies. The generalized summary Mendelian randomization (GSMR) analysis was used to analyze the corresponding effects of RHR on following different outcomes: 1) diagnosis of …

Seven-Day Dietary Nitrate Supplementation Clinically Significantly Improves Basal Macrovascular Function In Postmenopausal Women: A Randomized, Placebo-Controlled, Double-Blind, Crossover Clinical Trial, Jocelyn M. Delgado Spicuzza, Jigar Gosalia, Liezhou Zhong, Catherine Bondonno, Kristina S. Petersen, Mary Jane De Souza, Elmira Alipour, Daniel B. Kim-Shapiro, Yasina B. Somani, David N. Proctor

Research outputs 2022 to 2026

Introduction: Cardiovascular disease (CVD) is the leading cause of death in women, with increased risk following menopause. Dietary intake of beetroot juice and other plant-based nitrate-rich foods is a promising non-pharmacological strategy for increasing systemic nitric oxide and improving endothelial function in elderly populations. The purpose of this randomized, placebo-controlled, double-blind, crossover clinical trial was to determine the effects of short-term dietary nitrate (NO3−) supplementation, in the form of beetroot juice, on resting macrovascular endothelial function and endothelial resistance to whole-arm ischemia–reperfusion (IR) injury in postmenopausal women at two distinct stages of menopause. Methods: Early-postmenopausal [1–6 years following their final …