Medicine and Health Sciences Commons^™

Low Remnant Cholesterol And In-Hospital Bleeding Risk After Ischemic Stroke Or Transient Ischemic Attack, Zhiyuan Wu, Haiping Zhang, Yi Xu, Xia Li, Xingang Li, Lois Balmer, Xiuhua Guo, Qi Zhang, Xiang Han, Lixin Tao

Research outputs 2022 to 2026

BACKGROUND: Bleeding risk brought by intensive lipid-lowering therapy and low low-density lipoprotein cholesterol is concern-ing, while evidence regarding the relationship between remnant cholesterol and bleeding is frightening. This study aimed to investigate the association between remnant cholesterol at admission and an in-hospital bleeding event after acute ischemic stroke or transient ischemic attack (TIA). METHODS AND RESULTS: A total of 3222 eligible patients admitted to Shanghai Huashan Hospital between 2015 and 2021 with complete lipid data were analyzed. Patients were classified into low (<20.0 mg/dL), moderate (20.0–29.9 mg/dL), and high (≥30 mg/dL) groups by remnant cholesterol. The mean age of patients was 63.0± 13.1 years, including 2301 (71.4%) men and 651 (20.2%) with TIA. The median (interquartile range) of remnant cholesterol was 18.6 (13.5–25.9) mg/dL. After adjustment for confounding variables, patients with low remnant cholesterol had a higher risk of bleeding events (odds ratio, 2.56 [95% CI, 1.12–6.67]) than those with moderate remnant cholesterol. The high remnant cholesterol group was not significantly associated with bleeding risk. Combined assessment of low-density lipoprotein cholesterol and remnant cholesterol further identi-fied patients with the highest risk of bleeding events. CONCLUSIONS: Low remnant cholesterol levels were associated with bleeding events during the acute stage of ischemic stroke and TIA. The assessment of remnant cholesterol could inform the bleeding risk during hospitalization both for patients and physicians in clinical practice.

Resting State Electrophysiological Profiles And Their Relationship With Cognitive Performance In Cognitively Unimpaired Older Adults: A Systematic Review, Brenda Chino, David López-Sanz, Sandra Doval, Lucía Torres-Simón, Jaisalmer De Frutos Lucas, Lydia Giménez-Llort, Jonathan Zegarra-Valdivia, Fernando Maestú

Research outputs 2022 to 2026

Background: Aging is a complex and natural process. The physiological decline related to aging is accompanied by a slowdown in cognitive processes, which begins shortly after individuals reach maturity. These changes have been sometimes interpreted as a compensatory sign and others as a fingerprint of deterioration. Objective: In this context, our aim is to uncover the mechanisms that underlie and support normal cognitive functioning in the brain during the later stages of life. Methods: With this purpose, a systematic literature search was conducted using PubMed, Scopus, and Web of Science databases, which identified 781 potential articles. After applying inclusion and …

The Role Of Placental Kisspeptin In Trophoblast Invasion And Migration: An Assessment In Kiss1r Knockout Mice, Bewo Cell Lines And Human Term Placenta, E. N. Panting, J. H. Weight, J. A. Sartori, D. A. Coall, J. T. Smith

Research outputs 2022 to 2026

Context: There is mounting evidence implicating kisspeptin signalling in placental development and function. Aims: This study aimed to elucidate kisspeptin's role in trophoblast invasion and migration using three experimental models. Methods: First, we examined the mouse fetus and placenta in a kisspeptin receptor (Kiss1r) knockout (KO) model. Fetal/placental weights and gene expression (quantitative polymerase chain reaction) were assessed. Second, we determined kisspeptin effects on a human trophoblast (BeWo) cell line in vitro. Third, we examined KISS1 and KISS1R gene expression in human placenta from term and pre-Term pregnancies. Key results: No difference was found in fetal or placental weight between …

Application Of Histopathology Image Analysis Using Deep Learning Networks, Md Shamim Hossain, Leisa J. Armstrong, David M. Cook, Pauline Zaenker

Research outputs 2022 to 2026

As the rise in cancer cases, there is an increasing demand to develop accurate and rapid diagnostic tools for early intervention. Pathologists are looking to augment manual analysis with computer-based evaluation to develop more efficient cancer diagnostics reports. The processing of these reports from manual evaluation is time-consuming, where the pathologists focus on accurately segmenting individual cancer cells, a vital step in analysis. This paper describes the design and validation of an application which has been developed based on deep learning networks. The application includes a workflow of image pre-processing followed by synthetic image generation, which is crucial due to …

The Relationship Between Diet, Depression, And Alzheimer's Disease: A Narrative Review, Hilal Salim Said Al Shamsi, Stephanie R. Rainey-Smith, Samantha L. Gardener, Hamid R. Sohrabi, Rodrigo Canovas, Ralph N. Martins, Warnakulasuriya Mary Ann Dipika Binosha Fernando

Research outputs 2022 to 2026

Purpose of Review: This narrative review evaluates the role of diet in the relationship between depression and Alzheimer's disease (AD). Recent Findings: AD and depression are often comorbid, and depression appears to independently increase the future risk of AD. Evidence suggests diet influences the risk of both conditions directly and indirectly. Diet impacts neurochemical and biological processes that may affect the development and progression of depression and cognitive dysfunction. The dietary components offering the greatest protection against depression and AD are yet to be determined. Current evidence highlights the importance of polyphenolic compounds, folate, B vitamins, and polyunsaturated fatty acids, …

Normalization Of Rapid Force To Peak Force In An Isometric Hamstring Assessment Using Force Plates, R. Barber, J. T. Fahey, P. Comfort, N. J. Ripley

Research outputs 2022 to 2026

Purpose: The aim of this investigation was to determine the reliability of normalizing rapid force (RF) production to peak force assessed during an isometric knee flexor assessment, and to present a novel method of classifying athletes' potential training needs within the 90–90 isometric hamstring assessment. Procedures: Twenty elite female soccer players (age: 20.7 ± 4.7 years; height: 168.2 ± 5.5 cm; body mass: 62.8 ± 7.0 kg), with no recent (>6 months) history of hamstring strain injury, volunteered to participate in the study. Following a standardized warm-up, each participant performed three maximal isometric hamstring contractions, with their heel resting …

The Mccusker Subjective Cognitive Impairment Inventory (Mcsci): A Novel Measure Of Perceived Cognitive Decline, Hamid R. Sohrabi, Brandon E. Gavett, Michael Weinborn, Craig P. Speelman, Romola S. Bucks, Ralph N. Martins

Research outputs 2022 to 2026

Background: Subjective cognitive decline (SCD), i.e. self/other-reported concerns on one’s cognitive functioning without objective evidence of significant decline, is an indicator of dementia risk. There is little consensus on reliability and validity of the available SCD measures. Therefore, introducing a novel and psychometrically sound measure of SCD is timely.

Objective: The psychometric properties of a new SCD measure, the McCusker Subjective Cognitive Impairment Inventory–Self-Report (McSCI-S), are reported.

Methods: Through review of previously published measures as well as our clinical and research data on people with SCD, we developed a 46-item self-report questionnaire to assess concerns on six cognitive domains, namely, …

Transdermal Oestradiol And Exercise In Androgen Deprivation Therapy (Estracise): Protocol, Ilkka Jussila, Juha P. Ahtiainen, Eija K. Laakkonen, Aino Siltari, Antti Kaipia, Tiina Jokela, Minta Kärkkäinen, Rob Newton, Truls Raastad, Heini Huhtala, Teemu J. Murtola, Heikki Seikkula

Research outputs 2022 to 2026

Objective: To report the protocol of a study evaluating the efficacy of transdermal oestradiol (E2) gel in reducing the adverse effects of androgen deprivation therapy (ADT), specifically on sexual function, and to assess the utility of E2 in combination with supervised exercise. Study Design and Methods: The primary endpoint of this open-label Phase IIA randomized controlled trial is the efficacy of transdermal E2 gel. Secondary endpoints include: (i) the occurrence of ADT-induced adverse effects; (ii) the safety and tolerability of E2; (iii) the impact of E2 with or without exercise on physical, physiological, muscle, and systemic biomarkers; and (iv) quality …

An Examination Of The Career Decision-Making Self-Efficacy Of Final-Year Nursing Students, Edah Anyango, Esther Adama, Janie Brown, Irene Ngune

Research outputs 2022 to 2026

Background: One in four newly graduated registered nurses leave their employment positions within the first year. To reduce this attrition, nursing stakeholders could focus on the final year of nursing education because students at this stage make professional career plans, including their practice destination for the graduate year and their commitment to the profession. Previous studies provide evidence of nursing students' career preferences and specialty choices. However, there is a dearth of data that focuses on the students' career decision-making process. Aim: This study examined the self-efficacy or confidence of final-year nursing students in making career decisions and the factors …

Children And Young People's Self-Reported Experiences Of Asthma And Self-Management Nursing Strategies: An Integrative Review, H. Kemble, Mandie Foster, J. Blamires, R. Mowat

Research outputs 2022 to 2026

Aim: To explore children and young people's (CYP) (5–24 years of age) self-reported experiences of asthma self-management strategies (ASMS) with nursing involvement across various settings. Background: Childhood asthma is an increasingly significant health issue, highlighting the importance of acquiring self-management skills to optimise future health outcomes. Registered nurses play a pivotal role in delivering appropriate, personalized self-management support. Methods: This integrative review searched four electronic databases: Cumulated Index to Nursing and Allied Health Literature via Elton B. Stephens Company, Medical Literature Analysis and Retrieval System Online (MEDLINE), Object, View and Interactive Design (OVID), and PubMed, that followed the Preferred Reporting …

Accuracy Of Energy And Nutrient Intake Estimation Versus Observed Intake Using 4 Technology-Assisted Dietary Assessment Methods: A Randomized Crossover Feeding Study, Clare Whitton, Clare E. Collins, Barbara A. Mullan, Megan E. Rollo, Satvinder S. Dhaliwal, Richard Norman, Carol J. Boushey, Edward J. Delp, Fengqing Zhu, Tracy A. Mccaffrey, Sharon I. Kirkpatrick, Christina M. Pollard, Janelle D. Healy, Amira Hassan, Shivangi Garg, Paul Atyeo, Syed Aqif Mukhtar, Deborah A. Kerr

Research outputs 2022 to 2026

Background:

Technology-assisted 24-h dietary recalls (24HRs) have been widely adopted in population nutrition surveillance. Evaluations of 24HRs inform improvements, but direct comparisons of 24HR methods for accuracy in reference to a measure of true intake are rarely undertaken in a single study population.

Objectives:

To compare the accuracy of energy and nutrient intake estimation of 4 technology-assisted dietary assessment methods relative to true intake across breakfast, lunch, and dinner.

Methods:

In a controlled feeding study with a crossover design, 152 participants [55% women; mean age 32 y, standard deviation (SD) 11; mean body mass index 26 kg/m2, SD 5] were …

Exercise And Diet Support In Breast And Prostate Cancer Survivors: Findings From Focus Groups, Jack Dalla Via, Christopher R. Andrew, Brenton J. Baguley, Nina Stewart, Jonathan M. Hodgson, Joshua R. Lewis, Mandy Stanley, Mary A. Kennedy

Research outputs 2022 to 2026

Purpose: Cancer survival is improving, making optimal management of long-term treatment-related adverse effects increasingly important. Exercise and a healthy diet are beneficial and regularly recommended in cancer survivorship guidelines; however, few cancer survivors meet these recommendations so there is a need to explore why. This study aimed to understand experiences receiving exercise and diet support among Australian breast and prostate cancer survivors during and following treatment, and to explore what support they would like to receive. Methods: Adults who completed active treatment for breast or prostate cancer were recruited via a private cancer care centre. Using a qualitative descriptive study …

Identification Of Core Competencies For Exercise Oncology Professionals: A Delphi Study Of United States And Australian Participants, Mary A. Kennedy, Kelley Covington Wood, Anna Campbell, Melanie Potiaumpai, Christopher M. Wilson, Anna L. Schwartz, Jessica Gorzelitz, Maxime Caru, Kathryn H. Schmitz

Research outputs 2022 to 2026

Introduction: Integration of exercise into standard oncology care requires a highly skilled workforce of exercise professionals; however, competency requirements have not kept pace with advancements in the field. Therefore, the aim of this study was to obtain consensus on core competencies required for an exercise professional to be qualified to work with adults undergoing active cancer treatment. Materials and Methods: A three-round modified electronic Delphi process was used. In Round 1, an international group of 64 exercise oncology stakeholders (i.e., exercise oncology professionals (n = 29), clinical referrers (n = 21), and people with lived experience (n = 14)) responded …

Perceived Barriers And Enablers To Utilising The Australian National Disability Insurance Scheme For Adults With An Intellectual Disability And Their Families: A Scoping Review, Alice Zubrinich, Gideon De Jong, Nasim Salehi, Richard Lakeman

Research outputs 2022 to 2026

Background: The introduction of the National Disability Insurance Scheme (NDIS) in Australia in 2013 promised significant improvements in the lives of adults with intellectual disabilities. Although the scheme enables support, there are challenges associated with establishing eligibility and administering funds. This scoping review explored perceived barriers and enablers to effectively utilising the NDIS for adults with intellectual disabilities and their families. Method: A scoping review of the empirical literature on the NDIS and intellectual disabilities included nine studies in this review. These papers were subjected to thematic analysis and the findings were presented as a narrative synthesis. Results: The key …

The Experiences And Perceptions Of Healthy Siblings Of Children With A Long-Term Condition: Umbrella Review, Julie Blamires, Mandie Foster, Shayne Rasmussen, Maggie Zgambo, Evalotte Mörelius

Research outputs 2022 to 2026

Problem: The lives of healthy siblings living with a sibling with a long- term condition are often shaped by the family, type of illness, length of illness, age of the child, caregiver demands, and support provided to the family, ill sibling, and healthy sibling. While the experiences of healthy siblings are documented in the literature by parent proxy, literature on healthy siblings self-reported experiences of living with a sibling who has a long-term condition remains scarce. Purpose: This umbrella review aims to synthesize reviews on the self-reported experiences of healthy siblings of children living with a sibling who has a …

Allied Health Professionals Knowledge And Clinical Practice In Telehealth Exercise Behavioural Change For Multiple Sclerosis, Georgios Mavropalias, Shavaughn L. Baynton, Shaun Teo, Sarah J. Donkers, Fleur Eca Van Rens, Yvonne C. Learmonth

Research outputs 2022 to 2026

Background: The growing importance of telehealth in multiple sclerosis (MS) necessitates an understanding of current practices and training needs of health professionals. We aimed to evaluate the knowledge, preparedness, and training preferences of Australian allied health professionals (AHPs) in telehealth exercise therapy and exercise behavioural change for MS patients to inform the development of educational training. Methods: An online survey was completed by 58 Australian AHPs, including 34 physiotherapists, 14 exercise physiologists, and 10 occupational therapists, focusing on their current practices, preparedness, and training preferences in telehealth exercise and behavioural change for MS. The survey included multiple-choice, Likert scale, and …

Artificial Intelligence In Perinatal Mental Health Research: A Scoping Review, Wai Hang Kwok, Yuanpeng Zhang, Guanjin Wang

Research outputs 2022 to 2026

The intersection of Artificial Intelligence (AI) and perinatal mental health research presents promising avenues, yet uncovers significant challenges for innovation. This review explicitly focuses on this multidisciplinary field and undertakes a comprehensive exploration of existing research therein. Through a scoping review guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework, we searched relevant literature spanning a decade (2013–2023) and selected fourteen studies for our analysis. We first provide an overview of the main AI techniques and their development, including traditional methods across different categories, as well as recent emerging methods in the field. Then, through our …

Suppressive Effects Of Exercise-Conditioned Serum On Cancer Cells: A Narrative Review Of The Influence Of Exercise Mode, Volume, And Intensity, Francesco Bettariga, Dennis R. Taaffe, Daniel A. Galvão, Chris Bishop, Jin Soo Kim, Robert U. Newton

Research outputs 2022 to 2026

Cancer is a major cause of morbidity and mortality worldwide, and the incidence is increasing, highlighting the need for effective strategies to treat this disease. Exercise has emerged as fundamental therapeutic medicine in the management of cancer, associated with a lower risk of recurrence and increased survival. Several avenues of research demonstrate reduction in growth, proliferation, and increased apoptosis of cancer cells, including breast, prostate, colorectal, and lung cancer, when cultured by serum collected after exercise in vitro (i.e., the cultivation of cancer cell lines in an experimental setting, which simplifies the biological system and provides mechanistic insight into cell …

Antenatal Care Utilisation And Receipt Of Its Components In Nigeria: Assessing Disparities Between Rural And Urban Areas—A Nationwide Population-Based Study, Emmanuel O. Adewuyi, Asa Auta, Mary I. Adewuyi, Aaron Akpu Philip, Victory Olutuase, Yun Zhao, Vishnu Khanal

Research outputs 2022 to 2026

Introduction Antenatal care (ANC) is crucial for positive pregnancy outcomes, but it is underutilised in Nigeria, suggesting unmet needs, and potentially contributing to the country’s high burden of maternal and neonatal mortalities. This study comprehensively assesses ANC utilisation and receipt of its components in Nigeria, focusing on disparities between rural and urban areas. Methods We used the data disaggregation approach to analyse the Nigeria Demographic and Health Survey 2018. We estimated ANC utilisation, assessed the receipt of ANC components, and identified factors associated with eight or more (≥ 8) ANC contacts nationally and across rural and urban residences. Results Nationwide, …

Cancer-Related Cognitive Impairment As A Key Contributor To Psychopathology In Cancer Survivors: Implications For Prevention, Treatment And Supportive Care, Darren Haywood, Melissa Henry, Evan Dauer, Oscar Lederman, Morgan Farley, Ashley M. Henneghan, Moira O’Connor, Michael Jefford, Susan L. Rossell, Nicolas H. Hart

Research outputs 2022 to 2026

A significant proportion of cancer survivors will experience some form of mental health compromise across domains including mood, anxiety, psychosis, eating disorders, and substance use. This psychopathology within cancer survivors is related to a range of negative outcomes and can also have a substantial negative impact on quality of life. Along with psychopathology, cognitive impairments are also commonly experienced, resulting in deficits in memory, reasoning, decision-making, speed of processing, and concentration, collectively referred to as cancer-related cognitive impairment (CRCI). Within the non-oncology literature, cognitive deficits are consistently demonstrated to be a key transdiagnostic aetiological feature of psychopathology, functionally contributing to …

Completion Of Pembrolizumab In Advanced Non-Small Cell Lung Cancer—Real World Outcomes After Two Years Of Therapy (Copilot), Andrew Fantoni, Lydia Warburton, Benjamin Solomon, Marliese Alexander, Meghana Maddula, Lauren Julia Brown, Ines Pires Da Silva, Adnan Nagrial, Farah Abu Al-Hial, Malinda Itchins, Nick Pavlakis, Samantha Bowyer

Research outputs 2022 to 2026

Background: Seminal trials with first-line pembrolizumab for metastatic non-small cell lung cancer (NSCLC) mandated a maximum two-years treatment. We describe real-world outcomes of a multi-site Australian cohort of patients who completed two-years of pembrolizumab. Methods: Retrospective data were collected from the national AUstralian Registry and biObank of thoRacic cAncers (AURORA). Primary endpoints were progression rate post pembrolizumab discontinuation; and progression free survival (PFS). Local treatment of oligoprogressive disease during pembrolizumab was allowed. Results: A total of 71 patients from six centers, median age 66.0 years, 49% male and 90% ECOG ≤ 1 were identified. Patients were Caucasian (82%) or Asian …

Interventions With A Clear Focus On Achieving Behaviour Change Are Important For Maintaining Training-Related Gains In People With Chronic Obstructive Pulmonary Disease: A Systematic Review, Sarah Hug, Vinicius Cavalheri, Hollie Lawson-Smith, Daniel F. Gucciardi, Kylie Hill

Research outputs 2022 to 2026

Questions: In people with chronic obstructive pulmonary disease (COPD) who complete an exercise training program (ETP) offered at a sufficient dose to result in training-related gains, to what extent are these gains maintained 12 months after program completion? Do variables such as the application of behaviour change techniques moderate the maintenance of these training-related gains? Design: Systematic review, meta-analysis and meta-regression of randomised controlled trials. Participants: People with stable COPD. Intervention: Trials were included if they applied ≥ 4 weeks of a whole-body ETP and reported outcome data immediately following program completion and 12 months after initial program completion. The …

Lurbinectedin In Small Cell Lung Cancer: Real-World Experience Of A Multicentre National Early Access Programme, Marliese Alexander, Jennifer Rogers, Sagun Parakh, Paul Mitchell, Timothy D. Clay, Steven Kao, Brett G.M. Hughes, Malinda Itchins, Benjamin Y. Kong, Nick Pavlakis, Benjamin J. Solomon, Thomas John

Research outputs 2022 to 2026

Background and Aims: Lurbinectedin is a novel oncogenic transcription inhibitor active in several cancers, including small cell lung cancer (SCLC). We aimed to describe the first Australian experience of the clinical efficacy and tolerability of lurbinectedin for the treatment of SCLC after progression on platinum-containing therapy. Methods: Multicentre real-world study of individuals with SCLC initiating lurbinectedin monotherapy (3.2 mg/m2 three-weekly) on an early access programme between May 2020 and December 2021. Key outcomes were clinical utilisation, efficacy and tolerability. Progression-free survival (PFS) and overall survival (OS) were calculated using the Kaplan–Meier method. Outcome data were collected within the AUstralian Registry …

Management Of Malignant Pleural Effusion And Trapped Lung: A Survey Of Respiratory Physicians And Thoracic Surgeons In Australasia, Calvin Sidhu, Gavin Wright, Carolyn J. Peddle-Mcintyre, Ai Ling Tan, Yun Chor Gary Lee

Research outputs 2022 to 2026

Background:

Malignant pleural effusions (MPEs) are common, and a third of them have underlying trapped lung (TL). Management of MPE and TL is suspected to be heterogeneous. Understanding current practices in Australasia is important in guiding policies and future research.

Aims:

Electronic survey of Australia-New Zealand respiratory physicians, thoracic surgeons and their respective trainees to determine practice of MPE and TL management.

Results:

Of the 132 respondents, 56% were respiratory physicians, 23% were surgeons and 20% were trainees. Many respondents defined TL as >25% or any level of incomplete lung expansion; 75% would use large-volume thoracentesis to determine whether TL …

Prognostic Value Of The 1-Min Sit-To-Stand Test To Predict Post-Operative Complications In Patients With Lung Cancer Elected For Lung Resection, Kirsten Quadflieg, Rachael Higgins, Eva Arents, Heleen Demeyer, Maarten Criel, Marc Daenen, David Ruttens, Michiel Thomeer, Dieter Stevens, Andrew Maiorana, Martijn A. Spruit, Vinicius Cavalheri, Chris Burtin

Research outputs 2022 to 2026

No abstract provided.

The Palliative Care Service Enhancement Program: Specialised Palliative Care Services For People With Behaviours And Psychological Symptoms Of Dementia In Australia, Mustafa Atee, Thomas Morris, Daniel Whiting, Marie Alford

Research outputs 2022 to 2026

No abstract provided.

The Crosstalk Between Amyloid-Β, Retina, And Sleep For The Early Diagnosis Of Alzheimer's Disease: A Narrative Review, Isaiah Lorenzo De Guia, Shaun Eslick, Sharon L. Naismith, Swathi Kanduri, Tejal M. Shah, Ralph N. Martins

Research outputs 2022 to 2026

Alzheimer's disease (AD) is the most common type of dementia, which is characterised by progressive memory loss and accumulation of hallmark markers amyloid-β (Aβ) and neurofibrillary tangles in the diseased brain. The current gold standard diagnostic methods have limitations of being invasive, costly, and not easily accessible. Thus, there is a need for new avenues, such as imaging the retina for early AD diagnosis. Sleep disruption is symptomatically frequent across preclinical and AD subjects. As circadian activity, such as the sleep-wake cycle, is linked to the retina, analysis of their association may be useful additions for achieving predictive AD diagnosis. …

Investigating The Intersections Of Vulnerability Detection And Iomts In Healthcare, A Scoping Review Protocol For Remote Patient Monitoring, Kulsoom S. Bughio, David M. Cook, Syed Afaq Shah

Research outputs 2022 to 2026

Due to the rapid and ubiquitous development and acceptance of IoT, healthcare providers have changed their locational settings from solely based in clinics to extend more broadly into the reach of patients’ domestic homes. This IoMT focus extends to various medical devices and applications within the healthcare domain, such as any form of smartphones, surveillance cameras, wearable sensors, and actuators, that hold the capability to access IoT technologies. The aim of this scoping review has two important objectives. The first is to understand the best approaches towards acquisition and refinement of data in favour of an optimised cyber security posture …

Association Of Basal Forebrain Atrophy With Cognitive Decline In Early Alzheimer Disease, Ying Xia, Vincent Dore, Jurgen Fripp, Pierrick Bourgeat, Simon M. Laws, Christopher J. Fowler, Stephanie R. Rainey-Smith, Ralph N. Martins, Christopher Rowe, Colin L. Masters, Elizabeth J. Coulson, Paul Maruff

Research outputs 2022 to 2026

Background and Objectives: In early Alzheimer disease (AD), β-amyloid (Aβ) deposition is associated with volume loss in the basal forebrain (BF) and cognitive decline. However, the extent to which Aβ-related BF atrophy manifests as cognitive decline is not understood. This study sought to characterize the relationship between BF atrophy and the decline in memory and attention in patients with early AD.

Methods: Participants from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study who completed Aβ-PET imaging and repeated MRI and cognitive assessments were included. At baseline, participants were classified based on their clinical dementia stage and Aβ status, yielding groups …

Measure Do Not Guess: A Call To Action To End Assumed And Estimated Menstrual Cycle Phases In Research, Richard J. Burden, Marco Altini, Eva Ferrer, Tessa R. Flood, Gary Lewin, Sophia Nimphius, Stuart M. Phillips, Kirsty J. Elliott-Sale

Research outputs 2022 to 2026

No abstract provided.