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Aga Khan University

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Articles 9451 - 9480 of 9519

Full-Text Articles in Medicine and Health Sciences

Molecular Characterization Of Neurotransmitter Transporters, Saad Shafqat, M Velaz- Faircloth, A Guadaño- -Ferraz, R T Fremeau Jan 1993

Molecular Characterization Of Neurotransmitter Transporters, Saad Shafqat, M Velaz- Faircloth, A Guadaño- -Ferraz, R T Fremeau

Section of Neurology

No abstract provided.


Vocal Cord Paralysis Following Endotracheal Intubation, S Akhtar, Tanveer Janjua, Jameel Hyder Dec 1992

Vocal Cord Paralysis Following Endotracheal Intubation, S Akhtar, Tanveer Janjua, Jameel Hyder

Section of Otolaryngology, Head & Neck Surgery

No abstract provided.


Omeprazole In Short Term Treatment Of Reflux Oesophagitis, W Jafri, Z Abbas, S Hamid, S Abid, H Shah, H Khan Dec 1992

Omeprazole In Short Term Treatment Of Reflux Oesophagitis, W Jafri, Z Abbas, S Hamid, S Abid, H Shah, H Khan

Section of Gastroenterology

No abstract provided.


Yoghurt (Dahi): A Probiotic And Therapeutic View, Z Abbas, W Jafri Sep 1992

Yoghurt (Dahi): A Probiotic And Therapeutic View, Z Abbas, W Jafri

Section of Gastroenterology

No abstract provided.


Appearance Of A Methotrexate Binding Plasma Protein During High Dose Methotrexate Therapy, M P. Iqbal, I Malik, N Mehboobali Aug 1992

Appearance Of A Methotrexate Binding Plasma Protein During High Dose Methotrexate Therapy, M P. Iqbal, I Malik, N Mehboobali

Department of Biological & Biomedical Sciences

No abstract provided.


Renal Angiomyolipoma: An Uncommon Tumour, Zafar Nazir, Jamsheer J. Talati Jul 1992

Renal Angiomyolipoma: An Uncommon Tumour, Zafar Nazir, Jamsheer J. Talati

Section of Urology

No abstract provided.


Oesophageal Carcinoma Caused By Betel Nut, M Y. Sheikh, I H. Rizvi, I Ahmed Jun 1992

Oesophageal Carcinoma Caused By Betel Nut, M Y. Sheikh, I H. Rizvi, I Ahmed

Department of Radiology

No abstract provided.


Randomised Comparison Of Oral Ofloxacin Alone With Combination Of Parenteral Antibiotics In Neutropenic Febrile Patients, I A. Malik, Z Abbas, M Karim May 1992

Randomised Comparison Of Oral Ofloxacin Alone With Combination Of Parenteral Antibiotics In Neutropenic Febrile Patients, I A. Malik, Z Abbas, M Karim

Section of Gastroenterology

Prompt treatment with empirical antibiotics in neutropenic febrile patients reduces morbidity and mortality. Most patients have been treated with parenteral combination antibiotics, but newer antibiotics with broad-spectrum bactericidal activity have made monotherapy feasible. Ofloxacin, a broad-spectrum fluoroquinolone, has the additional advantage that bactericidal concentrations can be achieved with oral administration. We have compared ofloxacin as an oral single agent with standard parenteral combination antibiotics for the management of neutropenic febrile patients in a prospective, randomised trial. Patients with severe neutropenia (absolute neutrophil count less than or equal to 0.5 x 10(9)/l), fever above 38 degrees C, and ability to take …


Testotoxicosis: Gonadotrophin-Independent Male Sexual Precocity, A A. Aziz, S M. Jafri, N U. Haque Mar 1992

Testotoxicosis: Gonadotrophin-Independent Male Sexual Precocity, A A. Aziz, S M. Jafri, N U. Haque

Section of Pulmonary & Critical Care

In this era of rapidly developing investigational tools and pharmacology, the pathophysiology of precocious puberty is becoming well defined. What was previously thought to be a form of gonadotrophin releasing hormone (GNRH)-dependent central precocious puberty is now classified as GNRH-independent familial testotoxicosis. We present two such cases and review the clinical features, pathophysiology and treatment of testotoxicosis.


Family Medicine Postgraduate Training In Pakistan, Cynthia Lawrence Haq, Asma Fozia Qureshi, Rukhsana Wamiq Zuberi, S. N. Bazmi Inam, John H. Bryant Mar 1992

Family Medicine Postgraduate Training In Pakistan, Cynthia Lawrence Haq, Asma Fozia Qureshi, Rukhsana Wamiq Zuberi, S. N. Bazmi Inam, John H. Bryant

Department for Educational Development

There is no organized system of postgraduate training for family medicine or general practice in Pakistan. This paper describes the status of primary health care delivery in Pakistan and the growth of family medicine throughout the world. It stresses the need for organized postgraduate training relevant to the needs of primary health care in Pakistan and describes efforts currently under-way in this regard at the Aga Khan University Medical Center (AKUMC) in collaboration with the College of Physicians and Surgeons of Pakistan


An Unusual Presentation Of Ischiorectal Abscess, K Hameed, R Maniar Mar 1992

An Unusual Presentation Of Ischiorectal Abscess, K Hameed, R Maniar

Department of Surgery Docs

No abstract provided.


Prognostic Factors In Ganglionic And Thalamic Haemorrhages: A Clinical And Radiological Study., Aziz Sonawalla, Z Abbas, Mohammed Ataullah Khan Mar 1992

Prognostic Factors In Ganglionic And Thalamic Haemorrhages: A Clinical And Radiological Study., Aziz Sonawalla, Z Abbas, Mohammed Ataullah Khan

Department of Medicine

Clinical and radiological features of 43 patients admitted for ganglionic (21) and thalamic (22) haemorrhages were studied to ascertain the factors that would determine prognosis in the acute stage of the illness. Nineteen patients died, 16 of them in the first week. The adverse clinical factors were an altered state of consciousness, decorticate/decerebrate posturing, ataxic respiration, abnormalities of gaze and presence of bilateral Babinski's sign. Adverse radiological factors were the presence of thalamic haemorrhage of 3 cm or more, intraventricular spread of the haemorrhage and midline shift of 0.5 cm of more. The significance of these findings is discussed.


Prevention Of First Variceal Bleeding: New Prospects, S Hamid, W Jafri Feb 1992

Prevention Of First Variceal Bleeding: New Prospects, S Hamid, W Jafri

Section of Gastroenterology

No abstract provided.


Necrotizing Enterocolitis In Infants Weighing Less Than 2000 G, P Mufti, Z A. Bhutta Feb 1992

Necrotizing Enterocolitis In Infants Weighing Less Than 2000 G, P Mufti, Z A. Bhutta

Department of Paediatrics and Child Health

Over a 4 year period, nine of 180 (5%) infants weighing less than 2000 G, admitted to the Aga Khan University Hospital (AKUH) developed necrotizing enterocolitis (NEC). An outbreak of NEC occurred in 1989, during which six infants developed the clinical illness. Overall incidence was 1.1%. Thirty-one birth weight and gestation matched controls were selected for comparison. Risk factors usually considered as predisposing factors, i.e., low 5 min Apgar score, rate of maternal complications, respiratory distress syndrome, mechanical ventilation, umbilical catheterisation, patient ductus arteriosus, use of antibiotics and feeding practices were found with equal frequency in both cases and controls. …


Trichotillomania, Shahin H. Hussain Jan 1992

Trichotillomania, Shahin H. Hussain

Department of Psychiatry

No abstract provided.


Platelets And Leucocyte Counts In Pregnancy, Saadiya Aziz Karim, Javaid H. Rizvi, Iffat Rizwana, Mohammad Khurshid, Sadiqua N. Jafarey Jan 1992

Platelets And Leucocyte Counts In Pregnancy, Saadiya Aziz Karim, Javaid H. Rizvi, Iffat Rizwana, Mohammad Khurshid, Sadiqua N. Jafarey

Department of Obstetrics & Gynaecology

A study involving the obstetric clinic population of 3 major teaching hospitals of Karachi has been conducted to define changes in leucocyte and platelet counts as pregnancy progresses. 573 “normal” pregnant women - 183 in the first trimester, 195 in the second trimester and 194 in the third trimester were included in this analysis. We have found leucocytosis to be a feature of normal pregnancy; the change is subsequent to a progressive increase in granulocytes. Platelet counts were found to decrease slightly as pregnancy progresses


Role Of Thymectomy In Myasthenia Gravis, Sohaila Mohsin Ali, Aziz Sonawalla, Irfan Altafullah, Hizbullah Sheikh Jan 1992

Role Of Thymectomy In Myasthenia Gravis, Sohaila Mohsin Ali, Aziz Sonawalla, Irfan Altafullah, Hizbullah Sheikh

Section of Urology

Thirteen patients with myasthenia gravis underwent total thymectomy between January, 1988 and December, 1991. The duration of symptoms prior to surgery varied from 2 months to 20 years. In a follow-up ranging from 2 months to 4 years, 11 patients showed a significant improvement with either complete discontinuation of medication of a marked reduction in doses. One patient with a small benign thymoma showed some improvement but subsequently required stepping up of anticholinesterase medication and addition of steroids and immune suppressants; another patient with atrophic thymic tissue had complete remission after thymectomy but developed myasthenic symptoms six months later requiring …


Prevalence Of Iron Deficiency Anaemia In Children Of The Urban Slums Of Karachi, Ayesha Molla, Mohammad Khurshid, A. Majid Molla Jan 1992

Prevalence Of Iron Deficiency Anaemia In Children Of The Urban Slums Of Karachi, Ayesha Molla, Mohammad Khurshid, A. Majid Molla

Department of Pathology and Laboratory Medicine

A preliminary baseline survey was conducted to estimate the prevalence of anaemia in a group of 391 children aged 6-60 months, randomly selected from three urban slums of Karachi. Haemoglobin and the red cell indices including haematocrit, MCV, MCH, MCHC, ABC and red cell distribution width (RDW) were estimated for each of the selected children. Ferritin estimation was done on 354 (9 1%) children to assess the iron storage status. According to WHO criteria, the accepted cut-off point for anaemia screening in children is set at 11 gm/dl, 70 fI and 20 pg for haemoglobin, MCV and MCH respectively. Following …


Radiation Induced Tumor Lysis Syndrome In Patients With Leukemia, Imtiaz A. Malik, Paul Vellozo, Mohammad Khurshid, M. Ata Khan Jan 1992

Radiation Induced Tumor Lysis Syndrome In Patients With Leukemia, Imtiaz A. Malik, Paul Vellozo, Mohammad Khurshid, M. Ata Khan

Department of Medicine

Tumour lysis syndrome is a catastrophic complica­lion of treatment of certain neoplasms. It is usually seen with the tumours that have high growth fractions, increased bulk and extreme sensitivity to cytotoxic therapy. Most commonly it occurs in association with hematologic malignancies such as lymphomas and leukaemias. Rarely it has been observed with solid tumours like small cell lung cancer, seminoma and carcinoma of the breast. The syndrome develops due to massive cell lysis occurring within a few hours to a few days of starting the cytotoxic therapy. It is characterized by hyperuricemia, hyperkalemia, hyperphosphatemia and hypocalcaemia. Acute renal failure, cardiac …


Eosinophilic Gastroenteritis, S H. Shah, Z Abbas, S Abid, H Shaikh, T Qaseem, H Khan Dec 1991

Eosinophilic Gastroenteritis, S H. Shah, Z Abbas, S Abid, H Shaikh, T Qaseem, H Khan

Section of Gastroenterology

No abstract provided.


Supervised Training Of Practical Procedures In The Internal Medicine Residency, Z Abbas, S Abid, J A. Khan, A Jabbar Dec 1991

Supervised Training Of Practical Procedures In The Internal Medicine Residency, Z Abbas, S Abid, J A. Khan, A Jabbar

Section of Gastroenterology

In order to get feedback whether the medical residents are getting adequate supervised training to perform practical procedures, a questionnaire was distributed among the residents asking their involvement in sixteen frequently performed procedures in the medical unit of the Aga Khan University Medical Centre. Though the residents were satisfied about their training in doing lumbar punctures, pleural and peritoneal aspirations, bone marrow aspiration and trephine and chest tubes placement, they showed their concern about training in putting central lines, venous cut downs, cardiac pacing and biopsies. A better schedule training programme, organized subspecialty rotation, continuous evaluation of resident's skill, credentialing …


Yet Another Cause Of Chronic Viral Hepatitis?, H A. Shah, S Abid, S Hamid, S W. Jafri, Z Abbas, T Qaseem, H Shaikh, A H. Khan Nov 1991

Yet Another Cause Of Chronic Viral Hepatitis?, H A. Shah, S Abid, S Hamid, S W. Jafri, Z Abbas, T Qaseem, H Shaikh, A H. Khan

Section of Gastroenterology

The clinical features, course and histology of liver in 20 patients; mostly middle aged to elderly females, closely resembling chronic Non A Non B hepatitis is presented. They presented quite late in their disease and therefore, complications such as variceal bleeds, ascites and encephalopathy were frequent. Our patients were negative for hepatitis B and C virus serology. Metabolic and immune causes of chronic liver disease were also ruled out. To the best of our knowledge, this is the first study of its kind elaborating the clinical features, course and histology of liver in chronic Non B Non C hepatitis and …


Enterolithiasis Secondary To Intestinal Tuberculosis, M Y. Sheikh, I H. Rizvi, S A. Naeem, I Ahmad Nov 1991

Enterolithiasis Secondary To Intestinal Tuberculosis, M Y. Sheikh, I H. Rizvi, S A. Naeem, I Ahmad

Department of Radiology

No abstract provided.


Congenital Pyloric Atresia And Epidermolysis Bullosa, Zafar Nazir, Zeba Batool Attar, Farhat Moazam Oct 1991

Congenital Pyloric Atresia And Epidermolysis Bullosa, Zafar Nazir, Zeba Batool Attar, Farhat Moazam

Section of Paediatric Surgery

Congenital pyloric atresia with epidermolysis bul­losa is recognized as a rare but distinct entity which is uniformly fatal1,2. Until 1990 only 20 cases have been reported in the English literature3,4. We present an additional case managed at the Aga Khan University Hospital to demonstrate the difficulties encountered in the management of such infants.


Recent Concepts In Clinical Psychiatry: Drug Treatment In Schizophrenia, Shahin H. Hussain Sep 1991

Recent Concepts In Clinical Psychiatry: Drug Treatment In Schizophrenia, Shahin H. Hussain

Department of Psychiatry

No abstract provided.


Sertoli Cell Only Syndrome (Secos): Lessons From Case Studies, Jamsheer J Talati, Hizbullah Sheikh Sep 1991

Sertoli Cell Only Syndrome (Secos): Lessons From Case Studies, Jamsheer J Talati, Hizbullah Sheikh

Section of Urology

Between June 85 and December 87, 69 testicular biopsies were submitted for histopathological examination during investigation of infertility; ten (14%) patients had a Sertoli cell only syndrome. The history, clinical features, and hormonal profiles were analyzed in an attempt to categorize these patients on aetiological basis. Two followed treatment of malignancy--one by radiation for testicular cancer and one by cyclophosphamide for a lymphoma. One had unilateral cryptorchidism. Mumps was etiological factor in one patient. FSH levels determined in 6 patients were elevated in all suggesting a possible dependence of (sick) Sertoli cells on spermatogenic cells for production of inhibin. Alternative …


Collagenous Colitis, Z Abbas, S Abid, S Hamid, W Jafri, H Khan Sep 1991

Collagenous Colitis, Z Abbas, S Abid, S Hamid, W Jafri, H Khan

Section of Gastroenterology

No abstract provided.


A 5 Year Retrospective Case Study Of Penetrating Ocular Trauma At The Aga Khan University Hospital, Karachi, S Qarab Hasnain, Muzaffar Kirmani Aug 1991

A 5 Year Retrospective Case Study Of Penetrating Ocular Trauma At The Aga Khan University Hospital, Karachi, S Qarab Hasnain, Muzaffar Kirmani

Section of Ophthalmology

Ocular Trauma is an important cause of monocular visual impairment and blindness in younger age groups. We examined the cases of hospitalized ocular trauma from 1st January, 1985 through 30th July, 1990 using hospital medical records. The study comprised 27 patients (28 eyes), 51.8% of whom were under 16. The male-female ratio was 2.8:1. Right eye was more commonly involved (66.6%) and one patient had bilateral ruptured globes. Children at play were most vulnerable (33.3%) followed by road accidents which was the major cause (29.6%) in adults. Sixteen (64.0%) eyes suffered some complications and their mean duration of presentation after …


Hepatic Dysfunction In Falciparum Malaria, J Khan, J Akhter, H Sheikh, W Jafri Aug 1991

Hepatic Dysfunction In Falciparum Malaria, J Khan, J Akhter, H Sheikh, W Jafri

Department of Pathology and Laboratory Medicine

No abstract provided.


Current Concepts In The Diagnosis And Management Of Childhood Asthma, Z A. Bhutta Aug 1991

Current Concepts In The Diagnosis And Management Of Childhood Asthma, Z A. Bhutta

Department of Paediatrics and Child Health

No abstract provided.