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Aga Khan University

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Articles 9421 - 9450 of 9505

Full-Text Articles in Medicine and Health Sciences

Retained Stones In The Common Bile Duct: Results Of Management, Kamran Hamid, R Azami, W Jaffery, T Hameed May 1993

Retained Stones In The Common Bile Duct: Results Of Management, Kamran Hamid, R Azami, W Jaffery, T Hameed

Department of Surgery Docs

Seventeen patients underwent treatment for retained common bile duct stones. In 7 patients the stones were removed via a T-tube tract using steerable catheters while 5 patients underwent ERCP and sphincterotomy and 5 underwent surgical re-exploration. Considering morbidity, mortality, success rate and patients' stay in the hospital, non-operative modalities should be the treatment of choice for retained common bile duct stones.


Prevalence Of Thalassemia Minor Trait In Pakistani Population Presented At Akuh For Complete Blood Count Estimation (Cbc)., Alia Shaikh, Mohammad Khurshid May 1993

Prevalence Of Thalassemia Minor Trait In Pakistani Population Presented At Akuh For Complete Blood Count Estimation (Cbc)., Alia Shaikh, Mohammad Khurshid

Department of Pathology and Laboratory Medicine

No abstract provided.


Family Medicine: A Brief Review Of Its History And Concepts And Its Relevance To Pakistan, Rukhsana Wamiq Zuberi May 1993

Family Medicine: A Brief Review Of Its History And Concepts And Its Relevance To Pakistan, Rukhsana Wamiq Zuberi

Department for Educational Development

Inmost countries of the world some form of family medicine is being practiced by members of the medical profession. In over fifty countries distinct practitioners of this form of medicine are recognized and in some countries formal designation as specialists is accorded to them. In certain countries the physicians are called family practitioners and in others they are called general practitioners. Both terms are correct as these physicians have broad-based clinical skills (generalists) and also take care of the families. In Pakistan health care is usually available only to those who can afford it. A large segment of population consists …


Spontaneous Sub-Periosteal Hematoma Of The Orbit: Diagnosis On Computed Tomography, T A. Rana May 1993

Spontaneous Sub-Periosteal Hematoma Of The Orbit: Diagnosis On Computed Tomography, T A. Rana

Department of Radiology

No abstract provided.


The Ring Butterfly Fragment, Philippe D`Sousa, Masood Umer, Riaz Hussain Lakdawala Apr 1993

The Ring Butterfly Fragment, Philippe D`Sousa, Masood Umer, Riaz Hussain Lakdawala

Department of Surgery Docs

No abstract provided.


Cerebral Amoebiasis, T A. Rana, T Hameed, N Rao Apr 1993

Cerebral Amoebiasis, T A. Rana, T Hameed, N Rao

Department of Radiology

No abstract provided.


Sequential Induction Of Aplastic Anemia And Acute Leukemia By Chloramphenicol, Z Abbas, I Malik, A Khan Mar 1993

Sequential Induction Of Aplastic Anemia And Acute Leukemia By Chloramphenicol, Z Abbas, I Malik, A Khan

Section of Gastroenterology

No abstract provided.


Lymphoma Complicating Ulcerative Colitis, S H. Shah, A H. Khan, H Shaikh, A Ahmed Feb 1993

Lymphoma Complicating Ulcerative Colitis, S H. Shah, A H. Khan, H Shaikh, A Ahmed

Section of Gastroenterology

No abstract provided.


Penile Constrictive Band Injury, Zafar Nazir, Khalid Rasheed, Farhat Moazam Jan 1993

Penile Constrictive Band Injury, Zafar Nazir, Khalid Rasheed, Farhat Moazam

Section of Paediatric Surgery

Penile strangulation caused by a thread or human hair is an uncommon cause of urethral injury described in paediatric piactice. Five children presented with this entity to the Aga Khan University Hospital, Karachi between August, 1991 and August, 1992. Three children had uneventful recoveries after removal of the contricting agent. Two patients developed urethrocutaneaus fistulae and partial amputation of the penis because of late presentation Early recognition and removal of the constricting agent is necessary to prevent serious complications


Factor Xiii Deficiency In Pakistan, Aamir Nadeem Shaikh, Mohammad Khurshid Jan 1993

Factor Xiii Deficiency In Pakistan, Aamir Nadeem Shaikh, Mohammad Khurshid

Department of Pathology and Laboratory Medicine

Patients with undiagnosed haemostatic defects seen at The Aga Khan Hospital and Fatimid Blood Transfusion Centre during the period of 7 years (1 985-1 992) were screened with routine tests including bleeding time (BT), whole blood clotting time (CT), platelet count, activated partial thromboplastin time (APTT), prothrombin time (PT) and 5 molar urea test. Nine patients had a positive 5 molar urea test indicating factor XIII deficiency. Rest of the screening tests were normal in these patients. High incidence of consanguinity was observed in affected families. Clinical features included excessive bleeding from umbilical stump, bruising, post-traumatic bleeding, epistaxis, melaena and …


Cysticercosis In A Muslim Woman, Farrukh Aijaz, Altaf Ahmed Jan 1993

Cysticercosis In A Muslim Woman, Farrukh Aijaz, Altaf Ahmed

Department of Pathology and Laboratory Medicine

No abstract provided.


Salmonella Hadar Pericarditis, A Aziz, W Jafri, T A. Jawed, A Shaikh, B Farooqui, M K. Ashfaq, N Ul Haq Jan 1993

Salmonella Hadar Pericarditis, A Aziz, W Jafri, T A. Jawed, A Shaikh, B Farooqui, M K. Ashfaq, N Ul Haq

Department of Pathology and Laboratory Medicine

No abstract provided.


Management Of Diabetic Patient’S Undergoing Major Surgery Using Glucose Insulin Potassium Infusion, Fazal Hameed Khan, Rs Kamal Jan 1993

Management Of Diabetic Patient’S Undergoing Major Surgery Using Glucose Insulin Potassium Infusion, Fazal Hameed Khan, Rs Kamal

Department of Anaesthesia

No abstract provided.


Effect Of Alcohol On The Postnatal Development Of Cerebellar Cortex In Rat Guste 1-Histological And Morphometric Studies., Mansoor Saleh, M N. Saleh, M A. Desouky, Saadia Sayed, Entesar Saber Jan 1993

Effect Of Alcohol On The Postnatal Development Of Cerebellar Cortex In Rat Guste 1-Histological And Morphometric Studies., Mansoor Saleh, M N. Saleh, M A. Desouky, Saadia Sayed, Entesar Saber

Haematology and Oncology, East Africa

The effect of ethyl alcohol (10%) on the postnatal development of cerebellar cortex was studied using histological and morphometric methods. The external granular layer was much increased in thickness in alcohol fed rat than those of the control while the molecular and granular layer were reduced. The cells of themolecular layer showed neuronal degeneration and many spaces were present in this layer esp < /strong>ecially late postnatal. The Purkinje cells failed to reach their final position up the tenth day and still arranged in more than one row. The degenerative changes appeared at five days and increased with age. The extent …


Malabsorption Of Nutrients In Children With Diarrhoea Due To Unknown Aetiologies, Ayesha Molla, Mohammad Khurshid, Abdul Majid Molla, Makhduma Khatun Jan 1993

Malabsorption Of Nutrients In Children With Diarrhoea Due To Unknown Aetiologies, Ayesha Molla, Mohammad Khurshid, Abdul Majid Molla, Makhduma Khatun

Department of Pathology and Laboratory Medicine

Intake and coefficient of absorption of nutrients wefe measured in 72 children dufing acute diarrhoea and 2 weeks after fecovery. No diarrhooeal pathogens could be identified in 18 (25%) childfen (group I). Aetiology of diafrhoea was identified in fest of the 54 children (group II). Absofption of oalofie, fat and cafbohydrate during the recovery stage were similaf in all 72 children, In group I, absorption of nutrients improved from acute stage to recovery stage as follows: fat from 62 to 85%, calofies from 68 to 86% and carbohydrate from 81 to 91%. Absorption of nitrogen during the acute stage was …


Cloning And Expression Of A Novel Na(+)-Dependent Neutral Amino Acid Transporter Structurally Related To Mammalian Na+/Glutamate Cotransporters, Saad Shafqat, Balaji Tamarappoo, Michael S Kilberg, Ram S Puranam, James O. Mcnamara, Ana Guadaño -Ferraz, R.T. Fremeau Jan 1993

Cloning And Expression Of A Novel Na(+)-Dependent Neutral Amino Acid Transporter Structurally Related To Mammalian Na+/Glutamate Cotransporters, Saad Shafqat, Balaji Tamarappoo, Michael S Kilberg, Ram S Puranam, James O. Mcnamara, Ana Guadaño -Ferraz, R.T. Fremeau

Section of Neurology

A cDNA has been isolated from human hippocampus that appears to encode a novel Na(+)-dependent, Cl(-)-independent, neutral amino acid transporter. The putative protein, designated SATT, is 529 amino acids long and exhibits significant amino acid sequence identity (39-44%) with mammalian L-glutamate transporters. Expression of SATT cDNA in HeLa cells induced stereospecific uptake of L-serine, L-alanine, and L-threonine that was not inhibited by excess (3 mM) 2-(methylamino)-isobutyric acid, a specific substrate for the System A amino acid transporter. SATT expression in HeLa cells did not induce the transport of radiolabeled L-cysteine, L-glutamate, or related dicarboxylates. Northern blot hybridization revealed high levels …


Molecular Characterization Of Neurotransmitter Transporters, Saad Shafqat, M Velaz- Faircloth, A Guadaño- -Ferraz, R T Fremeau Jan 1993

Molecular Characterization Of Neurotransmitter Transporters, Saad Shafqat, M Velaz- Faircloth, A Guadaño- -Ferraz, R T Fremeau

Section of Neurology

No abstract provided.


Vocal Cord Paralysis Following Endotracheal Intubation, S Akhtar, Tanveer Janjua, Jameel Hyder Dec 1992

Vocal Cord Paralysis Following Endotracheal Intubation, S Akhtar, Tanveer Janjua, Jameel Hyder

Section of Otolaryngology, Head & Neck Surgery

No abstract provided.


Omeprazole In Short Term Treatment Of Reflux Oesophagitis, W Jafri, Z Abbas, S Hamid, S Abid, H Shah, H Khan Dec 1992

Omeprazole In Short Term Treatment Of Reflux Oesophagitis, W Jafri, Z Abbas, S Hamid, S Abid, H Shah, H Khan

Section of Gastroenterology

No abstract provided.


Yoghurt (Dahi): A Probiotic And Therapeutic View, Z Abbas, W Jafri Sep 1992

Yoghurt (Dahi): A Probiotic And Therapeutic View, Z Abbas, W Jafri

Section of Gastroenterology

No abstract provided.


Appearance Of A Methotrexate Binding Plasma Protein During High Dose Methotrexate Therapy, M P. Iqbal, I Malik, N Mehboobali Aug 1992

Appearance Of A Methotrexate Binding Plasma Protein During High Dose Methotrexate Therapy, M P. Iqbal, I Malik, N Mehboobali

Department of Biological & Biomedical Sciences

No abstract provided.


Renal Angiomyolipoma: An Uncommon Tumour, Zafar Nazir, Jamsheer J. Talati Jul 1992

Renal Angiomyolipoma: An Uncommon Tumour, Zafar Nazir, Jamsheer J. Talati

Section of Urology

No abstract provided.


Oesophageal Carcinoma Caused By Betel Nut, M Y. Sheikh, I H. Rizvi, I Ahmed Jun 1992

Oesophageal Carcinoma Caused By Betel Nut, M Y. Sheikh, I H. Rizvi, I Ahmed

Department of Radiology

No abstract provided.


Randomised Comparison Of Oral Ofloxacin Alone With Combination Of Parenteral Antibiotics In Neutropenic Febrile Patients, I A. Malik, Z Abbas, M Karim May 1992

Randomised Comparison Of Oral Ofloxacin Alone With Combination Of Parenteral Antibiotics In Neutropenic Febrile Patients, I A. Malik, Z Abbas, M Karim

Section of Gastroenterology

Prompt treatment with empirical antibiotics in neutropenic febrile patients reduces morbidity and mortality. Most patients have been treated with parenteral combination antibiotics, but newer antibiotics with broad-spectrum bactericidal activity have made monotherapy feasible. Ofloxacin, a broad-spectrum fluoroquinolone, has the additional advantage that bactericidal concentrations can be achieved with oral administration. We have compared ofloxacin as an oral single agent with standard parenteral combination antibiotics for the management of neutropenic febrile patients in a prospective, randomised trial. Patients with severe neutropenia (absolute neutrophil count less than or equal to 0.5 x 10(9)/l), fever above 38 degrees C, and ability to take …


Testotoxicosis: Gonadotrophin-Independent Male Sexual Precocity, A A. Aziz, S M. Jafri, N U. Haque Mar 1992

Testotoxicosis: Gonadotrophin-Independent Male Sexual Precocity, A A. Aziz, S M. Jafri, N U. Haque

Section of Pulmonary & Critical Care

In this era of rapidly developing investigational tools and pharmacology, the pathophysiology of precocious puberty is becoming well defined. What was previously thought to be a form of gonadotrophin releasing hormone (GNRH)-dependent central precocious puberty is now classified as GNRH-independent familial testotoxicosis. We present two such cases and review the clinical features, pathophysiology and treatment of testotoxicosis.


An Unusual Presentation Of Ischiorectal Abscess, K Hameed, R Maniar Mar 1992

An Unusual Presentation Of Ischiorectal Abscess, K Hameed, R Maniar

Department of Surgery Docs

No abstract provided.


Prognostic Factors In Ganglionic And Thalamic Haemorrhages: A Clinical And Radiological Study., Aziz Sonawalla, Z Abbas, Mohammed Ataullah Khan Mar 1992

Prognostic Factors In Ganglionic And Thalamic Haemorrhages: A Clinical And Radiological Study., Aziz Sonawalla, Z Abbas, Mohammed Ataullah Khan

Department of Medicine

Clinical and radiological features of 43 patients admitted for ganglionic (21) and thalamic (22) haemorrhages were studied to ascertain the factors that would determine prognosis in the acute stage of the illness. Nineteen patients died, 16 of them in the first week. The adverse clinical factors were an altered state of consciousness, decorticate/decerebrate posturing, ataxic respiration, abnormalities of gaze and presence of bilateral Babinski's sign. Adverse radiological factors were the presence of thalamic haemorrhage of 3 cm or more, intraventricular spread of the haemorrhage and midline shift of 0.5 cm of more. The significance of these findings is discussed.


Family Medicine Postgraduate Training In Pakistan, Cynthia Lawrence Haq, Asma Fozia Qureshi, Rukhsana Wamiq Zuberi, S. N. Bazmi Inam, John H. Bryant Mar 1992

Family Medicine Postgraduate Training In Pakistan, Cynthia Lawrence Haq, Asma Fozia Qureshi, Rukhsana Wamiq Zuberi, S. N. Bazmi Inam, John H. Bryant

Department for Educational Development

There is no organized system of postgraduate training for family medicine or general practice in Pakistan. This paper describes the status of primary health care delivery in Pakistan and the growth of family medicine throughout the world. It stresses the need for organized postgraduate training relevant to the needs of primary health care in Pakistan and describes efforts currently under-way in this regard at the Aga Khan University Medical Center (AKUMC) in collaboration with the College of Physicians and Surgeons of Pakistan


Prevention Of First Variceal Bleeding: New Prospects, S Hamid, W Jafri Feb 1992

Prevention Of First Variceal Bleeding: New Prospects, S Hamid, W Jafri

Section of Gastroenterology

No abstract provided.


Necrotizing Enterocolitis In Infants Weighing Less Than 2000 G, P Mufti, Z A. Bhutta Feb 1992

Necrotizing Enterocolitis In Infants Weighing Less Than 2000 G, P Mufti, Z A. Bhutta

Department of Paediatrics and Child Health

Over a 4 year period, nine of 180 (5%) infants weighing less than 2000 G, admitted to the Aga Khan University Hospital (AKUH) developed necrotizing enterocolitis (NEC). An outbreak of NEC occurred in 1989, during which six infants developed the clinical illness. Overall incidence was 1.1%. Thirty-one birth weight and gestation matched controls were selected for comparison. Risk factors usually considered as predisposing factors, i.e., low 5 min Apgar score, rate of maternal complications, respiratory distress syndrome, mechanical ventilation, umbilical catheterisation, patient ductus arteriosus, use of antibiotics and feeding practices were found with equal frequency in both cases and controls. …