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Articles 31 - 52 of 52
Full-Text Articles in Medicine and Health Sciences
Association Of Serum Albumin Levels And Guillain Barre Syndrome (Gbs) Outcome., Mazhar Badshah, Ghulam Shabbir, Sumaira Fazal Nabi, Daniyal Ahmed
Association Of Serum Albumin Levels And Guillain Barre Syndrome (Gbs) Outcome., Mazhar Badshah, Ghulam Shabbir, Sumaira Fazal Nabi, Daniyal Ahmed
Pakistan Journal of Neurological Sciences (PJNS)
Guillain-Barre syndrome (GBS) is a polyradiculoneuropathy characterized by a rapidly progressive bilateral paresis of the limbs. Nadir is typically reached within a number of days or weeks, followed by a recovery that is generally much slower and often incomplete. Guillain-Barre syndrome is usually preceded by infection or other immune stimulation that induces an aberrant autoimmune response targeting peripheral nerves and their spinal roots.IVIG and Plasmapheresis are used first line treatments in GBS treatment. For better assessment of treatment response, biomarkers reflecting Plasmapheresis and IVIG efficacy are needed. Aim of this study is to determine serum albumin as an independent biomarker …
Asian Midwifery In 2018, Rafat Jan, Edwin Van Teijlingen
Asian Midwifery In 2018, Rafat Jan, Edwin Van Teijlingen
Journal of Asian Midwives (JAM)
No abstract provided.
Neuroimmunology Diagnostics, Mohammad Saeed, Tariq Gazdar, Nadir Ali Syed, Arsalan Ahmad
Neuroimmunology Diagnostics, Mohammad Saeed, Tariq Gazdar, Nadir Ali Syed, Arsalan Ahmad
Pakistan Journal of Neurological Sciences (PJNS)
Neuroimmunology has led to advanced diagnostics of previously cryptic disorders, using autoantibody testing against neurological targets. Neuropsychiatric syndromes and autoimmune encephalitis can now be routinely diagnosed using specialized antibody tests such as immunofluorescence and immunoblot assays in specialized laboratories. This helps in early and accurate diagnosis, leading to favorable patient prognosis. Here, we briefly review the diagnostics for Neuroimmunologic and related disorders including autoimmune encephalitis, demyelinating diseases, neuropathies, paraneoplastic syndromes, stiffperson syndrome, inflammatory myopathies as well as Alzheimer’s disease.
An Uncommon And Elusive Cause Of Cerebral Venous Thrombosis, Farheen Niazi, Saadia Riaz
An Uncommon And Elusive Cause Of Cerebral Venous Thrombosis, Farheen Niazi, Saadia Riaz
Pakistan Journal of Neurological Sciences (PJNS)
We present a case of of young 27year male who was admitted with history of headache and vomiting for one week. He was diagnosed as having dural sinus thrombosis of superior sagittal, right lateral, right sigmoid sinus. There was previous history of uveitis 6 months prior to it. All thrombophilia workup was negative except homocysteine levels were moderately high. He was also found to be having recurring genital and oral ulcers. Pathergy test was negative. His HLA B 51/5 testing came back positive. Final diagnosis of Bechet’s disease was made and responded well to long term steroids and Colchicine. A …
Recurrent Cns Haemangioblastomas With New Onset Of Retinal Angiomas In A Female Patient Diagnosed As Von Hippel Lindau Syndrome, Javerya Sattar, Ateeq Ahmed Khan
Recurrent Cns Haemangioblastomas With New Onset Of Retinal Angiomas In A Female Patient Diagnosed As Von Hippel Lindau Syndrome, Javerya Sattar, Ateeq Ahmed Khan
Pakistan Journal of Neurological Sciences (PJNS)
Von hippellindau(VHL) disease being a rare genetic disorder, presents with broad spectrum of clinical manifestation and multiorgan neoplasms. The diagnostic criteria for VHL disease include (i) one central nervous system haemangioblastoma and visceral manifestation , (ii) more than one central nervous system haemangioblastomas and (iii) known family history of VHL disease and any of the visceral manifestation. We report a case of 35 years-female patient who presented with recurrent cerebellar and spinal haemangioblastomas with new onset of retinal angioma,hepatichaemangioma and pancreatic cyst, with previous history of surgical resection of cerebellar and spinal cord lesions. This report highlights the importance of …
Creutzfeldt-Jakob Disease: A Case Report Presenting To The Emergency Department, Muhammad Akbar Baig, Sadaf Sheikh
Creutzfeldt-Jakob Disease: A Case Report Presenting To The Emergency Department, Muhammad Akbar Baig, Sadaf Sheikh
Pakistan Journal of Neurological Sciences (PJNS)
Creutzfeldt-Jakob disease is lethal and most common spongiform encephalopathy worldwide and is rarely encountered in the Emergency department. For the benefit of patients and healthcare workers, rapid consideration of this condition needs to be sought in the setting of rapid neurological decline and myoclonic jerky movements. We present a case of a 54-year old male with behavioral changes, jerky body movements, cognitive dysfunction and left sided weakness developing over the course of few months and presented to our Emergency Department for the evaluation for stroke. Due to the non-specific nature of psychiatric and neurologic complaints, the initial diagnosis remained unclear. …
Pattern Of Mental Health Disorders In Adult Population Attending A Tertiary Mental Health Care Setting, Nasir Mehmood, Uroosa Talib, Raza Ur Rehman
Pattern Of Mental Health Disorders In Adult Population Attending A Tertiary Mental Health Care Setting, Nasir Mehmood, Uroosa Talib, Raza Ur Rehman
Pakistan Journal of Neurological Sciences (PJNS)
Mental health disorders contribute significantly to the global burden of disease (32.4%), . Mental health disorders are the 4th leading cause of disability in developed countries, and the most disabling disorders in low-income and middle-income countries (LAMIC). Over one third of people in most LIMIC fulfill sufficient diagnostic criteria for a mental health disorder at some point in their life.
Relationship Of Family Members’ Support With Practice Of Community Midwives In Rural Sindh, Pakistan, Farida Shah, Farhana Shahid, Jamila Haider, Syfoor Ali, Bibi Ara, Misri Bano
Relationship Of Family Members’ Support With Practice Of Community Midwives In Rural Sindh, Pakistan, Farida Shah, Farhana Shahid, Jamila Haider, Syfoor Ali, Bibi Ara, Misri Bano
Journal of Asian Midwives (JAM)
Background: Pakistan has one of the highest maternal mortality rates in the world. Community Midwives (CMWs) were introduced in 2006 as a new cadre of birth attendants who would bring midwifery services to rural areas by being based in designated communities. The CMWs face many obstacles and retaining them in practice is a challenge. This study aimed to examine whether there was a relationship between family support and CMWs retention in midwifery practice. We hoped to learn about influences on retention that might improve the Maternal Newborn and Child Health (MNCH) programme.
Methods: This was a cross-sectional survey conducted in …
Gender Inequalities And Childbearing: A Qualitative Study Of Two Maternity Units In Nepal, Lesley Milne, Jillian C M Ireland Ms, Edwin Van Teijlingen, Vanora Hundley, Padam P. Simkhada
Gender Inequalities And Childbearing: A Qualitative Study Of Two Maternity Units In Nepal, Lesley Milne, Jillian C M Ireland Ms, Edwin Van Teijlingen, Vanora Hundley, Padam P. Simkhada
Journal of Asian Midwives (JAM)
The role and status of women in South Asian countries like Nepal are widely recognised to be lower than that of men. This gender inequality can be found throughout all levels of society. Our study is about the influence of gender on pregnancy and childbirth, which are very much in the female domain in South Asia, both at home and in health facilities.
A mixed-method, qualitative research study was undertaken in two birthing facilities in Kathmandu Valley to examine barriers to women accessing these services from the perspective of hospital staff. Thematic analysis identified seven subthemes related to gender, namely: …
Determinants Of Inadequate Provision And Utilization Of Post Abortion Care Services In Pakistan, Marina Baig, Kiran Mubeen
Determinants Of Inadequate Provision And Utilization Of Post Abortion Care Services In Pakistan, Marina Baig, Kiran Mubeen
Journal of Asian Midwives (JAM)
Access to safe abortion services remain a challenge in many low and middle income countries like Pakistan. Evidence suggests that Pakistan shares a huge burden of abortion related morbidities and mortalities. Timely provision of Post Abortion Care (PAC) services could assist in preventing maternal deaths associated with unsafe abortions. However, there are certain socio-cultural, financial and political factors that restricts the provision and utilization of effective PAC services. This paper explores these determinants and suggest recommendations for policy and practice to promote PAC services in Pakistan.
Jam – Winter 2018, Edwin Van Teijlingen, Rafat Jan
Jam – Winter 2018, Edwin Van Teijlingen, Rafat Jan
Journal of Asian Midwives (JAM)
No abstract provided.
Treatment And Outcome In Patients With Infantile Spasms And Lennox Gastaut Syndrome, Arif Herekar, Nasir Yaqoob
Treatment And Outcome In Patients With Infantile Spasms And Lennox Gastaut Syndrome, Arif Herekar, Nasir Yaqoob
Pakistan Journal of Neurological Sciences (PJNS)
ABSTRACT: AIM: To measure and assess the efficacy of ACTH and Vigabatrin in Infantile Spasm and their Unresponsiveness in Lennox-Gastaut Syndrome in Pakistani Population MATERIALS AND METHODS A study was conducted between year 2006 to 2016 evaluating 120 patients presenting to Neurodiagnostic Centre, Hamdard University Hospital and National Medical Centre, Karachi. Infantile spasms and Salaam Attacks were the basic diagnosis both clinically and electroence phalographically. Age ranges between 1 month to 1.5 years. All patients were administered appropriate doses of Anti Epileptics, ACTH and vitamin supplements RESULTS Amongst 120 patients of Infantile Spasm that we have encountered in last decade …
Acute Disseminated Encephalomyelitis In A Middle Age Female, Hina Mushtaq, Maria Qureshi, Irfan Ahsan
Acute Disseminated Encephalomyelitis In A Middle Age Female, Hina Mushtaq, Maria Qureshi, Irfan Ahsan
Pakistan Journal of Neurological Sciences (PJNS)
Acute disseminated encephalomyelitis (ADEM) is an autoimmune condition that predominately involve demyelination of the white matter of the brain and spinal cord. It resembles other acute demyelinating syndromes like multiple sclerosis and most often presents in childhood.This is a case of a 52-year woman, presented with lower limb weakness, confusion and spasticity throughout the body with no preceding illness. CSF showed increased proteins with no oligoclonal bands. MRI Brain showed abnormal high intensity areas in bilateral parietal, periventricular region, with no contrast enhancement. She was given 1gram iv methylprednisolone based on the diagnosis of ADEM and responded well.
Bilateral Wrist Drop In A Middle Age Man, Ghulam Shabbir, Zakir Jan, Haris Majid Rajput
Bilateral Wrist Drop In A Middle Age Man, Ghulam Shabbir, Zakir Jan, Haris Majid Rajput
Pakistan Journal of Neurological Sciences (PJNS)
Peripheral neuropathy is a common disorder which often causes disability.Among metals lead intoxication leads to bilateral radial neuropathy. Patients with lead neuropathy present with weakness that primarily involves the wrist and finger extensors. Lead intoxication in humans causes axonal degeneration. We report a case of middle age male who presented with bilateral wristsdrop, workup revealed that he had bilateral radial nerve neuropathy which was secondary to his occupational exposure to lead causing lead intoxication. Chronic lead exposure as a risk factor for neuropathy should be identified and treated promptly as its avoidance and treatment can save major disabilities.
Direct Current Stimulation And Epilepsy In Developing Countries: Opportunity And Challenges, Abdulrahman Al-Thaqib, Baradi, Raidah Saleem, Shahid Bashir
Direct Current Stimulation And Epilepsy In Developing Countries: Opportunity And Challenges, Abdulrahman Al-Thaqib, Baradi, Raidah Saleem, Shahid Bashir
Pakistan Journal of Neurological Sciences (PJNS)
Transcranial direct current stimulation (tDCS) is one type of neuromodulation, which is an emerging technology that holds promise for the future studies on therapeutic and diagnosis applications in treatment of neurological and psychiatric diseases. Epilepsy is one of the commonest neurological disorders, caused by an enhanced cortical excitability favoring paroxysmal neuronal discharge. Cathodaldirect current stimulation (ctDCS) is a low-cost noninvasive portable neuro-stimulatory technique which can transiently decrease cortical excitability in humans. This was invasively demonstrated to reduce epileptiform discharges in animals.
The Loose End: Neurology Without Rehabilitation, Ahmad Zaheer Qureshi, Farooq Azam Rathore
The Loose End: Neurology Without Rehabilitation, Ahmad Zaheer Qureshi, Farooq Azam Rathore
Pakistan Journal of Neurological Sciences (PJNS)
In recent years, successive therapies for previously untreatable neurological conditions have been introduced in clinical practice and these advance interventions have remarkably changed the landscape of neurosciences1,2 .But, rehabilitation of the functional impairments caused by neurological diseases is often overlooked or sometimes even neglected. In other words, the role of a comprehensive and early multidisciplinary rehabilitation in neurological disease is unrecognized and poorly understood even among neurologists and neurosurgeons. Usually, lifesaving neurosurgical management or solving a diagnostic riddle in neurology is attributed to successful patient management; however in reality, this is the first step in establishing a care plan for …
Importance Of Bioethics In Healthcare, Rizwan Taj, Asima Khan
Importance Of Bioethics In Healthcare, Rizwan Taj, Asima Khan
Pakistan Journal of Neurological Sciences (PJNS)
Healthcare ethics deals with ethical issues in health care, medicine and science.Ethical codes and its application have long history from ancient era. In presentscenario, both advancement in medical field and the challenges are increasing in same pace for healthcare providers to deal with ethical issues. Therefore, the undoubtedly important role of bioethics emerges here. Bioethics in healthcare brings understanding and knowledge among healthcare professionals about medical practice.Stressing upon the ethical aspects of bioethics, medical professionals are capable oftagging along ethical codes while practicing especially while dealing with issues. As ethical tribulations are linked with issues in medical care, so by …
Effect Of Minor Surgery Under Propofol Anaesthesia On Brain Bdnf And Cognition, Muhammad Rafiq, Zahid Mahmood, Sajed Ali, Laure Pain
Effect Of Minor Surgery Under Propofol Anaesthesia On Brain Bdnf And Cognition, Muhammad Rafiq, Zahid Mahmood, Sajed Ali, Laure Pain
Pakistan Journal of Neurological Sciences (PJNS)
Brain Derived Neurotrophic Factor (BDNF) is a brain protein implicated in learning, memory and other cognitive functions. Changes in cellular brain functions as well as cognitive defects have been observed the days following anaesthesia, even for short-duration anaesthesia with/without surgery. Despites the role of neurotrophic factors in cognition, no data are still available on brain effects after anaesthesia. Purpose: To study the effect of minor surgery under short duration anaesthesia on cognition by investigating BDNF levels in plasma, hippocampus and cortex. METHODS: Male rats received an intra-peritoneal injection of either 120 mg/kg of propofol or intralipids solution or minor surgery …
Identification Of Different Personality Traits Among Teenagers And Their Effect On Behavioural Conduct, Muhammad Yasir Tarar, Umair Sharif, Muhammad Waqar Abbas
Identification Of Different Personality Traits Among Teenagers And Their Effect On Behavioural Conduct, Muhammad Yasir Tarar, Umair Sharif, Muhammad Waqar Abbas
Pakistan Journal of Neurological Sciences (PJNS)
To identify different personality traits among teenagers To give recommendations to help teenagers create a balance in personality development. METHODS: This research is based on a cross sectional study conducted at Services Institute of Medical Sciences, catering to the freshmen of MBBS. The tenure for the research lasted 8 months starting March 2017- October 2017.The estimated target population accounted to 100 teenage students who were incorporated for the research through convenient sampling. Selection criteria for the chosen sample was based on their age, institute and mental well-being. Any student over and above 19 years, not enrolled in SIMS or suffering …
Risk Factors For Stroke And Tia's In Pakistan: A Community-Based Study, Abdul Malik, Farrukh Malik, Ismail Khatri, Sadaf Nasir
Risk Factors For Stroke And Tia's In Pakistan: A Community-Based Study, Abdul Malik, Farrukh Malik, Ismail Khatri, Sadaf Nasir
Pakistan Journal of Neurological Sciences (PJNS)
OBJECTIVES: To estimate the frequency of risk factors for stroke and transient ischemic attacks in Pakistan; a multi-city community-based study. METHOD: This cross-sectional community-based study was conducted in various health care facilities including government funded District Head Quarters hospitals, private hospitals and medical centers, and community-based clinics across 27 cities all over Pakistan over a period of three years between 2013 and 2015. Nearly 900 patients were screened during stroke (Falij) screening camps at these facilities and the data regarding past stroke and transient ischemic attack (TIA) symptoms were recorded along with relevant neurological examinations. A 25 item self-administered questionnaire …
The Rare And The Unexpected; Miller Fisher Syndrome, Saad Waheed, Jawad Hussian, Aqsa Shehzadi
The Rare And The Unexpected; Miller Fisher Syndrome, Saad Waheed, Jawad Hussian, Aqsa Shehzadi
Pakistan Journal of Neurological Sciences (PJNS)
Miller Fisher Syndrome (MFS) is a rare variant of Guillain-Barré syndrome (GBS) which is an idiopathic neuromuscular paralysis. It is considered as autoimmune disease because there are antibodies which attack the nerve cell fibers resulting in paralysis of muscles. This disease exhibits a classic clinical triad of ataxia,areflexia, and ophthalmoplegiawhereas it could have more neurological symptoms.Basically it is diagnosed clinically but have a serological test for its confirmation i.e. anti-GQ1b antibody levels.Here, we report a stereotypical case of MFS with all of its cardinal symptoms with addition of some other symptoms like diplopia, ptosis of an eye and unilateral facial …
Biopsy Proven Case Of Creutzfeldt- Jacob Disease From Pakistan, Rizwana Shahid, Saad Shafqat
Biopsy Proven Case Of Creutzfeldt- Jacob Disease From Pakistan, Rizwana Shahid, Saad Shafqat
Pakistan Journal of Neurological Sciences (PJNS)
Creutzfeldt-Jakob disease (CJD) is a rare type of prion disease leading to a rapidly progressive dementia (RPD) and other associated neurological features specially startle myoclonus. The annual incidence of CJD has been reported to be 1 per million or 271 people in USA2, but from Asia especially from Pakistan, only few case reports have been published. The probable cause behind the rarity of this disease in our society is still unclear.The diagnosis of CJD requires a high level of suspicion and lack of the availability of specific markers like CSF 14-3-3 in our setup makes it more difficult. Similarly brain …