Medicine and Health Sciences Commons^™

A Positron Emission Tomography Study Of Brain Activation In Chinese-Speaking Stutterers, Feng-Chu Tseng, Jung-Lung Hsu, Yen-Kung Chen, Lin-Fen Hsieh, Hung-Che Wang, Fa-Shun Tsai, Ya-Ling Chao

Rehabilitation Practice and Science

Background/Purpose: Although neuroimage studies on English-speaking stutterers have been reported previously, there was few positron emission tomography (PET) study of brain activation in Chinese- speaking stutterers. The purpose of this study was to investigate brain activation patterns in stutterers who speak Chinese.Each subject was scanned via using a PET scanner with a [18F] deoxyglucose marker. The stutterers group received two separate PET scans, one during solo reading (stuttering condition) and the other during choral reading (fluent condition). The normal speakers had only one scan following solo reading.Significant statistical difference in brain activation between the stutterers during solo reading and normal …

Quantitative Evaluation Of Motor Control Of Upper Limbs After Neuro-Robot Rehabilitation, Shu-Min Chen, Yu-Chia Tsai, Ming-Shaung Ju, Bing-Cheng Kung

Rehabilitation Practice and Science

Function of the upper limbs is crucial in daily activities. Motor recovery of upper limbs after stroke is slower and less complete than of lower limbs. During the recovery period, abnormal synergies always disturb daily life activity. Various therapeutic techniques have been developed to improve the function of upper limbs after stroke, such as the neuro-rehabilitation robot, which was developed in recent years and shows numerous positive outcomes for upper-limb facilitation after stroke. For the evaluation of motor recovery after stroke, Brunnstrom stages and the Modified Ashworth scale are commonly used and convenient. However, both depend heavily on the evaluator …

Phase I Cardiac Rehabilitation Among Patients With Acute St-Elevation Myocardial Infarction, Yun-Yi Lin, Chi-Ming Lee, Ching Lan, Ssu-Yuan Chen, Shu-Fang Hsiao, Pei-Chen Lu, Pei-Chin Suen, Mei-Yu Chen, Yen-Ho Wang, Jin-Shin Lai

Rehabilitation Practice and Science

Background and Purpose: Phase I cardiac rehabilitation (CR) programs have been shown to be effective and beneficial for patients with acute myocardial infarction. However, only few studies have evaluated the determinants of treatment frequency in phase I CR. The aim of this study was to investigate the current administration of phase I CR for patients who have acute ST-elevation myocardial infarction (STEMI) and have undergone percutaneous coronary intervention (PCI) in a medical center in Taiwan.Methods: We retrospectively reviewarticleed the medical records of 30 patients with STEMI who were admitted to the coronary care unit (CCU) between December 2009 and March …

Kabuki Syndrome: A Casereport, Hsin-I Wu, Shih-Jay Tzeng, Chang-Hsien Yu

Rehabilitation Practice and Science

Kabuki syndrome (KS) is a rare congenital disorder characterized by distinctive facial features, skeletal anomalies, dermatoglyphic abnormalities, mild to moderate mental retardation and postnatal growth deficiency. Although first reported in Japan, it has been recognized in other parts of the world. The present case with KS is a five-year-old boy. Because of his pervasive developmental delay, he received care in rehabilitation programs hosted by our hospital. He had prominent ears, depressed nasal tip, long palpebral fissures, and long eyelashes. The common features of KS in him are postnatal growth retardation, moderate mental retardation, scoliosis, cleft palate, flat feet, fifth finger …

Torticollis As An Initial Sign Of Septo-Optic Dysplasia: A Casereport, Pei-Chi Hsiao, Yu-Kun Tsui, Li-Chen Tung, Shu-Han Yang, Willy Chou

Rehabilitation Practice and Science

Torticollis is characterized by a lateral head tilt with chin rotation toward the opposite side. Congenital muscular torticollis remains the most common etiology in infancy. However, many different conditions, including anomaly of central nervous system, can cause the condition. The differential diagnosis is therefore important.An 8-month-old baby girl presented to our rehabilitation clinic with torticollis since 3 months of age. Her body weight, height and general appearance were normal at birth. At examination, horizontal nystagmus was noted while she gazed toward the right side, as well as head tilting to the left and chin pointing at the opposite side. There …

The Associated Factors In Home-Based Rehabilitation Utilization Of Stroke Patients, Shu-Chuan Wu, Yu-Chia Chang, Te-Feng Yeh, Ting-Yu Chang, Wei-Chaio Lu, Chien-Tsai Huang, Chuan-Hsiung Lin, Li-Ling Huang

Rehabilitation Practice and Science

This study explores the factors correlated to the use of home-based rehabilitation services by stroke patients for whom care is provided according to the state policy pertaining to the 10-year long-term care plan.During July 2008–June 2010, data were collected from 759 stroke patients by using a long-term care management service evaluation form. These patients had initially applied for services at the long-term care centers of the Bureau of Public Health in Taichung County. Of these, 119(15.7%) eventually used home-based rehabilitation services. Using the Andersen health behavior model, we investigated how various factors influence the use of home-based rehabilitation services by …

The Comparison Of The Dynamic Balance Abilities Between Young And Elderly Adults, Chen-Yang Kao, Shun-Hwa Wei, Chao-Chih Lee, Fu-Kong Lieu

Rehabilitation Practice and Science

Background: Falls are one of high risk factors to the quality of health of elderly adults. A study with early screening for potential high risk factors for elderly adults is helpful to reduce the incidence of falls. Little research has been done to evaluate elderly adults in terms of limits of stability (LOS). Moreover, regarding elderly adult balance, most focuses have been placed on their feet when standing for long periods of time and looking at the static center of pressure (COP) change; few focuses have been placed on the dynamic parameter changes during weight shifting.Purpose: To compare dynamic balancing …

The Effect Of Unstable Sling Exercise Training For A Long Jump Athlete With Lumbar Spondylolysis: A Casereport, Shih-Chung Cheng, Chia-Lin Chen, Won-Jean Lin, Hsiao-Yun Chang

Rehabilitation Practice and Science

Spondylolysis is a common problem that may contribute to lower back pain in athletes participating in a variety of activities. We currently present a casereport describing an athlete aged 21 years who was participating in the long jump on the national stage with ranked 1 in Taiwan. A diagnosis of spondylolysis at the 5th lumbar vertebrae was made following complaints of pain in the lower back-diagnosis was confirmed using a radiology examination. The athlete was prescribed a conservative rehabilitation program that included regular physical therapy, an eight-week core stability training program, and a six-month unstable resistance training program. Treatment effectiveness …

Research News: 2012, No. 2, University Of Mississippi. School Of Pharmacy

Research News: Grants and Publications (2000-2014)

Grants and contracts recently awarded

The Effect Of Vibration On Shoulder Strength And Flexibility Of Volleyball Athletes, Yun-Tai Lin, Hsing-Kuo Wang, Shao-Yi Liu, Tzyy-Yuang Shiang

Rehabilitation Practice and Science

Purpose: The aim of this study was to compare the effect of vibration and static stretching on shoulder strength and flexibility of volleyball athletes.Methods: Fifteen female volleyball athletes were randomly divided into 2 groups: 8 athletes who received vibration training were allocated to the vibration-stretching group and 7 athletes who did not receive vibration training comprised the static-stretching group. During a 6-week training period, pre- and post-tests were conducted using a Biodex system to evaluate the shoulder flexibility and the maximal isokinetic torque of the biceps and the anterior deltoid muscle.Results: After 4 weeks of training, the maximal isokinetic torque …

Successfully Climbing The "Stairs": Surmounting Failed Translation Of Experimental Ischemic Stroke Treatments, Michael Kahle, Gregory J. Bix

Sanders-Brown Center on Aging Faculty Publications

The Stroke Therapy Academic Industry Roundtable (STAIR) provided initial (in 1999) and updated (in 2009) recommendations with the goal of improving preclinical stroke therapy assessment and to increase the translational potential of experimental stroke treatments. It is important for preclinical stroke researchers to frequently consider and revisit these concepts, especially since promising experimental stroke treatments continue to fail in human clinical trials. Therefore, this paper will focus on considerations for several key aspects of preclinical stroke studies including the selection and execution of the animal stroke model, drug/experimental treatment administration, and outcome measures to improve experimental validity and translation potential. …

Preparasi, Karakterisasi Dan Evaluasi Pelepasan Obat Dari Beads Kalsium Alginat Deksametason Dengan Metode Gelasi Ionik, Christye Aulia, Joshita Djajadisastra

Majalah Ilmu Kefarmasian

Inflammatory Bowel Disease (IBD) is a disease of inflammation in the colon. Targeted delivery systems for the treatment of IBD is designed to increase the drug concentration in the local tissue. Dexamethasone is a drug having anti-inflammatory and antifibrosis effects which is used to repair scar tissue arising from postoperative IBD. This research purpose to create calciumalginate beads dexamethasone to be released only in the colon. Beads were made by using sodium-alginate and Ca2+ as crosslinker by ionic gelation method, with ratio between sodium alginate-dexamethasone (3:1). A concentration of solution sodium alginate 3 % b/v with variation concentration of crosslinker …

Medical School Watercooler Newsletter - December 30, 2012, Lindsey Lyle

Watercooler Newsletter

This is the December 30, 2012 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• USA Physicians Named Best Doctors
• USA College of Medicine Mourns Loss of Dr. Susan Gibson

Regulation Of The Mouse And Human Β-Globin Genes By Krüppel Like Transcription Factors Klf1 And Klf2, Yousef N. Alhashem

Theses and Dissertations

Krüppel-like factors KLF1 and KLF2 are closely related transcription factors with three zinc finger domains in their carboxy-termini. KLF1 (erythroid Krüppel-like factor, or EKLF) plays essential roles in embryonic and adult erythropoiesis. KLF2 is a positive regulator of the mouse and human embryonic β- globin genes. KLF1 and KLF2 have overlapping roles in embryonic erythropoiesis, as demonstrated using single and double knockout (KO) mouse models. Ablation of the KLF1 or KLF2 gene causes embryonic lethality, and double KO embryos are more anemic and die sooner than either single KO. We have shown that KLF1 and KLF2 positively regulate the human …

Medicine In The Americas, Kristine A. Petre Mls, Cm, Ahip

Kristine A Petre, MLS, CM, AHIP

Medicine in the Americas is a freely available, searchable collection of historical medical Americana. The collection is part of the Digital Collections repository at the National Library of Medicine’s online digital archives. This review discusses the contents, searching functions, and additional features available in the collection.

Circularized Synthetic Oligodeoxynucleotides Serve As Promoterless Rna Polymerase Iii Templates For Small Rna Generation In Human Cells, Christine I. Seidl, Lodoe Lama, Kevin Ryan

Publications and Research

Synthetic RNA formulations and viral vectors are the two main approaches for delivering small therapeutic RNA to human cells. Here we report findings supporting an alternative strategy in which an endogenous human RNA polymerase (RNAP) is harnessed to make RNA hairpin-containing small RNA from synthetic single-stranded DNA oligonucleotides. We report that circularizing a DNA template strand encoding a pre-microRNA hairpin mimic can trigger its circumtranscription by human RNAP III in vitro and in human cells. Sequence and secondary structure preferences that appear to promote productive transcription are described. The circular topology of the template is required for productive transcription, at …

National Longitudinal Survey Of Public Health Systems: Comparative Report Of 2012 Results, Glen Mays

Glen Mays

The third wave of the National Longitudinal Survey of Public Health Systems was fielded in 2012 in a nationally-representative cohort of local communities. The survey measures the availability of 20 recommended public health activities in the community, the range of organizations that participate in performing each activity, and the perceived effectiveness of each activity. Prior waves of the survey were fielded in 1998 and 2006. Local health officials report data for this survey and receive a customized report of results that compare data for their community with national norms and with "peer groups" of similar communities. This document provides an …

Piscine Myocarditis Virus (Pmcv) In Wild Atlantic Salmon Salmo Salar, Torstein Tengs Dr.

Dr. Torstein Tengs

Cardiomyopathy syndrome (CMS) is a severe cardiac disease of sea-farmed Atlantic salmon Salmo salar L., but CMS-like lesions have also been found in wild Atlantic salmon. In 2010 a double-stranded RNA virus of the Totiviridae family, provisionally named piscine myocarditis virus (PMCV), was described as the causative agent of CMS. In the present paper we report the first detection of PMCV in wild Atlantic salmon. The study is based on screening of 797 wild Atlantic salmon by real-time RT-PCR. The samples were collected from 35 different rivers along the coast of Norway, and all individuals included in the study were …

Acute Hypersensitivity Of Pluripotent Testicular Cancer-Derived Embryonal Carcinoma To Low-Dose 5-Aza Deoxycytidine Is Associated With Global Dna Damage-Associated P53 Activation, Anti-Pluripotency And Dna Demethylation, Bijesh K. Biswal, Maroun J. Beyrouthy, Mary P. Hever-Jardine, David Armstrong, Craig R. Tomlinson, Brock C. Christensen, Carmen J. Marsit, Michael J. Spinella

Dartmouth Scholarship

Human embryonal carcinoma (EC) cells are the stem cells of nonseminoma testicular germ cells tumors (TGCTs) and share remarkable similarities to human embryonic stem (ES) cells. In prior work we found that EC cells are hypersensitive to low nanomolar doses of 5-aza deoxycytidine (5-aza) and that this hypersensitivity partially depended on unusually high levels of the DNA methyltransferase, DNMT3B. We show here that low-dose 5-aza treatment results in DNA damage and induction of p53 in NT2/D1 cells. In addition, low-dose 5-aza results in global and gene specific promoter DNA hypomethylation. Low- dose 5-aza induces a p53 transcriptional signature distinct from …

On The Interplay Of Telomeres, Nevi And The Risk Of Melanoma, Clara Bodelon, Ruth M. Pfeiffer, Valentina Bollati, Julien Debbache, Donato Calista, Paola Ghiorzo, Maria Concetta Fargnoli, Giovanna Bianchi-Scarra, Ketty Peris, Mirjam Hoxha, Amy Hutchinson, Laura Burke, Shenying Fang, Margaret A. Tucker, Alisa M. Goldstein, Jeffrey E. Lee, Qingyi Wei, Sharon A. Savage, Xiaohong R. Yang, Christopher Amos, Maria Teresa Landi

Dartmouth Scholarship

The relationship between telomeres, nevi and melanoma is complex. Shorter telomeres have been found to be associated with many cancers and with number of nevi, a known risk factor for melanoma. However, shorter telomeres have also been found to decrease melanoma risk. We performed a systematic analysis of telomere-related genes and tagSNPs within these genes, in relation to the risk of melanoma, dysplastic nevi, and nevus count combining data from four studies conducted in Italy. In addition, we examined whether telomere length measured in peripheral blood leukocytes is related to the risk of melanoma, dysplastic nevi, number of nevi, or …

Hyperosmolar Therapy For Raised Intracranial Pressure., Ethan A Benardete

Department of Neurosurgery Faculty Papers

No abstract provided.

Parallel Ngo Networks For Hiv Control: Risks And Opportunities For Ngo Contracting., Shehla Zaidi, Xaher Gul, Noureen Aleem Nishtar

Community Health Sciences

Policy measures for preventive and promotive services are increasingly reliant on contracting of NGOs. Contracting is a neo-liberal response relying on open market competition for service delivery tenders. In contracting of health services a common assumption is a monolithic NGO market. A case study of HIV control in Pakistan shows that in reality the NGO market comprises of parallel NGO networks having widely different service packages, approaches and agendas. These parallel networks had evolved over time due to vertical policy agendas. Contracting of NGOs for provision of HIV services was faced with uneven capacities and turf rivalries across both NGO …

The 'Art' Of Medicine: Building A Caring Relationship With Clients, Lisa Barkley

UCF Forum

On the first day of school each year at the UCF College of Medicine, Dean Deborah German asks our incoming class of students what they think makes a “good doctor.”

Integrated Services Post (Posyandu) As Sociocultural Approach For Primary Health Care Issue, Oedojo Soedirham

Kesmas

Kelahiran posyandu pada tahun 1980-an merupakan usaha pemerintah Indonesia untuk meningkatkan status kesehatan masyarakat, mengikuti panggilan internasional, Deklarasi Alma Ata (Kazakhstan) tentang kesehatan masyarakat tahun 1978. Konsep kunci deklarasi tersebut adalah partisipasi masyarakat. Di Indonesia, partisipasi masyarakat disebut “gotong royong”. Masyarakat memainkan peran penting dalam meningkatkan kesehatan masing-masing. Untuk melibatkan masyarakat dalam kesehatan masyarakat, relawan harus direkrut dan dilatih untuk mengenal isu-isu kesehatan masyarakat dasar. Gagasan mengenai relawan yang disebut kader (village health worker) tersebut diajukan agar relawan sebagai bagian dari masyarakat dapat lebih mudah menyampaikan program-program kesehatan karena lebih dekat dibandingkan pejabat kesehatan masyarakat. Di dalam artikel ini dibahas …

Kondisi Sosial Ekonomi Dan Stres Pada Wanita Hipertensi Anggota Majelis Taklim, Anna Fitriani

Kesmas

Proporsi hipertensi pada wanita selalu lebih tinggi dengan peningkatan usia populasi. Penelitian ini membahas hipertensi dan faktor risiko pada 105 wanita dewasa anggota Majelis Taklim Al-Amin Cilandak, Jakarta Selatan. Penelitian observasional dengan desain studi potong lintang ini dilatarbelakangi oleh hasil Riset Kesehatan Dasar (Riskesdas) 2007 dengan metode analisis uji Chi Square. Populasi target adalah seluruh anggota majelis taklim di Jakarta Selatan dengan sampel anggota Majelis Taklim Al-Amin di Kecamatan Cilandak yang datang pada saat pengambilan data. Hasil penelitian menunjukkan bahwa prevalensi hipertensi sebesar 41,7% lebih tinggi daripada provinsi DKI Jakarta (28,6%) dan angka nasional 2007 (31,7%). Hipertensi pada penelitian ini …

Perbedaan Gender Pada Kejadian Sindrom Metabolik Pada Penduduk Perkotaan Di Indonesia, Krisnawaty Bantas, Hari Koesnanto Yoseph, Budi Moelyono

Kesmas

Sindrom Metabolik (SM) merupakan faktor risiko penting penyakit kardiovaskuler yang merupakan penyebab utama kematian di Indonesia. Perbedaan gender pada SM berkontribusi terhadap perbedaan gender pada penyakit kardiovaskuler. Penelitian ini bertujuan mengetahui prevalensi dan risiko SM berdasarkan gender di perkotaan Indonesia menggunakan data Riset Kesehatan Dasar 2007 dan menggunakan rancangan penelitian potong lintang. Populasi penelitian terdiri dari 13.262 orang pria dan wanita yang tidak hamil berusia lebih dari 15 tahun yang bermukim di daerah perkotaan. Variabel penelitian meliputi variabel dependen sindrom metabolik. Variabel independen utama adalah gender dan variabel kovariat yang lain adalah level 1 (umur, status perkawinan, pendidikan, stres, merokok, …

An Assessment Of The Effects Of Desertification In Yobe State, Nigeria, Jibril Musa Phd

Confluence Journal Environmental Studies (CJES), Kogi State University, Nigeria

Desertification is one of the most serious environmental and socio-economic problems of our time. Desertification describes circumstances of land degradation in arid, semi-arid and dry sub-humid regions resulting from the climatic variation and human activities. The fundamental goal of this thesis was to assess the effects of desertification in Yobe State, Nigeria. The present threat of desertification in the sahel has reached an alarming stage where crops cultivation and animal rearing/grazing are no more productive, soil has lost its nutrient/fertility, various infrastructure had given way because of windstorm from the neighbouring Niger Republic and sand dunes had taken over. The …

Cytotoxic And Antioxidant Compounds From The Stem Bark Of Goniothalamus Tapisoides Mat Salleh, Kok Hoong Leong

Kok Hoong Leong

Eleven compounds:goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9-deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds were identified by spectroscopic analysis and, for known compounds, by comparison with published data. Goniothalamin (6) exhibited mild cytotoxic activity towards a colon cancer cell line (HT-29), with an IC50value of 64.17 ± 5.60 μM. Goniomicin B (2) give the highest antioxidant activity in the DPPH assay among all compounds tested, with an IC50 of 0.207 μM.

Multiple Subject Barycentric Discriminant Analysis (Musubada): How To Assign Scans To Categories Without Using Spatial Normalization, Hervé Abdi, Lynne J. Williams, Andrew C. Connolly, M. Ida Gobbini

Dartmouth Scholarship

We present a new discriminant analysis (DA) method called Multiple Subject Barycentric Discriminant Analysis (MUSUBADA) suited for analyzing fMRI data because it handles datasets with multiple participants that each provides different number of variables (i.e., voxels) that are themselves grouped into regions of interest (ROIs). Like DA, MUSUBADA (1) assigns observations to predefined categories, (2) gives factorial maps displaying observations and categories, and (3) optimally assigns observations to categories. MUSUBADA handles cases with more variables than observations and can project portions of the data table (e.g., subtables, which can represent participants or ROIs) on the factorial maps. Therefore MUSUBADA can …

Genomic Loss Of Tumor Suppressor Mirna-204 Promotes Cancer Cell Migration And Invasion By Activating Akt/Mtor/Rac1 Signaling And Actin Reorganization, Saadi J. Imam, Jason R. Plyler, Hima Bansal, Suresh Prajapati, Sanjay Bansal, Jennifer Rebeles, Jeffrey S. Dome, +12 Additional Authors

Pediatrics Faculty Publications

Increasing evidence suggests that chromosomal regions containing microRNAs are functionally important in cancers. Here, we show that genomic loci encoding miR-204 are frequently lost in multiple cancers, including ovarian cancers, pediatric renal tumors, and breast cancers. MiR-204 shows drastically reduced expression in several cancers and acts as a potent tumor suppressor, inhibiting tumor metastasis in vivo when systemically delivered. We demonstrated that miR-204 exerts its function by targeting genes involved in tumorigenesis including brain-derived neurotrophic factor (BDNF), a neurotrophin family member which is known to promote tumor angiogenesis and invasiveness. Analysis of primary tumors shows that increased expression …