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Articles 31 - 60 of 5013
Full-Text Articles in Medicine and Health Sciences
Spinal Intramedullary Arteriovenous Malformations With Tetraplegia: A Casereport, Ching-Yao Yang, Shin-Liang Pan, Yen-Ho Wang, Wei-Hwa Liaw
Spinal Intramedullary Arteriovenous Malformations With Tetraplegia: A Casereport, Ching-Yao Yang, Shin-Liang Pan, Yen-Ho Wang, Wei-Hwa Liaw
Rehabilitation Practice and Science
Spinal arteriovenous malformations is a rare disease. The initial signs are usually in the forms of nonspecific sensory symptoms such as pains and parasthesia; therefore, it is difficult to conclusively diagnose this disease. Here, we report the case of a 30-year-old woman who suffered from a sudden weakness in the 4 limbs 15 years ago. The symptoms subsided after supportive care; she was discharged from a local hospital without further follow ups. Approximately 5 years ago, she had a sudden attack of pains in her left shoulder. The symptoms rapidly progressed to paralysis of the 4 limbs. She was sent …
Associated Study Between Dopamine Drd2 Gene Polymorphism And Finger Tapping Test, Wen-Hsuan Hou, Tai-Jui Chen
Associated Study Between Dopamine Drd2 Gene Polymorphism And Finger Tapping Test, Wen-Hsuan Hou, Tai-Jui Chen
Rehabilitation Practice and Science
Neurotransmitter dopamine has relation with neuro-psychiatric disease, it also has effect on motor function for healthy individuals and also determines the outcome of rehabilitation for neuro-psychiatric disease patients. Finger Tapping Test (FTT), a neuro-psychological test, is thought to be associated with dopamine. Therefore, the goal of this study is to investigate the association relationship between dopamine genes polymorphism (DRD2 TaqI) and FTT. Method: We recruit healthy Han Chinese, age between 20 and 60 years old, having no neuro-psychiatric illness and family history for dopamine genes polymorphism (DRD2 TaqI) and FTT assessment. Result: Total 106 cases were enrolled in the study. …
Anomalous Constitutive Src Kinase Activity Promotes B Lymphoma Survival And Growth, Jiyuan Ke, R. Lakshman Chelvarajan, Vishal Sindhava, Darrell A. Robertson, Lazaros Lekakis, C. Darrell Jennings, Subbarao Bondada
Anomalous Constitutive Src Kinase Activity Promotes B Lymphoma Survival And Growth, Jiyuan Ke, R. Lakshman Chelvarajan, Vishal Sindhava, Darrell A. Robertson, Lazaros Lekakis, C. Darrell Jennings, Subbarao Bondada
Microbiology, Immunology, and Molecular Genetics Faculty Publications
Background: Previously we have shown that B cell receptor (BCR) expression and B cell receptor signaling pathways are important for the basal growth of B lymphoma cells. In particular we have shown that the activation of Syk, a non-src family protein tyrosine kinase and the mitogen activated protein kinases (MAPK), ERK and JNK that mediate BCR signals are required for the constitutive growth of B lymphoma cells. Since src family protein tyrosine kinases (SFKs) like Lyn are known to be needed for the phosphorylation of BCR co-receptors, Ig-alpha and Ig-beta, we hypothesized that one or more SFKs will be constitutively …
Clinical Experience Of Ventriculoperitoneal Shunt Dysfunction In A Patient With Hydrocephalus After Brain Injury: A Casereport, Shean-Jing Lin, Yun-Yee Chen, Mu-Jung Kao, Ching-Yang Lin, Sheng-Huang Hsiao
Clinical Experience Of Ventriculoperitoneal Shunt Dysfunction In A Patient With Hydrocephalus After Brain Injury: A Casereport, Shean-Jing Lin, Yun-Yee Chen, Mu-Jung Kao, Ching-Yang Lin, Sheng-Huang Hsiao
Rehabilitation Practice and Science
We report a case of an adult patient with post-traumatic hydrocephalus who was treated using a ventriculoperitoneal (VP) shunt with a fixed pressure setting valve. Slit ventricle syndrome was found two months later and an antisiphon device (ASD) was added. A fixed pressure valve with ASD was found not to be optimal in terms of improving his neurological symptoms and a programmable valve system was therefore implanted with a pressure setting of 140 mmH2O in the beginning. The valve then was gradually programmed to reduce down to 70 mmH2O over two months. This case demonstrates that selection of a shunting …
Clinical Diagnosis Of Mild Misalignment Of Symphysis Pubis Using Ct Scan With Three-Dimensional Reconstruction Of Pelvis: A Casereport, Cheng-Hung Lin, Ching-Hung Hung, Nam-Seng Goh, Chen-Chang Hsiung
Clinical Diagnosis Of Mild Misalignment Of Symphysis Pubis Using Ct Scan With Three-Dimensional Reconstruction Of Pelvis: A Casereport, Cheng-Hung Lin, Ching-Hung Hung, Nam-Seng Goh, Chen-Chang Hsiung
Rehabilitation Practice and Science
The patients who suffered from symphysis pubis injury would normally be treated in two clinical departments. Symphysis pubis diastasis is an uncommon intrapartum complication which may occur in women with some associative factors such as macrosomic fetus, small pelvis, and rapid descent of presenting part during spontaneous vaginal delivery. The automotive side impacts are a leading cause of injuries to the pubic symphysis which might be combined with major pelvic trauma. Other factors that might contribute to this type of injury is general fall events, although very rare, which would induce minor symphysis pubis injury. Recently, we presented with a …
Transcriptional Adaptations Following Exercise In Thoroughbred Horse Skeletal Muscle Highlights Molecular Mechanisms That Lead To Muscle Hypertrophy, Beatrice A. Mcgivney, Suzanne S. Eivers, David E. Machugh, James N. Macleod, Grace M. O'Gorman, Stephen D.E. Park, Lisa M. Katz, Emmeline W. Hill
Transcriptional Adaptations Following Exercise In Thoroughbred Horse Skeletal Muscle Highlights Molecular Mechanisms That Lead To Muscle Hypertrophy, Beatrice A. Mcgivney, Suzanne S. Eivers, David E. Machugh, James N. Macleod, Grace M. O'Gorman, Stephen D.E. Park, Lisa M. Katz, Emmeline W. Hill
Veterinary Science Faculty Publications
BACKGROUND: Selection for exercise-adapted phenotypes in the Thoroughbred racehorse has provided a valuable model system to understand molecular responses to exercise in skeletal muscle. Exercise stimulates immediate early molecular responses as well as delayed responses during recovery, resulting in a return to homeostasis and enabling long term adaptation. Global mRNA expression during the immediate-response period has not previously been reported in skeletal muscle following exercise in any species. Also, global gene expression changes in equine skeletal muscle following exercise have not been reported. Therefore, to identify novel genes and key regulatory pathways responsible for exercise adaptation we have used equine-specific …
Fagerstrom Test For Nicotine Dependence Vs Heavy Smoking Index In A General Population Survey, M. Pérez-Ríos, M. I. Santiago-Pérez, B. Alonso, A. Malvar, X. Hervada, Jose De Leon
Fagerstrom Test For Nicotine Dependence Vs Heavy Smoking Index In A General Population Survey, M. Pérez-Ríos, M. I. Santiago-Pérez, B. Alonso, A. Malvar, X. Hervada, Jose De Leon
Psychiatry Faculty Publications
BACKGROUND: The Fagerström Test for Nicotine Dependence (FTND) is used for assessing nicotine dependence. A shorter test derived from the FTND used for the general population is the Heavy Smoking Index (HSI) (six questions vs. two). The objective of this study is to compare the validity of the HSI versus the FTND.
METHODS: A survey of tobacco use in the general population was carried out in the northern Spanish region of Galicia using both the FTND and the HSI to study a representative sample of 1655 daily smokers. The HSI was compared with the FTND, considered the gold standard. Measures …
Rearrangement Of The Rna Polymerase Subunit H And The Lower Jaw In Archaeal Elongation Complexes, Sebastian Grünberg, Christoph Reich, Mirijam E. Zeller, Michael S. Bartlett, Michael Thomm
Rearrangement Of The Rna Polymerase Subunit H And The Lower Jaw In Archaeal Elongation Complexes, Sebastian Grünberg, Christoph Reich, Mirijam E. Zeller, Michael S. Bartlett, Michael Thomm
Biology Faculty Publications and Presentations
The lower jaws of archaeal RNA polymerase and eukaryotic RNA polymerase II include orthologous subunits H and Rpb5, respectively. The tertiary structure of H is very similar to the structure of the C-terminal domain of Rpb5, and both subunits are proximal to downstream DNA in pre-initiation complexes. Analyses of reconstituted euryarchaeal polymerase lacking subunit H revealed that H is important for open complex formation and initial transcription. Eukaryotic Rpb5 rescues activity of the ΔH enzyme indicating a strong conservation of function for this subunit from archaea to eukaryotes. Photochemical cross-linking in elongation complexes revealed a striking structural rearrangement of RNA …
Ccl2 Responses To Mycobacterium Tuberculosis Are Associated With Disease Severity In Tuberculosis, Zahra Hasan, Jacqueline M. Cliff, Hazel M. Dockrell, Bushra Jamil, Muhammad Irfan, Mussarat Ashraf, Rabia Hussain
Ccl2 Responses To Mycobacterium Tuberculosis Are Associated With Disease Severity In Tuberculosis, Zahra Hasan, Jacqueline M. Cliff, Hazel M. Dockrell, Bushra Jamil, Muhammad Irfan, Mussarat Ashraf, Rabia Hussain
Section of Pulmonary & Critical Care
Background
Leucocyte activating chemokines such as CCL2, CCL3, and CXCL8 together with proinflammatory IFNγ, TNFα and downmodulatory IL10 play a central role in the restriction of M. tuberculosis infections, but is unclear whether these markers are indicative of tuberculosis disease severity.
Methodology
We investigated live M. tuberculosis- and M. bovis BCG- induced peripheral blood mononuclear cell responses in patients with tuberculosis (TB) and healthy endemic controls (ECs, n = 36). TB patients comprised pulmonary (PTB, n = 34) and extrapulmonary groups, subdivided into those with less severe localized extrapulmonary TB (L-ETB, n = 16) or severe disseminated ETB (D-ETB, …
Proteolytic Regulation Of Toxin-Antitoxin Systems By Clppc In Staphylococcus Aureus, Niles P. Donegan, Earl T. Thompson, Zhibiao Fu, Ambrose L. Cheung
Proteolytic Regulation Of Toxin-Antitoxin Systems By Clppc In Staphylococcus Aureus, Niles P. Donegan, Earl T. Thompson, Zhibiao Fu, Ambrose L. Cheung
Dartmouth Scholarship
Bacterial toxin-antitoxin (TA) systems typically consist of a small, labile antitoxin that inactivates a specific longer-lived toxin. In Escherichia coli, such antitoxins are proteolytically regulated by the ATP-dependent proteases Lon and ClpP. Under normal conditions, antitoxin synthesis is sufficient to replace this loss from proteolysis, and the bacterium remains protected from the toxin. However, if TA production is interrupted, antitoxin levels decrease, and the cognate toxin is free to inhibit the specific cellular component, such as mRNA, DnaB, or gyrase. To date, antitoxin degradation has been studied only in E. coli, so it remains unclear whether similar mechanisms of regulation …
Stem Cell Matching For Patients Of Mixed Race, Ted C. Bergstrom
Stem Cell Matching For Patients Of Mixed Race, Ted C. Bergstrom
Ted C Bergstrom
Patients with leukemia and other blood diseases stand a good chance of recovery and a return to normal life if they receive a stem cell transplant from a living donor. In the absence of a transplant, their survival prospects are grim. For a transplant to be successful, the human leukocyte antigens (HLA) of the donor and recipient must be a close genetic match. To facilitate non-sibling matches, the developed nations of the world have set up national volunteer registries. The larges such registry is the NMDP (National Marrow Donor Program). We estimate the distribution of HLA types for individuals of …
Model Mitigasi Kebakaran Berbasis Masyarakat : Kajian Kualitatif Pada Aparat Pemerintah Dan Lsm, Fatmah Fatmah
Model Mitigasi Kebakaran Berbasis Masyarakat : Kajian Kualitatif Pada Aparat Pemerintah Dan Lsm, Fatmah Fatmah
Kesmas
Lingkungan masyarakat kota yang bebas kebakaran dapat tercipta melalui upaya pencegahan dan pemadaman kebakaran dini. Penelitian ini bertujuan mengembangkan model mitigasi kesiapsiagaan kebakaran berbasis masyarakat. Metoda kualitatif wawancara mendalam dilakukan terhadap 30 informan terpilih di Jabodetabek meliputi aparat kecamatan, kelurahan, Lembaga Swadaya Masyarakat, dan Suku Dinas Pemadam Kebakaran. Mayoritas informan mengenal organisasi Barisan Sukarelawan Kebakaran, tetapi dalam pelaksanaan ditemukan beberapa kendala antara lain meliputi tidak ada honorarium, status pekerjaan, dan anggota penduduk musiman. Hal tersebut berakibat banyak anggota yang berhenti dan sulit merekrut anggota baru. Bentuk upaya pencegahan kebakaran yang dilakukan masyarakat meliputi simulasi, penyuluhan, dan pelatihan bahaya kebakaran, serta …
Program Langit Biru : Kontribusi Kebijakan Pengendalian Pencemaran Udara Kota Terhadap Penurunan Penyakit Pernapasan Pada Anak, Laila Fitria
Program Langit Biru : Kontribusi Kebijakan Pengendalian Pencemaran Udara Kota Terhadap Penurunan Penyakit Pernapasan Pada Anak, Laila Fitria
Kesmas
Pencemaran udara perkotaan yang berdampak buruk terhadap kesehatan masyarakat sering dikaitkan dengan PM 10, NO2, dan ozon, polutan reaktif yang memicu kerusakan jaringan dalam saluran napas melalui mekanisme stres oksidatif dan inflamasi saluran napas. Pajanan jangka panjang polutan tersebut berpengaruh terhadap gangguan pernapasan, penurunan fungsi paru, asma, serta penyakit sistem pernapasan kronik lain seperti penyakit paru-paru obstruktif kronik. Program Langit Biru merupakan salah satu upaya mengurangi pencemaran udara dari sektor transportasi yang dicanangkan sejak tahun 1996. Hingga kini, kontribusi Program Langit Biru terhadap penurunan kasus gangguan pernapasan pada anak belum dapat diperkirakan, antara lain disebabkan oleh karena pelaksanaan program melalui …
Kesehatan Jiwa Yang Terabaikan Dari Target Milenium, Sri Idaiani
Kesehatan Jiwa Yang Terabaikan Dari Target Milenium, Sri Idaiani
Kesmas
Millenium Development Goals (MDG) yang dicanangkan pada tahun 2000 sangat didominasi oleh penyakit menular serta kesehatan ibu dan anak, tetapi mengabaikan berbagai masalah penyakit tidak menular. Tidak sedikitpun terlintas dalam benak para pemimpin dunia itu target dan indikator yang menyentuh atau berhubungan dengan masalah kesehatan jiwa. Tulisan ini bertujuan membahas posisi kesehatan jiwa di seluruh dunia yang cenderung semakin memprihatinkan, tetapi justru terabaikan dari target MDG. Pencapaian target milenium tampaknya tidak memperhitungkan beban penyakit akibat berbagai masalah kejiwaan. Padahal, jika dibiarkan, pada masa mendatang masalah kesehatan jiwa akan menjadi besar seperti yang tengah dihadapi oleh berbagai negara maju. Berdasarkan prediksi …
Potret Kebijakan Pengendalian Demam Berdarah Dengue Di Kabupaten Indramayu, Henri Peranginangin, Hasim Hasim, Bambang Pramudya, Sri Budiarti
Potret Kebijakan Pengendalian Demam Berdarah Dengue Di Kabupaten Indramayu, Henri Peranginangin, Hasim Hasim, Bambang Pramudya, Sri Budiarti
Kesmas
Penyakit demam berdarah dengue (DBD) masih menjadi masalah di Kabupaten Indramayu. Penelitian ini bertujuan mengidentifikasi elemen-elemen prioritas kebijakan pengendalian penyakit DBD di Kabupaten Indramayu menurut pakar berdasarkan metode Analytical Hierarchy Process (AHP). Hasil penelitian menunjukkan “strategi utama” pengendalian penyakit DBD di Kabupaten Indramayu adalah peningkatan kesehatan lingkungan permukiman; “aktor utama pengendalian” ialah Pemerintah Kabupaten Indramayu; “faktor utama pengendalian” adalah lingkungan; “tujuan utama pengendalian” ialah Kabupaten Indramayu bebas penyakit DBD; dan “kriteria utama pengendalian” adalah jumlah dan mutu sumber daya manusia. Agar implementasi strategi pengendalian itu efektif maka Pemerintah Kabupaten Indramayu perlu meningkatkan kerja sama lintas program dan sektoral; dukungan teknologi, …
Chylomicrons Promote Intestinal Absorption And Systemic Dissemination Of Dietary Antigen (Ovalbumin) In Mice, Yuehui Wang, Sarbani Ghoshal, Martin Ward, Willem De Villiers, Jerold Woodward, Erik Eckhardt
Chylomicrons Promote Intestinal Absorption And Systemic Dissemination Of Dietary Antigen (Ovalbumin) In Mice, Yuehui Wang, Sarbani Ghoshal, Martin Ward, Willem De Villiers, Jerold Woodward, Erik Eckhardt
Internal Medicine Faculty Publications
BACKGROUND: A small fraction of dietary protein survives enzymatic degradation and is absorbed in potentially antigenic form. This can trigger inflammatory responses in patients with celiac disease or food allergies, but typically induces systemic immunological tolerance (oral tolerance). At present it is not clear how dietary antigens are absorbed. Most food staples, including those with common antigens such as peanuts, eggs, and milk, contain long-chain triglycerides (LCT), which stimulate mesenteric lymph flux and postprandial transport of chylomicrons through mesenteric lymph nodes (MLN) and blood. Most dietary antigens, like ovalbumin (OVA), are emulsifiers, predicting affinity for chylomicrons. We hypothesized that chylomicron …
Today - December 23, 2009, Loma Linda University
Today - December 23, 2009, Loma Linda University
TODAY
Inside this issue:
-- Heart patient reunites with LLU Overseas Heart Surgery Team members 35 years after they saved her life in Saigon
-- CAPS welcomes Helping Hands Pantry to SACHS–Norton
-- Nursing professors research diabetes management in local community
-- LLU Heart & Surgical Hospital physician performs groundbreaking procedure
-- School of Public Health advances health geoinformatics education
-- Wyatt Caley raises funds to buy an Xbox 360 Elite for kids in Children’s Hospital
-- Milton Murray passes away
-- Trees of Hope bring beauty to Children’s Hospital lobby
-- LLU physician to appear on ‘The Doctors’
-- How …
Reduced Pain And Inflammation In Juvenile And Adult Rats Fed A Ketogenic Diet, David N. Ruskin, Masahito Kawamura Jr., Susan A. Masino
Reduced Pain And Inflammation In Juvenile And Adult Rats Fed A Ketogenic Diet, David N. Ruskin, Masahito Kawamura Jr., Susan A. Masino
Faculty Scholarship
The ketogenic diet is a high-fat, low-carbohydrate regimen that forces ketone-based rather than glucose-based cellular metabolism. Clinically, maintenance on a ketogenic diet has been proven effective in treating pediatric epilepsy and type II diabetes, and recent basic research provides evidence that ketogenic strategies offer promise in reducing brain injury. Cellular mechanisms hypothesized to be mobilized by ketone metabolism and underlying the success of ketogenic diet therapy, such as reduced reactive oxygen species and increased central adenosine, suggest that the ketolytic metabolism induced by the diet could reduce pain and inflammation. To test the effects of a ketone-based metabolism on pain …
Guyon's Canal Syndrome Due To Tortuous Ulnar Artery With Dequervain Stenosing Tenosynovitis, Ligamentous Injuries And Dorsal Intercalated Segmental Instability Syndrome, A Rare Presentation: A Case Report., Muhammad Zeeshan, Farhan Ahmed, Darakhshan Kanwal, Qazi Saad Bin Khalid, Muhammad Nadeem Ahmed
Guyon's Canal Syndrome Due To Tortuous Ulnar Artery With Dequervain Stenosing Tenosynovitis, Ligamentous Injuries And Dorsal Intercalated Segmental Instability Syndrome, A Rare Presentation: A Case Report., Muhammad Zeeshan, Farhan Ahmed, Darakhshan Kanwal, Qazi Saad Bin Khalid, Muhammad Nadeem Ahmed
Department of Radiology
The Guyon's canal syndrome is a well known clinical entity and may have significant impact on Patient's quality of life. We report a case of 43-year-old male who presented with complaints of pain and numbness in right hand and difficulty in writing for past one month. On imaging diagnosis of Guyon's canal syndrome because of tortuous ulnar artery was made with additional findings of DeQuervain's stenosing tenosynovitis and dorsal intercalated segmental instability syndrome with ligamentous injury and subsequently these were confirmed on surgery. Although it is a rare syndrome, early diagnosis and treatment prevents permanent neurological deficits and improve Patient's …
Gbdr Regulates Pseudomonas Aeruginosa Plch And Pchp Transcription In Response To Choline Catabolites, Matthew J. Wargo, Tiffany C. Ho, Maegan J. Gross, Laurie A. Whittaker, Deborah A. Hogan
Gbdr Regulates Pseudomonas Aeruginosa Plch And Pchp Transcription In Response To Choline Catabolites, Matthew J. Wargo, Tiffany C. Ho, Maegan J. Gross, Laurie A. Whittaker, Deborah A. Hogan
Dartmouth Scholarship
Pseudomonas aeruginosa hemolytic phospholipase C, PlcH, can degrade phosphatidylcholine (PC) and sphingomyelin in eukaryotic cell membranes and extracellular PC in lung surfactant. Numerous studies implicate PlcH in P. aeruginosa virulence. The phosphorylcholine released by PlcH activity on phospholipids is hydrolyzed by a periplasmic phosphorylcholine phosphatase, PchP. Both plcH gene expression and PchP enzyme activity are positively regulated by phosphorylcholine degradation products, including glycine betaine. Here we report that the induction of plcH and pchP transcription by glycine betaine is mediated by GbdR, an AraC family transcription factor. Mutants that lack gbdR are unable to induce plcH and pchP in media …
Corticosteroids For Pain Relief In Sore Throat: Systematic Review And Meta-Analysis, Gail Hayward, Matthew J. Thompson, Carl J. Heneghan, Rafael Perera, Paul P. Glasziou, Chris B. Del Mar
Corticosteroids For Pain Relief In Sore Throat: Systematic Review And Meta-Analysis, Gail Hayward, Matthew J. Thompson, Carl J. Heneghan, Rafael Perera, Paul P. Glasziou, Chris B. Del Mar
Christopher Del Mar
Objective: To evaluate whether systemic corticosteroids improve symptoms of sore throat in adults and children. Design: Systematic review and meta-analysis. Data sources: Cochrane Central, Medline, Embase, Database of Reviews of Effectiveness (DARE), NHS Health Economics Database, and bibliographies. Outcome measures: Percentage of patients with complete resolution at 24 and 48 hours, mean time to onset of pain relief, mean time to complete resolution of symptoms, days missed from work or school, recurrence, and adverse events. Results: We included eight trials, consisting of 743 patients in total (369 children, 374 adults). 348 (47%) had exudative sore throat, and 330 (44%) were …
Neuraminidase Inhibitors For Preventing And Treating Influenza In Healthy Adults: Systematic Review And Meta-Analysis, Tom Jefferson, Mark Jones, Peter Doshi, Chris Del Mar
Neuraminidase Inhibitors For Preventing And Treating Influenza In Healthy Adults: Systematic Review And Meta-Analysis, Tom Jefferson, Mark Jones, Peter Doshi, Chris Del Mar
Christopher Del Mar
Objectives: To update a 2005 Cochrane review that assessed the effects of neuraminidase inhibitors in preventing or ameliorating the symptoms of influenza, the transmission of influenza, and complications from influenza in healthy adults, and to estimate the frequency of adverse effects. Search strategy: An updated search of the Cochrane central register of controlled trials (Cochrane Library 2009, issue 2), which contains the Acute Respiratory Infections Group’s specialised register, Medline (1950-Aug 2009), Embase (1980-Aug 2009), and post-marketing pharmacovigilance data and comparative safety cohorts. Selection criteria: Randomised placebo controlled studies of neuraminidase inhibitors in otherwise healthy adults exposed to naturally occurring influenza. …
Transparent Development Of The Who Rapid Advice Guidelines, Holger J. Schunemann, Suzanne R. Hill, Meetali Kakad, Gunn E. Vist, Richard Bellamy, Lauren Stockman, Torbjorn Fosen Wisloff, Chris Del Mar, Frederick Hayden, Timothy M. Uyeki, Jeremy Farrar, Yazdan Yazdanpanah, Howard Zucker, John Beigel, Tawee Chotpitayasunondh, Tran Tinh Hien, Bulent Ozbay, Norio Sugaya, Andrew D. Oxman
Transparent Development Of The Who Rapid Advice Guidelines, Holger J. Schunemann, Suzanne R. Hill, Meetali Kakad, Gunn E. Vist, Richard Bellamy, Lauren Stockman, Torbjorn Fosen Wisloff, Chris Del Mar, Frederick Hayden, Timothy M. Uyeki, Jeremy Farrar, Yazdan Yazdanpanah, Howard Zucker, John Beigel, Tawee Chotpitayasunondh, Tran Tinh Hien, Bulent Ozbay, Norio Sugaya, Andrew D. Oxman
Christopher Del Mar
Emerging health problems require rapid advice. We describe the development and pilot testing of a systematic, transparent approach used by the World Health Organization (WHO) to develop rapid advice guidelines in response to requests from member states confronted with uncertainty about the pharmacological management of avian influenza A (H5N1) virus infection. We first searched for systematic reviews of randomized trials of treatment and prevention of seasonal influenza and for nontrial evidence on H5N1 infection, including case reports and animal and in vitro studies. A panel of clinical experts, clinicians with experience in treating patients with H5N1, influenza researchers, and methodologists …
Possible Harms Of Oseltamivir—A Call For Urgent Action, Tom Jefferson, Mark Jones, Peter Doshi, Chris Del Mar
Possible Harms Of Oseltamivir—A Call For Urgent Action, Tom Jefferson, Mark Jones, Peter Doshi, Chris Del Mar
Christopher Del Mar
Extract: Oseltamivir is a successful drug: between July, 2004, and June, 2009, more than 11·5 million new prescriptions were issued in the USA, and nearly all influenza pandemic plans recommend antiviral drugs as a mainstay of containment on a population basis and treatment on an individual basis, with oseltamivir preferred because of ease of administration and storage. Because 75% of the world production of oseltamivir has been used in Japan,¹ this is where to look for any serious harms the drug might cause. ¹ See note in article.
Digging Deeper: Quality Of Patient-Provider Communication Across Hispanic Subgroups, Lorraine S. Wallace, Jennifer E. Devoe, Edwin S. Rogers, Joanne Protheroe, Gillian Rowlands, George E. Fryer
Digging Deeper: Quality Of Patient-Provider Communication Across Hispanic Subgroups, Lorraine S. Wallace, Jennifer E. Devoe, Edwin S. Rogers, Joanne Protheroe, Gillian Rowlands, George E. Fryer
Faculty Publications and Other Works -- UT Graduate School of Medicine
Background
Recent research suggests that ethnic subgroup designation plays an important role in health-related disparities among Hispanics. Our objective was to examine the influence of Hispanics' self-reported ethnic subgroup designation on perceptions of their health care providers' communication behaviors.
Methods
Cross-sectional analysis of the 2005 Medical Expenditure Panel Survey (MEPS). Participants included non-institutionalized Hispanics (n = 5197; US population estimate = 27,070,906), aged ≥18 years, reporting visiting a health care provider within the past 12 months. Six (n = 6) items were used to capture respondents' perceptions of their health care providers' communication behaviors.
Results
After controlling for socio-demographic covariates, …
Germinal Center Reutilization By Newly Activated B Cells., Tanja A Schwickert, Boris Alabyev, Tim Manser, Michel C Nussenzweig
Germinal Center Reutilization By Newly Activated B Cells., Tanja A Schwickert, Boris Alabyev, Tim Manser, Michel C Nussenzweig
Department of Microbiology and Immunology Faculty Papers
Germinal centers (GCs) are specialized structures in which B lymphocytes undergo clonal expansion, class switch recombination, somatic hypermutation, and affinity maturation. Although these structures were previously thought to contain a limited number of isolated B cell clones, recent in vivo imaging studies revealed that they are in fact dynamic and appear to be open to their environment. We demonstrate that B cells can colonize heterologous GCs. Invasion of primary GCs after subsequent immunization is most efficient when T cell help is shared by the two immune responses; however, it also occurs when the immune responses are entirely unrelated. We conclude …
Party Favors For Sports: Strong Usoc, Spectacular World Cup, Rick Burton, Norm O'Relly
Party Favors For Sports: Strong Usoc, Spectacular World Cup, Rick Burton, Norm O'Relly
Sport Management - All Scholarship
No abstract provided.
Predicting Flavonoid Ugt Regioselectivity With Graphical Residue Models And Machine Learning., Arthur Rhydon Jackson
Predicting Flavonoid Ugt Regioselectivity With Graphical Residue Models And Machine Learning., Arthur Rhydon Jackson
Electronic Theses and Dissertations
Machine learning is applied to a challenging and biologically significant protein classification problem: the prediction of flavonoid UGT acceptor regioselectivity from primary protein sequence. Novel indices characterizing graphical models of protein residues are introduced. The indices are compared with existing amino acid indices and found to cluster residues appropriately. A variety of models employing the indices are then investigated by examining their performance when analyzed using nearest neighbor, support vector machine, and Bayesian neural network classifiers. Improvements over nearest neighbor classifications relying on standard alignment similarity scores are reported.
Defining The Role Of Syndecan-4 In Mechanotransduction Using Surfacemodification Approaches, Robert M. Bellin, James D. Kubicek, Matthew J. Frigault, Andrew J. Kamien, Robert L. Steward, Hillary M. Barnes, Michael B. Digiacomo, Luke J. Duncan, Christina K. Edgerly, Elizabeth M. Morse, Chan Young Park, Jeffrey J. Fredberg, Chao Min Cheng, Philip R. Leduc
Defining The Role Of Syndecan-4 In Mechanotransduction Using Surfacemodification Approaches, Robert M. Bellin, James D. Kubicek, Matthew J. Frigault, Andrew J. Kamien, Robert L. Steward, Hillary M. Barnes, Michael B. Digiacomo, Luke J. Duncan, Christina K. Edgerly, Elizabeth M. Morse, Chan Young Park, Jeffrey J. Fredberg, Chao Min Cheng, Philip R. Leduc
Biology Department Faculty Scholarship
The ability of cells to respond to external mechanical stimulation is a complex and robust process involving a diversity of molecular interactions. Although mechanotransduction has been heavily studied, many questions remain regarding the link between physical stimulation and biochemical response. Of significant interest has been the contribution of the transmembrane proteins involved, and integrins in particular, because of their connectivity to both the extracellular matrix and the cytoskeleton. Here, we demonstrate the existence of a mechanically based initiation molecule, syndecan-4. We first demonstrate the ability of syndecan-4 molecules to support cell attachment and spreading without the direct extracellular binding of …
Comparison Of Ammonia And Particulate Matter Air Sample Concentrations At Task-Locations Within Swine Confinement Buildings., Earl Dan Bembry
Comparison Of Ammonia And Particulate Matter Air Sample Concentrations At Task-Locations Within Swine Confinement Buildings., Earl Dan Bembry
Electronic Theses and Dissertations
Introduction: A task-associated analysis of ammonia and particulate matter concentrations was conducted on swine farms in breeding and gestation barns. The purpose of this study was to determine if specific tasks performed by workers increase concentrations of ammonia and particulate matter exposure.
Methods: An exploratory, descriptive design was used to determine if swine confinement workers have increased ammonia and particulate matter exposure when performing assigned tasks in breeding and gestation barns. A convenience sample of 8 workers volunteered from among all breeding and gestation workers (n=24). Data collection occurred in the morning at each of the 8 farms …