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2022

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Articles 4711 - 4719 of 4719

Full-Text Articles in Medicine and Health Sciences

Defining Genetic Underpinnings Of Cellular Diversity And Vulnerability In The Context Of Parkinson's Disease, Stephanie M. Boas Jan 2022

Defining Genetic Underpinnings Of Cellular Diversity And Vulnerability In The Context Of Parkinson's Disease, Stephanie M. Boas

All ETDs from UAB

Parkinson’s disease (PD) is a severe, progressive neurodegenerative movement disorder. Currently, there is no cure, nor effective treatments for prevention or modification of disease progression. Thus, novel approaches are required to understand etiological contributors to cell dysfunction and death in PD to enable rational drug design. Recently, huge advancements have been made in the technology involved in collection, storage, and processing of high-volume genetic information. Genome-wide association studies (GWAS) have been integral in identifying genomic loci with common, disease risk-associated variation. However, annotation and prioritization of GWAS-identified risk variants is far from straightforward, and the gap between the identification of …

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Three Essays On Federally Qualified Health Centers: Competition, Patient-Centered Medical Home Adoption, Quality Quartiles Ranking And Financial Performance, Hani Al-Maliki Jan 2022

Three Essays On Federally Qualified Health Centers: Competition, Patient-Centered Medical Home Adoption, Quality Quartiles Ranking And Financial Performance, Hani Al-Maliki

All ETDs from UAB

he following three essays examine the Federally Qualified Health Center (FQHC) industry. The first essay attempts to provide a description on what constitutes a competitive environment for FQHCs located in California, the second explores the impact of FQHC market competition on Patient Centered Medical Home (PCMH) adoption, and the third essay aims to test the relationship between the adoption of PCMH and FQHCs’ performance. The first essay utilizes Porter's Five Forces model to identify competitive forces in the FQHCs environment to fill a gap in the literature. Building on the first essay, the second essay using Porter’s generic strategies explores …

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Mevisit: Value-Based Approach To Primary Care Delivery By Mtelemedicine Utilization Applied Through Lean Principles, Neil Coyer Thornbury Jan 2022

Mevisit: Value-Based Approach To Primary Care Delivery By Mtelemedicine Utilization Applied Through Lean Principles, Neil Coyer Thornbury

All ETDs from UAB

Background: Significant issues of inconsistent patient services in the U.S. health system impact health outcomes and create high cost. Limitations of immobility, inefficiency, and accessibility sacrifice patient treatment, delay recovery, and escalate health risks from the lack of primary care physicians. The primary purpose of this study was to examine meVisit, a connective mobile technology, as a feasible primary care solution to address escalating health costs by reducing emergency room (ER) visits and inpatient admissions (IA). Methods: The feasibility study applied descriptive and inferential statistics to secondary data (n=4,024) and compared the two independent patient groups from the same large …

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Applying The Hospitalist Model Of Care To Cardiovascular Acute Care Delivery, Ginger K. Biesbrock Jan 2022

Applying The Hospitalist Model Of Care To Cardiovascular Acute Care Delivery, Ginger K. Biesbrock

All ETDs from UAB

The hospitalist model for managing patients in the hospital setting has been in existence for over 20 years. The hospitalist model for non-specialty care has been found to improve the efficiency of care, maintain quality of care, and support a higher degree of guideline adherence. However, there has been little research focusing on the use of the hospitalist model for specialty care. As cardiovascular programs have begun to adopt the hospitalist model, many are asking if this model is more effective than the traditional model. The main concern is the potential disruption to the patient-physician relationship that occurs with the …

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Analysing The Structural Dynamics Of Retinoid X Receptor Using Hydrogen Deuterium Exchange Mass Spectrometry, Nathalia Melo Jan 2022

Analysing The Structural Dynamics Of Retinoid X Receptor Using Hydrogen Deuterium Exchange Mass Spectrometry, Nathalia Melo

All ETDs from UAB

Nuclear receptors (NR) are ligand-activated transcription factors that are targets for drug discovery due to their ability to directly modulate gene expression. There are 48 NRs and approximately half of them require heterodimerization with retinoid X receptor (RXR) to function. Targretin (bexarotene) is an FDA-approved RXR specific (rexinoid) currently used to treat Cutaneous T-cell Lymphoma (CTCL); however, it causes hyperlipidemia toxicities. A functionally similar rexinoid developed at UAB, 9-cis-UAB30 (UAB30), is non-toxic and weak agonist in the liver. While UAB30 shows promise as a low toxicity chemopreventative drug, the mechanism of UAB30 action at the molecular level is poorly understood. …

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Molecular Mechanism And Impact Of Sox2 Regulation By The Transforming Growth Factor-Ss Members In Ovarian Cancer Survival And Metastasis, Zainab Shonibare Jan 2022

Molecular Mechanism And Impact Of Sox2 Regulation By The Transforming Growth Factor-Ss Members In Ovarian Cancer Survival And Metastasis, Zainab Shonibare

All ETDs from UAB

Ovarian cancer is the second most common and deadliest cancer of the female reproductive system affecting women in the United States and worldwide. The poor survival outcome seen in ovarian cancer is attributed to the subtleness of its early-stage symptoms, resulting in a majority of patients at initial diagnosis presenting with an advanced-stage disease with metastasis to other parts of the body. Hence, there is an urgent need to better understand the molecular etiology of metastasis to help develop effective therapeutic options and improve clinical outcomes in ovarian cancer patients. Ovarian cancer, an intra-abdominal cancer, most preferably undergoes metastasis via …

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The Role Of Nitric Oxide And Cyclic Guanosine Monophosphate Signaling In Arteriovenous Fistula Maturation, Maheshika S. Somarathna Jan 2022

The Role Of Nitric Oxide And Cyclic Guanosine Monophosphate Signaling In Arteriovenous Fistula Maturation, Maheshika S. Somarathna

All ETDs from UAB

Vascular access is the single most important component of the hemodialysis procedure and the arteriovenous fistula (AVF) is the most preferred type. However, 60% of AVFs created fail to mature successfully for dialysis use (AVF maturation failure). AVF maturation failure is primarily the result of 1) intimal hyperplasia formation (IH) and 2) poor vascular outward remodeling. Currently, a major unmet clinical need in the field is the lack of effective therapies to treat/prevent AVF maturation failure due to the poor understanding of molecular mechanisms. This proposal is designed to: 1) elucidate the pathologic significance of nitric oxide (NO) and cyclic …

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Role Of Morphological Awareness In Language And Literacy In Children With And Without Developmental Language Disorder, Melissa Phelan Jan 2022

Role Of Morphological Awareness In Language And Literacy In Children With And Without Developmental Language Disorder, Melissa Phelan

Graduate Student Theses, Dissertations, & Professional Papers

Past research has shown phonological awareness is highly correlated with language and literacy success in children with and without Developmental Language Disorder (DLD), but a less examined area of language and literacy is morphological awareness. Delayed morphology in children with DLD has been studied extensively in spoken language, but relatively little in written language in the DLD population. This study explored two research questions: 1) Is morphological awareness related to language and literacy success in children with and without DLD, and 2) Is morphological awareness impaired for those children with DLD and dyslexia similarly to that of phonological awareness. A …

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Voices Of The Often Unheard: The Environmental Impacts Of Catastrophic Wildfire Events On Individuals With Developmental Disabilities, Mary Madison Mckenzie Jan 2022

Voices Of The Often Unheard: The Environmental Impacts Of Catastrophic Wildfire Events On Individuals With Developmental Disabilities, Mary Madison Mckenzie

Graduate Student Theses, Dissertations, & Professional Papers

The Thomas Fire for a time was the largest wildfire in California history, burning 281,893 acres and destroying 1,063 structures. Within three years, the August Complex Fire, at 1,032,649 acres, almost quadrupled that record. Climate related disasters such as these have impelled social science researchers to heed calls for a paradigm shift in understanding the risks climate change poses to the social world, in particular, disaster risks for vulnerable groups. Existing research tends to focus on disasters such as hurricanes, featuring risks for vulnerable populations by race, class, and/or individuals with disabilities in general, but not for individuals with developmental …

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