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Articles 91 - 110 of 110
Full-Text Articles in Medicine and Health Sciences
Local Thrombolytic Treatment Of Cerebral Venous Thrombosis In Three Paediatric Patients, Mohammad Wasay, Rohit Bakshi, Alper Dai, Steve Roach
Local Thrombolytic Treatment Of Cerebral Venous Thrombosis In Three Paediatric Patients, Mohammad Wasay, Rohit Bakshi, Alper Dai, Steve Roach
Section of Neurology
There is increasing evidence that local thrombolysis can be used with relative safety and efficacy in adults with superior sagittal sinus thrombosis (SSST). However, little data is available on the use of local thrombolysis in children with SSST. We report three patients who received local thrombolysis for dural sinus thrombosis. Two patients received urokinase and one patient received urokinase followed by local TPA infusion. Recanalization was achieved in two patients.
Oral Contraceptives And Cerebral Venous Thrombosis: Case Report And A Brief Review Of Literature, Mughis Sheerani, Mian Zainul Sajadeen Urfy
Oral Contraceptives And Cerebral Venous Thrombosis: Case Report And A Brief Review Of Literature, Mughis Sheerani, Mian Zainul Sajadeen Urfy
Section of Neurology
Cerebral venous thrombosis remains an important and sometimes an elusive cause of strokes. Oral contraceptives seem to have a strong causative association with this entity. We describe a case that highlights the importance of asking specific questions about oral contraceptive use in patients with strokes due to cerebral venous sinus thrombosis, especially, where the cause remains cryptic.
Prognostic Indicators In Cerebral Venous Sinus Thrombosis, Bilal Hameed, Nadir Ali Syed
Prognostic Indicators In Cerebral Venous Sinus Thrombosis, Bilal Hameed, Nadir Ali Syed
Section of Neurology
Cerebral venous sinus thrombosis (CVT) can affect all age groups, particularly women of childbearing age. Overall prognosis for survival and functional independence is better than it was believed. Mortality usually ranges from 6-15% and transtentorial herniation is the major cause of death. Approximately 80% of patients are functionally independent in the long term. Altered mental status and cerebral haemorrhage at presentation are the strongest predictors of death and disability. Patients with CVT related to pregnancy and puerperium generally do better than patients with other causes. Septic CVT carries a worse prognosis than aseptic CVT and of the latter, patients with …
Ms In Asian Countries, M Wasay, I A. Khatri, B Khealani, M Sheerani
Ms In Asian Countries, M Wasay, I A. Khatri, B Khealani, M Sheerani
Section of Neurology
This paper reviews all available English language literature on MS from Asian countries published between 1970 and 2005. Although limited data are available, the review reveals that western Asia--including the Middle East--has the highest prevalence of MS across the continent, and that MS in Asia largely resembles conventional MS in western countries. Opticospinal MS (a distinct clinical entity from conventional MS) is more common in eastern Asian regions. Larger epidemiological and genetic studies, with more complete ascertainment in various Asian populations, are needed so that we can understand the diversity of Asian MS.
Limb-Shaking Transient Ischemic Attacks: Case Report And Review Of Literature, Saad Ali, Muhib Alam Khan, Bhojo Khealani
Limb-Shaking Transient Ischemic Attacks: Case Report And Review Of Literature, Saad Ali, Muhib Alam Khan, Bhojo Khealani
Section of Neurology
Background: Limb shaking Transient Ischemic Attack is a rare manifestation of carotid-occlusive disease. The symptoms usually point towards a seizure like activity and misdiagnosed as focal seizures. On careful history the rhythmic seizure like activity reveals no Jacksonian march mainly precipitated by maneuvers which lead to carotid compression. We here present a case of an elderly gentleman who was initially worked up as suffering from epileptic discharge and then later on found to have carotid occlusion.CASE PRESENTATION: Elderly gentleman presented with symptoms of rhythmic jerky movements of the left arm and both the lower limbs. Clinical suspicion of focal epilepsy …
The Long Shadow Of Cerebral Localization, Saad Shafqat
The Long Shadow Of Cerebral Localization, Saad Shafqat
Section of Neurology
In 1995, during my first week as a neurology resident at Massachusetts General Hospital, I had the privilege of meeting the late Raymond Adams. He was an established octogenarian by then, but the years had made no difference to his air of professionalism and academic authority. His reputation was made in the 1950s and 1960s, when he developed Boston as a major centre of clinical neurology. Among other things, he is immortalized through a famous textbook that has appeared in multiple editions. Our meeting took place at a clinical conference in which I was required to present a case. He …
Development Of A Comprehensive Epilepsy Surgery Programme In Pakistan, Mughis Sheerani
Development Of A Comprehensive Epilepsy Surgery Programme In Pakistan, Mughis Sheerani
Section of Neurology
No abstract provided.
Moyamoya Disease: An Elusive Diagnosis, K. B. Asumal, N. Akhtar, N. A. Syed, Saad Shafqat, S. M. Baig
Moyamoya Disease: An Elusive Diagnosis, K. B. Asumal, N. Akhtar, N. A. Syed, Saad Shafqat, S. M. Baig
Section of Neurology
Moyamoya disease is an idiopathic vasculopathy, affecting vessels of Circle of Willis.1 It usually manifests as stroke, but can also cause seizures and cognitive impairment.2 Ischemic strokes are common in children and hemorrhagic strokes in adults.1 We describe our experience with moyamoya disease in four patients who presented with ischemic strokes, at an academic tertiary care center and emphasize that this diagnosis should be considered in young patients, especially children, who present with stroke.
Clinical Practice Guidelines For The Management Of Ischemic Stroke In Pakistan, Saad Shafqat
Clinical Practice Guidelines For The Management Of Ischemic Stroke In Pakistan, Saad Shafqat
Section of Neurology
Ischemic stroke represents a huge global burden, being the leading cause of physical disability and the third leading cause of death worldwide1. Although rigorous epidemiological data from Pakistan are lacking, stroke is certainly the commonest reason for admission to a neurology ward in our part of the world, as elsewhere. Recent years have seen a number of new developments in the clinical approach to stroke, including in the areas of diagnostic work-up, acute treatment and secondary prevention. These developments enable the formulation of clinical practice guidelines for achieving standardized management of ischemic stroke, with the overall aini of …
Brainstem Encephalitis With Kikuchi-Fujimoto Disease, Saad Shafqat, Saima Bano Memon, Shiraz Hyder, Sheema H Hasan, Raymond A Smego
Brainstem Encephalitis With Kikuchi-Fujimoto Disease, Saad Shafqat, Saima Bano Memon, Shiraz Hyder, Sheema H Hasan, Raymond A Smego
Section of Neurology
A case of young woman is described who developed clinical and MRI features of brainstem encephalitis in the setting of fever and cervical lymphadenopathy. Lymph node biopsy revealed histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease), which may reflect host response to an unspecified immune insult.
Cost Of Acute Stroke Care At A Tertiary Care Hospital In Karachi, Pakistan, B. A. Khealani, Z. F. Javed, N. A. Syed, Saad Shafqat, Mohammad Wasay
Cost Of Acute Stroke Care At A Tertiary Care Hospital In Karachi, Pakistan, B. A. Khealani, Z. F. Javed, N. A. Syed, Saad Shafqat, Mohammad Wasay
Section of Neurology
Objective:To evaluate cost of acute stroke care and its determinants at a tertiary care hospital in Karachi and to find out predictors of high cost care. Acute stroke is a leading cause of morbidity and mortality. Cost of care is the single most important determinant in availability of acute stroke care at a tertiary care hospital in Pakistan.It is also an important factor in development of public health policies and medical insurance plans. Average nnual income in Pakistan is 4881 rupees (U$ 85).
Methods: Medical and billing records of 443 patients with acute stroke were retrospectively reviewed from …
Radiologic Features Of Hallervorden Spatz Disease, K B. Asumal, M Wasay, S N. Ali
Radiologic Features Of Hallervorden Spatz Disease, K B. Asumal, M Wasay, S N. Ali
Section of Neurology
Hallervorden Spatz Disease is a rare familial neurodegenerative disorder, which primarily affects children but also can occur in adults1 . Major clinical features are abnormal involuntary movements and cognitive impairment2 . Diagnosis is based on clinical and radiological features. The radiological features are hypointense signals in globus pallidus and substantia niagra on MR! of brain3 . Occasionally the pallidal hypointense signals surround hyperintense signals, this is known as “tigereye-sign”4 and is postulated to be specific for Hallervorden Spatz Disease. We report two brothers with such MRI findings.
Ischemic Stroke In Young Adults Of South Asia, A A. Razzaq, B A. Khan, S M. Baig
Ischemic Stroke In Young Adults Of South Asia, A A. Razzaq, B A. Khan, S M. Baig
Section of Neurology
Objective: To study the risk factors, etiology and management of ischemic stroke in young adults in a South Asian population.
Methods: Retrospective study conducted at a large tertiary hospital in Karachi. One hundred and eighteen patients between fifteen and forty-five years admitted over a five year period with a diagnosis of ischemic infarct constituted the study population. The study variables included the full clinical spectrum, spanning historical, laboratory, radiological and outcome parameters.
Results: Forty-three percent of patients were hypertensive and 30% were diabetic. The combination of diabetes and hypertension was found in 19.5% of patients, intra-cranial and carotid …
Takayasu's Arteritis Presenting As Ischemic Stroke--Case Report, B A. Khealani, S M. Baig
Takayasu's Arteritis Presenting As Ischemic Stroke--Case Report, B A. Khealani, S M. Baig
Section of Neurology
Takayasu’s Arteritis is a chronic, idiopathic, inflammatory disease that primarily affects large blood vessels such as aorta and its branches.1 Neurological symptoms occur in about 50% of cases but stroke occurs in about 10% of patients with Takayasu’s Arteritis2 . We report two such cases and emphasize the need for thorough evaluation of young patients with stroke to establish the underlying etiology.
Gram Negative Meningitis Resulting From Rupture Of A Spinal Epidural Abscess Into The Subarachnoid Space, S Lodhi, T Mozaffar, A R. Sarwari
Gram Negative Meningitis Resulting From Rupture Of A Spinal Epidural Abscess Into The Subarachnoid Space, S Lodhi, T Mozaffar, A R. Sarwari
Section of Neurology
No abstract provided.
Carotid Doppler Ultrasonography In Young Stroke Patients, A A. Razzaq, B A. Khan, C K. Jadoon, S M. Baig
Carotid Doppler Ultrasonography In Young Stroke Patients, A A. Razzaq, B A. Khan, C K. Jadoon, S M. Baig
Section of Neurology
Background: The present study focuses on the role of carotid doppler ultrasonography (CDUS) in the diagnosis and management of carotid stenosis in young stroke patients.
Methods: The findings of carotid doppler in 45 ischemic stroke patients between 15-45 years of age were reviewed retrospectively. The variables of interest for this study included risk factors for atherosclerotic disease, primary abnormality detected on carotid doppler ultrasonography (ulceration vs. stenosis), degree of stenosis and the type of plaque (soft vs. calcified).
Results: The prevalence of hypertension and diabetes was 50% and 35% respectively. The rate of carotid stenosis in the …
Ct And Mr Imaging In Young Stroke Patients, A A. Razzaq, B A. Khan, S Baig
Ct And Mr Imaging In Young Stroke Patients, A A. Razzaq, B A. Khan, S Baig
Section of Neurology
Background: This study investigates the role of CT and MR imaging in the diagnosis and management of young stroke patients.
Methods: CT scan findings of 108 patients and MR findings of 30 patients between 15-45 years of age were reviewed retrospectively. The variables included the territory of infarct on CT and MR imaging, the cortical distribution and size of infarct.
Results: About 80% of the patients had infarcts of the carotid territory and 20% the vertebro-basilar distribution. More than half of the infarcts were cortical (56%). The yield of MR imaging was much higher for deeper structures such …
Molecular Characterization Of Neurotransmitter Transporters, Saad Shafqat, M Velaz- Faircloth, A Guadaño- -Ferraz, R T Fremeau
Molecular Characterization Of Neurotransmitter Transporters, Saad Shafqat, M Velaz- Faircloth, A Guadaño- -Ferraz, R T Fremeau
Section of Neurology
No abstract provided.
Cloning And Expression Of A Novel Na(+)-Dependent Neutral Amino Acid Transporter Structurally Related To Mammalian Na+/Glutamate Cotransporters, Saad Shafqat, Balaji Tamarappoo, Michael S Kilberg, Ram S Puranam, James O. Mcnamara, Ana Guadaño -Ferraz, R.T. Fremeau
Cloning And Expression Of A Novel Na(+)-Dependent Neutral Amino Acid Transporter Structurally Related To Mammalian Na+/Glutamate Cotransporters, Saad Shafqat, Balaji Tamarappoo, Michael S Kilberg, Ram S Puranam, James O. Mcnamara, Ana Guadaño -Ferraz, R.T. Fremeau
Section of Neurology
A cDNA has been isolated from human hippocampus that appears to encode a novel Na(+)-dependent, Cl(-)-independent, neutral amino acid transporter. The putative protein, designated SATT, is 529 amino acids long and exhibits significant amino acid sequence identity (39-44%) with mammalian L-glutamate transporters. Expression of SATT cDNA in HeLa cells induced stereospecific uptake of L-serine, L-alanine, and L-threonine that was not inhibited by excess (3 mM) 2-(methylamino)-isobutyric acid, a specific substrate for the System A amino acid transporter. SATT expression in HeLa cells did not induce the transport of radiolabeled L-cysteine, L-glutamate, or related dicarboxylates. Northern blot hybridization revealed high levels …
The Undrained Brain: The Other Side Of The Foreign Medical Graduate Resident Issue, C M. Smythe
The Undrained Brain: The Other Side Of The Foreign Medical Graduate Resident Issue, C M. Smythe
Section of Neurology
No abstract provided.