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Full-Text Articles in Medicine and Health Sciences
Intensive Care Bundle With Blood Pressure Reduction In Acute Cerebral Hemorrhage Trial (Interact3): Study Protocol For A Pragmatic Stepped-Wedge Cluster-Randomized Controlled Trial, Lili Song, Xin Hu, Lu Ma, Xiaoying Chen, Menglu Ouyang, Laurent Billot, Qiang Li, Paula Muñoz-Venturelli, Carlos Abanto, Mohammad Wasay
Intensive Care Bundle With Blood Pressure Reduction In Acute Cerebral Hemorrhage Trial (Interact3): Study Protocol For A Pragmatic Stepped-Wedge Cluster-Randomized Controlled Trial, Lili Song, Xin Hu, Lu Ma, Xiaoying Chen, Menglu Ouyang, Laurent Billot, Qiang Li, Paula Muñoz-Venturelli, Carlos Abanto, Mohammad Wasay
Section of Neurology
Background: Early intensive blood pressure (BP) lowering remains the most promising treatment for acute intracerebral hemorrhage (ICH), despite discordant results between clinical trials and potential variation in the treatment effects by approach to control BP. As the third in a series of clinical trials on this topic, the INTEnsive care bundle with blood pressure Reduction in Acute Cerebral hemorrhage Trial (INTERACT3) aims to determine the effectiveness of a goal-directed care bundle protocol of early physiological control (intensive BP lowering, glycemic control, and pyrexia treatment) and reversal of anticoagulation, in acute ICH.
Methods: INTERACT3 is a pragmatic, international, multicenter, stepped-wedge (4 …
Predictors Of The Intracerebral Hemorrhage Volume In Hypertensive Patients, Mohammad Wasay, Adnan Yousuf, Darshan Lal, Safia Awan
Predictors Of The Intracerebral Hemorrhage Volume In Hypertensive Patients, Mohammad Wasay, Adnan Yousuf, Darshan Lal, Safia Awan
Section of Neurology
Background: Hemorrhage volume is an important predictor of outcome in Patients with intracerebral hemorrhage (ICH). It is not clear why in some Patients ICH volume is larger than in others. Identification of modifiable factors responsible for large-volume hemorrhage in hypertensive Patients may help to reduce ICH-related morbidity and mortality. Objective: The objective of this study was to identify predictors of large-volume ICH in hypertensive Patients. Methods:At a tertiary care center in Karachi (Pakistan), 157 hypertensive Patients with ICH were prospectively analyzed in 2008-2009, and hemorrhage volumes were determined using CT or MRI and various factors, including duration of hypertension, …