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Articles 1 - 5 of 5
Full-Text Articles in Medicine and Health Sciences
Gene Expression Pattern Characterises Development Of Multiple Sclerosis, Lotti Tajouri, Ekua Brenu, Kevin Ashton, Don Staines, Sonja Marshall-Gradisnik
Gene Expression Pattern Characterises Development Of Multiple Sclerosis, Lotti Tajouri, Ekua Brenu, Kevin Ashton, Don Staines, Sonja Marshall-Gradisnik
Kevin Ashton
No abstract provided.
Dna Barcoding Of Freshwater Fishes And The Development Of A Quantitative Qpcr Assay For The Species-Specific Detection And Quantification Of Fish Larvae From Plankton Samples, William Loh, P Bond, Kevin Ashton, David Roberts, I.R. Tibbetts
Dna Barcoding Of Freshwater Fishes And The Development Of A Quantitative Qpcr Assay For The Species-Specific Detection And Quantification Of Fish Larvae From Plankton Samples, William Loh, P Bond, Kevin Ashton, David Roberts, I.R. Tibbetts
Kevin Ashton
The barcoding of mitochondrial cytochrome c oxidase subunit 1 (coI) gene was amplified and sequenced from 16 species of freshwater fishes found in Lake Wivenhoe (south-eastern Queensland, Australia) to support monitoring of reservoir fish populations, ecosystem function and water health. In this study, 630-650 bp sequences of the coI barcoding gene from 100 specimens representing 15 genera, 13 families and two subclasses of fishes allowed 14 of the 16 species to be identified and differentiated. The mean ± s.e. Kimura 2 parameter divergence within and between species was 0·52 ± 0·10 and 23·8 ± 2·20% respectively, indicating that barcodes can …
High-Throughput Sequencing Of Plasma Microrna In Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, Ekua Brenu, Kevin Ashton, Jana Batovska, Don Staines, Sonja Marshall-Gradisnik
High-Throughput Sequencing Of Plasma Microrna In Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, Ekua Brenu, Kevin Ashton, Jana Batovska, Don Staines, Sonja Marshall-Gradisnik
Kevin Ashton
Background: MicroRNAs (miRNAs) are known to regulate many biological processes and their dysregulation has been associated with a variety of diseases including Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). The recent discovery of stable and reproducible miRNA in plasma has raised the possibility that circulating miRNAs may serve as novel diagnostic markers. The objective of this study was to determine the role of plasma miRNA in CFS/ME. Results: Using Illumina high-throughput sequencing we identified 19 miRNAs that were differentially expressed in the plasma of CFS/ME patients in comparison to non-fatigued controls. Following RT-qPCR analysis, we were able to confirm the significant up-regulation …
Natural Killer Cells In Patients With Severe Chronic Fatigue Syndrome, Ekua Brenu, Sharni Hardcastle, Gunn Atkinson, Mieke Van Driel, Sanne Kreijkamp-Kaspers, Kevin Ashton, Don Staines, Sonja Marshall-Gradisnik
Natural Killer Cells In Patients With Severe Chronic Fatigue Syndrome, Ekua Brenu, Sharni Hardcastle, Gunn Atkinson, Mieke Van Driel, Sanne Kreijkamp-Kaspers, Kevin Ashton, Don Staines, Sonja Marshall-Gradisnik
Kevin Ashton
Maintenance of health and physiological homeostasis is a synergistic process involving tight regulation of proteins, transcription factors and other molecular processes. The immune system consists of innate and adaptive immune cells that are required to sustain immunity. The presence of pathogens and tumour cells activates innate immune cells, in particular Natural Killer (NK) cells. Stochastic expression of NK receptors activates either inhibitory or activating signals and results in cytokine production and activation of pathways that result in apoptosis of target cells. Thus, NK cells are a necessary component of the immunological process and aberrations in their functional processes, including equivocal …
Chronic Fatigue Syndrome/Myalgic Encephalomyelitis And Parallels With Autoimmune Disorders, Ekua Brenu, Lotti Tajouri, Kevin Ashton, Don Staines, Sonja Marshall-Gradisnik
Chronic Fatigue Syndrome/Myalgic Encephalomyelitis And Parallels With Autoimmune Disorders, Ekua Brenu, Lotti Tajouri, Kevin Ashton, Don Staines, Sonja Marshall-Gradisnik
Kevin Ashton
Autoimmune disorders are known to affect a substantial number of people worldwide and in some cases may be fatal. They occur in the presence of unregulated inflammatory responses including failure in self-tolerance. Some unexplained disorders with immune compromises may demonstrate certain characteristics that suggest an autoimmune disorderincluding Chronic Fatigue syndrome/Myalgic Encephalomyelitis (CFS/ME). CFS/ME remains an unsolved disorder with multiple symptoms and no single causative factor. Thesesymptoms may include but are not limited to incapacitating fatigue, weakened short term memory or attentiveness, sore throat, tender cervical or axillary lymph nodes, muscle pain, severe headaches, impaired sleep and postexertional malaise. To date …