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Full-Text Articles in Medicine and Health Sciences

Consumer Involvement In Medicaid Nursing Facility Reimbursement: Lessons From New York And Minnesota For State Policymakers, Edward Alan Miller, Cynthia Rudder Nov 2011

Consumer Involvement In Medicaid Nursing Facility Reimbursement: Lessons From New York And Minnesota For State Policymakers, Edward Alan Miller, Cynthia Rudder

Gerontology Institute Publications

Medicaid is the major purchaser of nursing home care in the United States. State governments design their methods of reimbursing nursing homes to achieve desired policy objectives related to facility cost and quality, access to care, payment equity, service capacity, and budgetary control.

Often, participation in the process of developing Medicaid payment policy is limited to state agency officials and providers of care and, occasionally, union representatives and state legislative staff. Invited less frequently to reimbursement policy discussions are consumer representatives. Lack of consumer involvement in the development of state rate setting systems has the potential to result in the …


Elevated Stearoyl-Coa Desaturase In Brains Of Patients With Alzheimer's Disease, Giuseppe Astarita, Kwang-Mook Jung, Vitaly Vasilevko, Nicholas V. Dipatrizio, Sarah K. Martin, David H. Cribbs, Elizabeth Head, Carl W. Cotman, Daniele Piomelli Oct 2011

Elevated Stearoyl-Coa Desaturase In Brains Of Patients With Alzheimer's Disease, Giuseppe Astarita, Kwang-Mook Jung, Vitaly Vasilevko, Nicholas V. Dipatrizio, Sarah K. Martin, David H. Cribbs, Elizabeth Head, Carl W. Cotman, Daniele Piomelli

Sanders-Brown Center on Aging Faculty Publications

The molecular bases of Alzheimer's disease (AD) remain unclear. We used a lipidomic approach to identify lipid abnormalities in the brains of subjects with AD (N = 37) compared to age-matched controls (N = 17). The analyses revealed statistically detectable elevations in levels of non-esterified monounsaturated fatty acids (MUFAs) and mead acid (20:3n-9) in mid-frontal cortex, temporal cortex and hippocampus of AD patients. Further studies showed that brain mRNAs encoding for isoforms of the rate-limiting enzyme in MUFAs biosynthesis, stearoyl-CoA desaturase (SCD-1, SCD-5a and SCD-5b), were elevated in subjects with AD. The monounsaturated/saturated fatty acid ratio ('desaturation index')--displayed a strong …


Dental Service-Learning Curriculum And Community Outreach Programs Perception Vs. Practice, Barbara Gaeth Oct 2011

Dental Service-Learning Curriculum And Community Outreach Programs Perception Vs. Practice, Barbara Gaeth

Professional Projects

The purpose of this study is to determine if the service-learning aspect of Marquette’s dental education enhances the dental students’ knowledge of the barriers to access to dental care for underserved populations. The goal of this study is to obtain feedback about service-learning in the MUSoD curriculum and disseminate the findings to others who teach service-learning in dental school curricula. MUSoD students have the opportunity to participate in multiple diverse outreach experiences throughout their four years of Dental School. Their attitudes toward service experiences and their perception of service-learning curriculum before and after they perform rotations will be recorded. Volunteers …


Economic Empowerment And Hiv Prevention Among Young Women And Girls In Kenya: Lessons From The Study Of Economic Empowerment Programs, Samantha Van Putten Oct 2011

Economic Empowerment And Hiv Prevention Among Young Women And Girls In Kenya: Lessons From The Study Of Economic Empowerment Programs, Samantha Van Putten

Independent Study Project (ISP) Collection

One of the major issues facing Kenya is HIV/AIDS. With recognition by the global community that providing women with economic opportunities can help both those who are HIV positive, as well as in prevention for those who are not infected, programs combining microfinance and HIV education have started to emerge. While women in these programs 3 3 have shown preliminary signs of success, young girls did not respond as well in part due to lack of interest in the particular programs themselves. As such, this study examines two economic empowerment programs for girls and young mothers at the non-governmental organization …


A New Face In The Crowd: An Examination On The Social Integration Of Children With Disabilities, Christen Maguire Oct 2011

A New Face In The Crowd: An Examination On The Social Integration Of Children With Disabilities, Christen Maguire

Independent Study Project (ISP) Collection

Historically in India people with disabilities have been pushed to the side and have not been given the attention which they need and deserve. As a result this population has become extremely marginalized and has not been included in making decisions with the rest of society. The main reason why this has become such a marginalized group is because of a negative stigma which has been associated with mental disabilities. Slowly this stigma is beginning to change, but it still affects the way people view and act towards the disabled. The integration of people with disabilities into the rest of …


The Perfect Storm: How Pro-Abortion Activists In The Netherlands Incite Social Change From International Waters, Julia Ellis‐Kahana Oct 2011

The Perfect Storm: How Pro-Abortion Activists In The Netherlands Incite Social Change From International Waters, Julia Ellis‐Kahana

Independent Study Project (ISP) Collection

This project is a sociological ethnography of the Women on Waves foundation, founded in 1999 by Dr. Rebecca Gomperts. As an international non-profit organization, they employ a direct action method: sailing to countries where abortion is illegal and providing safe abortion access. Local women board the ship that then travels 12 miles to international waters, where Dutch law applies, and the abortion pill can be administered legally. Using a feminist perspective, I interviewed five of the women at the organization in addition to the ship’s captain in order to understand the ideological beliefs about the reproductive rights that have inspired …


Autism In Kenya: A Social, Educational And Political Perspective, Ariana Riccio Oct 2011

Autism In Kenya: A Social, Educational And Political Perspective, Ariana Riccio

Independent Study Project (ISP) Collection

Autism is a widely misunderstood developmental disability that is generally diagnosed in early childhood and has been the recent subject of much media and medical attention in developed nations worldwide. While there has been a noted improvement in diagnostic and therapeutic options for children and their families in developing nations, the attention placed on disability, particularly on autism, is considered underdeveloped and inadequate. This paper will attempt to address the current framework surrounding autism in the area of Nairobi, Kenya and discuss the social attitudes, diagnostic practices, educational opportunities, and government intervention programs available in the area. Given the lack …


Assessing Mental Health Care For Iraqi Refugees In Jordan Looking To New Solutions For The Future, Hannah B. Egan Oct 2011

Assessing Mental Health Care For Iraqi Refugees In Jordan Looking To New Solutions For The Future, Hannah B. Egan

Independent Study Project (ISP) Collection

Across the globe citizens flee their native countries in search of newfound safety and stability. These people are known as refugees. Since 2003 refugees from Iraq have entered Jordan in search of a better life. Unfortunately, the terrors that Iraqi refugees escape do not disappear after crossing country lines. These memories cause serious mental health conditions for Iraqi refugees. Such conditions are intensified by the living environment in Jordan where Iraqis are not granted legal status. While some refugees are wealthy and others are resettled to the United States or Europe, the majority remain “stuck” in Jordan.

This study seeks …


Reproductive Realities: Fulani Women & Contraception, Corrina Regnier Oct 2011

Reproductive Realities: Fulani Women & Contraception, Corrina Regnier

Independent Study Project (ISP) Collection

This paper is the product of three weeks of research on contraception and the lives of married Fulani women in Ngaoundéré, Cameroon. Based on interviews with Fulani women, conducted both in French and in the Fulani language of Fulfulde with the aid of a French interpreter, I discuss the cultural and religious influences on women’s lives that impact their decisions or abilities to use contraception, as well as the ways these influences and realities have changed, are changing, and are expected to change in the future. I also look into the more practical concern of the availability and accessibility of …


Differentiating The Vulnerability Of Kothis And Hijras To Hiv/Aids: A Case Study Of Lucknow, Uttar Pradesh, Poonam Daryani Oct 2011

Differentiating The Vulnerability Of Kothis And Hijras To Hiv/Aids: A Case Study Of Lucknow, Uttar Pradesh, Poonam Daryani

Independent Study Project (ISP) Collection

The present study aims to begin the process of differentiation between the various subpopulations that fall under the agenda of interventions targeted at Males who have Sex with Males (MSM). This separation is accomplished though an investigation of the sociocultural factors and behavioral patterns impacting the vulnerability of MSM and transgender (TG) 5 communities to HIV/AIDS. Specifically, the situation of kothi and hijra populations are compared in order to understand how the differences in their cultural practices and lifestyles create unique sexual health needs. The study was completed in Lucknow, Uttar Pradesh under the guidance of Bharosa Trust and MAAN …


“El Tema No Existe”: La Salud Sexual Lésbica En Valparaíso, Chile, Isabel Osgood-Roach Oct 2011

“El Tema No Existe”: La Salud Sexual Lésbica En Valparaíso, Chile, Isabel Osgood-Roach

Independent Study Project (ISP) Collection

This independent study project investigates the status of lesbian health care in Valparaíso, Chile. Over the course of three weeks, I conducted interviews with six women who engage in non-heterosexual intimate relationships. These individuals identify on a spectrum of sexual orientation that includes lesbian, bisexual and hetero-dissident. I also participated in a political demonstration organized by Acción Gay supporting a proposed Anti-Discrimination law. Finally, I attended a meeting of the recently formed lesbian health group Colectivo Ropa Tendida to gain insight into an organization working towards visibilizing lesbian realities. To contextualize my investigation, I worked with theories regarding essentialist and …


Social Support For Young Carers An Analysis Of The Available Social Support For Children Caring For Aids-Sick And Other-Sick Caregivers In Emoyeni, South Africa., Flannery Mcardle Oct 2011

Social Support For Young Carers An Analysis Of The Available Social Support For Children Caring For Aids-Sick And Other-Sick Caregivers In Emoyeni, South Africa., Flannery Mcardle

Independent Study Project (ISP) Collection

The dual epidemics of HIV/AIDS and non-communicable diseases in South Africa are the principal drivers of the worsening orphan epidemic in South Africa. As orphanhood is often far from a singular event but rather one preceded by months or even years of the parent or guardian’s declining health, many children will become the primary caregivers for a sick or dying adult. This study explores the lives of the young carers, specifically, the social support available for these children and how the support available for children caring for AIDS-sick caregivers may differ from that available for children caring for an adult …


Poor Women With Sexually Transmitted Infections: Providers’ Perspectives On Diagnoses, Genevieve R. Cox Oct 2011

Poor Women With Sexually Transmitted Infections: Providers’ Perspectives On Diagnoses, Genevieve R. Cox

Sociology

This article presents results from a study of health care providers, mainly nurses and nurse practitioners, who routinely diagnose sexually transmitted diseases (STDs) in rural low-income populations in West Virginia (WV). A qualitative analysis of eighteen semi-structured interviews reveals that providers who consistently work with low-income populations believe patients undergo a negative change in self-image in response to a chronic STD diagnosis. Providers express concerns about a number of issues related to low-income, rural women’s access to sexual health care and see the need for more sexuality education, more funding for free and reduced cost clinics, and more available health …


Reproductive Health Education In The Kibera Slum: Developing A Slum-Specific Curriculum, Susanna Schneider Banks Oct 2011

Reproductive Health Education In The Kibera Slum: Developing A Slum-Specific Curriculum, Susanna Schneider Banks

Independent Study Project (ISP) Collection

The principal objective of this Independent Study Project is to make recommendations for a slum-specific reproductive health curriculum to be used in primary schools that serve the Kibera Slum in Nairobi, Kenya. In order to obtain data and form a credible basis for the recommendations, interviews were conducted with teachers, focus groups were facilitated with students, and questionnaires were distributed to parents. Additionally, observations were made about the current state of reproductive health education at each school. Data was collected at Kibera School for Girls, a private school in Kibera, and Olympic Primary School, a public school at the edge …


Il Faut Manger: A Study Of Women’S Body Image And Obesity In Mali, Jennifer Denike Oct 2011

Il Faut Manger: A Study Of Women’S Body Image And Obesity In Mali, Jennifer Denike

Independent Study Project (ISP) Collection

Africa has long been a region of the world marked by the media as one of rail thin children with distended bellies and older men and women with cracked and wrinkled skin sagging off their bones. Media outlets like BBC, CNN, and the New York Times focus entire sections of their websites to special reports entitled ‘Famine in Africa’2, ‘Food Crisis in Niger’3, and ‘East Africa Famine 2011’4. Photos of children curled up on the ground, ribs and bones protruding at every angle grace the pages of nearly every magazine and newspaper. Nongovernmental organizations plead for donations and host fundraisers …


Migration, Vulnerability And Xenophobia: Central African Refugee And Asylum Seekers’ Access To Health Services In Durban, South Africa, Cathy Kaplan Oct 2011

Migration, Vulnerability And Xenophobia: Central African Refugee And Asylum Seekers’ Access To Health Services In Durban, South Africa, Cathy Kaplan

Independent Study Project (ISP) Collection

In 1998, South Africa passed historic legislation that bridged international conventions on refugees and asylum seekers with the protections and rights defined in the South African Constitution and Bill of Rights. The 1998 refugees act defined specific rights that refugees and asylum seekers are entitled in South Africa, the most important of which include the provision of legal and immigration documentation, employment, adequate housing, and health and social services. When asylum seekers arrive in Durban, many are in the need of immediate health services as a result of long journeys, pre-existing conditions, pregnancy, or illnesses contracted in refugee camps throughout …


“La Percepción Social De Vih/Sida En Chile Y Sus Efectos”, Philip Krause Oct 2011

“La Percepción Social De Vih/Sida En Chile Y Sus Efectos”, Philip Krause

Independent Study Project (ISP) Collection

Research Question—How does the social perception of HIV/AIDs in Chile affect the country’s prevention and treatment programs?

Background-- This paper investigated the social perception of HIV/AIDs in Chile through the opinions of experts who work closely to the issue, including regional and national political professionals, medical professionals on HIV/AIDs treatment teams in hospitals, and leaders of social organizations that had a relationship to HIV/AIDs representation and prevention. The professionals were also asked how they believed this perception affected the efforts of the Chilean government and national organizations in prevention and management of the HIV/AIDs epidemic in Chile. An …


La Etnia Y Las Cesáreas En Los Partos En El Hospital Público De Arica, Chile, Marisa Westbrook Oct 2011

La Etnia Y Las Cesáreas En Los Partos En El Hospital Público De Arica, Chile, Marisa Westbrook

Independent Study Project (ISP) Collection

The principal objective of this project was to explore the relationship between ethnicity and the causes for Caesarean section in the regional public hospital in Arica, Chile. All births recorded in the maternity register (n=907) were analyzed over a 4-month period in 2011. The regional public hospital had a 27% caesarean section rate, higher than the WHO-recommended 15%. Last names were analyzed and deemed to be either of Aymara descent (n=275) or of European descent (n=632) based on criteria used from CONADI, the National Corporation for Indigenous Development. The overall rate of Caesarean section did not differ between Aymara and …


Psychosocial Problems Of Refugees: Understanding And Addressing Needs, Catherine Doren Oct 2011

Psychosocial Problems Of Refugees: Understanding And Addressing Needs, Catherine Doren

Independent Study Project (ISP) Collection

Because all refugees have, by definition, left their country due to a “well-founded fear of persecution due to race, political opinion, ethnic origin, religion, or belonging to a particular social group,” it must be assumed that they have experienced trauma, making psychosocial problems ubiquitous among refugees (Bulbul, 2011; M. Carballo, personal communication, 29 September 2011). Research has shown that refugees often experience a range of psychosocial problems, yet research about the potential avenues for ameliorating these problems and their consequences is lacking and must be increased. Through a combination of interviews and a review of the field’s existing literature, it …


Effective, Efficient Health Care Reform The United States And Swiss Health Care Systems: A Comparative Analysis What Can The U.S. Learn From The Swiss Experience?, Rebecca Dittrich Oct 2011

Effective, Efficient Health Care Reform The United States And Swiss Health Care Systems: A Comparative Analysis What Can The U.S. Learn From The Swiss Experience?, Rebecca Dittrich

Independent Study Project (ISP) Collection

Home to 45 million people without health insurance while still spending 17% of its GDP on health care expenses, the United States has been in need of a massive health care overhaul for quite some time. Some have speculated that the Swiss system may be an ideal model for health care reform, and in fact, many aspects of the newly instated Patient Protection and Affordable Care Act (ACA) do reflect areas of LAMal, Swiss health care law. This paper evaluates the Swiss and United States health care systems (under ACA), their similarities and differences, and the pros and cons of …


Cap Centre : L’Epicerie Sociale, Ana De Pina Oct 2011

Cap Centre : L’Epicerie Sociale, Ana De Pina

Independent Study Project (ISP) Collection

Contrairement à autres study abroad programs, « The School of International Training (SIT) » donne les étudiants Américains une opportunité de découvrir la culture Française, d’apprendre la langue Française, et de s’intègre dans la société Française. Pendant notre séjour en France, nous avons fait de bénévolat dans une association que correspond à nos études aux États-Unis. Aux États-Unis j’étudie la sante publique. Je suis très intéressé pour l’administration des hôpitaux et autres institutions de santé et la relation entre la sécurité sociale et la bonne santé. Donc, pendant trois mois j’ai travaillé au CAP Centre, une épicerie sociale qui aide …


When Mountain Bellies Grow Round: Localized Knowledge And Behaviors Facilitating Pregnancy And Childbirth In Phaphlu, Nepal, Cailin Marsden Oct 2011

When Mountain Bellies Grow Round: Localized Knowledge And Behaviors Facilitating Pregnancy And Childbirth In Phaphlu, Nepal, Cailin Marsden

Independent Study Project (ISP) Collection

In attempts to gain a level of understanding of a community’s localized experiences, beliefs, practices, and roles around pregnancy and childbirth, ethnographic fieldwork was conducted with the mothers and fathers of Phaphlu in the Solukhumbu district of Nepal. Aimed at the validation of diverse and localized ways of knowing revealed during the fieldwork period, this paper applies anthropologist Bridgette Jordan’s theoretical framework of authoritative knowledge to the emergent themes of subjectively understood childbirth (knowledge acquisition and flow, role of the husband, and protective behavior.)


Activation Of Matrix Metalloproteinases Following Anti-Aβ Immunotherapy; Implications For Microhemorrhage Occurrence, Donna M. Wilcock, Dave Morgan, Marcia N. Gordon, Tiffany L. Taylor, Lisa A. Ridnour, David A. Wink, Carol A. Colton Sep 2011

Activation Of Matrix Metalloproteinases Following Anti-Aβ Immunotherapy; Implications For Microhemorrhage Occurrence, Donna M. Wilcock, Dave Morgan, Marcia N. Gordon, Tiffany L. Taylor, Lisa A. Ridnour, David A. Wink, Carol A. Colton

Sanders-Brown Center on Aging Faculty Publications

BACKGROUND: Anti-Aβ immunotherapy is a promising approach to the prevention and treatment of Alzheimer's disease (AD) currently in clinical trials. There is extensive evidence, both in mice and humans that a significant adverse event is the occurrence of microhemorrhages. Also, vasogenic edema was reported in phase 2 of a passive immunization clinical trial. In order to overcome these vascular adverse effects it is critical that we understand the mechanism(s) by which they occur.

METHODS: We have examined the matrix metalloproteinase (MMP) protein degradation system in two previously published anti-Aβ immunotherapy studies. The first was a passive immunization study in which …


Senior Transportation Abstracts: A Focus On Options, Helen Kerschner, Nina M. Silverstein Sep 2011

Senior Transportation Abstracts: A Focus On Options, Helen Kerschner, Nina M. Silverstein

Gerontology Institute Publications

This collection of abstracts represents a publication of importance for understanding the needs, challenges, solutions, and/or every day issues related to senior transportation services. While several of the abstracts include information about senior driver safety, the collection’s primary purpose is to present a holistic approach to transportation options for older adults. Such a collection is timely because, although the practice of providing transportation to older adults is not new, research and preparation of practical informational and technical materials related to older adult transportation service needs and service delivery are quite recent.


Civic Attitude And Activity Of Loma Linda University Dental Graduates, Gregory W. Olson Sep 2011

Civic Attitude And Activity Of Loma Linda University Dental Graduates, Gregory W. Olson

Loma Linda University Electronic Theses, Dissertations & Projects

Introduction: Dentistry is regarded as a profession and granted certain privileges, such as self-regulation. Associated with this status are stated and implied responsibilities which are widely debated. In recent years, dental professionalism seems to be on the decline. Evidence cited includes access-to-care issues and decreased public trust in dentists. In response, academia and professional organizations have developed curricula and statements intended to bolster professionalism. Meanwhile little is known about practicing dentists’ attitudes or participation in health-related civic matters. Objectives: This study seeks to examine the importance Loma Linda University (LLU) dental graduates place on public roles, their reported participation in …


Massachusetts Senior Legal Assistance Project Needs Evaluation: Current Demand For Legal Services, Alison Gottlieb, Lauren A. Martin, Ellen A. Bruce Sep 2011

Massachusetts Senior Legal Assistance Project Needs Evaluation: Current Demand For Legal Services, Alison Gottlieb, Lauren A. Martin, Ellen A. Bruce

Gerontology Institute Publications

The Gerontology Institute at the University of Massachusetts Boston was contracted to conduct a statewide needs assessment for the MSLAP. As agreed upon by the MSLAP Advisory Board, the focus of this assessment was to analyze the demand for services Massachusetts legal service providers have experienced recently as a means to understanding the legal needs of Massachusetts elders (age 60 and older). A second needs assessment was conducted by the Massachusetts Executive Office of Elder Affairs. That needs assessment surveyed home care workers and other elder agency personnel to gauge their assessment of elders’ legal needs in Massachusetts. Read together, …


Evaluation Of The Global Association Between Cholesterol-Associated Polymorphisms And Alzheimer's Disease Suggests A Role For Rs3846662 And Hmgcr Splicing In Disease Risk, Christopher R. Simmons, Fanggeng Zou, Steven G Younkin, Steven Estus Aug 2011

Evaluation Of The Global Association Between Cholesterol-Associated Polymorphisms And Alzheimer's Disease Suggests A Role For Rs3846662 And Hmgcr Splicing In Disease Risk, Christopher R. Simmons, Fanggeng Zou, Steven G Younkin, Steven Estus

Sanders-Brown Center on Aging Faculty Publications

BACKGROUND: Recent genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNP)s that are essentially unequivocally associated with peripheral cholesterol. Since the alleles of the APOE gene, which modulate peripheral cholesterol metabolism, and midlife plasma cholesterol are both associated with Alzheimer's disease (AD) risk, we have evaluated the hypothesis that SNPs associated with plasma cholesterol are also associated with AD.

RESULTS: Seventeen non-APOE SNPs reproducibly associated with cholesterol per GWAS were tested for association with AD in ~2,000 AD and ~4,000 non-AD subjects. As a group, these SNPs are associated with AD. Two SNPs in particular, rs3846662 and rs1532085, are …


Perceived Parent-Child Relationship And High-Risk Behaviors Among Christian College Students, Karla G. Lavin Williams Aug 2011

Perceived Parent-Child Relationship And High-Risk Behaviors Among Christian College Students, Karla G. Lavin Williams

Loma Linda University Electronic Theses, Dissertations & Projects

Background. Adolescents and young adults today are participating in high-risk behaviors such as dangerous sexual behaviors and drug and alcohol abuse at high rates. An increased incidence of negative effects associated with the aforementioned behaviors has led researchers to examine factors that influence and protect adolescents from certain devastating effects (Davis, Hendershot, George, Norris, & Heiman, 2007; Goldstein, Bamett, Pedlow, & Murphy, 2007; Hamilton, et al., 2007; Hingson, Heeren, & Winter, 2006; Hingson, Heeren, Winter, & Wechsler, 2003; Hingson, Heeren, Zakocs, Winter, & Wechsler, 2003; McCarty, et al., 2004; Mokdad, Marks, Stroup, & Gerberding, 2004; Mosher, Chandra, & Jones, 2005; …


Independent Living Program Evaluation For Rebuilding All Goals Efficiently, Patricia Armour, Debra Moulton, Araceli Pruett Aug 2011

Independent Living Program Evaluation For Rebuilding All Goals Efficiently, Patricia Armour, Debra Moulton, Araceli Pruett

UNLV Theses, Dissertations, Professional Papers, and Capstones

This paper evaluates the outcome of independent living (IL) services provided to clients with Spinal Cord Injuries (SCI) by a local non-profit organization, Rebuilding All Goals Efficiently (RAGE). Agency services are directed at increasing client self-sufficiency, self-advocacy, and maintenance of least restrictive living environment. Secondary data provided by RAGE for 22 SCI clients who received services in FY10 was used in the evaluation. Outcomes were measured for living arrangement at case closure, impact of services on client’s life, and cost effectiveness of services provided. Descriptive statistical analysis of the data revealed successful outcomes for all 22 SCI clients. All clients …


Epigenetic Silencing Of Nucleolar Rrna Genes In Alzheimer's Disease, Maciej Pietrzak, Grzegorz Rempala, Peter T. Nelson, Jing-Juan Zheng, Michal Hetman Jul 2011

Epigenetic Silencing Of Nucleolar Rrna Genes In Alzheimer's Disease, Maciej Pietrzak, Grzegorz Rempala, Peter T. Nelson, Jing-Juan Zheng, Michal Hetman

Sanders-Brown Center on Aging Faculty Publications

BACKGROUND: Ribosomal deficits are documented in mild cognitive impairment (MCI), which often represents an early stage Alzheimer's disease (AD), as well as in advanced AD. The nucleolar rRNA genes (rDNA), transcription of which is critical for ribosomal biogenesis, are regulated by epigenetic silencing including promoter CpG methylation.

METHODOLOGY/PRINCIPAL FINDINGS: To assess whether CpG methylation of the rDNA promoter was dysregulated across the AD spectrum, we analyzed brain samples from 10 MCI-, 23 AD-, and, 24 age-matched control individuals using bisulfite mapping. The rDNA promoter became hypermethylated in cerebro-cortical samples from MCI and AD groups. In parietal cortex, the rDNA promoter …