Medicine and Health Sciences Commons^™

Sugihara Causality Analysis Of Scalp Eeg For Detection Of Early Alzheimer's Disease, Joseph C. Mcbride, Xiaopeng Zhao, Nancy B. Munro, Greg A. Jicha, Frederick A. Schmitt, Richard J. Kryscio, Charles D. Smith, Yang Jiang

Sanders-Brown Center on Aging Faculty Publications

Recently, Sugihara proposed an innovative causality concept, which, in contrast to statistical predictability in Granger sense, characterizes underlying deterministic causation of the system. This work exploits Sugihara causality analysis to develop novel EEG biomarkers for discriminating normal aging from mild cognitive impairment (MCI) and early Alzheimer's disease (AD). The hypothesis of this work is that scalp EEG based causality measurements have different distributions for different cognitive groups and hence the causality measurements can be used to distinguish between NC, MCI, and AD participants. The current results are based on 30-channel resting EEG records from 48 age-matched participants (mean age 75.7 …

Increasing Response Time And Response Evaluation Time Compensates For Information Processing Difficulties In Persons At Risk For Alcoholism, Yasmin Akbari

Student Scholar Symposium Abstracts and Posters

Parental history of alcoholism is associated with increased alcoholism risk in their children. One factor increasing alcoholism risk is the presence of attention and information encoding disruptions in adult children of alcoholics (ACOA) compared to persons who are not ACOAs (NACOA). Alcohol ingestion reduces these disruptions in ACOAs. This study examined whether alterations of information processing parameters can function like alcohol and reduce processing disruptions experienced by the ACOA.

Participants were 80 ACOAs and 80 NACOAs, partitioned into four groups of 20 participants. During learning, subjects studied presentations of stimulus items followed by the presentation of associated response items. The …

Adjusting Learning Parameters To Increase Cognitive Resource Allocation In Persons With Alcoholism Risk, Brooke Snelgrove, Taylor Stephens, Yasmin Akbari, Reyn Yoshiura, Lilian Andrade

Student Scholar Symposium Abstracts and Posters

Parental history of alcoholism is associated with increased alcoholism risk in their children. One factor increasing alcoholism risk is the presence of attention and information encoding disruptions in adult children of alcoholics (ACOA) compared to persons who are not ACOAs (NACOA). Alcohol ingestion reduces these disruptions in ACOAs. This study examined whether alterations of information processing parameters can function like alcohol and reduce processing disruptions experienced by the ACOA. Participants were 80 ACOAs and 80 NACOAs, partitioned into four groups of 20 participants. During learning, subjects studied presentations of stimulus items followed by the presentation of associated response items. The …

Wellness And Food Preferences Among Children Of Latino Immigrant Families In The Arcadia Community Of Spartanburg County, Sarah Grace Keaveny

Student Scholarship

The topic of this capstone is the result of my synthesis across disciplines. As a student with majors in Biology and Spanish with a concentration in Medical Humanities, I wanted to research a topic that would include my disciplines in a way that would meaningfully prepare me to leave my undergraduate years for medical school. This project seeks to generate an understanding of the culturally created eating habits and perceptions of wellness in Latino children living in the Arcadia Community, as told by their mothers. By seeking this understanding, I hope that this project may serve as a tool to …

Let’S Talk About Sex, And What Happens When We Don’T: How Limited Sex Education In Nepal’S Government Schools Affects Women In Arranged Marriages, Isabelle Stillman

Independent Study Project (ISP) Collection

In Nepal’s government secondary schools, the reproductive health curriculum is often covered in a single week, and many teachers neglect to administer the lessons thoroughly due to beliefs that sex is a private matter, inappropriate or unnecessary for students. The government curriculum not only lacks detail about reproduction and intercourse, but, in the information it does include, defines male and female puberty processes, reproductive systems, sexual health, roles in family planning, and intercourse in ways that further the gender inequality so deeprooted in Nepali culture. Following secondary school, many women in Nepal are married in arranged matches, to men they …

Accessing Canal Pride: The Intersection Of Identities For Lgbt People With Physical Disabilities At A Global Event, Margaret Webb

Independent Study Project (ISP) Collection

This research is the study of the intersection between queerness and disability within the context of Amsterdam Gay Pride, specifically the Canal Parade. The study examines the intersection between LGBT identity and physical disability at the event and in surrounding organization and events within the Amsterdam LGBT community. The primary research question was: how does Amsterdam Canal Pride’s accessibility affect both the positioning of the LGBT and disabled identifying community in Amsterdam and the relevance of the event as a place of activism and celebration? Five interviewees identifying as lesbian or gay, possessing a physical disability, participating in activism within …

Ua1c11/57 Fall Graduation Photos, Wku Nursing

WKU Administration Documents

Unidentified photos from the December 2014 nursing graduation.

La Psiquiatría Comunitaria En La Corporación Bresky / Community Psychiatry In The Bresky Corporation, Connery O’Brien

Independent Study Project (ISP) Collection

The purpose of this paper is to provide insight on the community model of rehabilitation for individuals with mental health disorders in Chile with a specific focus on schizophrenia. Stigmas surrounding mental health are still very prevalent in this society. These stigmas make it difficult for patients to integrate themselves into society, and in turn, add stress to the patients’ families, who must support and care for them. The community model of mental health rehabilitation is important to consider in the efforts to re-integrate these patients into society. La Corporación Bresky, a rehabilitation center in Peñablanca, will be used as …

Promoción De La Salud En La Ciudad De Buenos Aires: Un Estudio Sobre El Trabajo De Los Promotores De Salud Y Las Percepciones De Su Rol En La Comunidad. / Health Promotion In The City Of Buenos Aires: A Study Of The Work Of Community Health Workers And Perceptions Of Their Role In The Community, Elizabeth Sherwin

Independent Study Project (ISP) Collection

Contextual information: At the global level, inequities exist with respect to access and quality of healthcare. Primary Health Care is a strategy to respond to these inequities. It adopts an integral concept of health that includes no only illness but also the wellbeing of a person affected by many environmental factors. It is a strategy that aims to improve access to medical care and health information through health promotion and has the goal of giving the population more control over their health. Community health workers, people from the same neighborhood in which they work promoting health, are recognized on the …

Effects Of Video Enhancement In A Stated-Choice Experiment On Medical Decision Making, Susanne Hoffmann, Joachim Winter, Francis G. Caro, Alison Gottlieb

Gerontology Institute Publications

Background. The internet can be useful in administering stated-choice experiments to understand medical decision making and refine the content of patient decision aids. In internet-based stated-choice experiments, video and audio files can be used to provide information to respondents. Quality of data may or may not be affected.

Objectives. In a methodological experiment concerned with administration of a stated-choice experiment on the internet concerned with knee-replacement surgery, we compared the data quality obtained with video-enhanced and conventional text formats.

Methods. Members of the RAND Corporation’s American Life Panel and 50 years of age or older (n=1616) were randomly assigned to …

Premature Births And Maternal Health: An Analysis Of Risk Factors That Affect The Rate Of Prematurity / Los Nacimientos Prematuros Y La Salud Materna: Un Análisis De Los Factores De Riesgo Que Afecta La Tasa De Prematuridad, Alexandria Mickler

Independent Study Project (ISP) Collection

Research Question: What are the major socio-demographic risk factors influencing the rate of preterm birth in Valparaiso, Chile? Objectives: The objective of this study is to identify risk factors that influence the rate of preterm birth in an urban population of women living in Valparaiso, Chile. This study aims to understand whether a relationship exists between socio-demographic characteristics, such as economic level, education, lifestyle, access to medical attention and resources and the risk of prematurity. The outcomes of this study seek to determine the major biological, cultural, and social relationships and identify at-risk social groups. Additionally, this study considers the …

Educar Para Liberar Una Investigación Del Sistema De Educación En Ex. Penitenciario Y Colina 2 Y Sus Efectos / Educating For Liberty An Investigation Of The Education System In Ex. Prison And Hill 2 And Its Effects, Patrick Miller

Independent Study Project (ISP) Collection

El objetivo de esta investigación es determinar cómo funciona el sistema de educación en las cárceles de Chile y aprender los efectos de educación en los hombres encarcelados. La investigación trata de responder las siguientes preguntas: 1) ¿Qué es la motivación del estado para educar personas encarceladas? 2) ¿Qué efectos tiene educación en las cárceles? 3) ¿Cuáles son los efectos en las personas una vez que salen en libertad? Son preguntas profundas y ésta investigación solo ofrece una breve respuesta a cada uno. Esta investigación realizó entrevistas formales con un director y sub director de un liceo dentro de un …

La Atención De Mujeres Con Complicaciones Post-Aborto En Un Hospital Público Del Partido De La Matanza: La Perspectiva De Los Profesionales De La Salud / The Perspective Of Health Professionals On The Quality Oftreatment For Women With Complications Post-Abortion Ina Public Hospital In La Matanza, Hannah Collins

Independent Study Project (ISP) Collection

Background: In Argentina, abortion is illegal under all circumstances except for when a woman has been raped, has a mental disability or her life is in danger. There are approximately 500,000 abortions practiced each year in Argentina, and the majority is performed in an unsafe manner, which can result in complications that require medical attention. In 2010, over 50,000 women were hospitalized because of complications post-abortion. These complications can include hemorrhages, infections, or other toxic illnesses. After the International Conference on Population and Development in 1994 they identified post-abortion care as a worldwide problem. Subsequently, Argentina created a guide for …

Sexual And Reproductive Health And Rights Of Aymara Women In The Intercultural Health System In Chile / Salud Y Derechos Sexuales Y Reproductivos De Las Mujeres Aymara En El Sistema De Salud Intercultural De Chile, Ariela Schnyer

Independent Study Project (ISP) Collection

This investigation seeks to understand how Aymara women navigate their sexual and reproductive health and rights (SRHR) in Chile’s intercultural health care model. Indigenous communities have their own practices that complicate the provision of sexual and reproductive health by requiring health care providers to be aware of two different worldviews and how they may conflict, as well as what is necessary to provide respectful care. However, an ethnically and culturally pertinent framework is vital to actually assuring successful SRHR provision, whose tenants include autonomous choice and care free of discrimination, coercion or violence. These interactions were investigated through semi-structured interviews …

¿Cómo Amigos Comparten La Salud? Las Redes Sociales Y Factores De Riesgo. / How Do Friends Share Health? Social Networks And Risk Factors., Joanna Emerson

Independent Study Project (ISP) Collection

Research question: How are health risk factors shared between people by means of their social networks? Objectives: The main objective of the study is to determine the correlation between a person's social network and which health risk factors are most prevalent in network members. The first specific objective is to evaluate the rates of the most common risk factors in social networks and how these disperse throughout the network. The second is to analyze whether people with similar health risk factors have similar social tendencies. The final objective is to identify the risk factors most transmittable through social networks. Background: …

A Community Conversation On Adolescent Pregnancy And Parenting Services: Networks Of Support, Gatekeepers To Care, And Non-Compulsory Fathering In A Black Urban Community, Tamara G.J. Leech, Elizabeth A. Adams, Marci Bounds Littlefield

Journal of Health Disparities Research and Practice

This study employed Community-Based Participatory Research (CBPR) methods to document needs and capacity around adolescent pregnancy and parenting in one predominately Black, low-income urban community. Using an iterative focus group method, we engaged 60 participants in a two-day community conversation. Quantitative data from an enrollment questionnaire and qualitative transcripts of the discussions are analyzed. Our results indicate that the community’s greatest capacity lies in a network of women. Men tend to participate in parenting more holistically once formal paternity is established. Neighborhood women typically introduce adolescents to prenatal care, so delays in revealing the pregnancy to them serves as a …

Hearing The Patient Voice: Using Video Intervention/Prevention Assessment To Understand Teens With Cystic Fibrosis, Susan Horky Lscw, Laura E. Sherman Msw, Julie Polvinen, Michael Rich Md

Patient Experience Journal

This qualitative study asked two questions: 1) How do teens with cystic fibrosis (CF) feel about their treatments; and 2) What factors lead teens to adhere, or not adhere, to treatments. To answer these questions we used an innovative approach (Video Intervention/Prevention Assessment or VIA), to learn about the experiences of teens with CF. We loaned video camcorders to teens with CF and asked them to create visual narratives of their lives. Researchers logged and coded videotapes, identifying themes that arose from the material. A primary theme was “Doctors don’t understand.” Participants also highlighted the value of routines and parental …

Alzheimer's Therapeutics Targeting Amyloid Beta 1-42 Oligomers I: Abeta 42 Oligomer Binding To Specific Neuronal Receptors Is Displaced By Drug Candidates That Improve Cognitive Deficits, Nicholas J. Izzo, Agnes Staniszewski, Lillian To, Mauro Fa, Andrew F. Teich, Faisal Saeed, Harrison Wostein, Thomas Walko Iii, Anisha Vaswani, Meghan Wardius, Zanobia Syed, Jessica Ravenscroft, Kelsie Mozzoni, Colleen Silky, Courtney Rehak, Raymond Yurko, Patricia Finn, Gary Look, Gilbert Rishton, Hank Safferstein, Miles Miller, Conrad Johanson, Edward Stopa, Manfred Windisch, Birgit Hutter-Paier, Mehrdad Shamloo, Ottavio Arancio, Harry Levine Iii, Susan M. Catalano

Sanders-Brown Center on Aging Faculty Publications

Synaptic dysfunction and loss caused by age-dependent accumulation of synaptotoxic beta amyloid (Abeta) 1-42 oligomers is proposed to underlie cognitive decline in Alzheimer's disease (AD). Alterations in membrane trafficking induced by Abeta oligomers mediates reduction in neuronal surface receptor expression that is the basis for inhibition of electrophysiological measures of synaptic plasticity and thus learning and memory. We have utilized phenotypic screens in mature, in vitro cultures of rat brain cells to identify small molecules which block or prevent the binding and effects of Abeta oligomers. Synthetic Abeta oligomers bind saturably to a single site on neuronal synapses and induce …

Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers Ii: Sigma-2/Pgrmc1 Receptors Mediate Abeta 42 Oligomer Binding And Synaptotoxicity, Nicholas J. Izzo, Jinbin Xu, Chenbo Zeng, Molly J. Kirk, Kelsie Mozzoni, Colleen Silky, Courtney Rehak, Raymond Yurko, Gary Look, Gilbert Rishton, Hank Safferstein, Carlos Cruchaga, Alison Goate, Michael A. Cahill, Ottavio Arancio, Robert H. Mach, Rolf Craven, Elizabeth Head, Harry Levine Iii, Tara L. Spires-Jones, Susan M. Catalano

Sanders-Brown Center on Aging Faculty Publications

Amyloid beta (Abeta) 1-42 oligomers accumulate in brains of patients with Mild Cognitive Impairment (MCI) and disrupt synaptic plasticity processes that underlie memory formation. Synaptic binding of Abeta oligomers to several putative receptor proteins is reported to inhibit long-term potentiation, affect membrane trafficking and induce reversible spine loss in neurons, leading to impaired cognitive performance and ultimately to anterograde amnesia in the early stages of Alzheimer's disease (AD). We have identified a receptor not previously associated with AD that mediates the binding of Abeta oligomers to neurons, and describe novel therapeutic antagonists of this receptor capable of blocking Abeta toxic …

Risk And Protective Factors Associated With Personal Mastery Among Sexual Minority African-American Female Sex Workers, Mance E. Buttram, Hilary L. Surratt, Steven P. Kurtz

CAHSS Faculty Articles

Research among sexual minorities has traditionally examined problems such as substance use, HIV risk, mental health problems, and victimization. Among sexual minority street-based female sex workers, these vulnerabilities can be magnified. Grounded in theories of resilience, this study examines risk and protective factors associated with a high level of personal mastery among a vulnerable population of women. Data are drawn from baseline interviews from street-based African American female sex workers enrolled in a randomized intervention trial in Miami, Florida. We compare sexual minority (N=197) and heterosexual (N=365) women on measures of risk and protective factors; among sexual minority women we …

Place Events Fall 2014, Place

PLACE Historical Documents

This document describes PLACE events at Linfield College for fall 2014.

Parental Factors That Influence Swimming In Children And Adolescents, Jennifer Pharr, Carol C. Irwin, Richard L. Irwin

Environmental & Global Health Faculty Research

Swimming can be an important source of physical activity across the life-span. Researchers have found that parents influence physical activity behaviors of their children. The purpose of this study was to determine what parental factors influenced the number of days that children swam. Survey respondents (n = 1,909) from six cities across the United States were surveyed at local YMCAs. Children were found to swim significantly more if their parents encouraged them to swim, members of the family knew how to swim and swam with them, or their parents were not afraid of the children drowning or afraid of …

Negotiating Masculinity: How Infertility Impacts Hegemonic Masculinity, Myscha Burton

Laurier Undergraduate Journal of the Arts

No abstract provided.

Health Insurance Among Young Adults Rebounds Post Recession: More Become Dependents On A Parent's Plan After Aca Extends Coverage To Adult Children, Michael J. Staley, Jess Carson

Carsey Publications

While much of the existing research explores young adults' insurance only in the post-recession period (that is, 2010 to present), authors Michael Staley and Jessica Carson assess young adults' rates of coverage within and beyond the context of the recession by examining changes across the entire 2007 to 2012 period.

Explaining Racial/Ethnic Disparities In Use Of High-Volume Hospitals: Decision-Making Complexity And Local Hospital Environments, Karl Kronebusch, Bradford H. Gray, Mark Schlesinger

Publications and Research

Racial/ethnic minorities are less likely to use higher-quality hospitals than whites. We propose that a higher level of informationrelated complexity in their local hospital environments compounds the effects of discrimination and more limited access to services, contributing to racial/ethnic disparities in hospital use. While minorities live closer than whites to high-volume hospitals, minorities also face greater choice complexity and live in neighborhoods with lower levels of medical experience. Our empirical results reveal that it is generally the overall context associated with proximity, choice complexity, and local experience, rather than differential sensitivity to these factors, that provides a partial explanation of …

The P38alpha Mitogen-Activated Protein Kinase Limits The Cns Proinflammatory Cytokine Response To Systemic Lipopolysaccharide, Potentially Through An Il-10 Dependent Mechanism, Adam D. Bachstetter, Bin Xing, Linda J. Van Eldik

Sanders-Brown Center on Aging Faculty Publications

BACKGROUND: The p38α mitogen-activated protein kinase (MAPK) is a well-characterized intracellular kinase involved in the overproduction of proinflammatory cytokines from glia. As such, p38α appears to be a promising therapeutic target for neurodegenerative diseases associated with neuroinflammation. However, the in vivo role of p38α in cytokine production in the CNS is poorly defined, and prior work suggests that p38α may be affecting a yet to be identified negative feedback mechanism that limits the acute, injury-induced proinflammatory cytokine surge in the CNS.

METHODS: To attempt to define this negative feedback mechanism, we used two in vitro and two in vivo models …

Self-Reported Memory Complaints: Implications From A Longitudinal Cohort With Autopsies, Richard J. Kryscio, Erin L. Abner, Gregory E. Cooper, David W. Fardo, Greg A. Jicha, Peter T. Nelson, Charles D. Smith, Linda J. Van Eldik, Lijie Wan, Frederick A. Schmitt

Sanders-Brown Center on Aging Faculty Publications

OBJECTIVE: We assessed salience of subjective memory complaints (SMCs) by older individuals as a predictor of subsequent cognitive impairment while accounting for risk factors and eventual neuropathologies.

METHODS: Subjects (n = 531) enrolled while cognitively intact at the University of Kentucky were asked annually if they perceived changes in memory since their last visit. A multistate model estimated when transition to impairment occurred while adjusting for intervening death. Risk factors affecting the timing and probability of an impairment were identified. The association between SMCs and Alzheimer-type neuropathology was assessed from autopsies (n = 243).

RESULTS: SMCs were …

Exploring Barriers: An Analysis Of Access To Effective Tuberculosis Care In Cape Town, Yvonne Okaka

Independent Study Project (ISP) Collection

My independent study project (ISP) examines factors that hinder access to tuberculosis (TB) healthcare and its effective implementation in Cape Town. In order to expand research on the topic, important barriers will be examined and explained. This project is relevant due to the high prevalence and mortality rates of tuberculosis in South Africa, as well as the fact that an overwhelming emphasis on HIV can lead to overlooking the serious nature of TB as a public healthcare issue. It is hoped that this study will provide more insight into improving access to TB care, and be a resource for those …

Chess Improves Cancer Caregivers' Burden And Mood: Results Of An Ehealth Rct, Lori L. Dubenske, David H. Gustafson, Kang Namkoong, Robert P. Hawkins, Amy K. Atwood, Roger L. Brown, Ming-Yuan Chih, Fiona Mctavish, Cindy L. Carmack, Mary K. Buss, Ramaswamy Govindan, James F. Cleary

Community & Leadership Development Faculty Publications

OBJECTIVE: Informal caregivers (family and friends) of people with cancer are often unprepared for their caregiving role, leading to increased burden or distress. Comprehensive Health Enhancement Support System (CHESS) is a Web-based lung cancer information, communication, and coaching system for caregivers. This randomized trial reports the impact on caregiver burden, disruptiveness, and mood of providing caregivers access to CHESS versus the Internet with a list of recommended lung cancer websites.

METHODS: A total of 285 informal caregivers of patients with advanced nonsmall cell lung cancer were randomly assigned to a comparison group that received Internet or a treatment group that …

Birthing, Blackness, And The Body: Black Midwives And Experiential Continuities Of Institutional Racism, Keisha La'nesha Goode

Dissertations, Theses, and Capstone Projects

Within the last decade, historical and contemporary accounts of midwives, along with the efficacy of the Midwives Model of Care for pregnancy, childbirth and general women's health, have become increasing popular in mainstream publications and documentaries. Yet, very few of these accounts represent historical or contemporary black midwives (and midwives of color, more generally). Despite a long history of midwifery in the black community, black women currently represent less than 2% of the nation's reported 15,000 midwives. Relatedly, black women and infants experience the worst birth outcomes of any racial-ethnic cohort in the United States.

In the early 20th century, …