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Full-Text Articles in Medicine and Health Sciences

Development And Evaluation Of A Body Weight Support Treadmill For Use With Locomotor Training On Pediatric Spinal Cord Injury Patients., Winston T Rauch Aug 2021

Development And Evaluation Of A Body Weight Support Treadmill For Use With Locomotor Training On Pediatric Spinal Cord Injury Patients., Winston T Rauch

Electronic Theses and Dissertations

The consequences of spinal cord injury (SCI) are devastating regardless of the age of a patient. When the injury occurs in children five years old or younger, however, the impact is magnified due to the inevitable development of scoliosis (96%) and hip dysplasia (57%) (Schottler et al., 2012). To reduce occurrence of these complications and improve the quality of life for these patients, specialized activity-based therapies such as locomotor training (LT) are being increasingly used to improve overall trunk control and muscle activity in the lower extremities (Harkema et al., 2012; Howland et al., 2014). The aim of this therapy …


Exploring Occupational Dysfunction And Occupational Performance For Youth In Homeless Shelters, Akio Ross Aug 2021

Exploring Occupational Dysfunction And Occupational Performance For Youth In Homeless Shelters, Akio Ross

Student Capstone Papers

The capstone project aims to explore and identify the role of occupational therapist in homeless youth shelters, to improve life skills necessary for independent living, and transition into the community of youths that occupy youth shelters. The proposed research project will fill the gap between occupational therapist, and youth shelters, by revealing barriers, while simultaneously developing and identifying a role for occupational therapist in homeless youth shelters.


Performance Effects Of A Strength Training Program In Collegiate Runners, Alyssa Younker Aug 2021

Performance Effects Of A Strength Training Program In Collegiate Runners, Alyssa Younker

Electronic Theses and Dissertations

Research has shown that lower limb asymmetries can negatively impact performance and risk of injury. However, there is little research on the effects of lower limb asymmetry on running performance, nor the effects of strength training on lower limb asymmetry in runners. The purpose of this study was to examine the relationship between jumping ability and asymmetry and long distance running performance, as well as to determine the performance effects a strength training program has on collegiate runners. Data from athlete monitoring of 10 collegiate distance runners and 6 sprinters were analyzed. Athletes (Distance Runners n = 10, Sprinters n …


No Evidence Of Stochastic Resonance In Postural Sway Response To Noisy Galvanic Vestibular Stimulation In Healthy Young Adults, Dominique Rice Aug 2021

No Evidence Of Stochastic Resonance In Postural Sway Response To Noisy Galvanic Vestibular Stimulation In Healthy Young Adults, Dominique Rice

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

The transcutaneous application of a sub-sensory electrical stimulation to the vestibular afferents, known as noisy galvanic vestibular stimulation (nGVS), is thought to cause a reduction in postural sway at optimal amplitude intensities due to a mechanism known as stochastic resonance (SR). SR is a phenomenon whereby the addition of low amplitude noise to a non-linear system can be beneficial rather than detrimental. In humans, behavioral markers of SR in postural sway have been inconsistent, potentially due to insufficient power or false positives. Therefore, the main purpose of this study was to determine whether the frequency of observing SR-like effects improves …


Mindfulness-Based Practices For The Impaired Performance Athlete, Mackenzie L. Campbell Aug 2021

Mindfulness-Based Practices For The Impaired Performance Athlete, Mackenzie L. Campbell

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Mindfulness-based programs are becoming commonly considered for the improvement of athlete's mental and physical state. However, their usage in improving performance in impaired athletes is limited and not fully understood. The purpose of this thesis was to review the standing literature on the topic of the application of mindfulness to improving athletic performance in wellbeing-impaired athletes. Seventy-three articles were included as references for this paper describing functional mechanisms, clinical significance and anecdotal evidence that points to the effectiveness of mindfulness in sport for the treatment of pain, injury recovery, prevention of injury, and chronic illness. Ultimately, this review supports the …


The Association Between Motor Capacity And Motor Performance In School-Aged Children With Cerebral Palsy: An Observational Study, Min-Hwa Suk, In-Kyeong Park, Soojin Yoo, Jeong-Yi Kwon Aug 2021

The Association Between Motor Capacity And Motor Performance In School-Aged Children With Cerebral Palsy: An Observational Study, Min-Hwa Suk, In-Kyeong Park, Soojin Yoo, Jeong-Yi Kwon

Health & Human Performance Faculty Publications

Background

This study aimed to investigate the association between motor capacity and motor performance in children with cerebral palsy (CP) aged 6–12 years with Gross Motor Function Classification System (GMFCS) levels I to III.

Methods

Forty-six children with CP (24 boys and 22 girls) classified as GMFCS levels Ⅰ, Ⅱ, or Ⅲ were included. Motor capacity was measured by the Gross motor function measure (GMFM), Pediatric balance scale (PBS), Timed up and go (TUG), and 6-min walk test (6MWT). Motor performance was measured by triaxial accelerometers. Estimations of physical activity energy expenditure (PAEE) (kcal/kg/day), percentage of time spent on …


The Relationship Between Participation In Recreational Therapy Physical Activity And Symptoms Of Mental Health Issues In Veterans, Krista F. Mcdonagh Aug 2021

The Relationship Between Participation In Recreational Therapy Physical Activity And Symptoms Of Mental Health Issues In Veterans, Krista F. Mcdonagh

Graduate Doctoral Dissertations

Background/Objective: The growing prevalence of mental health issues in veterans has triggered a wide-spread effort to identify and provide complementary intervention strategies to increase help-seeking behavior in this population. Posttraumatic stress disorder (PTSD) and substance use disorders (SUD) have become two of the most common mental health issues as a result of the demanding environment of military life. This study looks specifically at therapeutic recreation-based physical activity opportunities as a complementary treatment option for veterans at an increased risk for mental health issues.

Method: A correlational survey research design was used to examine relationships between factors of participation in different …


From Opportunity To Necessity: Development Of An Asynchronous Online Interprofessional Learning Experience, Kristen Mchenry, S. Alicia Williams, Florence M. Weierbach, Kate E. Beatty, Brian Cross Jul 2021

From Opportunity To Necessity: Development Of An Asynchronous Online Interprofessional Learning Experience, Kristen Mchenry, S. Alicia Williams, Florence M. Weierbach, Kate E. Beatty, Brian Cross

International Journal of Health Sciences Education

Incorporating interprofessional collaboration competencies into both undergraduate pre-licensure and graduate health science students poses challenges for academic health science centers. Certain student groups may have less opportunity to participate in interprofessional learning experiences due to demands of individual programs of study and conflicts in scheduling time with other disciplines. A group of interprofessional higher education faculty members created an innovative online asynchronous interprofessional experience with the primary goals of meeting accreditation standards for specific programs and providing interprofessional education (IPE) to students who were unable to participate in traditional face-to-face IPE experiences already established at the institution. This guide will …


Development And Implementation Of An Evaluation Tool For Measuring Cultural Competency Learning Activities In Health And Sport Science Undergraduate Students, Diana Cuy Castellanos, Haozhou Pu, Rachel Piero Jul 2021

Development And Implementation Of An Evaluation Tool For Measuring Cultural Competency Learning Activities In Health And Sport Science Undergraduate Students, Diana Cuy Castellanos, Haozhou Pu, Rachel Piero

International Journal of Health Sciences Education

Due to the diversity within the healthcare system, it is important to promote cultural competency in healthcare providers. The integration of pedagogical approaches to cultural competency into health-related programs cannot be understated. Therefore, the purpose of this study was to develop an instrument to examine the student engagement in cultural competency-related activities within health-related degree programs and determine the relationship between engagement and cultural competency. Participants of the study included first- and fourth-year undergraduate students studying within a health-related program at a mid-sized, private university in the Midwestern US. Participants completed a cultural competency inventory questionnaire which included activities identified …


Systematic Review Shows Tele-Rehabilitation Might Achieve Comparable Results To Office-Based Rehabilitation For Decreasing Pain In Patients With Knee Osteoarthritis, Tamila Latif-Zade, Brian Tucci, Danna Verbovetskaya, Elizabeth Bialkin, Brian Ng, Stephan Heddon, Jean-Philippe Berteau Jul 2021

Systematic Review Shows Tele-Rehabilitation Might Achieve Comparable Results To Office-Based Rehabilitation For Decreasing Pain In Patients With Knee Osteoarthritis, Tamila Latif-Zade, Brian Tucci, Danna Verbovetskaya, Elizabeth Bialkin, Brian Ng, Stephan Heddon, Jean-Philippe Berteau

Publications and Research

Background and Objectives This systematic review aims to evaluate the efficacy of Tele-Rehabilitation for decreasing pain in patients with knee osteoarthritis (OA). Materials and Methods: Following the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), three electronic databases (CINAHL, PubMed, PEDro), along with the addition of grey literature, were used to collect information. Randomized control trials (RCTs) comparing tele-rehabilitation (TR) to office-based-rehabilitation (OB) were critically appraised using the 2005 University of Oxford Standard. A total of 139 articles (PubMed = 132, CINAHL = 5, PEDro = 0, grey literature = 2) were acquired. Results: After the screening, …


Neurophysiological Changes Of Brain And Spinal Cord In Individuals With Patellofemoral Pain: A Systematic Review And Meta-Analysis Protocol, Jing Nong Liang, Savanna Budge, Austin Madriaga, Kara Meske, Derrick Nguyenton, Kai-Yu Ho Jul 2021

Neurophysiological Changes Of Brain And Spinal Cord In Individuals With Patellofemoral Pain: A Systematic Review And Meta-Analysis Protocol, Jing Nong Liang, Savanna Budge, Austin Madriaga, Kara Meske, Derrick Nguyenton, Kai-Yu Ho

Physical Therapy Faculty Research

Introduction: Reduced neuromuscular control due to altered neurophysiological functions of the central nervous system has been suggested to cause movement deficits in individuals with patellofemoral pain (PFP). However, the underlying neurophysiological measures of brain and spinal cord in this population remain to be poorly understood. The purpose of this systematic review is to evaluate the evidence for altered cortical and spinal cord functions in individuals with PFP.

Methods and analysis: The protocol for conducting the review was prepared using the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols guidelines. We will systematically search the literature that examines cortical and …


Understanding Factors Relevant To Poor Sleep And Coping Methods In People With Schizophrenia, Yen-Ching Chang, Megan C. Chang, Yun-Jou Chang, Ming-De Chen Jul 2021

Understanding Factors Relevant To Poor Sleep And Coping Methods In People With Schizophrenia, Yen-Ching Chang, Megan C. Chang, Yun-Jou Chang, Ming-De Chen

Faculty Research, Scholarly, and Creative Activity

Background

Sleep disruption is pervasive in people with schizophrenia, but few studies have explored their sleep experiences. This study aims to identify factors relevant to sleep problems and explore coping methods used by community-dwelling people with schizophrenia.

Methods

Eighteen participants with schizophrenia were recruited from three mental health centers in Taiwan. They completed a semi-structured interview and the Pittsburgh Sleep Quality Index (PSQI) assessment. The Person-Environment-Occupation model offered a framework to assess factors related to sleep. Thematic analysis was used for the qualitative data analysis.

Results

Factors related to sleep were classified under person, environment, and occupation domains. The person …


Knowledge, Attitude, And Practice Of Orthopedic Manual Physical Therapists Toward Lifestyle Screening And Education: A Descriptive Study, Jillian M. Zollinger, Sozina Katuli Jul 2021

Knowledge, Attitude, And Practice Of Orthopedic Manual Physical Therapists Toward Lifestyle Screening And Education: A Descriptive Study, Jillian M. Zollinger, Sozina Katuli

Faculty Publications

Introduction. Lifestyle-focused rehabilitation plans need to become part of the standard system of care for the treatment of chronic diseases. To achieve this goal, the KAP of rehabilitation professionals toward lifestyle medicine needs to be understood. This study investigated the niche of orthopedic manual physical therapy and is purposed as a foundational model for continued research. Method. A survey instrument was designed to investigate the KAP of orthopedic manual physical therapists toward lifestyle screening and education. Results. There were 155 participants of which 58.1-72.3% reported frequently talking to their patients about lifestyle topics, while 78.1-80.6% felt highly confident and competent …


Ikebana: An Ancient Tradition Of Contemporary Healing And Artful Practice, Jennifer K. Fortuna Phd, Otr/L Jul 2021

Ikebana: An Ancient Tradition Of Contemporary Healing And Artful Practice, Jennifer K. Fortuna Phd, Otr/L

The Open Journal of Occupational Therapy

Dr. Ricardo Carrásco, PhD, OTR/L, FAOTA, is an occupational therapy professor and ikebana artist. He provided the cover art for the Summer 2021 edition of The Open Journal of Occupational Therapy (OJOT). Ikebana is the ancient Japanese art of arranging flowers. “Kanta of the Wind, Sun and Moon” is an ikebana design made from blue and white Phalaenopsis orchids, chrysanthemum, bear grass, and heirloom driftwood. This gendaika, or freestyle design, is a haiku tribute to the wind, sun, and moon. Dr. Carrásco has been practicing occupational therapy and ikebana for more than 5 decades. As an occupational scientist and …


The Potential Of Virtual Reality In Social Skills Training For Autism: Bridging The Gap Between Research And Adoption Of Virtual Reality In Occupational Therapy Practice, Vineeta Pandey, Lori Vaughn Jul 2021

The Potential Of Virtual Reality In Social Skills Training For Autism: Bridging The Gap Between Research And Adoption Of Virtual Reality In Occupational Therapy Practice, Vineeta Pandey, Lori Vaughn

The Open Journal of Occupational Therapy

Impairments in social functioning greatly hinder children and youth with autism spectrum disorder (ASD) from responding appropriately and adapting to various social situations. As a result, individuals with ASD get fewer opportunities for social inclusion, physical well-being, and forming interpersonal relationships. Virtual reality (VR) has been studied extensively in this area, where a large body of evidence shows that VR is a promising tool for social skills training (SST) in individuals with ASD. With the flexibility and projected effectiveness that VR offers, it can provide more opportunities to learn and practice strategies for recognizing daily challenges that involve forming social …


Cognitive Orientation To Daily Occupational Performance (Co-Op): 1-Week Group Intervention With Children Referred For Motor Coordination Difficulties, Rose Martini, Jacinthe Savard Jul 2021

Cognitive Orientation To Daily Occupational Performance (Co-Op): 1-Week Group Intervention With Children Referred For Motor Coordination Difficulties, Rose Martini, Jacinthe Savard

The Open Journal of Occupational Therapy

Background: The aim of this study was to explore the effectiveness of a Cognitive Orientation to daily Occupational Performance (CO-OP) intervention delivered in a group format in a 1-week summer day camp program for children referred for motor coordination difficulties. Transfer of learned skills to self-selected tasks not addressed in the group intervention was also explored.

Method: A quasi-experimental one group pretest-posttest design with a 1-month follow-up was used. Changes in nine children’s self-selected occupational performance goals, as well as their sense of self-efficacy for these goals, were determined using nonparametric statistics.

Results: Findings indicate a significant …


A Comparison Of Two Keyboarding Instruction Methods Over 2 Years For Elementary Students, Denise K. Donica, Peter Giroux, Young Joo Kim, Sydney Branson Jul 2021

A Comparison Of Two Keyboarding Instruction Methods Over 2 Years For Elementary Students, Denise K. Donica, Peter Giroux, Young Joo Kim, Sydney Branson

The Open Journal of Occupational Therapy

Background: As computer and digital device use continues to grow in prevalence for school and work tasks, it is important for elementary-aged students to develop efficient keyboarding skills to support future academic and vocational success.

Method: A quasi-experimental pre-test and post-test study design was used to compare the effect of two different keyboarding instructional approaches on elementary students over a consecutive 2-year period. One group used Keyboarding Without Tears (KWT; N = 592) both years while the other group used free web-based activities the first year and Keyboarding Without Tears the second year (mixed methods; N = 714). …


A Comparison Of Activity Participation Between Children With And Without Asthma, Jacqueline R. Jezioro, Sharon A. Gutman, Stephanie Lovinsky-Desir, Virginia Rauh, Frederica P. Perera, Rachel L. Miller Jul 2021

A Comparison Of Activity Participation Between Children With And Without Asthma, Jacqueline R. Jezioro, Sharon A. Gutman, Stephanie Lovinsky-Desir, Virginia Rauh, Frederica P. Perera, Rachel L. Miller

The Open Journal of Occupational Therapy

Background: Asthma affects approximately 6 million children in the United States and can greatly impact quality of life and occupational engagement. Although occupational therapists are well-equipped to address participation limitations, insufficient evidence exists to support the role of occupational therapists in asthma treatment.

Method: The purpose of this study was to further understand the occupational limitations experienced by children with asthma. We also explored a dual diagnosis of asthma and obesity. The participants included children with (n = 84) and without (n = 63) asthma living in New York City. The Child Behavior Checklist, Youth Self Report, Brief …


Promoting Population Health In Local Communities: Parental Perceptions Of An Embedded Movement And Physical Activity Program For A Preschool Population, Jennifer Hight, Shirley P. O'Brien, Colleen M. Schneck Jul 2021

Promoting Population Health In Local Communities: Parental Perceptions Of An Embedded Movement And Physical Activity Program For A Preschool Population, Jennifer Hight, Shirley P. O'Brien, Colleen M. Schneck

The Open Journal of Occupational Therapy

Background: Many children reach kindergarten lacking age-appropriate motor skills because of a lack of access to early intervention services or a lack of continued early intervention beyond 3 years of age. Research suggests sedentary children become sedentary adults, which contributes to a growing population of unhealthy Americans with chronic health conditions, such as high blood pressure, diabetes, heart disease, and psychosocial difficulties. Parents often are not aware of the benefits of engaging in physical activity or possess a lack of awareness of their local resources. A community based preschool movement program was created to foster physical activity and promote …


Preliminary Measurement Properties Of The Early Childhood Occupational Profile (Ecope), Cary C. Moore Jul 2021

Preliminary Measurement Properties Of The Early Childhood Occupational Profile (Ecope), Cary C. Moore

The Open Journal of Occupational Therapy

Background: This study established the preliminary psychometric properties of the Early Childhood Occupational Profile (ECOPE; Moore & Bowyer, 2018) and investigated the perspectives of occupational therapists on the clinical utility of the tool.

Method: An embedded mixed methods research design was used to support the use of different research questions and unique sets of data. National and international occupational therapists administered the ECOPE on video case studies and on children from their caseload. These data were analyzed using the Rasch goodness of fit statistics to evaluate the validity and reliability of the ECOPE. The participating occupational therapists also …


Plagiocephaly Perception And Prevention: A Need To Intervene Early To Educate Parents, Sonja Burmeister, Allison N. Kayne, Ali R. Yazdanyar, J. Nathan Hagstrom, David B. Burmeister Jul 2021

Plagiocephaly Perception And Prevention: A Need To Intervene Early To Educate Parents, Sonja Burmeister, Allison N. Kayne, Ali R. Yazdanyar, J. Nathan Hagstrom, David B. Burmeister

The Open Journal of Occupational Therapy

Background: Plagiocephaly is a condition where the cranium has been malformed because of external forces or premature cranial suture fusion. This study’s objective was to gather and examine data regarding parent and caregiver awareness of plagiocephaly and its potential impact on development as well as to determine their rate of concern for positional flattening.

Method: A cross-sectional survey study was conducted. Categorical variables were described by frequency and proportions. The study was conducted across eight outpatient pediatric sites. Approximately 1,100 parents and caregivers were targeted. Inclusion criteria required participants to be willing to answer the questionnaire, to be …


Use Of A Caregiver Coaching Model For Implementation Of Intensive Motor Training For Hemiplegic Cerebral Palsy: A Case Study, Sheryl Eckberg Zylstra, Aimee Sidhu Jul 2021

Use Of A Caregiver Coaching Model For Implementation Of Intensive Motor Training For Hemiplegic Cerebral Palsy: A Case Study, Sheryl Eckberg Zylstra, Aimee Sidhu

The Open Journal of Occupational Therapy

Background: There is extensive literature to support the efficacy of both pediatric constraint-induced movement therapy (pCIMT) and hand-arm bimanual intensive therapy (HABIT) for children with hemiplegic cerebral palsy. In addition, there is increasing evidence to support the training of caregivers (parents and other care providers) to carry out therapy interventions in the home. The Family Activity Adaptation Model (FAAM) presents guidelines for parent and caregiver coaching for intensive therapies used in occupational therapy practice.

Method: In this descriptive case study the FAAM was used to frame caregiver training to answer the question: Is a coaching model, using a …


Observing And Promoting Normative Developmental Outcomes: Reciprocity Is Key, Nicki L. Aubuchon-Endsley, Bryan M. Gee, Heather L. Ramsdell, Nancy Devine, Hillary E. Swann-Thomsen, Nicholas Burgett, Leah R. Kollmeyer, Michele R. Brumley Jul 2021

Observing And Promoting Normative Developmental Outcomes: Reciprocity Is Key, Nicki L. Aubuchon-Endsley, Bryan M. Gee, Heather L. Ramsdell, Nancy Devine, Hillary E. Swann-Thomsen, Nicholas Burgett, Leah R. Kollmeyer, Michele R. Brumley

The Open Journal of Occupational Therapy

Background: Occupational therapists focus on caregiver-infant reciprocity, which is influenced by a host of biopsychosocial factors and is predictive of developmental outcomes across domains. It is important for early intervention professions to understand how different forms of reciprocity may predict infant development in salient domains (i.e., language, mobility, and co-occupation). Therefore, the purpose of this study was to investigate associations among related measures of development in and across age, while also exploring how reciprocity influences the acquisition of developmental milestones.

Method: We examined these important areas of development in relation to novel caregiver-infant co-occupational constructs in addition to …


Occupational Therapists’ Perceptions Of Intraprofessional Collaboration When Working With Young Children Aged Birth To 3 Years, Christine Rocchio Mueller, Mindy Garfinkel Jul 2021

Occupational Therapists’ Perceptions Of Intraprofessional Collaboration When Working With Young Children Aged Birth To 3 Years, Christine Rocchio Mueller, Mindy Garfinkel

The Open Journal of Occupational Therapy

Background: Birth to 3 years of age is a critical period in a child’s development, and occupational therapy intervention during this period can serve many purposes. While pediatric occupational therapists may be working in different settings with different specialties, the foundational knowledge all occupational therapists possess provides a common lens through which they approach treatment. Intraprofessional collaboration is considered best practice, as it is not uncommon for young children to receive occupational therapy services by more than one therapist, and in more than one practice setting at the same time.

Method: This study used a qualitative, phenomenological approach. …


Adaptations To Early Intervention Service Delivery During Covid-19, Lauren Little, Ashley Stoffel Jul 2021

Adaptations To Early Intervention Service Delivery During Covid-19, Lauren Little, Ashley Stoffel

The Open Journal of Occupational Therapy

Background: Early Intervention (EI) systems made a rapid shift to telehealth during the COVID-19 pandemic. Given the limited preparation of EI providers in the telehealth service delivery model, it is unclear how providers implemented adaptations. The purpose of this study was to evaluate the factor structure of the Service Delivery Adaptations Questionnaire and examine the influence of provider type, years of EI experience, and willingness to return to in-person services on the questionnaire’s subscales.

Method: We used exploratory factor analysis (EFA) to examine the structure of the Service Delivery Adaptations Questionnaire among n = 704 EI providers. We …


Occupational Therapists’ Perspectives On Family-Centered Practices In Early Intervention, Irma J. Pereira, Francine M. Seruya Jul 2021

Occupational Therapists’ Perspectives On Family-Centered Practices In Early Intervention, Irma J. Pereira, Francine M. Seruya

The Open Journal of Occupational Therapy

Background: Early intervention (EI) requires service provision in natural settings while incorporating interventions based on family-centered practice (FCP). This study sought to understand (a) how occupational therapists define and implement FCP in their daily interventions and (b) therapists’ perspectives on using this model of practice in EI.

Method: This study used a qualitative, phenomenological approach. Nine licensed occupational therapists from six states with a minimum of 3 years of working experience in the area of EI participated. Semi-structured interviews were recorded, transcribed, and subsequently coded and analyzed for emergent themes.

Results: The therapists had an average of …


They Said: Preparing Future Ei Providers Across Disciplines Through An Academic Partnership, Beth K. Elenko Jul 2021

They Said: Preparing Future Ei Providers Across Disciplines Through An Academic Partnership, Beth K. Elenko

The Open Journal of Occupational Therapy

No abstract provided.


They Said: Coaching Alongside Families In Early Intervention, Beth K. Elenko Jul 2021

They Said: Coaching Alongside Families In Early Intervention, Beth K. Elenko

The Open Journal of Occupational Therapy

No abstract provided.


Bringing The Family To The Center Of Early Intervention Practice In Occupational Therapy, Beth K. Elenko Jul 2021

Bringing The Family To The Center Of Early Intervention Practice In Occupational Therapy, Beth K. Elenko

The Open Journal of Occupational Therapy

No abstract provided.


Myonuclear Transcriptional Dynamics In Response To Exercise Following Satellite Cell Depletion, Yuan Wen, Davis A. Englund, Bailey D. Peck, Kevin A. Murach, John J. Mccarthy, Charlotte A. Peterson Jul 2021

Myonuclear Transcriptional Dynamics In Response To Exercise Following Satellite Cell Depletion, Yuan Wen, Davis A. Englund, Bailey D. Peck, Kevin A. Murach, John J. Mccarthy, Charlotte A. Peterson

Physical Therapy Faculty Publications

Skeletal muscle is composed of post-mitotic myofibers that form a syncytium containing hundreds of myonuclei. Using a progressive exercise training model in the mouse and single nucleus RNA-sequencing (snRNA-seq) for high-resolution characterization of myonuclear transcription, we show myonuclear functional specialization in muscle. After 4 weeks of exercise training, snRNA-seq reveals that resident muscle stem cells, or satellite cells, are activated with acute exercise but demonstrate limited lineage progression while contributing to muscle adaptation. In the absence of satellite cells, a portion of nuclei demonstrates divergent transcriptional dynamics associated with mixed-fate identities compared with satellite cell replete muscles. These data provide …