Medicine and Health Sciences Commons^™

What Makes An Effective Chief Of Pediatric Cardiology: Insights From Chiefs Of North American Pediatric Programs, Michael E. Kim, Wayne Franklin, Anne M. Dubin, Jeffrey J. Kim, Shubhayan Sanatani, R. Krishna Kumar, Shubhika Srivastava, Thomas R. Kimball, Mark Lewin, Joseph Rossano, Colin J. Mcmahon

Department of Medicine Faculty Papers

BACKGROUND: Although the position of a pediatric cardiology chief is often seen as the apex of one's academic career, its roles, responsibilities, and qualifications are not well defined in the literature. This study was done to gain further insight of the role and attributes of a pediatric cardiology chief by surveying those who are currently serving the position across North American centers.

METHODS AND RESULTS: This was a mixed-methods study with a survey given to North American pediatric cardiology chiefs at programs with fellowship training programs. The survey was a semistructured questionnaire that was independently reviewed by 3 cardiologists. Smaller …

The Personality Profile And Leadership Style Of U.S. Vice President And 2024 Democratic Presidential Nominee Kamala Harris, Aubrey Immelman, Anne Marie Griebie, Elise Vomacka

Psychology Faculty Publications

The paper presents the results of an indirect personality assessment of U.S. vice president Kamala Harris, Democratic presidential nominee in the 2024 U.S. presidential election, from the conceptual perspective of personologist Theodore Millon.

Psychodiagnostically relevant data about Harris were collected from biographical sources and media reports and synthesized into a personality profile using the Millon Inventory of Diagnostic Criteria (MIDC), which yields 34 normal and maladaptive personality classifications congruent with DSM-III-R, DSM-IV, and DSM-5-TR.

The personality profile yielded by the MIDC was analyzed in accordance with interpretive guidelines provided in the MIDC and Millon Index of Personality …

Digital Health Intervention For Children With Adhd To Improve Mental Health Intervention, Patient Experiences, And Outcomes: A Study Protocol, Nancy Herrera, Franceli L. Cibrian, Lucas M. Silva, Jesus Armando Beltran, Sabrina E. B. Schuck, Gillian R. Hayes, Kimberley D. Lakes

Engineering Faculty Articles and Research

Background

Attention Deficit Hyperactivity Disorder (ADHD) is the most prevalent childhood psychiatric condition with profound public health, personal, and family consequences. ADHD requires comprehensive treatment; however, lack of communication and integration across multiple points of care is a substantial barrier to progress. Given the chronic and pervasive challenges associated with ADHD, innovative approaches are crucial. We developed the digital health intervention (DHI)—CoolTaCo [Cool Technology Assisting Co-regulation] to address these critical barriers. CoolTaCo uses Patient-Centered Digital Healthcare Technologies (PC-DHT) to promote co-regulation (child/parent), capture patient data, support efficient healthcare delivery, enhance patient engagement, and facilitate shared decision-making, thereby improving access to …

‘Foundations Of The Mind, Brain, And Behavioral Relationships’: A Combined Faculty And Student’S Perspective Of A New Textbook On Clinical Neuroscience, Richard J. Addante, Jahdiel Perez Caban, Sarah E. Smith

Psychology Faculty Publications

The textbook, ‘Foundations of the Mind, Brain, and Behavioral Relationships’ (Moini et al., Citation2023), is one of the newest textbooks in neuroscience to arrive. The market for textbooks in the field of neuroscience is competitive among several excellent comparators, but critical market gaps still remain to be filled, notably the area of clinical neuroscience that is both advanced in content but accessible to students. One of the reasons that this gap has existed in the field is precisely because it can be a very difficult a mark to hit: how does one present neurobiological content that is …

Nerve Injury Inhibits Oprd1 And Cnr1 Transcription Through Rest In Primary Sensory Neurons, Ashok Subedi, Asieh Etemad, Aadhya Tiwari, Yuying Huang, Biji Chatterjee, Samantha M Mcleod, Yungang Lu, Diangelo Gonzalez, Krishna Ghosh, Mario Sirito, Sanjay K Singh, Elisa Ruiz, Sandra L Grimm, Cristian Coarfa, Hui-Lin Pan, Sadhan Majumder

Faculty, Staff and Students Publications

The transcription repressor REST in the dorsal root ganglion (DRG) is upregulated by peripheral nerve injury and promotes the development of chronic pain. However, the genes targeted by REST in neuropathic pain development remain unclear. The expression levels of four opioid receptor genes (Oprm1, Oprd1, Oprl1 and Oprk1) and the cannabinoid CB1 receptor (Cnr1) gene in the DRG regulate nociception. In this study, we determined the role of REST in controlling their expression in the DRG induced by spared nerve injury (SNI). SNI induced chronic pain hypersensitivity in wild-type mice and was accompanied by increased levels of Rest transcript and …

Data-Driven Cutoff Selection For The Patient Health Questionnaire-9 Depression Screening Tool, Brooke Levis, Parash Mani Bhandari, Dipika Neupane, Suiqiong Fan, Ying Sun, Chen He, Yin Wu, Ankur Krishnan, Zelalem Negeri, Mahrukh Imran, Danielle B Rice, Kira E Riehm, Marleine Azar, Alexander W Levis, Jill Boruff, Pim Cuijpers, Simon Gilbody, John P A Ioannidis, Lorie A Kloda, Scott B Patten, Roy C Ziegelstein, Daphna Harel, Yemisi Takwoingi, Sarah Markham, Sultan H Alamri, Dagmar Amtmann, Bruce Arroll, Liat Ayalon, Hamid R Baradaran, Anna Beraldi, Charles N Bernstein, Arvin Bhana, Charles H Bombardier, Ryna Imma Buji, Peter Butterworth, Gregory Carter, Marcos H Chagas, Juliana C N Chan, Lai Fong Chan, Dixon Chibanda, Kerrie Clover, Aaron Conway, Yeates Conwell, Federico M Daray, Janneke M De Man-Van Ginkel, Jesse R Fann, Felix H Fischer, Sally Field, Jane R W Fisher, Daniel S S Fung, Bizu Gelaye, Leila Gholizadeh, Felicity Goodyear-Smith, Eric P Green, Catherine G Greeno, Brian J Hall, Liisa Hantsoo, Martin Härter, Leanne Hides, Stevan E Hobfoll, Simone Honikman, Thomas Hyphantis, Masatoshi Inagaki, Maria Iglesias-Gonzalez, Hong Jin Jeon, Nathalie Jetté, Mohammad E Khamseh, Kim M Kiely, Brandon A Kohrt, Yunxin Kwan, Maria Asunción Lara, Holly F Levin-Aspenson, Shen-Ing Liu, Manote Lotrakul, Sonia R Loureiro, Bernd Löwe, Nagendra P Luitel, Crick Lund, Ruth Ann Marrie, Laura Marsh, Brian P Marx, Anthony Mcguire, Sherina Mohd Sidik, Tiago N Munhoz, Kumiko Muramatsu, Juliet E M Nakku, Laura Navarrete, Flávia L Osório, Brian W Pence, Philippe Persoons, Inge Petersen, Angelo Picardi, Stephanie L Pugh, Terence J Quinn, Elmars Rancans, Sujit D Rathod, Katrin Reuter, Alasdair G Rooney, Iná S Santos, Miranda T Schram, Juwita Shaaban, Eileen H Shinn, Abbey Sidebottom, Adam Simning, Lena Spangenberg, Lesley Stafford, Sharon C Sung, Keiko Suzuki, Pei Lin Lynnette Tan, Martin Taylor-Rowan, Thach D Tran, Alyna Turner, Christina M Van Der Feltz-Cornelis, Thandi Van Heyningen, Paul A Vöhringer, Lynne I Wagner, Jian Li Wang, David Watson, Jennifer White, Mary A Whooley, Kirsty Winkley, Karen Wynter, Mitsuhiko Yamada, Qing Zhi Zeng, Yuying Zhang, Brett D Thombs, Andrea Benedetti, Depression Screening Data (Depressd) Phq Group

Faculty, Staff and Students Publications

IMPORTANCE: Test accuracy studies often use small datasets to simultaneously select an optimal cutoff score that maximizes test accuracy and generate accuracy estimates.

OBJECTIVE: To evaluate the degree to which using data-driven methods to simultaneously select an optimal Patient Health Questionnaire-9 (PHQ-9) cutoff score and estimate accuracy yields (1) optimal cutoff scores that differ from the population-level optimal cutoff score and (2) biased accuracy estimates.

DESIGN, SETTING, AND PARTICIPANTS: This study used cross-sectional data from an existing individual participant data meta-analysis (IPDMA) database on PHQ-9 screening accuracy to represent a hypothetical population. Studies in the IPDMA database compared participant PHQ-9 …

Burnout And Employee Satisfaction Of Mental Health Clinicians In Corrections, Jeremy C. Capuyon, Lindsay Gietzen

Pacific Journal of Health

Approximately 1.9 million individuals are currently incarcerated within the United States. Rehabilitation and preparation for parole back into the community is common goal amongst correctional facilities. Mental health clinicians (social workers and psychologists) within the correctional facilities are providers who assist in the rehabilitation of inmates. Unfortunately, mental health clinicians in correctional facilities experience high rates of burnout and low levels of job satisfaction, resulting in an increase in turnover rates. This research project looks to investigate the impact burnout and employee satisfaction has on mental health clinicians who work in correctional settings. Furthermore, this research project compares burnout and …

On The Role Of Prediction In Streaming Hierarchical Learning, Ramy Mounir

USF Tampa Graduate Theses and Dissertations

In today's world, AI systems need to make sense of large amounts of data as it unfolds in real-time, whether it's a video from surveillance and monitoring cameras, streams of egocentric footage, or sequences in other domains such as text or audio. The ability to break these continuous data streams into meaningful events, discover nested structures, and predict what might happen next at different levels of abstraction is crucial for applications ranging from passive surveillance systems to sensory-motor autonomous learning. However, most existing models rely heavily on large, annotated datasets with fixed data distributions and offline epoch-based training, which makes …

Mental Fatigue And Self-Care In Informal Oncology Caregivers: A Descriptive Mixed Methods Study, Megan Wayne

MUSC Theses and Dissertations

Purpose:

This dissertation study aimed to enhance understanding of informal caregiver wellbeing by exploring the presence of mental fatigue, the relationships among mental fatigue, self-care, and informal oncology caregiver quality of life (QOL), and determining whether differences exist in self-care engagement and QOL between caregivers who report high and low levels mental fatigue.

Problem:

Healthcare is becoming increasingly reliant on informal caregivers for the management and care of individuals with serious illnesses such as cancer. Previous research has shown that informal caregivers routinely experience many negative effects as a result of providing care including decreased mental health and …

No-Self, No Problem: A Buddhist Approach To Self-Concept Obsessive-Compulsive Disorder, Adam Brandt, Laura Smestad

Journal of Faith Integration Counseling (JFIC)

While exposure and response prevention is an effective treatment for obsessive-compulsive disorder, it may not fully address the psycho-spiritual concerns of clients whose obsessive-compulsive disorder symptoms threaten and leave them in distress about their self-concept. This article addresses this problem by introducing the term self-concept obsessive-compulsive disorder and offering Buddhist psychology, a theoretical orientation based on the Buddhist principles of nonjudgment, mindfulness, and no-self as a useful framework to couple with traditional obsessive-compulsive disorder treatment.

Use Of Peripheral Nerve Blocks For Total Hip Arthroplasty, Leon Grinman, Brett Elmore, Alberto E Ardon, Adnan Hussain, Mohammed Faysal Malik, Nadia Hernandez, Mackenzie Janice Jacoby

Faculty, Staff and Student Publications

Purpose of review: The purpose of this review is to summarize the recent literature regarding regional anesthesia (RA) techniques and outcomes for total hip arthroplasty (THA) in the face of changing surgical techniques and perioperative considerations.

Recent findings: Based on large meta-analyses, peripheral nerve blocks are indicated for THA. Each block has its own risks and benefits and data for outcomes for particular techniques are limited. New surgical techniques, improved use of multimodal analgesia, and improved ultrasound guided regional anesthetics lead to better pain control for patients undergoing THA with less associated risks. Block selection continues to be influenced by …

Conceptions Of Latinos And Latinas About The Grieving Process And Associate Concepts Of Dying, Death, Bereavement, And Loss: A Covid-19-Post-Pandemic Case Study, Rosario Garcia Ortiz

Dissertations

The purpose of this study was to recognize the grieving process and the related concepts of Latinos who lost a loved one to the COVID-19 pandemic. Death and dying have been studied in the United States, with limited studies focusing on the Latino culture. The COVID-19 pandemic was a devastating experience for the world and continues to be studied for understanding and lessons in the aftermath. This research included four participants from the Latino culture who lost a loved one during the COVID-19 pandemic. An inductive approach and data analysis were used to form theoretical constructs. Three main categories were …

Development Of A Facility-Level Second Victim Syndrome Peer-Mentor Program: Program Design And Future Directions, Jacqueline Trammell, Noah Zanville, Caryn Alper

HCA Healthcare Journal of Medicine

Background

Despite efforts to prevent errors, studies show that iatrogenic, or health care-related, errors continue to occur. Understandably, these errors, which can range in severity from near-misses to serious harm, can be devastating for the health care professionals involved, creating a potential second set of victims, in addition to the patient(s) that were harmed directly. Studies show that individuals struggling with second-victim syndrome (SVS) can be at increased risk for depression, burnout, and poor work performance. However, programs designed to develop peer mentors to support individuals struggling with SVS are poorly described.

Methods

Following a review of the literature, our …

Kajian Risiko Kesehatan Terkait Pajanan Benzene, Toluene Dan Xylene Pada Pekerja Kilang Minyak Pt. X, Putri Noer Halizah, Mila Tejamaya

National Journal of Occupational Health and Safety

Workers in oil and gas production units are at risk of exposure to chemical hazards. One of the ingredients in petroleum is volatile organic compounds (VOC), with examples of ingredients known for their toxicity being benzene, toluene and xylene. This study aims to assess health risks related to exposure to benzene, toluene and xylene of oil refinery workers at PT. X. This study will analyze personal exposure to inhalation routes from benzene, toluene and xylene chemicals using the Chemical Health Risk Assessment (CHRA) method from the Department of Safety and Health, Malaysia. The study results showed that the risk level …

Gambaran Persepsi Pengawas Terhadap Efektivitas Geotab Dalam Mengendalikan Risiko Kecelakaan Kendaraan Ringan Di Divisi X, Aisyah Yasmin Zafirah, Chandra Satrya

National Journal of Occupational Health and Safety

This study aims to understand supervisors' perceptions of the effectiveness of Geotab as a control measure for mitigating the risk of collisions involving light vehicles. Conducted in Division X of PT. X, a mining industry, from February to June 2023, this descriptive, semi-qualitative study collected data through control effectiveness questionnaires, interviews, and document review. The variables studied include the relevance, coverage, reliability, reactivity, resource competence, and supervision system of Geotab. Questionnaire results showed supervisor perception scores of 3.09 for relevance (appropriate), 3.10 for coverage (appropriate), 3.06 for reliability (appropriate), 2.99 for reactivity (appropriate), 2.93 for resource competence, and 2.95 for …

Using Geographic Momentary Assessment To Explore Spatial Environment Influences On Wellbeing In People With Hiv, Rayna E. Gasik, Ethan A. Smith, Simone J. Skeen, Stephanie Tokarz, Gretchen Clum, Erica Felker-Kantor, Katherine P. Theall

School of Public Health Faculty Publications

Place-based socio-economic and racial inequities contribute to health disparities among people with HIV (PWH). We used geographic ecological momentary assessment (GEMA) methodologies to explore the interplay between psychosocial outcomes in daily diaries and community spatial measures among PWH in New Orleans. PWH (N = 69) were recruited from a clinic-based cohort study. Micro-longitudinal data were collected via smartphone-based daily diaries and geospatial tracking over 14 days. First, correlations were run between diary derived outcomes (e.g., feeling safe in current location, stress), and spatial measures (e.g., violent crime, alcohol outlets, and vacant lots) within a half-mile buffer around each diary point …

A Veteran Mental Health Approach Sustaining Identity Post-Military Life: A Comprehensive Overview, Darren Sosa, Lindsay Gietzen

Pacific Journal of Health

Veterans and their mental health face readjustment challenges based on veteran identity, intersectionality, and experiences from their time serving in the military. This comprehensive overview and PRISMA analysis investigate the current evidence-based practices of veterans' identity and intersectionality. Specifically, psychoeducation and evidence-based practices for veterans readjusting back into their communities. A gap identified in this research’s findings calls for suggestions for future research on the veteran population and intersectionality. No specific psychoeducation or evidence-based practices tailored for identity readjustment or veteran intersectionality were found. This research constructs a tailored framework of suggestions for current and future evidence-based practices for the …

A Trans-Theoretical Systematization Of Clinical Interventions Based On Dynamical Systems Research (Dsr), Giulio De Felice, David Pincus

Psychology Faculty Articles and Research

The scientific literature focused on the categorization of therapists’ interventions in clinical sessions, and their effects on patients, is not very extensive and often autoreferential. The most relevant findings clearly show the eclecticism of clinicians, grounding only 10–14% of their interventions on the specific theoretical approach to which they belong. Despite that, a trans-theoretical systematization of clinical interventions is lacking. The present work aims to verify the feasibility of a trans-theoretical categorization of clinical interventions based on Dynamical Systems Research in psychotherapy (DSR). For this purpose, the authors present the results of three literature reviews. The first sections of this …

Analisis Aktivitas Fisik Pekerja Mal Pelayanan Publik Kota Cilegon, Muhammad Syifa Abdy Mulya, Indri Hapsari Hapsari Susilowati

National Journal of Occupational Health and Safety

Physical activity is important because it has so many benefits. Even so, there are still many workers who are exposed to the risk of lack of physical activity. For this reason, it is necessary to know what affects the implementation of physical activity in workers. Quantitative design was used with a cross sectional study on 58 Cilegon Public Service Mall workers who met the criteria. As a result, 65.5% of workers are classified as active, 34.5% of workers are inactive and 12% of workers do not carry out any physical activity at all. Level of education (p value = 0.005), …

Young Children’S Mental Well-Being In Low-Income South African Settings: A Qualitative Study, Catherine E. Draper, Caylee J. Cook, Elizabeth A. Ankrah, Jesus A. Beltran, Franceli L. Cibrian, Jazette Johnson, Kimberley D. Lakes, Hanna Mofid, Lucretia Williams, Gillian R. Hayes

Engineering Faculty Articles and Research

This qualitative study aimed to capture community perspectives of the risks and protective factors for social emotional development and mental health of young children in low-income South Africa settings, and was conducted as one component of a larger study with the ultimate aim of co-designing the Mazi Umntanakho (‘know your child’) digital tool. Twenty focus group discussions (n = 154, 97% female) were held with staff of community-based organisations (CBOs) and community health worker (CHW) programmes in urban and rural sites from four geographical regions. Data were analysed thematically, and grouped according to components of nurturing care (responsive caregiving, safety …

Neural Correlates Of Socially Rewarding Memories In Posttraumatic Stress Disorder, Kyle P. Blidy

MUSC Theses and Dissertations

Significance. Memory disturbances for emotional content are central to PTSD, yet most research focuses on trauma memories. Recent evidence suggests that enhancing access to positive memories could improve mood, affect regulation, self-esteem, and integration of trauma memories. However, the neurocognitive mechanisms underlying positive memory encoding in PTSD are poorly understood. No study has examined memory for positive social items in PTSD, which is important because PTSD entails social withdrawal and reduced accessibility to positive memory. Additionally, positive memories embedded in a social context have enhanced subjective value and strengthening their accessibility may confer greater benefits to wellbeing compared to non-social …

Local Crime And Substance Use Disorders: A Comparison Of Midlife Adults In The 1990s And 2000s, Jennifer W. Robinette, Jason D. Boardman, Kathleen Mullan Harris

Psychology Faculty Articles and Research

This study investigated how sociopolitical changes in the United States between the 1990s and 2000s may explain the increase in substance use disorders and reduced longevity in more recent cohorts of US midlife adults. The 2008 recession which drastically increased unemployment rates across the country may have had negative implications for downstream contextual and individual processes, including both local crime rates and substance use disorders. The Midlife in the United States Survey cohort (1995; n = 6148; 20–75 years) and the MIDUS Refresher cohort (2011; n = 3543; 23–76 years) reported on substance use disorders. These data were linked to …

Understanding The Role Of Perceived Racial Discrimination On Adolescent Mental Health During The Covid-19 Pandemic, Jill V. Klosky, Delia Lang, Briana Woods-Jaeger, Julie Gazmararian

Journal of the Georgia Public Health Association

Abstract

Background: Adolescent mental health declined during the COVID-19 pandemic. Racial discrimination, which may negatively affect adolescent mental health, has increased. This study sought to understand whether pre-pandemic reports of racial discrimination predicted changes in adolescent depression, anxiety, and self-esteem from before to during the COVID-19 pandemic.

Methods: Two online surveys were administered at two public high schools in semi-rural, north-central Georgia; one in Spring 2020, just before the closing of public schools due to COVID-19; the other to the same students in Fall 2020.

Results: Most participants were White (62%) and the majority (88%), reported the same or better …

Maternal Cortisol Concentration Is Associated With Reduced Brain Activation To Infant Cry And More Intrusive Parenting Behavior, Andrew Erhart, Sarah Enos Watamura, Aviva K. Olsavsky, Alexander J. Dufford, Rebekah C. Tribble, Tom Yeh, Pilyoung Kim

Psychology: Faculty Scholarship

Previous research indicates that maternal cortisol function and maternal brain response to infant are each in turn related to variations in parenting behavior. However, little is known about how maternal cortisol and maternal brain function are associated, thus studying these two mechanisms together may improve our understanding of how maternal cortisol assessed during interactions with own infant is associated with brain response to infant cry. First-time mothers (N = 59) of infants aged 3-4 months old were recruited to participate. Mothers' cortisol concentration was measured during a naturalistic interaction with their infant and their behavior was coded for two parenting …

Correcting Misperceptions About Very Low Nicotine Cigarettes For Cigarette-Only Smokers, Dual/Poly Smokers, Other Tobacco Users, And Non-Tobacco Users, Rui Shi, Robert Feldman, Jiaying Liu, Pamela I. Clark

College of Communication & Creative Arts Departmental Research

Background

Methods

Outcomes Of Alcohol-Associated Hepatitis In Hospitalized Patients With Prior Bariatric Surgery: A Nationwide Analysis, 2016-2020, Sarpong Boateng, Prince A. Ameyaw, Karthik Mathialagan, Basile Njei

Posters

Alcohol-associated hepatitis (AAH) is a severe liver condition often necessitating hospitalization and has a one-year mortality of 40%. The increasing prevalence of obesity has led to a rise in bariatric surgery (BS), which can alter the outcomes of various comorbid conditions. There are some concerns about possible increased risk and severity of alcohol related disorders in patients with a history of BS due to alteration in alcohol metabolism after surgery.

The Psychological Impacts Of Algorithmic And Ai-Driven Social Media On Teenagers: A Call To Action, Sunil Arora, Sahil Arora, John Hastings

Research & Publications

This study investigates the meta-issues surrounding social media, which, while theoretically designed to enhance social interactions and improve our social lives by facilitating the sharing of personal experiences and life events, often results in adverse psychological impacts. Our investigation reveals a paradoxical outcome: rather than fostering closer relationships and improving social lives, the algorithms and structures that underlie social media platforms inadvertently contribute to a profound psychological impact on individuals, influencing them in unforeseen ways. This phenomenon is particularly pronounced among teenagers, who are disproportionately affected by curated online personas, peer pressure to present a perfect digital image, and the …

Empowering Students Is “Perfectly Normal:" The Case For 𝘐𝘵'𝘴 𝘗𝘦𝘳𝘧𝘦𝘤𝘵𝘭𝘺 𝘕𝘰𝘳𝘮𝘢𝘭 In Middle Schools, Caroline H. Peabody

OUR Journal: ODU Undergraduate Research Journal

In September of 2023, a middle school teacher wrote an open letter to the Lexington County, Virginia school board expressing outrage over the “graphic sexual content” included in the county middle school’s library. Swiftly following the letter, the school board removed two books from the county’s Lylburn Middle School library without due process and avowed to reconsider the guidelines for including books in the library. One of the two books in question was It’s Perfectly Normal, a non-fiction illustrated book intended to educate readers ten and up on sex, intercourse, and puberty. It’s Perfectly Normal and should be available …

Vesicular Monoamine Transporter-2 Inhibitor Jpc-141 Prevents Methamphetamine-Induced Dopamine Toxicity And Blocks Methamphetamine Self-Administration In Rats, Cassie M. Chandler, Justin R. Nickell, A. George Wilson, John P. Culver, Peter A. Crooks, Michael T. Bardo, Linda P. Dwoskin

Psychology Faculty Publications

Previous research has demonstrated therapeutic potential for VMAT2 inhibitors in rat models of methamphetamine use disorder. Here, we report on the neurochemical and behavioral effects of 1-(2-methoxyphenethyl)-4-phenethypiperazine (JPC-141), a novel analog of lobelane. JPC-141 potently inhibited (Ki = 52 nM) [3H]dopamine uptake by VMAT2 in striatal vesicles with 50 to 250-fold greater selectivity for VMAT2 over dopamine, norepinephrine and serotonin plasmalemma transporters. Also, JPC-141 was 57-fold more selective for inhibiting VMAT2 over [3H]dofetilide binding to hERG channels expressed by HEK293, suggesting relatively low potential for cardiotoxicity. When administered in vivo to rats, JPC-141 prevented the METH-induced reduction in striatal dopamine …

An Examination Of Food And Alcohol Disturbance Based On Sexual Orientation In A Sample Of Women Who Binge Eat, Alicia M. Moulder

Psychology Theses & Dissertations

Food and alcohol disturbance (FAD), characterized by disordered eating behaviors in the context of drinking alcohol to enhance intoxication, counteract alcohol’s calories, or both, is associated with increased risk of negative drinking consequences. Previously established as a phenomenon occurring in college students, research has begun to support that FAD may also occur in nonstudents. Three particularly vulnerable groups for FAD may include women, individuals with history of binge eating, as well as sexual minority individuals. Consequently, the goals of the current study were to elucidate differences in FAD engagement between sexual minority women (SMW) and heterosexual women using a sample …