Medicine and Health Sciences Commons^™

Biological Validation Of Peak-Width Of Skeletonized Mean Diffusivity As A Vcid Biomarker: The Markvcid Consortium, Alison M Luckey, Saptaparni Ghosh, Chen-Pin Wang, Alexa Beiser, Rebecca Bernal, Zhiguang Li, Djass Mbangdadji, Elyas Fadaee, Haykel Snoussi, Angel Gabriel Velarde Dediós, Hector A Trevino, Monica Goss, Laura J Hillmer, Christopher E Bauer, Adam M Staffaroni, Lara Stables, Marilyn Albert, Jayandra J Himali, Thomas H Mosley, Lars Forsberg, Vilmundur Guðnason, Baljeet Singh, Herpreet Singh, Kristin Schwab, Joel H Kramer, Gary A Rosenberg, Karl G Helmer, Steven M Greenberg, Mohamad Habes, Danny J J Wang, Brian T Gold, Hanzhang Lu, Arvind Caprihan, Myriam Fornage, Lenore J Launer, Konstantinos Arfanakis, Sudha Seshadri, Charles Decarli, Pauline Maillard, Claudia L Satizabal

Faculty, Staff and Student Publications

BACKGROUND: Peak-width of skeletonized mean diffusivity (PSMD), a neuroimaging marker of cerebral small vessel disease (SVD), has shown excellent instrumental properties. Here, we extend our work to perform a biological validation of PSMD.

METHODS: We included 396 participants from the Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia (MarkVCID-1) Consortium and three replication samples (Cohorts for Heart and Aging Research in Genomic Epidemiology = 6172, Rush University Medical Center = 287, University of California Davis Alzheimer's Disease Research Center = 567). PSMD was derived from diffusion tensor imaging using an automated algorithm. We related PSMD to a composite measure …

Us Or Them: How Covid-19 Vaccine Priority Influences Perceptions Of Local-Migrant Worker Relations, Tengjiao Huang, Haochen Zhou, Liz Jones, Chin Wen Cong

Research Collection School of Social Sciences

The COVID-19 pandemic laid bare pre-existing societal fault lines, placing immense strain on intergroup relations and giving rise to xenophobic sentiments. Drawing on Realistic Conflict Theory (RCT) and Social Identity Approach (SIA), our study examined how the public allocation of COVID-19 variant vaccines could influence the dynamics between local citizens and migrant workers, and under what conditions. One key idea is that valued resource distribution that favour migrant workers may produce increased perceptions of realistic threats among local citizens which could lead to exacerbated negative attitudes and behaviours of high-status local citizens towards low-status migrants, whereas higher fairness perceptions of …

The Personality Profile Of Libya’S Muammar Gaddafi, Aubrey Immelman

Psychology Faculty Publications

This research report, prepared for the France 5 television documentary “Le Monde en face: Kadhafi, la folie d’un dictateur,” presents the results of an indirect personality assessment of Libyan dictator Muammar Gaddafi from the conceptual perspective of personologist Theodore Millon.

Association Of Common And Rare Variants With Alzheimer’S Disease In More Than 13,000 Diverse Individuals With Whole-Genome Sequencing From The Alzheimer’S Disease Sequencing Project, Wan-Ping Lee, Seung Hoan Choi, Margaret G Shea, Po-Liang Cheng, Beth A Dombroski, Achilleas N Pitsillides, Nancy L Heard-Costa, Hui Wang, Katia Bulekova, Amanda B Kuzma, Yuk Yee Leung, John J Farrell, Honghuang Lin, Brian W Kunkle, Adam Naj, Elizabeth E Blue, Frederick Nusetor, Dongyu Wang, Eric Boerwinkle, William S Bush, Xiaoling Zhang, Philip L De Jager, Josée Dupuis, Lindsay A Farrer, Myriam Fornage, Eden Martin, Margaret Pericak-Vance, Sudha Seshadri, Ellen M Wijsman, Li-San Wang, Alzheimer's Disease Sequencing Project;, Gerard D Schellenberg, Anita L Destefano, Jonathan L Haines, Gina M Peloso

Faculty, Staff and Student Publications

INTRODUCTION: Alzheimer's disease (AD) is a common disorder of the elderly that is both highly heritable and genetically heterogeneous.

METHODS: We investigated the association of AD with both common variants and aggregates of rare coding and non-coding variants in 13,371 individuals of diverse ancestry with whole genome sequencing (WGS) data.

RESULTS: Pooled-population analyses of all individuals identified genetic variants at apolipoprotein E (APOE) and BIN1 associated with AD (p < 5 × 10

DISCUSSION: We observed that complementary pooled-population and subgroup-specific analyses offered unique insights into the genetic architecture of AD.

HIGHLIGHTS: We determine the association of genetic variants with Alzheimer's disease (AD) using …

The Informal, Non-Prescribed Use Of Antiretroviral Medications For Prep Among A National Us-Based Sample Of Gay, Bisexual, And Other Men Who Have Sex With Men: A Cross-Sectional Study, Mance E. Buttram, Matthew S. Ellis, Krishen D. Samuel, Matthew Hayhurst

Health, Human Performance and Recreation Faculty Publications and Presentations

This brief report presents findings on informal, non-prescribed PrEP use among an online sample of gay, bisexual and other men who have sex with men (n = 196). Mean age was 33.4. Participants were Hispanic (13.3%), African American (15.8%), white (63.8%), and other race/ethnicity (6.6%). Informal PrEP users (11%) more frequently reported past year sexually transmitted infections (p < 0.001), group sex (p < 0.001), sex in public (p < 0.01), transactional sex (p < 0.001), ever receiving a formal PrEP prescription (p < 0.05), and ease of finding diverted HIV medications on gay dating/sex apps (p < 0.05). Formal PrEP uptake should be encouraged to mitigate potential negative consequences of informal use.

Artificial Intelligence And Machine Learning In Cancer Pain: A Systematic Review, Vivian Salama, Brandon Godinich, Yimin Geng, Laia Humbert-Vidan, Laura Maule, Kareem A Wahid, Mohamed A Naser, Renjie He, Abdallah S R Mohamed, Clifton D Fuller, Amy C Moreno

Faculty, Staff and Student Publications

Background/objectives: Pain is a challenging multifaceted symptom reported by most cancer patients. This systematic review aims to explore applications of artificial intelligence/machine learning (AI/ML) in predicting pain-related outcomes and pain management in cancer.

Methods: A comprehensive search of Ovid MEDLINE, EMBASE and Web of Science databases was conducted using terms: "Cancer," "Pain," "Pain Management," "Analgesics," "Artificial Intelligence," "Machine Learning," and "Neural Networks" published up to September 7, 2023. AI/ML models, their validation and performance were summarized. Quality assessment was conducted using PROBAST risk-of-bias andadherence to TRIPOD guidelines.

Results: Forty four studies from 2006 to 2023 were included. Nineteen studies used …

Predictors Of Belongingness In First-Year College Students: Examining Mental Health And Adjustment, Jordan D. Foreman-Black

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

The initial transition to college is a pivotal moment for emerging adults, often influencing whether a student will remain successful. Students face a significant challenge adapting to the new environment that has been compounded by their experiences through the COVID-19 pandemic. Despite these challenges, a sense of belonging for students has been shown to be a key aspect of a successful transition to college. Students are often confronted with increasing levels of mental health challenges throughout the transition, specifically experiencing increasing mental health difficulties or challenges throughout their initial adjustment to college. Moreover, parents have become increasingly involved in students’ …

The Effects Of First Responder Stress & Trauma On Spouses And Romantic Partners, Eden Thiess

UNLV Theses, Dissertations, Professional Papers, and Capstones

First responder jobs pose unique difficulties due to the sheer number of traumatic events that they witness and personally experience. Research has demonstrated some effects of stress and trauma on family relationships, but the literature lacks an understanding of the ways that first responder trauma and stress affects their marriages and romantic relationships. The current study’s purpose was to investigate the experiences of first responder spouses and partners within the Las Vegas area in regards to stress, trauma, and relationship dynamics as influenced by the first responder role. In this study, 11 participants who were in a marriage or romantic …

Investment By Maternal Grandmother Buffers Children Against The Impacts Of Adverse Early Life Experiences, Samuli Helle, Antti O. Tanskanen, David A. Coall, Gretchen Perry, Martin Daly, Mirkka Danielsbacka

Research outputs 2022 to 2026

Exogenous shocks during sensitive periods of development can have long-lasting effects on adult phenotypes including behavior, survival and reproduction. Cooperative breeding, such as grandparental care in humans and some other mammal species, is believed to have evolved partly in order to cope with challenging environments. Nevertheless, studies addressing whether grandparental investment can buffer the development of grandchildren from multiple adversities early in life are few and have provided mixed results, perhaps owing to difficulties drawing causal inferences from non-experimental data. Using population-based data of English and Welsh adolescents (sample size ranging from 817 to 1197), we examined whether grandparental investment …

Development Of A Multidimensional Index Of Fall Risk For Older Adults: The Cache County Study, Alexandra G. Hammond

All Graduate Theses and Dissertations, Fall 2023 to Present

One out of four adults over the age of 65 are estimated to fall each year in the U.S. alone, with that number expected to rise to 52 million falls per year by the year 2030. Improving accuracy for identification of older adults at a higher risk of falling is increasingly important and may be integral in informing the distribution of limited resources and assist in preventing falls in older adults. This project examined the relationship between previously identified risk factors and fall risk to create multidimensional fall risk indexes for older adults, specific for each sex.

Factors best associated …

Study Abroad Angst: A Literature Review On The Mental Health Of International Students During Covid-19, Daisuke Akiba, Michael Perrone, Caterina Almendral

Publications and Research

Background: The COVID-19 pandemic presented unique and unprecedented challenges for international students, those studying at institutions of higher education outside of their home countries, due to their distinct circumstances and vulnerabilities. This literature review examines the multifaceted mental health burdens they experienced and highlights the need for targeted support and interventions. Methods: A rigorous search across three databases (i.e., PubMed, PsycINFO, and ERIC) yielded 50 empirical studies for inclusion in this literature review. A six-phase thematic analysis framework was employed to identify and synthesize key themes. Results: Seven prominent themes emerged: (1) academic and professional disruptions; (2) challenges navigating international …

Exploring Mental Health Providers' Willingness To Integrate Digital Applications For Gen-Z Students, Chanlinee Karawek

Undergraduate Research Symposium Lightning Talks

Mental health services have expanded significantly throughout recent years, alongside the virtualization of said services since the COVID-19 pandemic. As a result, digital mental health applications (DMHAs) are now widely available. Generation-Z college students are a demographic that both grew up with this technology and is associated with a high risk of mental illness development during their time in higher education. Integration of familiar technology and necessary mental health services could potentially help address their unique psychological needs. This study explores mental healthcare providers’ perspectives on incorporating DMHAs into their therapy services to Gen-Z college students. An anonymous survey was …

The Role Of Uncertainty In Illness: Insights Into Psychological Adjustment In Systemic Lupus Erythematosus, Theresa A. Skojec

MUSC Theses and Dissertations

There are currently few studies that directly explore the relationship between uncertainty in illness and psychological adjustment to Systemic Lupus Erythematosus (SLE), highlighting a critical gap in understanding how patients cope with and adjust to the emotional and mental challenges posed by this chronic condition. This dissertation comprises three manuscripts focused on filling this knowledge gap. The first is an integrative review guided by Mishel’s Uncertainty in Illness Theory, which examines how uncertainty affects patients' psychological and emotional well-being during illness and explores strategies to manage or reduce this uncertainty. The integrative review included 27 publications that examined uncertainty in …

Initiation Of Hearing Aids Use And Incident Dementia Among Mid-To-Late Life Adults: The Health And Retirement Study 2010-2018, Jingkai Wei, Kun Li, Youngran Kim, Rahul Ghosal, Donglan Zhang, Anwar T Merchant, Casey Crump

Faculty, Staff and Student Publications

BACKGROUND AND OBJECTIVES: Hearing aids may reduce the risk of dementia among individuals with hearing loss. However, no evidence is available from randomized controlled trials (RCTs) on the effectiveness of hearing aids use in reducing incident dementia. Using target trial emulation, we leveraged an existing longitudinal cohort study to estimate the association between hearing aids initiation and risk of dementia.

RESEARCH DESIGN AND METHODS: The Health and Retirement Study was used to emulate target trials among non-institutionalized participants aged ≥50 years with self-reported hearing loss, without dementia at baseline, and without use of hearing aids in the previous 2 years. …

Moving From Traits To The Dynamic Process: The Next Steps In Research On Human Resilience, Yannick Hill, Michael L. Dolezal, Patric C. Nordbeck, Ruud J. R. Den Hartigh, David Pincus, Adam W. Kiefer, Bernard P. Ricca

Psychology Faculty Articles and Research

The current literature on resilience shows a trend toward a dynamic process conceptualization, moving away from the previous trait-approach. However, the term “dynamic” is increasingly treated as a buzzword and is thereby oversimplified in the literature. The aim of this article is to develop a unified language pertaining to resilience as a dynamic process, so as to ensure progress in this field. First, we briefly introduce the traditional trait approach alongside the implicit assumption on which it is built. Next, we contrast this approach by discussing what dynamics entail and how this approach differs from mainstream psychological approaches. Specifically, dynamics …

Fgf21 Acts In The Brain To Drive Macronutrient-Specific Changes In Behavioral Motivation And Brain Reward Signaling, Md Shahjalal H. Khan, Sora Q. Kim, Robert C. Ross, Florina Corpodean, Redin A. Spann, Diana A. Albarado, Sun O. Fernandez-Kim, Blaise Clarke, Hans Rudolf Berthoud, Heike Münzberg, David H. Mcdougal, Yanlin He, Sangho Yu, Vance L. Albaugh, Paul L. Soto, Christopher D. Morrison

School of Medicine Faculty Publications

Objective: Dietary protein restriction induces adaptive changes in food preference, increasing protein consumption over carbohydrates or fat. We investigated whether motivation and reward signaling underpin these preferences. Methods and Results: In an operant task, protein-restricted male mice responded more for liquid protein rewards, but not carbohydrate, fat, or sweet rewards compared to non-restricted mice. When the number of responses required to access protein reward varied, protein-restricted mice exhibited higher operant responses at moderate to high response requirements. The protein restriction-induced increase in operant responding for protein was absent in Fgf21-KO mice and mice with neuron-specific deletion of the FGF21 co-receptor …

Attachment Styles As Moderators Of Loneliness In Remote Work, Brody Tj Loughlin

Doctoral Dissertations

This dissertation investigates the role of attachment styles in moderating the relationship between remote work and loneliness. Drawing on attachment theory, which posits that early life experiences shape attachment styles and influence social interactions, the study examines whether attachment styles (anxious, avoidant, and secure) moderate the association between remote work and feelings of loneliness. The research targets 394 remote workers, using a quantitative, cross-sectional survey design with proportional stratified sampling to reflect the distribution of hybrid and fully remote work arrangements in the U.S. workforce. The Extent of RemoteWork measure, the Three-Item Loneliness Scale, and the Adult Attachment Scale assess …

Personality Feedback With Tailored Self-Care Recommendations Improves Self-Efficacy For Cancer Management: A Randomized Controlled Trial, Laura M. Perry, Brenna Mossman, Sofia F. Garcia, Sheetal M. Kircher, Addison Dunn, Sarah Alonzi, Sanjana Easwar, Michael Hoerger

School of Medicine Faculty Publications

Objective: To test whether a personality feedback intervention improves three domains of cancer self-management: self-awareness, self-efficacy, and positive affect. Methods: From 11/2020-02/2021, 372 adults diagnosed with cancer participated in a randomized controlled trial (RCT) of an intervention that entailed reading a brief personality-related excerpt during an online survey. Eligibility included self-reported age ≥ 18 years, current or past cancer diagnosis, and ability to read English. The survey included a baseline assessment with a personality questionnaire, then randomized participants to one of two groups. The intervention group (n = 184) received a personality feedback report with tailored self-care tips, whereas the …

The Effect Of Exercise Type On Working Memory, Ariana Gonzalez, William R. Kochen

Journal for Sports Neuroscience

Martial arts encompass a wide range of sports and techniques that have been practiced for self-defense and combat for thousands of years. It has expanded to include various styles such as Brazilian Jiu-Jitsu, Taekwondo, judo, and karate. It has also been practiced as a form of exercise and entertainment. Martial arts have been associated to discipline, integrity, improved stamina, and increased mental and problem-solving capabilities. Unlike other exercise methods, most martial arts require focus, skill, and technique, which have been hypothesized to improve memory. The purpose of the study was to determine if there was a significant improvement in the …

Driving Healthy Behaviors Through Social Support: The Role Of Co-Responsibility In Weight Loss And Maintenance, Melanie Knufinke-Meyfroyt, Carlo Lancia, Yentl Lodewijks, Simon Nienhuijs, Eva Deckers

Patient Experience Journal

Objective: The effectiveness of out of hospital lifestyle interventions in healthcare is likely co-dependent on social support from involved one's. We sought to investigate the interrelationships between patient-partner Co-responsibility, Spousal Support, and Self-efficacy and the mechanisms through which they contribute to health behaviors and outcomes relevant to weight loss and maintenance. Methods: Co-responsibility, Spousal Support, self-efficacy, health outcomes and health behaviors like total weight loss, physical activity, OBESI-Q, and health satisfaction were assessed through a questionnaire among 868 individuals attempting to lose weight. Full and semi-partial correlations were used to understand the association between Co-responsibility, Spousal Support, Self-efficacy …

Hans Holbein's Portrait Of Henry Viii: England's Own Personal Jesus, Amy Pitsor

Best Integrated Writing

Pitsor explores the possibility that Holbein’s late-stage change in the composition of the portrait from a three-quarter view of Henry to a frontal view held a motive to present Henry as the head of the newly established Church of England and as equal to the pope, and possibly to Christ himself.

La Falta De Los Supermercados En El Oeste De Dayton: Cómo Obtienen Los Estudiantes Comida Fresca En Los Desiertos Alimentarios (Un Ensayo Expositivo-Argumentativo, Catherine Iacobacci

Best Integrated Writing

After having learned about how poverty can affect children’s educational outcomes in one of her classes, Iacobacci wanted to learn more about how the issue affected the area where she lived and went to school. What she found out was incredibly shocking, and only furthered the idea that students are struggling with opportunity gaps, not achievement ones. Unfortunately, due to discriminatory loan practices from long ago, children from the 21st century are suffering physically, emotionally, and academically.

The Journey Within: My Travel Journel, Devonique Jones

Best Integrated Writing

This project is a multigenre research exploration that delves into Jones's personal journey of self discovery and growth during her first solo trip.

Investigation Of Ndv In Southern African Waterfowl Reveal Insightful Geographic And Biodiversity Trends To Help Contain The Virus, Lauren Goodwill

Best Integrated Writing

This study assesses the infection rates and trends of Newcastle disease in southern African waterfowl, a project carried out by Emily Murphy in Dr. Jeffrey Peters’ laboratory

Analysis Of The Integration Of Race And Cultural Concordant Doulas Into The Birth Experience Of African American Women, Cherissa Garcia

Best Integrated Writing

Garcia's study looks at how integrating race and cultural-concordant doulas into the birth experience of African American women would impact outcomes. She found similar studies that provided strong evidence to support doula integration. However, most did not select study populations that appropriately reflected the African American women at increased risk of poor outcomes. As a result, Garcia designed a study that looked at race and cultural concordance between doulas and patients from a wide range of SES backgrounds and varying degrees of pregnancy risk.

The Foreigner In Our Midst: Jewish Rights Debates In Revolutionary France, William Evans

Best Integrated Writing

The debates surrounding Jewish rights during the French Revolution concerned many of the same subjects that divide the Western world today. The fear of the other, immigration as a political tool, and the disagreements over assimilation are all subjects which feature prominently today. In this essay Evans sets out to explore these debates while fairly assessing the historical informants.

Junebug In January: A Novel Excerpt, Hannah Carson

Best Integrated Writing

This section of Junebug in January is the beginning of a much longer story that follows eighteen-year-old June and her small family as she attempts to survive the harsh reality of living in the era of the Great Depression and her attempts to survive her Papa’s tasks for her. This story challenges the boundaries of family loyalty, investigates the concept of “saving yourself,” and explores the limits of redemption.

Best Integrated Writing Fall 2024 - Complete Edition, Wright State University School Of Humanities And Cultural Studies, Kristie Mckiernan, Tracy Smith

Best Integrated Writing

Best Integrated Writing includes excellent student writing from Integrated Writing courses taught at Wright State University.

It’S Complicated: The Level Of Risk Assigned To A Missing Person, Time They Were Missing For, And The Tasks Performed By Police Investigators., Karen Shalev, Craig Collie

International Journal of Missing Persons

This study examines the number of tasks police investigators perform by the level of risk assigned to cases and the length of time the investigations take to resolve. It analyses 40,091 solved cases from 2019 using data from eight English police forces, as part of a wider research project of missing person investigations demand on police resources. The findings show that (1) low and high risk with a search area cases have a relationship to the duration of the investigation; (2) there is a relationship between the risk classification and the number of tasks assigned to the case; (3) the …

Supporting & Protecting Repeat Missing Children From Different Residential Environments: A Scoping Review, Kirsty Bennett Dr, Petra Salisbury, Rebecca O'Keefe, Sharon Vincent, Bethany Mccarthy

International Journal of Missing Persons

Repeat missing children pose a significant financial burden onto services, including the police, social services, and health providers. Recognising that 37 to 65 percent of missing child reports each year are repeats, efforts have been made by academics and practitioners to understand this societal problem. Research has identified the risks causing children to go missing and the harms that they experience, but these focus primarily on children missing from residential care only. This PRISMA (2020) scoping review of 76 studies explores strategies implemented to prevent repeat missing episodes, and the role/influence of the home environment (e.g., with parents/guardians, and foster …