Medicine and Health Sciences Commons^™

The Formulation And Physical Analyses Of Antibiotic Aerosol Foams For The Development Of Potential Topical Dermatologicals, Joseph Alexander Woelfel

University of the Pacific Theses and Dissertations

Within the last two decades the consumer market has been deluged with a diversity of aerosol products. The acceptability and utility of these products is reflected by the number found in the household and industry.

An antibiotic foam would obviate the necessity of manual application as is the case with the ointment or cream type products. Therefore, there would be less irritation to the already traumatized or infected sites by mechanical, chemical, or bacterial vectors.

Thus, the objective of this research will be to systematically develop suitable aerosol foam systems which contain therapeutically effective topical antibiotics with a subsequent evaluation …

Spectrophotometric And Microbiological Determination Of The Stability Of Sodium Ampicillin As Affected By Ph, Enrico Frank Raffanti

University of the Pacific Theses and Dissertations

The specific purpose of this investigation was to determine the effect of pH on the stability of ampicillin sodium for injection. Then, to correlate this information, a pH profile may be established to predict chemical stability with ampicillin sodium alone or when other drugs may be included in the admixture. With a pH profile the pharmacist could predict the length of time after which more than a 10 percent loss of activity would occur. Stability measurements were to be accomplished through a microbiological assay after adding ampicillin sodium to different buffer solutions. At the end of four hours, eight hours, …

The Effects Of Indomethacin On A Strain Of Fibroblasts Cultivated In Vitro, John Thomas Mccloskey

University of the Pacific Theses and Dissertations

Man has always searched for greater understanding of himself and his environment. As a result, much scientific investigation has been directed towards the understanding of the life process. In recent years, such scientific inquiry has become increasingly focused on the fundamental biochemical events taking place at the cellular, subcellular, and molecular levels. In the course of investigation into the nature of living things, research has often necessitated the development of new techniques and investigational tools to serve as experimental systems. Very often such new methods have made possible the discovery of previously unknown processes. One very interesting and useful investigational …

Effects Of And Recovery From High And Low Oxygen Tensions On A Strain Of Mouse Fibroblasts Cultivated In Vitro, David Harold Shaw

University of the Pacific Theses and Dissertations

No abstract provided.

The Preparation Of Coordination Compounds Of Rhodium (Iii) And Glutamic Acid And Substituted Glutamic Acids, Herman William Kalberer

University of the Pacific Theses and Dissertations

The father of coordination chemistry was Alfred Werner (1866- 1919). Werner's theory was largely responsible for the renewed interest in, and rapid growth of, inorganic chemistry around the turn of the century. He postulated that there were two types of valence, primary and secondary, which correspond, in modern terminology, to oxidation state and coordination number. The primary valences must be either negative ions, neutral molecules or, occasionally even, positive ions (11). He also postulated that the secondary valences are directed in space about the central ion, not only in the solid state, but also when the complex is in solution. …