Medicine and Health Sciences Commons^™

Compatibility And Stability Of 8% Amino Acids Solution In Combination With Electrolytes, Vitamins And Antibiotics, David Harold Schuetz

University of the Pacific Theses and Dissertations

For centuries, researchers have attempted to devise the ideal parenteral nutritional product readily amenable to physiological requirements. Hyperalimentation, intravenous alimentation, parenteral alimentation, parenteral feeding, and total parenteral nutrition are synonyms which refer to a method of complete intravenous nutrition reserved for patients demonstrating negative nitrogen balance.

The nutrient solution appeared to accommodate levels of potassium phosphate, calcium gluconate, and magnesium sulfate well in excess of “usual” therapeutic concentrations. Similarly, commonly employed vitamin supplements and insulin were examined in combination with the hyperalimentation solution and failed to demonstrate signs of physical incompatibility. However, instrumental analysis, i.e., U.V. spectroscopy and thin-layer chromatography, …

A Study Of Selected Antineoplastic, Antibiotic, And Corticosteroid Drugs In Intravenous Admixtures, Melvin Philip Mcrae

University of the Pacific Theses and Dissertations

The benefits of intravenous therapy have become more and more apparent over the years. Medications can be given rapidly with an expectant rapid onset of action. The response to the drugs or fluids can often be closely controlled by regulating the dose or rate of administration. Frequently, adequate blood and tissue levels needed to eradicate many serious infections can be reached only by this route. Intravenous therapy is an especially appropriate method when the use of the oral tract, for one reason or another, cannot be used.

The development of intravenous therapy, however, did not proceed without its difficulties. Problems …

The Formulation And Physical Analyses Of Antibiotic Aerosol Foams For The Development Of Potential Topical Dermatologicals, Joseph Alexander Woelfel

University of the Pacific Theses and Dissertations

Within the last two decades the consumer market has been deluged with a diversity of aerosol products. The acceptability and utility of these products is reflected by the number found in the household and industry.

An antibiotic foam would obviate the necessity of manual application as is the case with the ointment or cream type products. Therefore, there would be less irritation to the already traumatized or infected sites by mechanical, chemical, or bacterial vectors.

Thus, the objective of this research will be to systematically develop suitable aerosol foam systems which contain therapeutically effective topical antibiotics with a subsequent evaluation …

Spectrophotometric And Microbiological Determination Of The Stability Of Sodium Ampicillin As Affected By Ph, Enrico Frank Raffanti

University of the Pacific Theses and Dissertations

The specific purpose of this investigation was to determine the effect of pH on the stability of ampicillin sodium for injection. Then, to correlate this information, a pH profile may be established to predict chemical stability with ampicillin sodium alone or when other drugs may be included in the admixture. With a pH profile the pharmacist could predict the length of time after which more than a 10 percent loss of activity would occur. Stability measurements were to be accomplished through a microbiological assay after adding ampicillin sodium to different buffer solutions. At the end of four hours, eight hours, …