Medicine and Health Sciences Commons^™

Characterization Of A 30s Ribsomal Subunit Intermediate Found In Escherichia Coli Cells Growing With Neomycin And Paromomycin., Cerrone Renee Foster

Electronic Theses and Dissertations

The bacterial ribosome is a target for inhibition by numerous antibiotics. Neomycin and paromomycin are aminoglycoside antibiotics that specifically stimulate the misreading of mRNA by binding to the decoding site of 16S rRNA in the 30S ribosomal subunit. Recent work has shown that both antibiotics also inhibit 30S subunit assembly in Escherichia coli and Staphylococcus aureus cells. This work describes the characteristics of an assembly intermediate produced in E.coli cells grown with neomycin or paromomycin. Antibiotic treatment stimulated the accumulation of a 30S assembly precursor with a sedimentation coefficient of 21S. The particle was able to bind radio labeled antibiotics …

Placental Insufficiency Results In Temporal Alterations In The Renin Angiotensin System In Male Hypertensive Growth Restricted Offspring, Daniela Grigore, Norma B. Ojeda, Elliot B. Robertson, Antoinette S. Dawson, Contrina A. Huffman, Erick A. Bourassa, Robert C. Speth, K Bridget Brosnihan, Barbara T. Alexander

HPD Articles

Reduced uterine perfusion initiated in late gestation in the rat results in intrauterine growth restriction (IUGR) and development of hypertension by 4 wk of age. We hypothesize that the renin angiotensin system (RAS), a regulatory system important in the long-term control of blood pressure, may be programmed by placental insufficiency and may contribute to the etiology of IUGR hypertension. We previously reported that RAS blockade abolished hypertension in adult IUGR offspring; however, the mechanisms responsible for the early phase of hypertension are unresolved. Therefore, the purpose of this study was to examine RAS involvement in early programmed hypertension and to …

Optical Monitoring System With Molecular Filters, Robert A. Lodder, John Carberry

Pharmaceutical Sciences Faculty Patents

An optical monitoring system for determining the constituents of a sample or specimen. An absorption spectrum is obtained from a sample and is passed through one or more filters having a specified absorption spectrum defined by a single atom or a compound. If the filter's absorption spectrum is included in the sample's absorption spectrum, then the sample contains that atom or compound. The apparatus includes a switching assembly that sequentially places one or more filters into the light path to determine if the subject atom or compound is contained in the sample.

A Protein Interaction Map Of The Mitotic Spindle, Jonathan Wong, Yuko Nakajima, Stefan Westermann, Ching Shang, Jung-Seog Kang, Crystal Goodner, Pantea Houshmand, Stanley Fields, Clarence S.M. Chan, David Drubin, Georjana Barnes, Tony R. Hazbun

Borch Department of Medicinal Chemistry and Molecular Pharmacology Faculty Publications

The mitotic spindle consists of a complex network of proteins that segregates chromosomes in eukaryotes. To strengthen our understanding of the molecular composition, organization, and regulation of the mitotic spindle, we performed a system-wide two-hybrid screen on 94 proteins implicated in spindle function in Saccharomyces cerevisiae. We report 604 predominantly novel interactions that were detected in multiple screens, involving 303 distinct prey proteins. We uncovered a pattern of extensive interactions between spindle proteins reflecting the intricate organization of the spindle. Furthermore, we observed novel connections between kinetochore complexes and chromatin-modifying proteins and used phosphorylation site mutants of NDC80/TID3 to gain …

2007 Apothecary, Southwestern Oklahoma State University

Apothecary

The 2007 Apothecary staff would like to offer our congratulations to the graduating seniors. We wish you the best of luck as you begin your careers as practicing pharmacists. We hope this edition of the apothecary will serve as a reminder of all you have accomplished here at Southwestern Oklahoma State University College of Pharmacy.

Expansion Of Experiential Learning Opportunities Through Medication Reconciliation Participation, Jane M. Gervasio, Julie M. Koehler, Kevin M. Tuohy, Julie L. Williams, Mary H. Andritz

Scholarship and Professional Work – COPHS

Abstract from the American Association of Colleges of Pharmacy Annual Meeting, Orlando, FL, July 12-18, 2007.

Research News: 2007, No. 2, University Of Mississippi. School Of Pharmacy

Research News: Grants and Publications (2000-2014)

Grants, publications, technology transfer, special announcements

Compounds Of Use In The Treatment Of Epilepsy, Seizure, And Electroconvulsive Disorders, Peter A. Crooks, Aimee K. Bence, David Robert Worthern

Pharmaceutical Sciences Faculty Patents

The present invention provides pharmaceutical preparations and the uses thereof for preventing and/or treating seizures and other electroconvulsive disorders by administering a pharmaceutically effective amount of a therapeutic compound . . .

To view the rest of this abstract, please download this patent.

Commencement Program 2007, Loma Linda University

Commencement Programs

CONTENTS

2 | 2006 Events of Commencement

3 | The Academic Procession

4 | Significance of Academic Regalia

5 | The Good Samaritan

6 | The Speakers

13 | The University Honorees

21 | The School Honorees

33 | The Program

• School of Medicine, 34
• School of Pharmacy, 45
• School of Dentistry, 50
• School of Science and Technology and School of Religion, 60
• School of Nursing, 68
• School of Allied Health Professions - Physical Therapy, 75
• School of Allied Health Professions, 82
• School of Public Health, 91

The Pharmacokinetics Of Taurolidine Metabolites In Healthy Volunteers., Li Gong, Howard E Greenberg, James L Perhach, Scott A Waldman, Walter K. Kraft

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Taurolidine is an experimental antibacterial and antiendotoxic compound whose clinical utility as an antitumor agent is being investigated in human clinical trials. Taurolidine in aqueous solution exists in equilibrium with taurultam. Taurultam is subsequently transformed to taurinamide. The pharmacokinetic profiles of these metabolites are not well established. In this study, 18 healthy volunteers were administered 5.0 g of taurolidine in 250 mL of 5% polyvinylpyrrolidone in water over 2, 1, or 0.5 hours by intravenous infusion in a parallel-group design. All subjects noted discomfort at the infusion site, although there were no serious adverse events. t(max) generally occurred at the …

Permeable, Water Soluble, Non-Irritating Prodrugs Of Chemotherapeutic Agents With Oxaalkanoic Acids, Peter A. Crooks, Tadeusz Cynkowski, Grazyna Cynkowska, Hong Guo, Paul Ashton

Pharmaceutical Sciences Faculty Patents

The present invention relates to the field of prodrugs of chemotherapeutic agents and method of use thereof.

Developing A Pharmacy Professional Elective Course: Underserved Populations, Courtney Ann Hedrick

Undergraduate Honors Thesis Collection

Objectives. To ascertain the current curriculum exposure, knowledge, and interest in medically underserved populations of 3rd and 4th year professional pharmacy students enrolled at Butler University. Methods. An eleven item survey was designed, involving multiple choice, Likert scale, and open response questions. The survey was administered through the web-based survey software company, Survey Monkey, utilizing the Butler College of Pharmacy and health Sciences email listserv to all P3 and p4 students. Results. P3 and P4 students showed a high degree of interest in taking a professional elective focusing on medically underserved populations. Many of these students also felt the current …

L'Avenir De La Pharmacie: Une Comparaison Des Modèles Français Et Américain, Amber Castle

Senior Honors Projects

“The counting and pouring now often alleged to be the pharmacist’s chief occupation will in time be done by technicians and eventually by automation. The pharmacists of tomorrow will function by reason of what he knows, increasing the efficiency and safety of drug therapy and working as a specialist in his own right.” --Linwood F. Tice, D. Sc., Dean, Philadelphia College of Pharmacy and Science (1966) More than forty years ago the pharmacy profession realized that it cannot continue to perform solely distributive functions. The world will not pay pharmacists to carry out tasks that do not require their level …

Pharmacy Security: A Survey On Pharmacists' Perceptions And And Preparedness To Handle Prescription Fraud And Pharmacy Robbery, Amy Nicole Lenell

Undergraduate Honors Thesis Collection

Objective: To evaluate the perceptions of the community pharmacist with respect to prescription fraud and pharmacy robbery as well as their preparedness to handle such situations, with the intent to assess the need for a continuing education program on this topic. Methods: A survey was sent to licensed Indiana pharmacists using a listserv provided by Butler University. Only data from pharmacists currently practicing in the community (retail) setting was accepted and analyzed. The survey includes questions regarding prescription fraud, pharmacy robbery, security measures and demographics. Results: Of 1000 surveys sent, 80 surveys were returned, 47 met selection criteria, and 43 …

Medication Errors And Patient Safety Resources, Joseph A. Woelfel, W. Tom

School of Pharmacy Faculty Articles

No abstract provided.

Medications For Constipation, J. Allen, Joseph A. Woelfel

School of Pharmacy Faculty Articles

No abstract provided.

Novel Carbopol-Wax Blends For Controlled Release Oral Dosage Forms, Natarajansoundarapandian Mariageraldrajan

Theses and Dissertations (ETD)

Carbopol is crosslinked acrylic acid. Carbopol can be used in developing formulations for transdermal, oral, rectal use. It is forms strong gel in low concentration. Therefore, it can be used in low concentration in developing controlled release formulations. This increases the cost effectiveness and number of formulation options. In spite of its effectiveness, carbopol is one of the most efficient however underutilized polymer in oral controlled drug delivery system development. This is attributed to the difficulty in processing the carbopol. Carbopol has poor flow characteristics and stickiness. Objective of our research is to eliminate processing difficulties of carbopol using hot …

The Development Of A Gc/Ms Protocol For The Analysis Of Polysaccharides In Echinacea Purpurea, Michaela Knapp

Undergraduate Theses and Capstone Projects

Echinacea purpurea is an herbal supplement used to reduce symptoms of common colds and flu-like illnesses. As of right now, it is not well understood what chemical components in the plant are immunologically active. The four main potentially immunologically active chemical components in E. purpurea are caffeic acid derivatives, alkamides, polyacetylenes, and polysaccharides. In this investigation, a protocol was developed in an attempt to identify polysaccharides present in Puritan’s Pride E. purpurea (aerial) “non-irradiated” herbal supplement First, an estimate of the crude total polysaccharide content in Puritan’s Pride and in a ChromaDex certified botanical standard (E. purpurea -powdered root) was …

Development Of A Decision Support Tool To Facilitate Primary Care Management Of Patients With Abnormal Liver Function Tests Without Clinically Apparent Liver Disease [Hta03/38/02]. Abnormal Liver Function Investigations Evaluation (Alfie), Peter T. Donnan, David Mclernon, Douglas Steinke, Stephen Ryder, Paul Roderick, Frank M. Sullivan, William Rosenberg, John F. Dillon

Pharmacy Practice and Science Faculty Publications

BACKGROUND: Liver function tests (LFTs) are routinely performed in primary care, and are often the gateway to further invasive and/or expensive investigations. Little is known of the consequences in people with an initial abnormal liver function (ALF) test in primary care and with no obvious liver disease. Further investigations may be dangerous for the patient and expensive for Health Services. The aims of this study are to determine the natural history of abnormalities in LFTs before overt liver disease presents in the population and identify those who require minimal further investigations with the potential for reduction in NHS costs.

METHODS/DESIGN: …

Methamphetamine: The New Epidemic, Jessica Gingery

Honors Capstones

Capstone submitted as a graduation requirement for the BSU Honors Program.