Medicine and Health Sciences Commons^™

Nsu Sharks Rx-Winter, 2018, Nova Southeastern University

NSU Sharks Rx

No abstract provided.

Scalable Feature Selection And Extraction With Applications In Kinase Polypharmacology, Derek Jones

Theses and Dissertations--Computer Science

In order to reduce the time associated with and the costs of drug discovery, machine learning is being used to automate much of the work in this process. However the size and complex nature of molecular data makes the application of machine learning especially challenging. Much work must go into the process of engineering features that are then used to train machine learning models, costing considerable amounts of time and requiring the knowledge of domain experts to be most effective. The purpose of this work is to demonstrate data driven approaches to perform the feature selection and extraction steps in …

Impact Of Rapid Identification Of Gram Negative Blood Cultures In A Community Hospital System, Carley Thompson Pharmd

Pharmacy Residency

Presentation given at Great Lakes Pharmacy Residency Conference 2018

Impact Of Body Weight On Hemodynamic Response To Fixed Dose Vasopressin In Septic Shock, Corissa Piatka

Pharmacy Residency

Presentation given at Great Lakes Pharmacy Residency Conference 2018

Implementation Of Non-Opioid Order Panels In Parkview Health Emergency Departments, Brandon James Euen

Pharmacy Residency

Presentation given at Great Lakes Pharmacy Residency Conference 2018

Hypothermia Protocol, Jason Eakins Pharmd

Pharmacy Residency

Presentation given at Great Lakes Pharmacy Residency Conference 2018

Evaluation Of A Hospital-Based Pharmacist-Driven Transitions Of Care Service, Jordan Holder Pharmd

Pharmacy Residency

Presentation given at Great Lakes Pharmacy Residency Conference 2018

Vancomycin Dosing: Bayesian Derived Auc/Mic Vs. Trough Only Monitoring, Meagan Ellinger Pharmd

Pharmacy Residency

Presentation given at Great Lakes Pharmacy Residency Conference 2018

Impact Of Customized Response Options On Medication Alert Salience, Alissa Keillor Pharmd

Pharmacy Residency

Presentation given at Great Lakes Pharmacy Residency Conference 2018

Evaluation Of Pharmacist Involvement In Outpatient Transitional Care Management, Katharine Lundy Pharmd

Pharmacy Residency

Presentation given at Great Lakes Pharmacy Residency Conference 2018

Implementation Of A Pilot Program For Medication-Assisted Treatment In The Emergency Department, Jenna Deininger Pharmd

Pharmacy Residency

Presentation given at Great Lakes Pharmacy Residency Conference 2018

Intranasal Administration Of A Two-Dose Adjuvanted Multi-Antigen Tmv-Subunit Conjugate Vaccine Fully Protects Mice Against Francisella Tularensis Lvs Challenge, Alison A. Mccormick, Aisha Shakeel, Chris Yi, Hardeep Kaur, Ahd M. Mansour, Chandra Shekhar Bakshi

Faculty Publications & Research of the TUC College of Pharmacy

Tularemia is a fatal human disease caused by Francisella tularensis, a Gram-negative encapsulated coccobacillus bacterium. Due to its low infectious dose, ease of aerosolized transmission, and lethal effects, the CDC lists F. tularensis as a Category A pathogen, the highest level for a potential biothreat agent. Previous vaccine studies have been conducted with live attenuated, inactivated, and subunit vaccines, which have achieved partial or full protection from F. tularensis live vaccine strain (LVS) challenge, but no vaccine has been approved for human use. We demonstrate the improved efficacy of a multi-antigen subunit vaccine by using Tobacco Mosaic virus (TMV) as …

Pharmacy Technician-Administered Vaccines: On Perceptions And Practice Reality, Alex J. Adams, Shane P. Desselle, Kimberly C. Mckeirnan

Faculty Publications & Research of the TUC College of Pharmacy

Doucette and Schommer recently surveyed U.S. community pharmacy technicians on their willingness to perform tasks including the administration of vaccines. They found that 47.1% of technicians reported they were “unwilling” to administer a vaccine, although this finding must be placed into proper context. The first nationwide survey of U.S. pharmacist perceptions on immunizations in 1998 revealed only 2.2% of pharmacist respondents had administered adult vaccines and only 0.9% had administered childhood vaccines. They also found pharmacists to be “slightly negative on administering immunizations” with many perceived barriers. Nonetheless, pharmacist-provided immunizations have been an unqualified public health success. The theory of …

Microneedle-Assisted Delivery Of Anti-Migraine Drugs Across Porcine Skin: Almotriptan Malate And Naratriptan Hydrochloride, Iqra Ahmad, Kevin B. Ita, Matthew J. Morra, Inna E. Popova

Faculty Publications & Research of the TUC College of Pharmacy

Migraine is a common neurological disorder characterized by nausea, vomiting, photophobia, aching, fever, pain and chills. Triptans are selective serotonin agonists which can used to relieve migraine symptoms. Almotriptan malate and naratriptan hydrochloride are currently used for the management of migraine in the form of oral tablets. Oral tablets may be problematic for patients experiencing nausea and vomiting which are often associated with migraine. The microneedle-assisted transdermal drug delivery of these triptans may improve patient compliance. A vertical six-celled, static Franz diffusion cell system was used to conduct in vitro permeation experiments on porcine ear skin to determine the influence …

Impact Of Clinical Guideline Implementation Of Adult Ketamine Dosing In The Emergency Department, Julia Dickman Pharmd

Pharmacy Residency

Presentation given at Great Lakes Pharmacy Residency Conference 2018

Ketamine Dosing For Sedation In Mechanically Ventilated Patients, Zsanett Kormanyos Pharmd

Pharmacy Residency

Presentation given at Great Lakes Pharmacy Residency Conference 2018

Sugammadex Vs. Neostigmine Vs. Spontaneous Reversal In Pulmonary Complications Post Surgery, Allison Clemens Pharmd

Pharmacy Residency

Presentation given at Great Lakes Pharmacy Residency Conference 2018

Surveys Of Substance Use Disorders Education In Us Pharmacy Programs, Kelan L. Thomas, Andrew J. Muzyk

Faculty Publications & Research of the TUC College of Pharmacy

Introduction: Substance use disorders (SUDs) are a significant US health problem affecting roughly 20 million Americans, but there continues to be limited access to SUD treatment and inadequate addiction medicine training. Therefore, it is important to understand how SUD education is being delivered to US health professionals, including pharmacists.

Methods: A recent survey of US pharmacy programs' neuropsychiatry curricula was evaluated to identify any progress made toward increasing SUD education since the last national survey in 2004 and determine any remaining gaps between what is currently being taught and American Association of Colleges of Pharmacy (AACP) curricular guidelines for SUD …

Real-World Usage And Clinical Outcomes Of Alectinib Among Post-Crizotinib Progression Anaplastic Lymphoma Kinase Positive Non-Small-Cell Lung Cancer Patients In The Usa, Marco D. Dibonaventura, William Wong, Bijal M. Shah-Manek, Mathias Schulz

Faculty Publications & Research of the TUC College of Pharmacy

Background: Alectinib is an approved treatment for anaplastic lymphoma kinase (ALK)-positive patients with advanced non-small-cell lung cancer. Despite positive supporting clinical data, there is a lack of real-world information on the usage and patient outcomes of those treated with alectinib post-crizotinib progression.

Methods: Participating oncologists (N=95) in the USA were recruited from an online physician panel to participate in a retrospective patient chart review. Physicians randomly selected eligible patients (ie, patients who progressed on crizotinib as their first ALK inhibitor and were treated with alectinib as their second ALK inhibitor), collected demographics and clinical history from their medical charts, and …

Divergent Humoral Responses To 23-Valent Pneumococcal Polysaccharide Vaccine In Critically-Ill Burn And Neurosurgical Patients, Scott W. Mueller, Laura J. Baumgartner, Rob Maclaren, Robert Neumann, Arek J. Wiktor, Tyree H. Kiser, Gordon Lindberg, Luis Cava, Douglas N. Fish, Edward N. Janoff

Faculty Publications & Research of the TUC College of Pharmacy

INTRODUCTION: Critically ill hospitalized patients are at increased risk of infection so we assessed the immunogenicity of 23-valent pneumococcal polysaccharide vaccine (PPSV23) administered within six days of injury.

METHODS: This prospective observational study compared the immunogenicity of PPSV23 among critically ill burn and neurosurgical patients at a tertiary, academic medical center. Patients received PPSV23 vaccination within six days of ICU admission per standard of care. Consent was obtained to measure concentrations of vaccine-specific IgG to 14 of 23 serotype capsule-specific IgG in serum prior to and 14-35 days following PPSV23. A successful immunologic response was defined as both a ≥2-fold …

An Improved Tobacco Mosaic Virus (Tmv)-Conjugated Multiantigen Subunit Vaccine Against Respiratory Tularemia, Ahd A. Mansour, Sukalyani Banik, Ragavan V. Suresh, Hardeep Kaur, Meenakshi Malik, Alison A. Mccormick, Chandra Bakshi

Faculty Publications & Research of the TUC College of Pharmacy

Francisella tularensis, the causative agent of the fatal human disease known as tularemia is classified as a Category A Select Agent by the Centers for Disease Control. No licensed vaccine is currently available for prevention of tularemia in the United States. Previously, we published that a tri-antigen tobacco mosaic virus (TMV) vaccine confers 50% protection in immunized mice against respiratory tularemia caused by F. tularensis. In this study, we refined the TMV-vaccine formulation to improve the level of protection in immunized C57BL/6 mice against respiratory tularemia. We developed a tetra-antigen vaccine by conjugating OmpA, DnaK, Tul4, and SucB proteins of …

Gender-Based Differences Among Pharmacy Students Involved In Academically Dishonest Behavior, Eric J. Ip, Jai Pal, Shadi Doroudgar, Monica K. Bidwal, Bijal M. Shah-Manek

Faculty Publications & Research of the TUC College of Pharmacy

Objective. To determine whether differences based on gender exist among pharmacy students involved in cases of admitted cheating or other academic dishonesty and to assess perceptions of academic dishonesty.

Methods. Two cohorts of second-year male and female pharmacy students from four Northern California pharmacy programs were invited to complete a 45-item cross-sectional survey. Descriptive statistics and Pearson’s chi-squared test were used for statistical analysis.

Results. There were 330 surveys completed with a 59% response rate. No significant gender-based differences were found regarding admitted cheating in pharmacy school and in regards to participating in various forms of academically dishonest behavior. Female …

Ethics: A Problem In Pharmacy?, Keith I. Yoshizuka

Faculty Publications & Research of the TUC College of Pharmacy

Ethics, or the lack or attenuation thereof, is an important issue facing practicing pharmacists today. There are both statutory and regulatory provisions to support the requirement of ongoing education and training in ethics. Evidence of formal disciplinary actions by the California State Board of Pharmacy faced requiring pharmacists to take a formal course in ethics as a condition of retention of licensure is sufficient to demonstrate that pharmacists are deviating from the expectations consistent with ethical behavior. Periodic review of the principles of beneficence, non-malfeasance, autonomy, and justice would benefit pharmacists in practice, as evidence infers that a pharmacist’s moral …

Kv7 Channels Of The Urinary Bladder Smooth Muscle: Functional Roles And Therapeutic Potential, Aaron Provence

Theses and Dissertations

Overactive bladder (OAB) is a pervasive and debilitating condition for which effective therapeutic modalities are lacking. As potential novel pharmacological targets for lower urinary tract dysfunction, our recent studies have demonstrated voltage-gated KV7 channels (KV7.1-KV7.5) to be functionally expressed in detrusor smooth muscle (DSM) of the urinary bladder. Nonetheless, the specific roles of individual KV7 channel subtypes remains poorly understood. Using Western blot, immunocytochemistry, isometric DSM tension recordings, ratiometric fluorescence Ca2+ imaging, and patch-clamp electrophysiology, we demonstrated expression and key physiologic roles for the KV7.2/KV7.3 channels in guinea pig DSM using the novel and selective KV7.2/KV7.3 channel opener N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide (ICA-069673). …

Pharmacy Personnel Assessments Of Workflow Associated With Medication Therapy Management Conducted During Transitions-Of-Care, Allan W. Tao

MPA/MPP/MPFM Capstone Projects

Pharmacists are known for their expertise with medications and are the first medical professionals that many patients seek for their day-to-day concerns. The importance of understanding one’s medication and having appropriate oversight over the regimen cannot be understated. There is exists a method, known as Medication Therapy Management (MTM), with which pharmacists can ensure medication therapy safety and appropriateness via patient interview and receive reimbursement from third-party payers like insurance companies. However despite this, MTM is not a widely known service amongst eligible patients.

This study focuses on the process of MTM in UK Healthcare outpatient clinics and works to …

Population Pharmacokinetics And Pharmacodynamics Of Piperacillin In Critically Ill Patients During The Early Phaseof Sepsis, Waroonrat Sukarnjanaset

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Piperacillin/Tazobactam is frequently used for empirical treatment in patients with sepsis. Pathophysiological changes during the early phase of sepsis have significant effects on pharmacokinetic/pharmacodynamic (PK/PD) behaviors. This study aimed to characterize the population PKs of piperacillin and investigate probability of target attainment (PTA) and cumulative fraction of response (CFR) of various dosage regimens in critically ill patients during the early phase of sepsis. Methods: Forty-eight patients treated with piperacillin/tazobactam were recruited. Five blood samples were drawn before and during 0-0.5, 0.5-2, 2-4 and 4-6 or 8 hours after administration. Free piperacillin concentrations were determined using HPLC. Population PKs was …

Method Development And Pharmacokinetic Study Of Jy08, A Dual Opioid-Npff Receptor Ligand, Sydney Harrison

Honors Theses

Within the United States and worldwide, a rapidly developing public health crisis is at hand due to the abuse of opioids. With high percentages of Americans experiencing both acute and chronic pain and limited treatment routes, opioid analgesics are highly prescribed in clinical practice. These drugs act on central nervous system to activate opioid receptors in regions of the brain regulating pain and reward. However, these compounds are associated with many unwanted adverse effects including tolerance, dependence, hyperalgesia, and addiction. Thus, there is a need to for the development of new drug candidates that can serve as analgesics for long-term …

A Comprehensive Examination Of The Pharmacist's Role In Mental Illness, Kaleb D. Barnes

Honors Theses

The number of people receiving mental illness diagnoses has increased in the last two decades. As one of the most accessible healthcare professionals, pharmacists need to be prepared to assist in the management of patients with mental illness. In this study, the objective was to see how pharmacists' mental illness knowledge, acceptable social distance, familiarity, and perceived barriers may predict pharmacists' attitude toward patients with mental illness and also their willingness to provide care to patients with mental illness. The secondary objectives of this study were to test for differences in knowledge, attitude, perceived barriers, and willingness to provide care …

The Role Of Cannabinoids And Terpenes In Cannabis Mediated Analgesia In Rats, Margaret A. Rousseau

Honors Theses

Objective: This research examined the contributions of terpenes (volatile oil) and cannabinoids in cannabis mediated analgesia in rats. Methods: In experiment 1, separate groups of rats received IP administration of either vehicle, 5, 10, or 15 mg/kg cannabis extract, one of three concentrations of volatile oil alone in these cannabis extracts, one of three concentrations of these extracts with volatile oils removed, 2.5, 5, or 7.5 mg/kg Δ9-THC, or 10 or 18 mg/kg morphine 30 m before hotplate and tail-flick tests of thermal nociception. One week later, separate groups of rats received a second administration of these test articles IP …

Preparation And Evaluation Of Cefuroxime Axetil Gastro-Retentive Floating Drug Delivery System For Improved Delivery Via Hot-Melt Extrusion Technology, Rahul Madhukar Lalge

Electronic Theses and Dissertations

Purpose: The objective of the present study was to develop lipid-based gastro-retentive floating drug delivery system of amorphous Cefuroxime Axetil (CA) to minimize the enzymatic degradation in the gastro intestinal tract utilizing hot-melt extrusion technology for improved absorption.

Methods: Preliminary studies were performed to select the appropriate lipids. Selected ratios of CA and lipids were extruded using a twin screw hot-melt extruder. Extrudates obtained were milled to obtain floating granules and were further evaluated for drug content, floating strength and micromeritic properties. In vitro drug release studies were performed in 900 mL of simulated gastric fluid (without enzyme) of pH …