Medicine and Health Sciences Commons^™

Model-Based Dose-Exposure-Response Assessment For Lead And Backup Spectinamide In A Mouse Model Of Tuberculosis, Santosh Janardan Wagh

Theses and Dissertations (ETD)

Despite decades of research, tuberculosis remains the oldest pathogen-based disease that is the leading cause of death from a single infectious agent. Among many anti-tubercular therapies under investigation, the semisynthetic compounds spectinamides are a promising novel class of anti-tuberculosis agents. One such lead candidate, spectinamide 1810, and backup spectinamide 1599 have demonstrated excellent efficacy, safety, and drug-like properties in various in vitro and in vivo assessments. The dose-ranging and dose fractionation studies were designed to characterize the dose-exposure-response relationship for lead and backup spectinamide in a mouse model of Mycobacterium tuberculosis infection. In this current study, we used 26 and …

Investigational Anti Sars-Covid 19 Medication, Gazmend Temaj, Kumrije Sopi Xharra, Shefki Xharra, Angelika Moder, Jasmin Nurkovic, Hilada Hefic, Rifat Hadziselimovic

UBT International Conference

The newly identified severe acute respiratory syndrome coronavirus-2 (SARS-CoV- 2) that originated in December 2019 in Wuhan, China. By July 2020, the WHO reported over 17 million confirmed cases in over 200 countries around the globe. This review discusses how the COVID-19 pandemic may affect healthy people, structure and replication cycle of SARS- CoV-2; targets and therapeutics SARS- CoV-2 and anti-COVID drugs: strategies and perspectives.

Pharmacogenetics- Gene And Sars-Covid 19 Medication, Gazmend Temaj, Kumrije Sopi Xharra, Shefki Xharra, Angelika Moder, Jasmin Nurkovic, Hilada Hefic, Hilada Hefic, Rifat Hadziselimovic

UBT International Conference

An analysis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes collected from the patients worldwide has identified mutations in the virus that could aid in drug and vaccine development. The researchers found that the virus’s genetic diversity in most countries is similar to what it is globally, suggesting that it was introduced repeatedly by many infected people in each country rather than by a “patient zero.” The genetic analysis found 198 mutations that have occurred more than once. “Mutations in themselves are not a bad thing it is nothing to suggest SARS-CoV-2 is mutating faster or slower than expected. …

Determination Of Aerobic Mesophilic Bacteria As Well As Coliforms In A Raw Milk In The Region Of Prizren, Suhareka And Rahovec, Hyzer Rizani, Shkëlzim Ukaj, Shkumbim Shala, Magbule Rizani, Naser Kamberi, Smajl Rizani, Duresa Uka

UBT International Conference

The microbiological quality of raw milk is a key to the quality production of dairy products. Alternation is a term that describes the change of composition, taste and smell at those points where it is inedible for the consumer. Microbial alternation of milk often involves degradation of proteins, carbohydrates and fats of organisms and their enzymes. Milk and dairy consumption has increased considerably in Kosovo over the last decade, and a large part of local production comes from small-scale distributors across the country. In this research, 50 milk samples were taken at some of the cumulative sites and from dairy …

Use Of Natural-Based Laxatives On The Constipation Treatment: A Survey Of The Pharmacists Perspective, Flora Doko, Erda Aliu, Bujar Qazimi

UBT International Conference

The study was based on a questionnaire for self-adminstered laxatives. Part of this study were 76 pharmacists from Municipality of Tetovo. The questionnaire was developed in two different languages, Albanian and Macedonian. The response format included multiple choice questions in which the participants were asked to choose the most reasonable answer for them on the given list of options. 35% of patients have taken laxatives with doctor's recommendation, 36% from pharmacists recommendation. Only 17% of patients have taken laxatives without recommendations. 48% of healthcare professionals for constipation treatment recommend use of synthetic laxatives and 51% of them recommend use of …

Determination Of Volatile Aroma Compounds In Fresh Origanum Vulgare And Hyssopus Officinalis: Headspace Gc/Fid/Ms Profile, Bujar Qazimi, Gjoshe Stefkov, Marija Karapandzova, Ivana Cvetkovikj Karanfilova, Shpend Dragusha, Valon Ejupi, Svetlana Kulevanova

UBT International Conference

Origanum vulgare and Hyssopus officinalis are important aromatic and medicinal plants. The chemical composition of the volatile aroma compounds was defined in the fresh aerial part of Origanum vulgare (f-O) and Hyssopus officinalis (f-H), collected in Valbona (Albania). The analysis were made by gas chromatography – mass spectrometry (GC/FID/MS) on HP5-ms column and equipped with automated headspace (HS) system. 0,3 g fresh plant material (homogenized samples from flower, leaf and stem) was put in sealed vials, heated (80 ͦC) and the gas phase was investigated. Total of 21 individual volatile aroma compounds were identified in f-O sample, 14 monoterpenes (78.35%) …

Perampanel-Induced Cataplexy In A Young Male With Generalized Epilepsy, Kelsey Kenaan, Mohsin Zafar, Ronnie Bond, Barbara L. Gracious

HCA Healthcare Journal of Medicine

Perampanel (Fycompa) is a newer anti-epileptic drug believed to exert its effects in the central nervous system by inhibiting post-synaptic glutamate receptors. However, the precise therapeutic mechanism is unknown. The most common neuropsychiatric side effect is affective dysregulation; there are also reports of psychosis. We describe a 32 year old African American male with recurring generalized tonic-clonic (GTC) seizures, who presented to our hospital with onset of mood lability for several months, after Perampanel was added to his antiepileptic medications. Perampanel administration was temporarily withheld, and subsequently on restarting, noted to be coincident with neuropsychiatric symptomatology, including motor weakness in …

International Conference On Pharmaceutical And Natural Sciences, University For Business And Technology - Ubt

UBT International Conference

UBT Annual International Conference is the 9th international interdisciplinary peer reviewed conference which publishes works of the scientists as well as practitioners in the area where UBT is active in Education, Research and Development. The UBT aims to implement an integrated strategy to establish itself as an internationally competitive, research-intensive university, committed to the transfer of knowledge and the provision of a world-class education to the most talented students from all background. The main perspective of the conference is to connect the scientists and practitioners from different disciplines in the same place and make them be aware of the recent …

Assessment Of Community Pharmacists’ Involvement In Public Health Promotion Services In Beirut, Lebanon, Mira Medawar, Maha Aboul Ela, Souraya Domiati

BAU Journal - Health and Wellbeing

Background: The role of pharmacists is growing globally; the shift from the traditional role of preparing and dispensing medications, to a role in medication therapy management and public health services is started to be acceptable worldwide.

Objective: The aim of the study was to assess the participation level of community pharmacists’ in certain public health services promotion as well as the barriers that hindered such provision.

Method: A questionnaire based study has been carried targeting Lebanese community pharmacists working in Beirut, Lebanon. Socio-demographic information, types of public health consultations offered in the pharmacy, and the barriers confronted by the community …

Quantitative Assay Of Binary And Ternary Cardiovascular Mixtures Using Absorption Subtraction Spectrophotometric Method, Marwa Khaled El Jamal

BAU Journal - Health and Wellbeing

Objective: Development and validation of specific spectrophotometric analytical method for the simultaneous determination of co-administered cardiovascular mixtures consisting of Aspirine (ASP) and Prasugrel (PRA) binary mixture and Ticagrelor (TICA), Irbesartan (IRB) and Hydrochlorothazide (HCT) ternary mixture.

Methods: The proposed spectrophotometric method was based on Absorbance Subtraction, where, when a mixture of two drugs X and Y having overlapped spectra, intersecting at isoabsorptive point and Y spectrum is extended more than X, while X doesn’t show any absorbance (A₂) at another wavelength (λ₂), X and Y could be determined in the mixture by simple mathematical manipulation

Results: …

The Inclusion Of Health Data Standards In The Implementation Of Pharmacogenomics Systems: A Scoping Review, Don Roosan, Angela Hwang, Anandi V. Law, Jay Chok, Moom Roosan

Pharmacy Faculty Articles and Research

Background: Despite potential benefits, the practice of incorporating pharmacogenomics (PGx) results in clinical decisions has yet to diffusewidely. In this study,we conducted a review of recent discussions on data standards and interoperability with a focus on sharing PGx test results among health systems. Materials & methods:We conducted a literature search for PGx clinical decision support systems between 1 January 2012 and 31 January 2020. Thirty-two out of 727 articles were included for the final review. Results: Nine of the 32 articles mentioned data standards and only four of the 32 articles provided solutions for the lack of …

Risk Factors For Delayed Viral Suppression On First-Line Antiretroviral Therapy Among Persons Living With Hiv In Haiti, 2013-2017, Shannan N. Rich, Robert L. Cook, Lusine Yaghjyan, Kesner Francois, Nancy Puttkammer, Ermane Robin, Jungjun Bae, Nadjy Joseph, Luisa Pessoa-Brandão, Chris Delcher

Institute for Pharmaceutical Outcomes and Policy Faculty Publications

Studies of viral suppression on first-line antiretroviral therapy (ART) in persons living with human immunodeficiency virus (PLHIV) in Haiti are limited, particularly among PLHIV outside of the Ouest department, where the capital Port-au-Prince is located. This study described the prevalence and risk factors for delayed viral suppression among PLHIV in all geographic departments of Haiti between 2013 and 2017. Individuals who received viral load testing 3 to 12 months after ART initiation were included. Data on demographics and clinical care were obtained from the Haitian Active Longitudinal Tracking of HIV database. Multivariable logistic regression was performed to predict delayed viral …

Analysis Of Glutathione Supplementation Effects On Female Metabolic Syndrome Condition Using Classification Techniques, Nur Rasyidah Hasan Basri

Student Works (2020-2029)

Lesser known to the public that main antioxidants in our body, Glutathione are also said to influence the metabolic syndrome (MS) condition. Oral supplementation consisting of glutathione precursors and vitamin C introduced in the study was to improve glutathione (GSH) status of the consumer and the main objective of this study is to investigate GSH effects on selected MS condition. Several known studies had proven that oral supplementation improved GSH level of consumer. However, there is no definite proof on how it’s affecting MS parameters. Also, there is less study carried out on the relationship between glutathione levels and metabolic …

Purdue College Of Pharmacy Experience With Blood Pressure Screenings At The Indiana State Fair, Samuel L. Stukey, Emily B. Vahary, Allison M. Kenneally, Casey J. Bernier, Bruce C. Carlstedt, Jane E. Krause

Purdue Journal of Service-Learning and International Engagement

The objective of this community outreach initiative is to develop and implement a student-led blood pressure screening at the Indiana State Fair in conjunction with the Purdue College of Pharmacy and the Hook’s Drug Store Museum. Under the mentorship of two pharmacy faculty members, third- and fourth-year professional PharmD students and pharmacy fellows hold a nine-hour blood pressure screening at the Indiana State Fair each year. The screening is held at the Hook’s Drug Store Museum and the students and fellows sign-up in teams of 3-4 to host the event. Fair-goers visiting the screening have their blood pressure taken using …

Student Pharmacists Bridging The Gap With Community Partnerships: Purdue University College Of Psychiatric And Neurologic Pharmacists Chapter, Fatima A. Khan, Elise M. Mann

Purdue Journal of Service-Learning and International Engagement

The CPNP Purdue chapter is a student organization that strives to advance mental health awareness and education, reduce stigma, and volunteer in the local community. CPNP Purdue is strengthened by collaboration with partner organizations, including the National Alliance on Mental Illness (NAMI) and Home with Hope, a Lafayette-based recovery housing center. NAMI advocates for effective treatment and education for families affected by mental illness in the surrounding community. Home with Hope provides a continuum of care and environment conducive to recovery following treatment for substance use disorders. These nonprofit partnerships rely heavily upon volunteers, donations, and advocates to provide services …

Research News. Publications, 2020. Volume 3, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period July 1 through September 30, 2020

Research News. Grants, 2020. Volume 3, Soumyajit Majumdar

Grants (2015-)

Grants and contracts awarded during July - September 2020

D01. Bms Department Poster, University Of Mississippi. Department Of Biomolecular Sciences

Annual Poster Session 2020

Corresponding author (BioMolecular Sciences): Candace Lowstuter, [email protected]

R17. Solid Crystal Suspensions Of Carbamazepine Using Hot-Melt Extrusion: A Solubility Enhancement Approach, Sagar Narala, Neeraja Komanduri, Dinesh Nyavanandi, Suresh Bandari, Michael A. Repka

Annual Poster Session 2020

Corresponding author (Pharmaceutics and Drug delivery): Sagar Narala, [email protected]

D04. Department Of Pharmaceutics And Drug Delivery, Michael A. Repka, Walt G. Chambliss, Soumyajit Majumdar, S. N. Murthy, Seong Bong Jo, Chalet Tan, Mahavir Chougule, Eman Ashour

Annual Poster Session 2020

Corresponding author (Pharmaceutics and Drug Delivery): Eman Ashour, [email protected]

R07. Identification Of Antifungal Bisphosphocholines From Medicinal Gentiana Species, Xing-Cong Li, Siyu Ren, Kejun Deng, Shi Qiu, Mei Wang, Bharathi Avula, Siddharth K. Tripathi, Melissa R. Jacob, Limin Gong, Wei Wang, Ikhlas A. Khan

Annual Poster Session 2020

Corresponding author (NCNPR): Xing-Cong Li, [email protected]

R13. Formulation Development Of Loratadine Immediate-Release Tablets Using Hot-Melt Extrusion Coupled With 3d-Printing Technology, Sundus Hussain Omari, Eman A. Ashour, Mashan Amutairi, Rasha Elkanayati, Michael A. Repka

Annual Poster Session 2020

Corresponding author (Pharmaceutics and Drug delivery): Sundus Hussain Omari, [email protected]

R11. Challenges And Future Directions Of Potential Natural Products Leads Against 2019-Ncov Outbreak, Meirambek Ospanov, Francisco León, Janar Jenis, Ikhlas A. Khan, Mohamed A. Ibrahim

Annual Poster Session 2020

Corresponding author (NCNPR): Mohamed A. Ibrahim, [email protected]

R08. Characterization Of Key Metabolites In Serum Of Fuzheng Huayu Phase Ii Clinical Trial, Yan-Hong Wang, Zachara Catchings, Bharathi Avula, Mei Wang, Huashi Bian, Ikhlas A. Khan

Annual Poster Session 2020

Corresponding author (NCNPR): Yan-Hong Wang, [email protected]

R03. Hiv Tat Protein Activates Plasma Kallikrein-Kinin System In The Doxycycline-Inducible Astrocyte Specific Hiv-1 Tat Transgenic Mice, Logan Sneed, Fakhri Mahdi, Salahoddin Mohamed, Jason J. Paris, Zia Shariat-Madar

Annual Poster Session 2020

Corresponding author (BioMolecular Sciences): Logan Sneed, [email protected]

R18. Preparation And Characterization Of Pegylated Nanostructured Lipid Carrier Systems For The Ocular Delivery Of Antineoplastic Agent, Sushrut Marathe, Narender Dudhipala, Soumyajit Majumdar

Annual Poster Session 2020

Corresponding author (Pharmaceutics and Drug delivery): Sushrut Marathe, [email protected]

D02. Ncnpr Activities At Coy Waller Complex, Mahmoud A. Elsohly, Suman Chandra, Mohamed M. Radwan, Hemant Lata, Amira Wanas, Chandrani G. Majumdar

Annual Poster Session 2020

Corresponding author (NCNPR, School of Pharmacy): Mohamed M. Radwan, [email protected]

R06. Identification Of The Cellular Pathways Targeted By Two Antifungal Natural Products Using Rna-Seq Analysis, Ameeta K. Agarwal, Siddharth K. Tripathi, Qin Feng, Ranga Rao Ravu, Xing-Cong Li, Alice M. Clark

Annual Poster Session 2020

Corresponding author (NCNPR): Ameeta Agarwal, [email protected]

R09. New Atractylon Derivatives Generated In Processed Rhizomes Of Atractylodes Macrocephala Koidz, Chunmei Zhai, Jianping Zhao, Amar G. Chittiboyina, Yonghai Meng, Mei Wang, Ikhlas A. Khan

Annual Poster Session 2020

Corresponding author (NCNPR): Jianping Zhao, [email protected]

R15. Development And Characterization Of Hot-Melt Extruded Ocular Inserts Of Moxifloxacin For Bacterial Keratitis, Ruchi Thakkar, Nagireddy Dumpa, Narendar Dudhipala, Michael A. Repka, Soumyajit Majumdar

Annual Poster Session 2020

Corresponding author (Pharmaceutics and Drug delivery): Ruchi Thakkar, [email protected]