Medicine and Health Sciences Commons^™

Patterns Of Adverse Drug Reactions In Tuberculosis Treatment: A Literature Review, Jasmine R. Aisyah, Ivan S. Pradipta, Widya N. Insani

Pharmacology and Clinical Pharmacy Research

Tuberculosis (TB) treatment is often interrupted by adverse drug reactions (ADRs). However, few studies have thoroughly examined these ADR patterns in TB treatment, and no research has assessed the prevalence of ADRs in specific organs. This narrative review describes the patterns of ADRs in tuberculosis treatment, including how common each type is and its impact on organs across different countries and populations. A structured narrative literature review was conducted to identify relevant original studies published in PubMed database between 2019 and 2025. The search combined Medical Subject Headings (MeSH) and free-text terms related to ``tuberculosis'' and ``adverse drug reactions''. Eligible …

Evaluation Of The Compliance Of Ultra-Low Dose Drugs Available In Local Iraqi Markets With Regulatory Weight Variation Test, Yousif K. Younis

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Mixing and formulation of drugs with very low dose is a brutal challenge to formulators sometimes due to all kinds of difficulties like segregation, content uniformity and physicochemical stability issues. A careful consideration of all related factors is essential during manufacturing of very low dose drug products. The aim of this study is to evaluate the quality control of ultra-low dose drugs of different companies available in local Iraqi and their compliance with regulatory weight variation test. Quantitative analysis conducted to five drugs using weight variation technique with 20 randomly selected tablets for each drug. All of these drugs passed …

A Comparative Study Examining The Effects Of Nifedipine And Minoxidil On Stimulating Hair Growth Using A Mouse Model, Nihad Hussein Ahmed, Rabei Abdullah Salih, Shereen M. Mekkey

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Hair loss is a common human scalp condition caused by chemotherapy, chronic diseases, and aging. Currently, it is estimated that approximately 50% of males and 15–30% of females experience hair loss issues. Minoxidil is considered a preferred treatment for hair loss in men and women. Nifedipine is effective in improving blood circulation and blood supply via its vasodilator action. To compare nifedipine and minoxidil in terms of their effect on stimulating hair growth using a mouse model. Fifteen female albino mice, aged 8 to 10 weeks, were randomly assigned to three groups of five mice each, all with shaved dorsal …

Buccal Films As An Emerging Drug Delivery System: A Comprehensive Review, Syed Faizan Syed Nizamuddin, Nishan N. Bobade, Vikrant P. Wankhade, Sandeep C. Atram, Shrikant D. Pande, Nakul S. Dhore, Shraddha P. Malpani, Ashwin A. Pahurkar

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Oral administration through the digestive tract is still the most common means by which drugs are given, as it is simple and cheap. However, it has some biopharmaceutical limitations in general, such as varying gastrointestinal conditions, enzymatic degradation, and extensive hepatic first-pass metabolism, which decrease drug stability and bioavailability To address these challenges, drug delivery through the oral mucosa (OMDD) has emerged as a potential non-invasive option. The buccal mucosa is well supplied with blood, provides a relatively mild environment, and avoids hepatic first-pass metabolism, thereby resulting in a faster onset of action and improved bioavailability. Mucoadhesive buccal films have …

Ethnopharmacology, Phytochemistry, And Pharmacological Potential Of Philenoptera Laxiflora: An Emerging African Medicinal Plant For Drug Discovery, Albashir Tahir

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Medicinal plants remain an important source of therapeutic agents and play a significant role in modern drug discovery. Philenoptera laxiflora (Fabaceae) is a tropical African plant widely used in traditional medicine, but the scientific evidence supporting its therapeutic potential remains fragmented. This review aims to comprehensively summarize the current knowledge on the ethnomedicinal uses, phytochemical composition, pharmacological activities, and toxicological profile of P. laxiflora, while highlighting research gaps and future directions for drug discovery. A comprehensive literature search was conducted using electronic scientific databases, including PubMed, Google Scholar, Scopus, Web of Science, and ScienceDirect. Relevant publications on the ethnobotany, …

Prevalence Of Medication Prescription Patterns For Iraqi Outpatients Visiting Otolaryngology Clinics, Mirna. K. Faiq

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Objectives: To assess the prevalence of drug use patterns among ENT outpatient settings in Kirkuk, Iraq. Methods: This retrospective observational study was conducted in Kirkuk, Iraq, involving the collection of data from the e-Prescribing system and the review of written prescriptions, including 582 outpatient records from ENT clinics, from January 2024 to December 2024. Results: Most patients were below 20yr age (18.73%), with a male predominance (57%). Ear-related complaints like otitis media were the most frequent (35.22%). The average number of drugs per prescription was 2.82. The percentage of prescriptions in which an antibiotic was prescribed was 84.7%. The percentage …

Preparation And In-Vitro Evaluation Of Tizanidine Flash Oral Dispersible Tablet, Ahmed Yousif Fadhel, Yousif K. Younis

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Background: Oral administration is the most common and preferred route for drug delivery. Oral dispersible tablets (ODTs) are solid dosage forms that disintegrate into saliva without the need for water. Tizanidine is a centrally acting muscle relaxant used to manage spasticity from spinal or brain injuries. Preparing it as a flash (ODT) tablet may enhance patient compliance and potentially improve bioavailability by bypassing part of the first-pass metabolism. Methods: Six formulations of tizanidine flash tablets were developed using varying concentrations of mannitol (bulk-forming agent), glycine (to aid tablet collapse), and gelatin (matrix-forming agent). The formulations were evaluated for weight variation, …

Bioactive Constituents And Pharmacological Activities Of Curcuma Zedoaria: A Mini-Review, Abdulmutalib Allaq, Muneer M. Saleh Mohammed Saleh Alsayadi, Mustapha Salihu, Hasan M. Agha, Amena Hassan Hassan Gheeth, Fatimah Salim, Norrizah Jaafar Jaafar Sidik

AUIQ Complementary Biological System

Curcuma zedoaria Rosc. (white turmeric) is a rhizomatous medicinal plant in the Zingiberaceae family, widely used in traditional Asian medicine. In recent years, increasing scientific attention has focused on its diverse pharmacological properties and bioactive constituents. This mini review summarises current knowledge of the phytochemical composition and biological activities of C. zedoaria, with particular emphasis on its antimicrobial, antioxidant, anti-inflammatory, and anticancer effects. Phytochemical investigations using analytical techniques such as GC–MS and HPLC have revealed the presence of numerous bioactive compounds, including sesquiterpenes (example, germacrone, curzerenone, and curdione) and curcuminoids, which contribute to its therapeutic potential. Experimental studies demonstrate …

Raising The Barb: Evaluation Of Phenobarbital Use For Alcohol Withdrawal In Patients On General Medicine Floors, Seth Arakawa, Jason Frederick, Anthony Le

Books, Presentations, Posters, Etc.

Abstract: Alcohol withdrawal syndrome (AWS) can present as a spectrum of symptoms such as a mild headache, gastrointestinal issues, and diaphoresis. However, if not treated properly, it can progress to severe hallucinations, seizures, or delirium tremens. Current guidelines from the American Society of Addiction Medicine (ASAM) recommend benzodiazepines as first line agents for alcohol withdrawal with phenobarbital recommended as an adjunct agent or replacement to benzodiazepines by providers who are familiar with its use. Although most evidence supporting phenobarbital in AWS comes from critical care settings, emerging data suggest it may also be safe and effective in general ward patients. …

Charity Pharmacies: An Integrative Overview Of Operations: A Continuing Education Program For Pharmacists, Stella Bertram

Honors Theses

PROGRAM DESCRIPTION

The goal of this activity is to educate pharmacists about Charity Pharmacies by creating an integrative overview of their purpose, laws and regulations, processes and procedures, eligibility, and opportunities for involvement. This course will ensure pharmacists are competent in the operations involved in volunteering or working within a charitable pharmacy.

Additionally, the information provided supports pharmacists in understanding their roles as well as roles of volunteers. They will understand the importance of their role in the community and the depth of their service within Charity Pharmacies.

Score Data 2026, M. Barnard, T. Johnson, A. Ford-Wade, M. Godfrey, C. Compretta, E. Dehon, B. Wade

Faculty and Student Publications

This data file includes data for four years of Project SCORE implementation.

Coordinated Telehealth For People With Parkinson’S Disease: A Qualitative Comparison Of Providers’ And Patients’ Experiences, Erin J. Bush, Reshmi L. Singh, Josephine Cox, Merrill R. Landers, Annalisa V. Piccorelli

The Qualitative Report

Telehealth increases access to allied healthcare in rural areas. People with Parkinson’s disease (PD) need improved access to health care, and from a patient-centered perspective, the coordination of their healthcare should be a priority. Four speech-language pathologists, two physical therapists, two pharmacists, and two study coordinators provided a coordinated allied healthcare intervention for people with PD in rural Wyoming and Nevada. Both the providers of the intervention, as well as the participants who received it, were interviewed about their experiences with the eight-week intervention and asked about aspects that were successful or unsuccessful. Through a naturalistic paradigm using a qualitative …

Behavioral Effects Of Cocaine After Activation Of Cb1 Cannabinoid Receptors In Male And Female Mice, Cade Baughman, Jejun Lee, Jessica Acheampong, Jihoon Choi, Sarah Seeley, Manoranjan Dsouza

ONU Student Research Colloquium

The goal of this study was to assess the behavioral effects of cocaine following activation of CB1 cannabinoid receptors in male and female mice. This study was undertaken because recently published data suggest sex-dependent behavioral differences after CB1 receptor activation. However, the sex-dependent effects of CB1 receptor activation on the rewarding and psychomotor effects of cocaine have not been systematically evaluated. This study aimed to address this gap in knowledge. The study will use adult male and female C57BL6 mice. CB1 receptors will be activated using synthetic cannabinoid WIN 55212. Behavioral effects assessed after CB1 receptor activation will include both …

A Single Administration Of Psilocybin Is Ineffective In Reversing Ptsd-Like Sequelae In A Rat Model Of Stress-Enhanced Fear Learning, Kylie M. King, Marisa J. Savini, Noelle M. Molnar, Evelynn J. Schneider, Savannah E. Straub, Joe Parker, Lillianna P. Puppel, Aleece K. Al-Olimat, Allison M. Bach, Phillip R. Zoladz

ONU Student Research Colloquium

Single treatments with psychedelics produce rapid, long-lasting antidepressant effects. Psychedelics may also exert anxiolytic effects and be useful in treating more complex psychiatric conditions, such as PTSD. However, less is known about the impact of these agents on PTSD-related symptoms. Thus, we aimed to determine whether a single administration of psilocybin could reverse PTSD-like sequelae induced by stress-enhanced fear learning in rats. Sprague-Dawley rats were placed in Context A (circular, white conditioning box) and exposed to several uncontrollable footshocks (Stress) or no footshocks (No Stress). The next day, the rats were placed in Context B (square conditioning box with clear …

Psilocybin And The Related Tryptamine, Norbaeocystin, Exert Acute Anxiogenic Effects That Depend On Sex, Marisa J. Savini, Kylie M. King, Noelle M. Molnar, Evelynn J. Schneider, Savannah E. Straub, Joe Parker, Lillianna P. Puppel, Aleece K. Al-Olimat, Allison M. Bach, Andrew Jones, Phillip R. Zoladz

ONU Student Research Colloquium

Single treatments with psychedelics have demonstrated rapid, long-lasting antidepressant effects. However, psychedelics often produce unfavorable psychoactive effects that could worsen existing psychological distress. Thus, we compared the effects of psilocybin and the related tryptamine, norbaeocystin, on anxiety-like behavior in male and female rats. In Experiment 1, rats were treated with 1 mg/kg psilocybin (PSIL), 1 mg/kg norbaeocystin (NOR), or vehicle 30 min before a 5-min trial on an elevated plus maze (EPM) or in an open field test (OFT). On the EPM, PSIL led to decreased open arm time and fewer arm entries in males and females. NOR led to …

How To Best Utilize Outcomesmtm In Patient Care Settings, Anna Spalvieri

ONU Student Research Colloquium

Pharmacies are essential for the reception and filling of prescriptions, but they can also be vital for the monitoring and managing of different patient conditions and medication regimens. Patients, especially those who are older or live with chronic conditions, can be prescribed many different medications and therapies. Inversely, they might not have the medications and therapies needed to address their conditions. ONU Healthwise Pharmacy and the pharmacy call center utilize a platform called OutcomesMTM as a way of providing Medication Therapy Management (MTM) services to help patients control their chronic conditions and manage their health. These services, delivered through phone …

Iron-Based Nanoparticles As Delivery Tools, Keykavous Parang, Rajesh Vadlapatla, Ajoy Koomer, Victoria Moran, Lanie Jackson, Amir Nasrolahi Shirazi

Pharmacy Faculty Articles and Research

Iron-based nanoparticles, particularly iron oxide nanostructures (IONPs), have emerged as versatile and clinically relevant platforms for drug delivery and theranostic applications. Among these, superparamagnetic iron oxide nanoparticles (SPIONs), including magnetite (Fe₃O₄) and maghemite (γ-Fe₂O₃), are the most extensively investigated due to their biocompatibility, magnetic responsiveness, and established safety profiles. Their unique superparamagnetic behavior enables external magnetic-field-guided targeting, magnetic resonance imaging (MRI) contrast enhancement, and magnetically triggered hyperthermia, enabling simultaneous diagnosis and therapy. Surface functionalization with polymers, silica, lipids, peptides, and biomolecules further improves colloidal stability, circulation time, targeting specificity, and controlled drug …

Addition Of Prg4 To Optimize The Anti‑Adhesive Properties Of Tissue Barrier Sepraflm®, Ava J. Marks, Khaled A. Elsaid, Ling X. Zhang, Timmy Lin, Janette Baird, Tannin A. Schmidt, Gregory D. Jay

Pharmacy Faculty Articles and Research

Purpose

Postsurgical adhesion remains a significant clinical challenge. Seprafilm^® is widely used as a barrier to reduce adhesion formation, however its efficacy may be inconsistent. Recombinant human proteoglycan-4 (rhPRG4), a surface-active, anti-inflammatory glycoprotein found in synovial fluid inhibits cell and protein adhesion. This study investigated whether coating Seprafilm with rhPRG4 could enhance its anti-adhesive potential.

Methods

Macrophages (J774), human fibroblast-like synoviocytes (HFLS), and melanoma (A375) cells were cultured on tissue culture wells treated with rhPRG4 or bovine submaxillary mucin (BSM) to determine optimal seeding density. Seprafilm sheets were coated with rhPRG4 or BSM (0.78–200 µg/mL). Cell adhesion was quantified …

Swosu Research And Scholarly Activity Fair 2026, Swosu Office Of Sponsored Programs

SWOSU Research and Scholarly Activity Fair Programs

On behalf of the University Research and Scholarly Activity Committee (URSAC) and the Office of Sponsored Programs (OSP) at Southwestern Oklahoma State University, we are pleased to welcome you to the Thirty-Fourth SWOSU Research and Scholarly Activity Fair.

Techno-Enviro-Economic Analysis Of Precipitated Calcium Carbonate Production From Carbon Dioxide In Cement Industry Flue Gas And Calcium Hydroxide, Natalia Debora Panggabean, Widodo Wahyu Purwanto

Journal of Materials Exploration and Findings

CCUS is a technological solution to reduce emissions from the cement industry, which is the second largest CO2-intensive industry. This study aims to analyze technical, economic, and environmental performance of Precipitated Calcium Carbonate (PCC) synthesis in cement industry flue gas. The process simulation includes the CO2 capture system from cement plant, CO2 captured used as feedstock for PCC synthesis process through its reaction with calcium hydroxide. The simulation was carried out using ASPEN Plus software. Technical analysis was performed to determine the CO2 capture efficiency and PCC synthesis efficiency. Economic analysis was conducted to calculate CO2 capture cost and production …

Feasibility Analysis Of Thermal Oxidizer To Determine Remaining Life Using Fitness- For-Service Level 3 Method, Yudhi Yudistirawan, Donanta Dhaneswara, Wahyuaji Narottama Putra, Gama Widyaputra, Dewi Kurnia Suci, Agung Putra Mahardhika

Journal of Materials Exploration and Findings

An aged thermal oxidizer (TOX) in the oil and gas industry necessitates a comprehensive evaluation to ensure its continued safe operation. This study presents a Remaining Life Assessment (RLA) and a Fitness for Service (FFS) evaluation for the four main components of the TOX, in accordance with API 510, API 579/ASME FFS-1, and ASME BPVC Section VIII Div-1 standards. The investigation includes the determination of maximum stress and maximum temperature required to assess the operational viability of the reactor. The four components are radiant, convection, transition, and stack sections—were modeled using the finite element method (FEM). Following the geometric modeling, …

Dispensing Discovery: A Summer Camp Approach To Pharmacy Recruitment., Mary Wines-Samuelson, Gabriela Cipriano, Ankit Rochani, Ramil Sapinoro, Juliette Miller, Kaylee Schelah, Jill C. Hardy, Christine R. Birnie Phd

Fisher Showcase 2026

No abstract provided.

Innovations In Pharmacy Resident Research To Streamline Preceptor Workload And Improve Publication Rates, Kathryn A. Connor, Nicole M. Acquisto, Jennifer Iuppa Melaragno, Samantha C. Heacock, Stephen Rappaport

Fisher Showcase 2026

Organization: Nine-hospital health system (includes 886-bed academic medical center, 261-bed academic community hospital, 12 outpatient pharmacies, specialty pharmacy program); pharmacy residency program spans 2 hospitals.

Residency Programs: Currently, 5 PGY1 Pharmacy (3 academic medical center, 2 community teaching hospital), 2 PGY1 community-based pharmacy and 7 PGY2 programs in ambulatory care, critical care, emergency medicine, infectious diseases, oncology, pediatrics, and specialty pharmacy administration and leadership.

Pharmacy Research Committee (PRC): Comprised of ~10 clinical pharmacists and local pharmacy school faculty members including 2 co-chairs, research administrative pharmacist, biostatistician, and clinical informatics pharmacist experienced in research methods who meet monthly and otherwise communicate …

Development And Pilot Implementation Of A Generative Ai-Powered Virtual Learning Assistant (Vla) In First-Year Pharm.D. Courses, Vivek S. Dave, Ankit Rochani, Priyanka Bhatt

Fisher Showcase 2026

To develop and implement a generative AI-powered Virtual Learning Assistant (VLA) within foundational Pharm.D. pharmaceutics courses (Pharmaceutics I & II).

Brain Delivery Of Antibody-Derived Biologicals For Alzheimer’S Disease: An Updated Narrative Review, Rachita K. Sumbria, Ruben J. Boado

Pharmacy Faculty Articles and Research

Antibodies directed against β-amyloid (Aβ) have been developed for the treatment of Alzheimer’s disease (AD). However, the in vivo central efficacy is reduced by the poor penetration of antibodies across the blood–brain barrier (BBB). In addition, these antibodies have been associated with adverse effects like amyloid-related imaging abnormalities. Thus, the development of new antibody-based therapies for AD with improved transport across the BBB may improve efficacy and reduce adverse effects. Antibodies targeting the BBB transferrin receptor (TfR) are able to cross the BBB through receptor-mediated transcytosis, producing a global distribution throughout the brain. Along the same line, bispecific antibodies directed …

Ethical Decision-Making Frameworks In Ai-Driven Pharmaceutical Research & Development, Dhaval Dinesh Panchal, Osama Mohd Hash Ansari, Sudha Divya Madhuri Kallam

Harrisburg University Dissertations and Theses

Artificial intelligence is increasingly being utilized in pharmaceutical research and development to speed up drug discovery, enhance clinical trial design, and support regulatory decision-making. However, the increasingly rapid adoption of AI in the pharma industry has outpaced the development of consistent ethical governance, raising concerns related to data privacy, transparency, regulatory compliance, and stakeholder trust. This study explored the methods by which project managers could develop and utilize ethical decision-making frameworks to facilitate responsible AI implementation in pharmaceutical research and development. Guided by the Responsible Innovation framework, this research employed a mixed-methods design combining semi-structured interviews and quantitative surveys with …

Comparative Physicochemical Characterization Of Porcine, Fish, And Bovine Gelatin In Gummy Candies: Toward Halal Nutraceutical Development, Marlyn Dian Laksitorini, Cici Darsih, Nunung Yuniarti, Rumiyati Rumiyati, Mohammad Zainal Abidin

Pharmaceutical Sciences and Research

Gummy candies have emerged as one of the most popular dosage forms for multivitamins and nutraceutical supplements, including those for brain health. Gelatin is the primary gelling agent used to achieve the gummy texture; however, the influence of different gelatin sources on the physicochemical properties of gummies has not been systematically examined. This study investigated the physicochemical characteristics of gummies prepared with porcine, bovine, and fish gelatin. The gummies were evaluated for mechanical properties (gumminess, hardness, cohesiveness, springiness, adhesiveness, and stringiness), color, water activity, antioxidant activity, and protein content. Additionally, the effects of intentional adulteration—specifically the addition of porcine gelatin …

Assessing Current Telehealth Mobile Applications In The United States: Accessibility, Privacy, And Care Delivery, Rosemary K. Frugé

Honors Theses

Telehealth has improved patient access by reducing barriers to convenient, cost-effective, and quality health care. Telehealth mobile applications allow individuals to remotely access services through smartphone-based platforms. The purpose of this study was to evaluate leading telehealth applications available in the United States, analyzing key factors that influence platform selection, including cost, prescribing and diagnostic capabilities, user feedback, and data privacy practices. Applications were identified through keyword-based searches of major app stores using the term “telehealth,” and each app was systematically evaluated using predefined criteria. Findings highlight variability across platforms in pricing transparency, service offerings, and privacy disclosures, despite generally …

Structural Transformation Of A Hydrogel-Forming Cell Division Protein Zapb Of Multidrug Resistant Klebsiella Pneumoniae With Small Molecules, Ayesha Khan, M. Iqbal Choudhary, Sumaira Javaid, Humaira Zafar, Innokentiy Maslennikov, Atia-Tul Wahab

Pharmacy Faculty Articles and Research

Septal ring assembly protein ZapB (EMR18431.1) is involved in Z-ring formation, and nucleoid segregation during the bacterial cell division . It promotes cell division in the initial stages of the cell cycle through direct interaction with FtsZ, thus stimulating Z-ring assembly. The ZapB inhibition can make bacterial cell susceptible to primary antibiotics, and therefore considered as an important approach for adjuvent therapy against MDR bacterial infections. Hence in the current study, ZapB protein of multidrug resistant Klebsiella pneumoniae was cloned, and expressed in E. coli system. To understand its role, and to assess the mechanism of ZapB activation, the characteristic …

Improving Anesthesia Provider Confidence In The Identification, Management, And Treatment Of Postoperative Delirium, Brittany M. Whistle, Charles Dustin Phelps

Scholars Week

Purpose: Postoperative Delirium (POD) is a potentially devastating complication of anesthesia that is poorly understood by clinical staff leading to poor outcomes for surgical patients. This study is meant to determine if a focused knowledge presentation accompanied by visual aids could increase anesthesia providers confidence in identifying, diagnosing, and treating Postoperative Delirium.

Methodology: Utilizing a statistical model to analyze respondents results on a standardized test administered before and after an informational presentation with visual aids on the topic of Postoperative Delirium.

Results: Results indicated a statistically significant difference between pretest and posttest scores, with a p-value of .002, t(11) = …