Medicine and Health Sciences Commons^™

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Parental Notification And Abortion: A Review And Recommendation To West Virginia's Legislature, David W. Frame West Virginia University College Of Law

West Virginia Law Review

No abstract provided.

Experience With Biosynthetic Human Insulin In Diabetes, Davida F. Kruger, Fred W. Whitehouse, Dorothy M. Kahkonen, Jean O. Partamian, J. David Fachnie, José Goldman, David Leach

Henry Ford Hospital Medical Journal

Thirty diabetic patients new to insulin were entered in an open label prospective study of biosynthetic human insulin (BHI). All patients experienced symptomatic control of diabetes attributable to dietary and BHI insulin therapy. Detailed six-month evaluation data were reviewed in 19 patients. A significant drop in fasting plasma glucose and glycosylated hemoglobin was noted at two months, and a further modest decrease occurred at six months. E. coli polypeptide antibodies were unchanged from baseline at six months, indicating that no bacterial protein contamination of BHI occurred. Percent binding of serum antibodies to human insulin measured in 19 patients at baseline …

The Artificial Pancreas Today, James F. Mcmurry Jr.

Henry Ford Hospital Medical Journal

An artificial pancreas is now available in selected centers for clinical use in blood glucose control. With information derived from 24-30 hours of "closed-loop" insulin administration by means of the artificial pancreas, subcutaneous insulin doses may be determined for insulin-dependent diabetic patients. Eleven poorly controlled diabetic patients had their insulin doses reevaluated with the artificial pancreas. Ten of 11 patients showed improved glucose control when their insulin doses were modified by this method.

Current Management Of Pregnancy In The Diabetic: A Team Approach, Seth G. Kivnick, J. David Fachnie, Chang Y. Lee

Henry Ford Hospital Medical Journal

We reviewed details of 89 pregnancies in diabetic women who were delivered from 1980 through 1982. Data are presented on the obstetrical outcome and the level of diabetic control in patients with White classifications of B through R. Although the mean blood glucose levels of all groups failed to meet the criteria for ideal metabolic control (fasting less than 105 mg/dl, postprandial less than 120 mg/dl), the perinatal mortality rate of 4% compared favorably with reports from other centers. Fifty-six percent of our patients were delivered at 37 weeks gestation or later. The primary Caesarean section rate was 37%, and …

Recommendations For Care Of The Asymptomatic Patient, James D. Bridges, Thomas Killip, N. Kevin Krane, David B. Macdougall, Carlos F. Petrozzi, Michael E. Somand, Susan Steigerwalt

Henry Ford Hospital Medical Journal

We present a set of reasonable guidelines for the care of healthy, asymptomatic individuals based upon recommendations prepared by an Internal Medicine review committee of Henry Ford Hospital. There recommendations have four goals: to prevent disease, to detect disease in an asymptomatic and potentially curable state, to enhance the patient's quality of life, and to help physicians teach patients good health habits. Recommendations are made for infectious diseases, cancer, metabolic diseases, neurosensory conditions like visual and hearing loss, and general health habits. Some recommendations are at variance with those of well recognized authorities and should be viewed only as a …

Hemolytic-Uremic Syndrome In A Patient Receiving Mitomycin C And 5-Fluorouracil, Glen R. Willie, Stanley M. Levy, Robert S. Michaels, Richard M. Zirkin

Henry Ford Hospital Medical Journal

Recently, an association was reported between a form of hemolytic-uremic syndrome and the use of adjuvant chemotherapy with mitomycin C and 5-fluorouracil. Our report presents the clinical course of a patient with this syndrome along with detailed renal pathological studies (including electron and immunofluorescence microscopy). This information is not available for most previous reports.

Drug-Induced Glomerulopathy: A Selective Review, Francis Dumler

Henry Ford Hospital Medical Journal

Tbe pathogenesis of drug-induced glomerular disease is becoming better understood because of recent advances in the study of glomerular physiology and metabolism. Various classes of drugs may produce nephrotoxicity. This review is limited to types of drugs whose use may result in glomerular functional and metabolic abnormalities leading to proteinuria and/or renal insufficiency. Drugs which cause tubular necrosis are excluded. Nonsteroidal anti-inflammatory agents are examples of drugs that induce glomerular proteinuria and minimal change nephropathy. Gold, penicillamine, and captopril produce drug-induced glomerular proteinuria in association with membranous nephropathy. Finally, semustine and mitomycin are examples of drugs that induce glomerular sclerosis …

Editorials

Henry Ford Hospital Medical Journal

No abstract provided.

Dynamic In-Patient Therapy: A Team Approach, Le Van Cao

Loma Linda University Electronic Theses, Dissertations & Projects

The paper reports on the philosophy and clinical results of an individualized but concentrated team approach to hospitalized patients undergoing a psychological crisis. The team focuses on the patient’s key vital coping technique as the source of his vulnerability and assists the patient toward constructive self-understanding. The approach favors maximum therapeutic benefit from a short hospital stay. Follow-up of the first fifteen cases managed by this method discloses a significantly low percentage of relapse and rehospitalization, and demonstrates that even such relapses can be turned to therapeutic benefit.

Mandibular Repositioning With Frankel Appliance Therapy, Clark E. Schneekluth

Loma Linda University Electronic Theses, Dissertations & Projects

A sample of twelve Frankel appliance (FR-2) treated patients, in the mixed dentition stage, were selectively chosen by an orthodontist based on the Class II correction and evaluated from before treatment and end of treatment laminagraphic and lateral cephalometric radiographs. The average treatment period was 22 months (1 yr. 10 mos.). The average pre-treatment age was 9.5 years with a range from 8 to 11 years old, while the average post-treatment age was 11.3 years with a range of 10 to 13 years.

Frankel appliance therapy was the only form of mechanics used in this study.

The before treatment lateral …

Registered Nurses' Ability To Discriminate Similar Human Need Fulfillment Alterations Specific To Chronic Obstructive Pulmonary Disease And To Diabetes Mellitus, Kathleen Bowen Waite

Ellmer School of Nursing Theses & Dissertations

The problem for this research study was to ascertain if registered nurses of varying educational backgrounds and experience discriminated similar human needs as being altered by specific pathologic states. The two pathologic states studied were chronic obstructive pulmonary disease and diabetes mellitus, chosen for their high prevalence in the population. A population sample of 55 registered nurses practicing on medical units in five hospital settings were surveyed. Data for this study were collected using the Human Needs Assessment Scales developed for this study. It was determined that registered nurses in this study did discriminate similar human need fulfillment alterations specific …

Vital Signs, Spring 1983, Boonshoft School Of Medicine

Vital Signs

A twenty five page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

Oncolog, Volume 28, Number 02, April - June 1983, The University Of Texas Md Anderson Cancer Center, Donna R. Copeland Phd, Jorge R. Quesada Md, David A. Swanson, Antonio Trindade, Jordan U. Gutterman Md

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Advanced Staging Procedures Promote Survival in Patients with Hodgkin's Disease
• Implantable Pump Allows Unlimited Treatment Without Extended Periods of Hospitalization
• Hypnotherapy Offers Relief from Discomfort and Anxiety for Receptive Pediatric Patients
• Leukocyte Interferon Potential Therapy for Patients with Metastatic Renal Cell Carcinoma

Editorials

Henry Ford Hospital Medical Journal

No abstract provided.

The Role Of Major Hepatic Resections For Liver Metastases From Colorectal Cancer, Angelos A. Kambouris

Henry Ford Hospital Medical Journal

Of the more than 120,000 new patients with colorectal cancer in 1982, at least 20% will develop liver metastases either at initial presentation or after treatment of the primary lesion. The median survival in such patients has been variously estimated at between five and nine months, and in spite of treatment by chemotherapeutic agents, only rarely do such patients survive five years. By contrast, patients who survive the longest after treatment of liver metastases from colorectal cancer have had major hepatic resections alone or combined with chemotherapy as part of their management. The present report describes five patients who were …

Clinical Note: Excision Of A Large Ovarian Leiomyoma In A Centenarian, James A. Sapala, M. Andrew Sapala

Henry Ford Hospital Medical Journal

Leiomyoma of the ovary is a rare neoplasm; only 28 cases in the literature are known to us. In 1979, we encountered a tumor of this type and are reporting it here because of its great size and its occurrence in a 103-year-old woman. The patient has been well for two years since the tumor was removed.

The Role Of Splenectomy In Endocarditis, Donald J. Magilligan Jr., Edward L. Quinn

Henry Ford Hospital Medical Journal

Five patients with endocarditis, persistent sepsis, and positive liver-spleen scans underwent splenectomy. Three had splenectomy performed concomitantly with cardiac valve replacement, one after valve replacement and one as an isolated procedure. Four of five spleens contained abscesses, and bacterial cultures of two were positive. Histologic study of one spleen revealed splenitis. All patients improved after splenectomy, and all are well two to twenty months postoperatively. An aggressive approach to splenic abscess in endocarditis may lead to reduced mortality from bacterial endocarditis and infected prosthetic valves.

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

The Regional Acceleratory Phenomenon: A Review, Harold M. Frost

Henry Ford Hospital Medical Journal

The regional acceleratory phenomenon (RAP) is a complex reaction of mammalian tissues to diverse noxious stimuli. The phenomenon occurs regionally in the anatomical sense, involves both soft and hard tissues, and is characterized by an acceleration and domination of most ongoing normal vital tissue processes. It may represent an "SOS" mechanism which evolved to potentiate tissue healing and local tissue defensive reactions. When a RAP is obtunded, retarded healing and lowered resistance to infection and mechanical abuse may ensue. When ignored in experimental design, the phenomenon can seriously perturb studies of metabolic bone disease and of the effects of mechanical, …

The Acquired Double Pylorus, Klaus Anselm, Arthur H. Halprin

Henry Ford Hospital Medical Journal

Four patients with the double pylorus are reported. In view of an earlier history of peptic ulcer disease, the double pylorus is considered to have been acquired in all four. The literature involving 54 reported cases is reviewed, and the natural history of the double pylorus is discussed.

Endoscopic Sclerotherapy In The Treatment Of Recurrent Bleeding From Esophageal Varices, Martin C. Zonca, Dominic K. H. Wong, Surinder K. Batra, Bernard M. Schuman

Henry Ford Hospital Medical Journal

Endoscopic sclerotherapy as a method to treat bleeding esophageal varices was first performed by Crafoord and Erenckner in 1939 but was not widely accepted. Surgical therapy, using the portocaval shunt, became the preferred method of preventing hemorrhage from bleeding varices. Over the years, enthusiasm for the surgical approach has waned because the mortality rate with certain patients is prohibitively high. Conversely, interest in endoscopic sclerotherapy is growing as a result of several favorable reports. We present our initial experience with this procedure in the management of patients with bleeding esophageal varices.

Management Of Colonic Trauma: Six-Year Experience At Henry Ford Hospital, Farouck N. Obeid, Victor Sorensen, Gilford Vincent, Deepak Vij, H. Mathilda Horst, D. Paul Horan

Henry Ford Hospital Medical Journal

Surgical management of 114 patients with colonic injuries related to trauma who were treated over a six-year period is reviewed. Eighty-three (73%) injuries were secondary to gunshot wounds. Twenty-six patients (24%) had isolated colonic injuries. The majority of patients (60%)) were treated with colostomies: exteriorization of the injury, repair with proximal colostomy, or resection with colostomy and mucous fistula. Exteriorization of repaired colon, primary repair, and resection with primary anastomosis were performed in 40% of the patients. Six patients (5.3%) in our series died, and 24% had complications directly related to the colon injury. Based on this study, no standard …

The Other Breast: Indications For Biopsy And/Or Mastectomy, Charles S. Rogers

Henry Ford Hospital Medical Journal

A search for malignant and premalignant lesions in 162 contralateral biopsy and/or mastectomy specimens yielded 45 (27.8%,) malignancies and 54 (33%) premalignant lesions (atypical epithelial hyperplasia, Wellings grades III and IV). In those with no palpable or mammographic suspicion of malignancy, the cancer incidence was 73.8%. Eight malignancies occurred one month to three years after antecedent biopsies which revealed premalignant lesions. No cancer has been detected after biopsies which revealed hyperplasia of grade II or less. Cancer size at time of discovery varied significantly with the method of detection: average 2.7 cm by palpation; 1.6 cm by mammography; 0.5 cm …

Current Concepts In Otitis Media, Michael M. Paparella

Henry Ford Hospital Medical Journal

Otitis media continues to be a common and disabling problem which has become, in recent years, a fertile area for research. Based on studies in animals and humans, otitis media is classified into four groups: acute purulent otitis media (POM), serous otitis media (SOM), and mucoid or secretory otitis media (MOM). Together, these are referred to as otitis media with effusion (OME). The types can overlap and evolve into another type to become chronic otitis media and mastoiditis, characterized by the presence of granulation tissue or cholesteatoma. The biochemistry, microbiology, and pathology as well as clinical features of the disease …

How Useful Is Peritoneal Lavage Amylase?, Eugene Meyer, James C. Gruenberg

Henry Ford Hospital Medical Journal

Prospectively for 23 months, 289 patients with penetrating and 317 patients with blunt trauma to the lower chest and/or abdomen had amylase determinations in the peritoneal lavage as part of their initial evaluation. In nine (1.5%) of the 606 patients, the amylase in the lavage was higher than normal serum values and, when elevated, it identified intra-abdominal injury. Intra-abdominal injuries usually involved a hollow viscus injury—either isolated or combined with solid organ injuries—rather than pancreatic injury. Although elevation of the lavage amylase was a reliable indication of intra-abdominal injury in this series, we feel that routine use of this test …

Therapeutic Hemapheresis, Sheikh M. Saeed, B. K. S. Raman

Henry Ford Hospital Medical Journal

No abstract provided.

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Nefom: Board Of Trustees: Meeting Minutes 1983-1-6, New England Foundation For Osteopathic Medicine

William Kirmes, D.O. Collection

Meeting Minutes for the NEFOM meeting January 6, 1983.

Comparison Of Intermediate-Dose Methotrexate With Cranial Irradiation For The Post-Induction Treatment Of Acute Lymphocytic Leukemia In Children, Arnold I. Freeman , M.D., Vivian Weinberg, Martin L. Brecher , M.D., Barbara Jones , M.D., Arvin S. Glicksman , M.D., Lucius F. Sinks , M.D., Marise Weil , M.D., Hansjuerg Pleuss , M.D., Juliet Hananian , M.D., E. Omer Burgert , Jr., M.D., Gerald S. Gilchrist , M.D., Thomas Necheles , M.D., Michael Harris , M.D., Faith Kung , M.D., Richard B. Patterson , M.D., Harold Maurer , M.D., Brigid Leventhal , M.D., Louise Chevalier , M.D., Edwin Forman , M.D., James F. Holland , M.D.

Pediatrics Publications

Abstract

We compared two regimens with respect to their ability to prolong disease-free survival in 506 children and adolescents with acute lymphocytic leukemia. All responders to induction therapy were randomized to treatment with 2400 rad of cranial irradiation plus intrathecal methotrexate or to treatment with intermediate-dose methotrexate plus intrathecal methotrexate, as prophylaxis for involvement of the central nervous system and other "sanctuary" areas. Patients were then treated with a standard maintenance regimen. Complete responders were stratified into either standard-risk or increased-risk groups on the basis of age and white-cell count at presentation.

Among patients with standard risk, hematologic relapses occurred …