Medicine and Health Sciences Commons^™

Hormonal Management Of Advanced Adenocarcinoma Of The Prostate, Brian J. Miles

Henry Ford Hospital Medical Journal

No abstract provided.

Advances In The Diagnosis Of Urothelial Neoplasia, John D. Crissman, Richard J. Zarbo, Terri Johnson, V. Ramesh Babu, Fazlul H. Sarkar, Brian J. Miles, Joseph C. Cerny

Henry Ford Hospital Medical Journal

Urothelial neoplasia is a unique cancer in that it consists of a spectrum of tumors with different biologic behaviors. The most common urothelial neoplasm is the low grade superficial papillary carcinoma or papilloma which may recur numerous times but does not result in significant morbidity or mortality. A variant of the superficial papillary carcinoma, which represents approximately 10% of the tumors, is the noninvasive papillary neoplasm which progresses to a less differentiated invasive transitional cell carcinoma (TCC). Considerable effort has been directed at identifying which of the superficial well differentiated papillary tumors will persist, recur and progress to invasive cancer …

Effect Of Cyclosporine On The Rate Of Renal Function Recovery After Renal Transplantation, Francis Dumler

Henry Ford Hospital Medical Journal

To assess the effect of cyclosporine therapy on the rate of renal function recovery after renal transplantation, patients with no clinical evidence of rejection and who were treated with either cyclosporine or azathioprine in addition to steroid therapy were studied (n = 74). Of the patients with immediate renal function (n = 57), those receiving organs from living, related donors had a faster recovery rate of glomerular filtration than patients with cadaveric grafts (azathioprine, 15 ± 2 versus 7 ± 1 mL/min/day, P = 0.0001; cyclosporine, 14 ± 3 versus 6 ± 1 mL/min/day, P = 0.001). Recipients of cadaveric …

Quinidine-Induced Immune Thrombocytopenia, Mansoor N. Saleh, Nadhav Dhodaphar, Karen Allen, Albert F. Lobuglio

Henry Ford Hospital Medical Journal

We have identified six cases of quinidine-induced immune thrombocytopenia based on clinical evidence and in association with elevated amounts of platelet surface IgG. The degree of thrombocytopenia did not correlate with severity of clinical symptoms, nor did it predict the amount of IgG on the platelet surface. Three of the patients recovered promptly after drug discontinuation alone whereas the other patients received additional corticosteroid therapy. The clinical presentation, mode of diagnosis, and therapeutic considerations in the treatment of drug-induced thrombocytopenia are discussed.

Surgical Management Of Spinal Epidural Disease: An Update, Jack P. Rock, Dale V. Hoekstra, Henry H. Schmidek

Henry Ford Hospital Medical Journal

Management of spinal cord compression from metastatic malignant disease remains unsatisfactory. Results of surgical decompression are at best less than those of radiation therapy alone. However, new surgical approaches now focus on removing the anterior-situated tumor tissue which produces neural compression in about 85% of the cases. The results of these procedures that allow removal of the ventrally compressing tumor show significant improvement in the management of patients with spinal epidural disease. We review the surgical strategy of these new approaches and the attendant results.

Echo-Doppler Features Of Pulmonary Valve Endocarditis, Jihad Bitar, Mohsin Alam

Henry Ford Hospital Medical Journal

Three patients with fever and pneumonitis were found to have pulmonary valve vegetations by echocardiography. Pulsed and color flow Doppler studies demonstrated mild to moderate pulmonary valve insufficiency in these patients. All patients responded to the appropriate antibiotics without requiring valve surgery. Echocardiography is of value in diagnosing pulmonary valve endocarditis and should be considered in every patient with recurrent pneumonitis.

Digitalis Intoxication Or Intrinsic Conduction System Disease, Hooman Mahdyoon, Howard S. Rosman, Demetrios N. Mermiges, Mihai Gheorghiade

Henry Ford Hospital Medical Journal

No abstract provided.

Cerebral Infarction Associated With Cocaine Use, Iliana Meza, Carlos A. Estrada, Justo A. Montalvo, Walter N. Hidalgo, Jennie Andresen

Henry Ford Hospital Medical Journal

We report the case of a young man with an acute infarction of the left putamen and caudate nucleus, whose symptoms appeared six hours after intranasal use of approximately 0.5 g of cocaine hydrochloride. It seems probable that in this patient cocaine consumption played a role in the development of stroke.

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Adenocarcinoma Of The Prostate: An Overview, Brian J. Miles, Robert Chapman, Joseph C. Cerny

Henry Ford Hospital Medical Journal

No abstract provided.

The Radial Forearm Donor Site: A Locus Minoris Resistentiae., Geoffrey G. Hallock Md

Department of Surgery

No abstract provided.

Correspondence: Unecom: Hall To Kirmes 1989-2-1, Randy Hall

William Kirmes, D.O. Collection

A letter from Randy Hall to Dr. Kirmes describing his experiences applying to and interviewing at several Colleges of Osteopathic Medicine as well as his final decision to attend TCOM.

University Of New England Board Of Trustees: The New England Endowment For Osteopathic Medicine Brochure, University Of New England

William Kirmes, D.O. Collection

A brochure for the New England Endowment for Osteopathic Medicine detailing various ways one can contribute to the fund.

University Of New England Faculty Senate By-Laws, University Of New England

Gene Yonuschot, Ph.D. Collection

By-Laws of the University of New England (UNE) Faculty Senate approved in 1989.

Southeastern University Of Health Sciences Catalog 1989-1991, Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Design And Implementation Of A Sports Medicine Clinic With Emphasis On The High School Student-Athlete, Christopher Allen Mumaw

Theses Digitization Project

No abstract provided.

Hemoglobin Subunit-Subunit Affinity-Determinant Of Hemoglobin Formation, Ali Mansouri, Inge R. Carter

Journal of the Arkansas Academy of Science

Hemoglobin A₂ is often elevated in β-thalassemia and decreased in α-thalassemia. This might be due to hemoglobin subunit-subunit affinity variation. It has been inferred from the study of abnormal hemoglobins that the a subunits have higher affinity for β subunits than for δ subunits. However, only in one study has the affinity of α, β, and δ subunits for each other been measured. In this work we have attempted to measure the hemoglobin subunit-subunit affinity with somewhat different approach, i.e., hybridization of hemoglobin A and A₂. It is shown that hybridization and recombination of equal amounts of hemoglobins A and …

Oncolog, Volume 34, Number 04, October-December 1989, Gabriel N. Hortobagyi Md

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• For Cancer Patients, Home May Be Their Hospital
• Neoadiuvant Chemotherapy for Patients with Stage III Breast Cancer
• Newer Methods of Delivery To Enhance GI Cancer Treatment

Oncolog, Volume 34, Number 03, July-September 1989, Stephen L. Huber Ms, Nicky Dozier Pharmd, Naguib A. Samaan Md, Phd

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Understanding Dose Intensity is Essential for Optimizing Chemotherapeutic Regimens
• Dysplastic Nevus Syndrome Identifies Patients at High Risk for Melanoma
• Multiple Endocrine Neoplasia Syndromes

Oncolog, Volume 34, Number 02, April-June 1989, Vicki Huff Phd

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Bone Marrow Transplantation Supports Patients through High-Dose Chemotherapy
• Genetic Linkage Analysis of Familial Wilms' Tumor
• Osteosarcoma: Expandable Prostheses and Allografts Reduce the Need for Amputation

Oncolog, Volume 34, Number 01, January-March 1989, Mark S. Roh Md, Lillian M. Fuller Md

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Treatment Options for Colorectal Liver Metastases
• Improved Treatments for Non-Hodgkin's Lymphoma
• Early Discharge for Mastectomy Patients Does Not Increase Morbidity

Digest Of The Philadelphia College Of Osteopathic Medicine (Winter 1989), Philadelphia College Of Osteopathic Medicine

Digest

The Winter 1989 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• President's Perspective
• New Appointments & Promotions
• A Profile of Courage and Loyalty
• Recent Improvements Upgrade - Hospital Operations
• The Family Greer
• On Campus
• The Long Distance Diagnosis
• Class Acts
• In Memorium
• Calendar

Neonatal Screening For Congenital Hypothyroidism In Pakistan, Murntaz Lakhani, Mohammad Khurshid, Shehla H. Naqvi, Mohammad Akber

Department of Paediatrics and Child Health

Congenital hypothyroidism is a preventable cause of mental retardation. Since clinical signs of congenital hypothyroidism do not generally become obvious before three months of age, screening programmes have been introduced in North America and Europe, which consist of T4 or TSH screening on newborn infants on the third day of life. The screening for congenital hypothyroidism was initiated in Pakistan by the Aga Khan University Hospital (AKUH) in March 1987. By April 1988, 5000 neonates were screened and five cases of congenital hypothyroidism were diagnosed. The study revealed the incidence of hypothyroidism to be one case per 1000 newborns which …

The Role Of The Insulin Receptor Tyrosine Kinase In Two Models Of Insulin Resistance, Nancy Barchus Block

MUSC Theses and Dissertations

Activation of the insulin receptor tyrosine kinase in vitro and in vivo was studied in two rat models of insulin resistance: hypercortisolemia and streptozotocin-induced diabetes. In control rats, intravenous insulin administration resulted in dose-dependent in vivo activation of the skeletal muscle insulin receptor kinase. Chronic cortisone treatment did not affect the kinase activity of receptors solubilized from muscle after activation with insulin in vivo or in vitro. In contrast, diabetes depressed skeletal muscle insulin receptor kinase activation in vivo by ~50%. Diabetes impaired the in vitro insulin stimulation of receptor kinase activity from skeletal muscle and liver towards the substrate …

Animal Bite Infections., Joel D. Klein, Md

Department of Pediatrics Faculty Papers

Animal bites have become alarmingly common and may represent a quiet epidemic. It is estimated that between 1 and 3.5 million animal bites occur annually in the United States. The highest incidence has consistently been in 5-to-14-year-old schoolchildren, who have greater contact with animals, especially house pets, on a daily basis. This article discusses the epidemiology, microbiology, clinical findings and management of animal bites infections.

Local Anaesthetic Cream For The Alleviation Of Pain During Venepuncture In Tanzanian Schoolchidren, U. Hellgren, C.M. Kihamia, Zul Premji, K. Danielson

Pathology, East Africa

The analgesic effect and the usefulness of EMLA cream 5% in connection with venous blood-sampling was investigated in 42 Tanzanian schoolchildren. Approximately 2.5 g EMLA was applied to the right cubital fossa for a minimum of 120 min. The analgesic effect was pronounced - 93% of the venepunctures were pain-free and no child experienced severe pain. No adverse reactions were observed and the children could continue normal school work during the application time.

Quinidine-Induced Immune Thrombocytopenia, Mansoor Saleh, Nadhav Dhodaphar, Karren Allen, Albert Lobuglio

Haematology and Oncology, East Africa

D rugs may cause thrombocytopenia by three principal mechanisms: suppression of platelet production, direct platelet toxicity, or antibody-mediated platelet destmction (1). With the advent of assays specifically capable of detecting and quantifying IgG on the platelet surface (2), it has become increasingly possible to recognize cases of drug-induced immune thrombocytopenia based on the detection of elevated levels of platelet surface bound IgG in association with ingestion of causative dmgs. Consequendy, dmg-induced immune thrombocytopenia is no longer a disease diagnosed primarily by exclusion. The occurrence of quinidine-induced thrombocytopenia, though uncommon, was documented as early as 1965 (3) and has been thought …

Effect Of Intravenous Gammaglobulin On Circulating And Platelet-Bound Antibody In Immune Thrombocytopenia, G Garbano, Mansoor Saleh, P G. Mori, A F. Lobuglio, D Shaw

Haematology and Oncology, East Africa

Ten patients with idiopathic thrombocytopenic purpura (ITP) were studied before and following a rise in circulating platelets subsequent to infusions of intravenous gammaglobulin (400 mg/kg/day x 5 days). We quantitated the amount of circulating IgG capable of binding to normal donor platelets in vitro using an 125I-monoclonal anti-human IgG assay, as well as the amount of IgG associated with the patients' platelets before and following therapy. We found no evidence for a decrease in platelet-specific IgG antibodies in these patients undergoing an acute response to therapy. These data suggest that the short-term efficacy of intravenous gammaglobulin is due to effects …

Efficacy Of A Home Made Quality Control Serum, Rukbsana Lalani, Ayesha Molla, Mohammad Khurshid

Section of Haematology/Oncology

With increasing automation in Clinical Laboratories, the requirements for quality control material have greatly increased in order to monitor performance. The constant use of commercial control material is not economically feasible for many countries because of non-availability or the high cost of these materials. Here we describe a simple technique to prepare Home Made Quality Control serum using blood from polycythaemic patients. This preparation is stable for about six months without any alterations in the concentration of any of the chemical constituents. Extensive use of Home Made Quality Control sera in our laboratories have saved about 69% of the amount …

Urinary Tract Infection, B J Farooqui, Mehboob Alam, Mohammad Khurshid

Department of Pathology and Laboratory Medicine

Over two years, 9892 mid-stream urine samples from patients attending the Aga Khan University Hospital, Karachi were cultured. Significant bacterial growth was seen in 23.5% samples. Further iden­tification of these organisms Eevealed 40% of E.coli, 16% Pseudomonas aeruginosa, 11% Klebsiella aerogenes, 5.0% Enterobacter sp., 13% Protdus sp., 4.0% Serratia liquifaciens, 1.0% Acinetobacter sp., 3.0% Citrobacter sp., 4.0% Enterococci, 0.5% Staphylococcus aureus. Results of sensitivity tests performed with antibiotics Ampicillin, Cotrimoxa.zole, Nitrofurantoin, Nalidixic acid, Gentamicin, Amikacin, Pipemedic acid, Cefotaxime, Azactain and Carbenicillin did not reveal any distinct pattern