Medicine and Health Sciences Commons^™

Endovascular Stenting For Carotid Artery Stenosis: Results Of Local Experience At Aga Khan University Hospital, Karachi, Muhammad Azeem Uddin, Tanveer Ul Haq, Ishtiaque Ahmed Chishty, Zafar Sajjad, Basit Salam

Department of Radiology

Objective: To evaluate the results, complications and initial follow-up of patients after percutaneous stent placement for carotid artery disease.Methods: A retrospective study was carried out on patients treated with carotid artery stenting at the Radiology Department of Aga Khan University Hospital, Karachi, from September 2002 to December 2005. The patients were selected according to the institutional guidelines for Carotid Angioplasty and stenting. Preliminary angiogram was performed in all patients followed by stent deployment. Distal protection device was used in 12 patients. All patients underwent pre and post procedure independent neurological examinations. Follow-up consisted of serial duplex ultrasonography and clinical assessment.Results: …

Analytical Approaches To Detect Maternal/Fetal Genotype Incompatibilities That Increase Risk Of Pre-Eclampsia, Neeta Parimi, Gerard Tromp, Helena Kuivaniemi, Jyh Nien, Ricardo Gomez, Roberto Romero, Katrina Ab Goddard

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

In utero interactions between incompatible maternal and fetal genotypes are a potential mechanism for the onset or progression of pregnancy related diseases such as pre-eclampsia (PE). However, the optimal analytical approach and study design for evaluating incompatible maternal/offspring genotype combinations is unclear.

Methods

Using simulation, we estimated the type I error and power of incompatible maternal/offspring genotype models for two analytical approaches: logistic regression used with case-control mother/offspring pairs and the log-linear regression used with case-parent triads. We evaluated a real dataset consisting of maternal/offspring pairs with and without PE for incompatibility effects using the optimal analysis based …

Labrad : Vol 33, Issue 1 - January 2008, Aga Khan University Hospital, Karachi

LABRAD - Departments of Pathology & Laboratory Medicine and Radiology Archives

• Diagnosis of Malaria
• Imaging Feature of Synovial Sarcoma in Pediatrics Patients
• Fine Needle Aspiration Biopsy: The best test to differentiate benign from malignant thyroid nodules
• HLA-B27 and Disease Association
• Bacterial Contamination of Blood Components
• Pathology Quiz
• Biochemical Investigations
• Leishmaniasis
• Answers to Quiz
• CD55 and CD59 for the Diagnosis of PNH
• Meeting Report

Waiting For Child Developmental And Rehabilitation Services: An Overview Of Issues And Needs, Anton R. Miller, Robert Armstrong, Louise C. Mâsse, Anne F. Klassen, Jane Shen, Maureen E. O’Donnell

Paediatrics and Child Health, East Africa

Concern about the length of time that children, young people, and families may have to wait to access assessment, diagnostic, interventional, therapeutic, and supportive child developmental and rehabilitation (CDR) services is widespread, but adequate data collection and research on this issue remain limited. We review key concepts and issues relevant to waiting for CDR services from the published literature, a national workshop devoted to this topic, and international experience. We conclude that gaps in data, evidence, and consensus challenge our ability to address the issue of waiting for CDR services in a systematic way. A program of research coupled with …

Distinguishing Post-Treatment Changes From Recurrent Disease In Cholangiocarcinoma: A Case Report., Timothy N Showalter, A Omer Nawaz, Frederick M Fellin, Pramila R Anne, Ernest L Rosato, Adam P Dicker

Department of Radiation Oncology Faculty Papers

INTRODUCTION: Three-dimensional techniques for radiotherapy have expanded possibilities for partial volume liver radiotherapy. Characteristic, transient radiographic changes can occur in the absence of clinical radiation-induced liver disease after hepatic radiotherapy and must be distinguished from local recurrence. CASE PRESENTATION: In this report, we describe computed tomography changes after chemoradiotherapy for cholangiocarcinoma as an example of collaboration to determine the clinical significance of the radiographic finding. CONCLUSION: Because of improved three-dimensional, conformal radiotherapy techniques, consultation across disciplines may be necessary to interpret post-treatment imaging findings.

Tampons And Menstrual Hygiene Products, Shibani Kanungo, Hatim A. Omar

Obstetrics and Gynecology Faculty Publications

No abstract provided.

One-Year Treatment With Mometasone Furoate In Chronic Obstructive Pulmonary Disease, Peter M.A. Calverley, Stephen I. Rennard, Harold S. Nelson, Jill P. Karpel, Eduardo H. Abbate, Paul Stryszak, Heribert Staudinger

Journal Articles: Pulmonary & Critical Care Med

Many patients with chronic obstructive pulmonary disease (COPD) are treated with twice daily (BID) inhaled corticosteroids (ICS). This study evaluated whether daily PM mometasone furoate administered via a dry powder inhaler (MF-DPI) was equally effective compared to twice daily dosing.In a 52-week, randomized, double-blind, placebo-controlled study, 911 subjects with moderate-to-severe COPD managed without ICS received MF-DPI 800 microg QD PM, MF-DPI 400 microg BID, or placebo. The change from baseline in postbronchodilator forced expiratory volume in 1 second (FEV1), total COPD symptom scores, and health status as well as the percentage of subjects with a COPD exacerbation were assessed. Adverse …

Correlation Of Three Immunohistochemically Detected Markers Of Neuroendocrine Differentiation With Clinical Predictors Of Disease Progression In Prostate Cancer, Hammad Ather, Farhat Abbas, Nuzhat Faruqui, Mohammad Israr, Shahid Pervez

Section of Urology

Background: The importance of immuno-histological detection of neuroendocrine differentiation in prostatic adenocarcinoma with respect to disease at presentation and Gleason grade is gaining acceptance. There is limited literature on the relative significance of three commonly used markers of NE differentiation i.e. Chromogranin A (CgA), Neuron specific enolase (NSE) and Synaptophysin (Syn). In the current work we have assessed the correlation of immuno-histological detection of neuroendocrine differentiation in prostatic adenocarcinoma with respect to disease at presentation and Gleason grade and to determine the relative value of various markers.
Materials and Methods: Consecutive samples of malignant prostatic specimens (Transurethral resection of prostate …

Oncolog Volume 53, Number 11, November 2008, John Lebas, Sunni Hosemann

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Options for Malignant Pleural Mesothelioma
• House Call: Saying No to Smoking: When You Need More than Willpower
• Intermediate-Stage Bladder Cancer: Deciding on Preoperative Chemotherapy and Urinary Diversion

Oncolog Volume 53, Number 07/08, July/August 2008, John Lebas, Sunni Hosemann

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Multiple Myeloma: Increasing Response, Remission, and Survival Rates in a Complex Disease
• House Call: A Guide to Radiation Therapy
• In Brief: Researchers Enhance Anticancer Activity of Natural Killer Cells in Laboratory
• Beyond Images: Advances in Interventional Radiology
• Radioembolotherapy Using Yttrium 90

Oncolog Volume 53, Number 05, May 2008, John Lebas, Joe Munch, Alexander V. Prokhorov Md, Phd

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Hepatocellular Carcinoma: New Standards in Therapy Emerging
• House Call: When Diagnosis Meets Denial
• In Brief: Overweight, Obese Patients Fare Worse with Breast Cancer, Researchers Find
• DiaLog: ASPIRE to Stop Teen Smoking, by Alexander V. Prokhorov, MD, PhD, Project Director, ASPIRE, Professor, Department of Behavioral Science
• A Reverse Approach to Adrenal Gland Resection

Oncolog Volume 53, Number 03, March 2008, John Lebas, Gordon B. Mills Md, Phd

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• In Search of the Answer
• DiaLog: Mapping the Cancer Genome, by Gordon Mills, MD, PhD, Director, Kleberg Center for Molecular Markers, Chair, Department of Systems Biology
• House Call: The Basics of Biopsies

Oncolog Volume 53, Number 02, February 2008, Joe Munch, Diane Witter, Guillermo Garcia-Manero Md

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Assessing Symptom Burden in Cancer
• DiaLog: Making Headway in Hematology, by Guillermo Garcia-Manero, MD, Associate Professor, Department of Leukemia
• Helping Kids Make Smart Food Choices
• Expanding Therapy Options for Advanced Cancer

Oncolog Volume 51, Number 01, January 2006, Stephanie P. Deming, Diane Witter

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Fertility After Cancer
• Improving the Odds in Lung Cancer
• House Call: Understanding the Basics of Melanoma

Oncolog Volume 53, Number 06, June 2008, Karen Stuyck, Virginia M. Mohlere, David Stouter, David Jenkins

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Psychotherapy Extends Cancer Care Beyond the Physical
• House Call: Understanding How Cancer Spreads
• DiaLog: Teaming Spiritual and Medical Care, by Rev. David Stouter, Chaplain, Department of Chaplaincy and Pastoral Education, and Rev. David Jenkins, Director, Department of Chaplaincy and Pastoral Education
• Radical Trachelectomy: A Fertility-Sparing Option for Invasive Cervical Cancer

Oncolog Volume 53, Number 01, January 2008, John Lebas, Don Norwood

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Prostate Cancer: A Tale of Two Therapies
• In Brief: Newly Identified Gene May Stop Development of Lung Cancers
• House Call: What You Should Know About Male Cancers
• Making Headway Against Myeloproliferative Disorders

Oncolog Volume 53, Number 04, April 2008, Diane Witter, John Lebas, Sunni Hosemann

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Cancer as a Chronic Disease
• In Brief: Cancer-Promoting Protein in Ovarian Cancer May Be Stopped with RNA Liposome
• House Call: Caring for the Caregiver
• Barely Benign

Oncolog Volume 53, Number 09, September 2008, Maude Veech, Dawn Chalaire

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Deciphering Metastatic Colorectal Carcinoma
• House Call: Planning Ahead with Advance Directives
• A Child-Centered Approach to Anesthesia for Proton Therapy

Oncolog Volume 53, Number 10, October 2008, Joe Munch, Sunita Patterson

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Pancreatic Cancer: The Prognosis Is Changing
• Delivering “The Guardian of the Genome”
• House Call: “Seeing” Cancer from the Outside
• Catching Pancreatic Cancer Early

Digest Of The Philadelphia College Of Osteopathic Medicine (Winter 2008), Philadelphia College Of Osteopathic Medicine

Digest

The Winter 2008 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Opening Remarks
• PCOM Updates and Kudos
• Women in Medicine: A Legacy of Achievement
• Reflections from the Past
• Leaders in Academic Medicine
• Advocates of Women’s Health
• Physician Workforce Issues: Bridging the Gender Gap
• Specialties: Breaking Down Barriers
• Founders’ Day
• James H. Black, DO ’62, O.J. Snyder Memorial Medal
• Sallee Ann Eckler, PhD, (DO ’08), Mason W. Pressly Memorial Medal
• Harm Reduction Therapy
• Willing and Able to Make a Difference
• Class Notes
• In Memoriam
• My Turn Essay
• Alumni Weekend 2008
• PCOM Events

Sevoflurane Enhances Ethanol-Induced Cardiac Preconditioning Through Modulation Of Protein Kinase C, Mitochondrial Katp Channels, And Nitric Oxide Synthase, In Guinea Pig Hearts., Kazuhiro Kaneda, Masami Miyamae, Shingo Sugioka, Chika Okusa, Yoshitaka Inamura, Naochika Domae, Junichiro Kotani, Vincent M. Figueredo

Division of Cardiology Faculty Papers

BACKGROUND: Volatile anesthetics and regular ethanol consumption induce cardioprotection mimicking ischemic preconditioning. We investigated whether sevoflurane enhances ethanol preconditioning and whether inhibition of protein kinase C (PKC) and mitochondrial K(ATP) channels attenuated this enhanced cardioprotection. The effects of regular ethanol consumption on expression of inducible (iNOS) and endothelial (eNOS) nitric oxide synthase were determined. METHODS: Isolated perfused guinea pig hearts underwent 30-min global ischemia and 120-min reperfusion (Control: CTL). The ethanol group (EtOH) received 2.5% ethanol in their drinking water for 6 wk. Anesthetic preconditioning was elicited by 10-min exposure to sevoflurane (1 minimum alveolar anesthetic concentration; 2%) in ethanol …

Primary Drug Resistance To Antituberculous Drugs In Nwfp Pakistan, Arshad Javaid, Abdul Ghafoor, Abdul Rab, Anila Basit, Zia Ullah, Shaukat Ali, Afia Zafar, Rumina Hasan

Department of Pathology and Laboratory Medicine

Objective: To assess the prevalence of Primary drug resistance to Antituberculous drugs in NWFP
Method: A cross-sectional prevalence study was undertaken to evaluate the prevalence of drug resistance among new TB patients, using a non-probability convenience sampling methodology. Sample size was calculated according to the population and WHO's estimated incidence of smear positive tuberculosis in the province/country. Sputum samples were obtained from 122 newly diagnosed patients of pulmonary tuberculosis from centres in Peshawar and Abbotabad in NWFP.
Results: Sensitivities were performed by proportion method which showed the following resistance values in 118 eligible patients: 15 (12.7 %) …

Sensitization Of Ovarian Cancer Cells To Cisplatin By Genistein: The Role Of Nf-Kappab, Leigh A. Solomon, Shadan Ali, Sanjeev Banerjee, Adnan R. Munkarah, Robert T. Morris, Fazlul H. Sarkar

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Platinum-resistance (PR) continues to be a major problem in the management of epithelial ovarian cancer (EOC). Response to various chemotherapeutic agents is poor in patients deemed PR. Genistein, a soy isoflavone has been shown to enhance the effect of chemotherapy in prostate and pancreatic cancer cells in vitro and in vivo by reversing chemo-resistance phenotype. The goal of this study was to investigate the effects of combination therapy with genistein and cisplatin as well as other cytotoxic conventional chemotherapeutic agents in platinum-sensitive (PS) and resistant EOC cells.

Methods

The PS human ovarian cancer cell line A2780 and its …

A Stable Explant Culture Of Her2/Neu Invasive Carcinoma Supported By Alpha-Smooth Muscle Actin Expressing Stromal Cells To Evaluate Therapeutic Agents, Marie P. Piechocki

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

To gain a better understanding of the effects of therapeutic agents on the tumor microenvironment in invasive cancers, we developed a co-culture model from an invasive lobular carcinoma. Tumor cells expressing HER2/neu organize in nests surrounded by alpha-Smooth Muscle Actin (α-SMA) expressing tumor stroma to resemble the morphology of an invading tumor. This co-culture, Mammary Adenocarcinoma Model (MAM-1) maintains a 1:1 ratio of HER2/neu positive tumor cells to α-SMA-reactive stromal cells and renews this configuration for over 20 passages in vitro.

Methods

We characterized the cellular elements of the MAM-1 model by microarray analysis, and immunocytochemistry. We developed …

Functional Analysis Of Human Beta Defensin-1: Novel Insight Into Its Role In Prostate Cancer, Rebecca S. Bullard

MUSC Theses and Dissertations

Prostate cancer is the second leading cause of cancer-related deaths in men in the United States. The molecular pathogenesis of this disease includes genetic alterations, infection, and exposure to inflammatory or dietary oxidants. Recently, research has focused on the role of host defense peptides in tumor immunity. Defensins, a highly conserved multigene family of proteins that possess antimicrobial and antiviral properties, play an essential role in innate and adaptive immunity. These peptides are categorized into alpha- and beta-defensins based upon the spacing and connection between the six conserved cysteine residues of the mature peptide. Human Beta Defensin-1 (hBD-1), an important …

Physician Assistant Class Of 2008, Philadelphia College Of Osteopathic Medicine

All Yearbooks

Includes the White Coat Ceremony, Classroom candids, Class outings, Fall Retreat 2006, Halloween Party 2006, Christmas Party 2006, Clinical Skills Lab, PCOM Prom 2007, Powderpuff Football 2007, PA Olympics 2007, Senior Fridays.

The Impact Of Traumatic Stress And Alcohol Exposure On Youth: Implications For Lawyers, Judges, And Courts, Frank E. Vandervort

Articles

Since its inception in the late nineteenth century, the juvenile court has been concerned with the legal problems of children and their families. From the court’s earliest days, it has sought to address child abuse and neglect and juvenile delinquency as social problems that result from familial and community breakdown. Over the decades, researchers from various disciplines have provided varying explanations of how and why family systems break down, why some parents fail to nurture their children, why some physically or sexually abuse their children, and why some children become delinquent.

Bone Stress Injury Of The Ankle In Professional Ballet Dancers Seen On Mri., Ilan Elias, Adam C Zoga, Steven M Raikin, Judith R Peterson, Marcus P Besser, William B Morrison, Mark E Schweitzer

Department of Orthopaedic Surgery Faculty Papers

BACKGROUND: Ballet dancers have been shown to have a relatively high incidence of stress fractures of the foot and ankle. It was our objective to examine MR imaging patterns of bone marrow edema (BME) in the ankles of high performance professional ballet dancers, to evaluate clinical relevance. METHODS: MR Imaging was performed on 12 ankles of 11 active professional ballet dancers (6 female, 5 male; mean age 24 years, range 19 to 32). Individuals were imaged on a 0.2 T or 1.5 T MRI units. Images were evaluated by two musculoskeletal radiologists and one orthopaedic surgeon in consensus for location …

Focus On The Profession: Academic And Clinical Departments, Robert Armstrong

Paediatrics and Child Health, East Africa

The departments within the Faculty of Medicine at UBC play a central role in achieving the goals of the expanded medical school, and the goals of the broader health care system. Four strategies are needed for success: make professionalism the tie that binds the Faculty of Medicine and the health authorities; engage clinical and academic de­partments as key drivers of professionalism; ensure knowledge development and continuous learning are recognized as central to professionalism; challenge government to focus on supporting professionalism.

Obesity, Hypertension, And Mental Health Evaluation In Adolescents: A Comprehensive Approach, Stefan G. Kiessling, Kimberly K. Mcclanahan, Hatim A. Omar

Pediatrics Faculty Publications

The global epidemic of childhood and adolescent obesity in developing and developed countries has become a major public health concern. Given the relation between obesity and hypertension as documented in several landmark studies, it is no surprise that as the prevalence of obesity has increased in the pediatric population, the rates of hypertension have also increased substantially. Hypertension is one of the most important risk factors for cardiovascular diseases and stroke; therefore, evaluation and initiation of appropriate treatment are extremely important in the pediatric population. Evaluation for secondary causes of hypertension, including renovascular, renoparenchymal, and endocrine disease is the approach …