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Aga Khan University

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Articles 6871 - 6891 of 6891

Full-Text Articles in Medicine and Health Sciences

Clinical Features And Management Of Malignant Ascites, I Malik, S Abubakar, I Rizwana, F Alam, J Rizvi, A Khan Feb 1991

Clinical Features And Management Of Malignant Ascites, I Malik, S Abubakar, I Rizwana, F Alam, J Rizvi, A Khan

Section of Cardiology

Retrospective analysis of 45 patients (33 females, 12 males) with cytologically-proven malignant ascites is presented. Abdominal pain was the most frequent symptom (69%). Fiftythree percent cases had low serum albumin. Ascitic fluid was haemorrhagic or serosanguinous in 48% cases, in the rest it was clear or straw-coloured. Peritoneal effusion was exudative in 84% cases. Mean glucose content of ascitic fluid was 95 mg/dl and the mean white cell count of 919 cells/cmm. Vast majority (82%) of the cases had metastatic adenocarcinomas. Primary malignancy was mostly ovarian (47%) followed by non-Hodgkin's lymphoma (11%) and gall bladder carcinoma (9%). Primary site could …


The Undrained Brain: The Other Side Of The Foreign Medical Graduate Resident Issue, C M. Smythe Jan 1991

The Undrained Brain: The Other Side Of The Foreign Medical Graduate Resident Issue, C M. Smythe

Section of Neurology

No abstract provided.


Save A Life- Diagnose Subarachnoid Haemorrhage!, Rashid Jooma, Iqtidar H. Bhatti May 1990

Save A Life- Diagnose Subarachnoid Haemorrhage!, Rashid Jooma, Iqtidar H. Bhatti

Section of Neurosurgery

No abstract provided.


Extracorporeal Shock Wave Lithotripsy, Jamsheer J Talati Jan 1990

Extracorporeal Shock Wave Lithotripsy, Jamsheer J Talati

Section of Urology

After circumcision the first operations done on man were for bladder stone. Done by charlatans the operation often resulted in loss of life and caused the early lithotomists to maintain a peri­patetic existence, vanishing from the town the night after surgery was performed. About two centuries ago stones became a common disease amongst kings: surgeons took over from the charlatans and commenced blind skilful mechanical lithotripsy where a curved instrument was introduced per urethram, its jaws opened to engage the stone which was then crushed by a mechanical (screw driven) closure of the jaws. Now-a-days urinary bladder lithotripsy is done …


Serum Cholesterol In Neonates And Their Mothers. A Pilot Study, S.H. Badruddin, R. Lalani, Mohammad Khurshid, A. Molla, R. Qureshi, M.A. Khan Jan 1990

Serum Cholesterol In Neonates And Their Mothers. A Pilot Study, S.H. Badruddin, R. Lalani, Mohammad Khurshid, A. Molla, R. Qureshi, M.A. Khan

Department of Medicine

Reports from the Aga Khan University indicate that 58% of 400 school children studied had undesirably high serum cholesterol levels. The present study was undertaken to determine whether the high cholesterol levels are present at birth and to determine the relationship between cord blood, maternal blood cholesterol and maternal diet. Cord blood from 58 neonates and fasting venous blood form 45 mothers were analyzed for total serum cholesterol. Mothers were interviewed regarding their usual diet during pregnancy. Mean cord blood cholesterol was 56.90 mg/dl (range 26 to 123 mg/dI). Mean maternal blood cholesterol was 232.4mg/dl (range 141-382 mg/dl). Mean maternal …


Serum Alkaline Phosphatase In Apparently Healthy Karachi Population, Ayesha Molla, Rukhsana Lalani, Mohammad Khurshid, Anis Alam, William Wt. Manser Jan 1990

Serum Alkaline Phosphatase In Apparently Healthy Karachi Population, Ayesha Molla, Rukhsana Lalani, Mohammad Khurshid, Anis Alam, William Wt. Manser

Department of Pathology and Laboratory Medicine

Serum alkaline phosphatase (AP) was estimated in a total of 786(418 males and 386 females) apparently healthy people aged between 1-75 years selected randomly from a sample of the Karachi population. Reference ranges for AP level were obtained for the males and females stratified into ten successive age groups. The study population was also divided into two main age groups, a paediatric aged between 1-14 years and an adult group aged between 15 to over 50 years to see if the mean AP levels differ significantly between the two groups. Mean AP level for the male paediatric age group was …


Rubella Susceptibility And Continuing Risk Of Infection In Pregnancy, Saadiya Rasul, Mohammad Khurshid, Javaid Rizvi, Shahbanu Rizvi Jan 1990

Rubella Susceptibility And Continuing Risk Of Infection In Pregnancy, Saadiya Rasul, Mohammad Khurshid, Javaid Rizvi, Shahbanu Rizvi

Section of Haematology/Oncology

Sera of 2000 pregnant women attending the antenatal clinic of the Aga Khan University Hospital were tested for rubella antibodies. Of these 1684(84.2%) were Immune and 316(15.8%) were susceptible to rubella. Majority (99.8%) of the women were Asian in origin. Susceptibility decreased with increasing age and parity. We conclude that apart from vaccination of all young children greater attention should be paid to immunization of women of child-bearing age


Neonatal Screening For Congenital Hypothyroidism In Pakistan, Murntaz Lakhani, Mohammad Khurshid, Shehla H. Naqvi, Mohammad Akber Jan 1989

Neonatal Screening For Congenital Hypothyroidism In Pakistan, Murntaz Lakhani, Mohammad Khurshid, Shehla H. Naqvi, Mohammad Akber

Department of Paediatrics and Child Health

Congenital hypothyroidism is a preventable cause of mental retardation. Since clinical signs of congenital hypothyroidism do not generally become obvious before three months of age, screening programmes have been introduced in North America and Europe, which consist of T4 or TSH screening on newborn infants on the third day of life. The screening for congenital hypothyroidism was initiated in Pakistan by the Aga Khan University Hospital (AKUH) in March 1987. By April 1988, 5000 neonates were screened and five cases of congenital hypothyroidism were diagnosed. The study revealed the incidence of hypothyroidism to be one case per 1000 newborns which …


Local Anaesthetic Cream For The Alleviation Of Pain During Venepuncture In Tanzanian Schoolchidren, U. Hellgren, C.M. Kihamia, Zul Premji, K. Danielson Jan 1989

Local Anaesthetic Cream For The Alleviation Of Pain During Venepuncture In Tanzanian Schoolchidren, U. Hellgren, C.M. Kihamia, Zul Premji, K. Danielson

Pathology, East Africa

The analgesic effect and the usefulness of EMLA cream 5% in connection with venous blood-sampling was investigated in 42 Tanzanian schoolchildren. Approximately 2.5 g EMLA was applied to the right cubital fossa for a minimum of 120 min. The analgesic effect was pronounced - 93% of the venepunctures were pain-free and no child experienced severe pain. No adverse reactions were observed and the children could continue normal school work during the application time.


Efficacy Of A Home Made Quality Control Serum, Rukbsana Lalani, Ayesha Molla, Mohammad Khurshid Jan 1989

Efficacy Of A Home Made Quality Control Serum, Rukbsana Lalani, Ayesha Molla, Mohammad Khurshid

Section of Haematology/Oncology

With increasing automation in Clinical Laboratories, the requirements for quality control material have greatly increased in order to monitor performance. The constant use of commercial control material is not economically feasible for many countries because of non-availability or the high cost of these materials. Here we describe a simple technique to prepare Home Made Quality Control serum using blood from polycythaemic patients. This preparation is stable for about six months without any alterations in the concentration of any of the chemical constituents. Extensive use of Home Made Quality Control sera in our laboratories have saved about 69% of the amount …


Urinary Tract Infection, B J Farooqui, Mehboob Alam, Mohammad Khurshid Jan 1989

Urinary Tract Infection, B J Farooqui, Mehboob Alam, Mohammad Khurshid

Department of Pathology and Laboratory Medicine

Over two years, 9892 mid-stream urine samples from patients attending the Aga Khan University Hospital, Karachi were cultured. Significant bacterial growth was seen in 23.5% samples. Further iden­tification of these organisms Eevealed 40% of E.coli, 16% Pseudomonas aeruginosa, 11% Klebsiella aerogenes, 5.0% Enterobacter sp., 13% Protdus sp., 4.0% Serratia liquifaciens, 1.0% Acinetobacter sp., 3.0% Citrobacter sp., 4.0% Enterococci, 0.5% Staphylococcus aureus. Results of sensitivity tests performed with antibiotics Ampicillin, Cotrimoxa.zole, Nitrofurantoin, Nalidixic acid, Gentamicin, Amikacin, Pipemedic acid, Cefotaxime, Azactain and Carbenicillin did not reveal any distinct pattern


Epidemic Non-A Non-B Hepatitis In Urban Karachi, Pakistan, R A Jr Smego, A A. Khaliq May 1988

Epidemic Non-A Non-B Hepatitis In Urban Karachi, Pakistan, R A Jr Smego, A A. Khaliq

Section of Gastroenterology

An outbreak of icteric non-A non-B (NANB) hepatitis occurred in a residential community of urban Karachi, Pakistan, from August 1986 through October 1986. Of the 114 cases reported from this community during the 1986 calendar year, a clustering of 85 cases was seen during the above period. Twenty-seven percent of 226 households and 9% of 1,250 individuals were affected. Five persons were hospitalized and 1 death occurred in a young pregnant woman. Cases occurred predominantly in the less than or equal to 29-year-old age group (72%), with a male:female ratio of 1.8:1. Thirty-four cases occurred singly within households, while in …


Nutritional Parameters Predicting Postoperative Infections, Jamsheer Talati, M. Shameem, Mohammad Khurshid Jan 1988

Nutritional Parameters Predicting Postoperative Infections, Jamsheer Talati, M. Shameem, Mohammad Khurshid

Department of Surgery

Thirteen nutritional parameters viz body mass index (BMI), mid arm circumference (MAC), mid calf circumference (MCC), triceps skin fold thickness (TST), abdominal skin fold thickness (ASFT), abdominal girth at umbilicus (AG U), haemoglobin (Hb), total leucocytes count (WBC), absolute lymphocyte count (ALC), serum proteins (Prot.), serum albumin (AIb), serum total iron binding capacity (TIBC) and serum iron (Fe) were estimated in 52 (36 male and 16 female) consecutive patients admitted to a surgical service at the Abbasi Shaheed Hospital, Karachi. Nine males and one female developed surgical infections whilst the wounds of 27 males and 15 females healed by primary …


Anaemia In Pregnancy: Occurrence In Two Economically Different Clinic Populations Of Karachi, Saadiya Aziz Karim, Mohammad Khurshid, Javed H. Rizvi Jan 1988

Anaemia In Pregnancy: Occurrence In Two Economically Different Clinic Populations Of Karachi, Saadiya Aziz Karim, Mohammad Khurshid, Javed H. Rizvi

Section of Haematology/Oncology

According to previous WHO standards, anaemia in pregnancy denoted a haemoglobin level of 11.0 gms/dl or less, but this is now considered to be variable1 as it differs from country to country depending on local reference ranges and socio-economic conditions. Each country should “lay down minimal acceptable standards” below which an individual is considered to be anaemic, taking into account the available fmancial and manpower resources and other health needs of the country2. There is a wide divergence in the quoted prevalence of anaemia in Pakistan and neigh­bouring countries.3-6 This study was undertaken to determine a …


Efficacy Of Internal And External Quality Control In Chemical Pathology, Rukhsana Lalani, Mirza Naqi Zafar, Mohammad Khurshid Jan 1988

Efficacy Of Internal And External Quality Control In Chemical Pathology, Rukhsana Lalani, Mirza Naqi Zafar, Mohammad Khurshid

Department of Pathology and Laboratory Medicine

Quality control in chemical pathology is based on internal and external quality assessment. The internal quality control in clinical chemistry section of AKUH laboratory is based on the analysis of commercially available Beckman norma! and abnormal range control sera. These have known concentra­tions of blood chemistry constituents. After repeated estimations, mean values of all constituents were established for both normal and abnormal sera. Patients samples were analysed only when both controls were within ± 2SD from the mean or one control reads within ± 2SD and the other read between ± 2—3SD (once only) for each constituent. Samples were not …


Dexamethasone And The Serious Head Injury, Rashid Jooma Jan 1987

Dexamethasone And The Serious Head Injury, Rashid Jooma

Section of Neurosurgery

No abstract provided.


Intracranial Tumour In An Infant Presenting As Iron Deficiency Anaemia, Rashid Jooma, D N. Grant Mar 1984

Intracranial Tumour In An Infant Presenting As Iron Deficiency Anaemia, Rashid Jooma, D N. Grant

Section of Neurosurgery

No abstract provided.


Spinal Disease Presenting As Acute Abdominal Pain, M J. Torrens, Rashid Jooma Aug 1983

Spinal Disease Presenting As Acute Abdominal Pain, M J. Torrens, Rashid Jooma

Section of Neurosurgery

No abstract provided.


Spinal Disease Presenting As Acute Abdominal Pain: Report Of Two Cases, Rashid Jooma, M J. Torrens, R J. Veerapen, H B. Griffith Jul 1983

Spinal Disease Presenting As Acute Abdominal Pain: Report Of Two Cases, Rashid Jooma, M J. Torrens, R J. Veerapen, H B. Griffith

Section of Neurosurgery

No abstract provided.


The Influence Of Electrical Stimulation Of The Leg During Surgical Operations On The Subsequent Development Of Deep-Vein Thrombosis, L R Dejode, Mohammad Khurshid, W W Walther Jan 1973

The Influence Of Electrical Stimulation Of The Leg During Surgical Operations On The Subsequent Development Of Deep-Vein Thrombosis, L R Dejode, Mohammad Khurshid, W W Walther

Section of Haematology/Oncology

The effect of galvanic stimulation of the calf muscles during surgical operations on the development of postoperative deep-vein thrombosis was assessed using 125I fibrinogen in 64 patients over 40 years of age undergoing major surgery. Alternate legs were stimulated in alternate patients using the opposite leg as a control. No significant difference in the incidence of deep-vein thrombosis was observed either in the immediate postoperative period or later.


Proptosis Of Eye: An Atypical Presentation Of Prostatic Malignancy., Amna Amjad, Asif Husain Osmani, Ghulam H Mar 205

Proptosis Of Eye: An Atypical Presentation Of Prostatic Malignancy., Amna Amjad, Asif Husain Osmani, Ghulam H

Section of Pulmonary & Critical Care

Orbital metastasis is a rare occurrence found only in about 3 - 10% of all prostate cancers. A 72 years male presented with proptosis of the left eye associated with pain, blurred vision and frequent headaches for the past 8 months. Past medical history had symptoms of bladder outflow obstruction for 3 years. MRI brain and orbit with contrast was consistent with a large soft tissue mass in the left frontal region. The mass was surgically excised in order to achieve palliation. Histopathology revealed poorly differentiated malignant neoplasm with immunohistochemistry favoring metastatic prostate carcinoma. Postoperative radiotherapy was administered with a …