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Articles 43411 - 43440 of 45149

Full-Text Articles in Medicine and Health Sciences

Prevalence Of Asthma And Asthma-Like And Allergic Symptoms In The Urban Adult Population Of Elazığ, Tuncer Tuğ, Yasemi̇n Açik, Esra Tuğ Jan 2002

Prevalence Of Asthma And Asthma-Like And Allergic Symptoms In The Urban Adult Population Of Elazığ, Tuncer Tuğ, Yasemi̇n Açik, Esra Tuğ

Turkish Journal of Medical Sciences

The aim of this study was to determine the prevalence of asthma, asthma-like symptoms and atopy in the adult population of the city of Elazığ. A specific questionnaire, adopted from the European Community Respiratory Health Survey including social status and smoking tendencies of people was filled in by 2454 randomly chosen (1088 male, 1366 female) subjects. The cumulative prevalence of asthma and asthma-like symptoms for males, females and the general population was 22.0%, 28.7%, and 25.7%, respectively. The periodic prevalences of them were 17.3%, 20.5%, and 19.1%, while rates of previously diagnosed asthma were 2.6%, 3.5%, and 3.1%. Subjects suffering …

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A Simple Comparison Between Simultaneous Kidney-Pancreas (Skptx) And Kidney-Alone (Ktx) Transplants In Type I Diabetic Nephropaty, Tanju Acar, Arshad Mahmood Jan 2002

A Simple Comparison Between Simultaneous Kidney-Pancreas (Skptx) And Kidney-Alone (Ktx) Transplants In Type I Diabetic Nephropaty, Tanju Acar, Arshad Mahmood

Turkish Journal of Medical Sciences

Simultaneous kidney-pancreas transplantation (SKPtx) is an established procedure at many transplant centres for the treatment of end-stage renal disease from type I diabetes mellitus. A successful transplant normalises glucose metabolism and may prevent or reverse some of the complications of diabetes. Concerning graft survival and morbidity rates, the usefulness of this procedure is still questioned by some authors (1,2). We undertook a retrospective study to investigate the differences between survival rates of SKPtx and kidney alone transplant (Ktx) recipients.We also evaluated morbidity rates and complications in both groups. There were no significant differences in 12 and 36 month survival rates. …

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Prenatal Diagnosis Of Thanatophoric Dysplasia In Second Trimester, Hali̇l Aslan, Volkan Ülker, Necla Ülker, Nesli̇han Yerebasmaz, Cemal Ark Jan 2002

Prenatal Diagnosis Of Thanatophoric Dysplasia In Second Trimester, Hali̇l Aslan, Volkan Ülker, Necla Ülker, Nesli̇han Yerebasmaz, Cemal Ark

Turkish Journal of Medical Sciences

LAN Volkan ÜLKER Necla ÜLKER Neslihan YEREBASMAZ Cemal ARK Department of Perinatology, SSK Bakırköy Maternity and Children Hospital, İstanbul, Turkey

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Maxillary Sinus Aplasia, Murat Baykara, Nuri̇ Erdoğan, Mustafa Öztürk, Mustafa Erkan Jan 2002

Maxillary Sinus Aplasia, Murat Baykara, Nuri̇ Erdoğan, Mustafa Öztürk, Mustafa Erkan

Turkish Journal of Medical Sciences

YKARA^1 Nuri ERDOĞAN^1 Mustafa ÖZTÜRK^1 Mustafa ERKAN^2 Departments of ^1Radiology, ^2Otorhinolaryngology, Faculty of Medicine, Erciyes University, Kayseri - Turkey

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Gene Therapy In Human Breast Cancer, Ogan D. Abaan, Wayne E. Criss Jan 2002

Gene Therapy In Human Breast Cancer, Ogan D. Abaan, Wayne E. Criss

Turkish Journal of Medical Sciences

Gene therapy, being a novel treatment for many diseases, is readily applicable for the treatment of cancer patients. Breast cancer is the most common cancer among women. There are many clinical protocols for the treatment of breast cancer, and gene therapy is now being considered within current protocols. This review will focus on the basic concepts of cancer gene therapy strategies (suicide gene, tumor suppressor gene, anti-angiogenesis, immunotherapy, oncolytic viruses and ribozyme/antisense targeting) and current approaches for breast cancer gene therapies.

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The Effects Of Fenthion On Lipid Peroxidation And Some Liver Enzymes: The Possible Protective Role Of Vitamins E And C, İrfan Altuntaş, Namik Deli̇baş Jan 2002

The Effects Of Fenthion On Lipid Peroxidation And Some Liver Enzymes: The Possible Protective Role Of Vitamins E And C, İrfan Altuntaş, Namik Deli̇baş

Turkish Journal of Medical Sciences

The effects of fenthion on the serum activities of cholinesterase (ChE), enzymes concerning liver damage and lipid peroxidation (LPO), and the ameliorating effects of a combination of vitamins E and C against fenthion toxicity were investigated. The results of the in vivo experiment showed that fenthion caused a significant increase in LPO and the activities of aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyltransferase (GGT) and lactate dehydrogenase (LDH), and a significant decrease in the activities of ChE and alanine aminotransferase (ALT). In addition, treatment with a combination of vitamins E and C led to a significant decrease in LPO and …

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Behaviours And Attitudes Of Medical Students Towards Smoking, Rezan Demi̇ralay Jan 2002

Behaviours And Attitudes Of Medical Students Towards Smoking, Rezan Demi̇ralay

Turkish Journal of Medical Sciences

This study was carried out to assess the behaviours and attitudes of medical students towards smoking and perceptions of their future role in this matter as doctors. For this purpose, a questionnaire was given to 215 medical students enrolled in the Faculty of Medicine of Süleyman Demirel University in Isparta, Turkey, during the 2000-2001 session. Of the students, 106 (49.3%) had never smoked and 17 (7.9%) were former smokers. Of the 92 (42.8%) students who had smoked for at least six months in their lifetime, 11 (12.0%) were ex-smokers. Of the current smokers, 61 (75.3%) were daily smokers and 20 …

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Chronic Recurrent Appendicitis In Children: An Insidious And Neglected Cause Of Surgical Abdomen, Fati̇h Andiran, Sabri̇ye Dayi, Muzaffer Çaydere, Hüseyi̇n Üstün Jan 2002

Chronic Recurrent Appendicitis In Children: An Insidious And Neglected Cause Of Surgical Abdomen, Fati̇h Andiran, Sabri̇ye Dayi, Muzaffer Çaydere, Hüseyi̇n Üstün

Turkish Journal of Medical Sciences

In addition to the familiar acute inflammation of the appendix, chronic inflammation has long been a controversial disease entity. However, some recent reports announced that chronic recurrent appendicitis is by no means an established disease of the appendix. Therefore, we reviewed our appendectomies in children to determine the underestimated cases of chronic recurrent appendicitis and discuss this disease entity in children. The records of children who had undergone appendectomy upon initial clinical diagnosis of appendicitis were reviewed for a period of 42 months. Incidental appendectomies were excluded. The diagnoses of acute appendicitis, negative explorations and chronic recurrent appendicitis were made …

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Necrotizing Sialometaplasia Report Of Five Cases Including Uncommon Localizations, Uğur Pabuççuoğlu, Esra Özkara, Sülen Sarioğlu Jan 2002

Necrotizing Sialometaplasia Report Of Five Cases Including Uncommon Localizations, Uğur Pabuççuoğlu, Esra Özkara, Sülen Sarioğlu

Turkish Journal of Medical Sciences

UÇÇUOĞLU Esra ÖZKARA Sülen SARIOĞLU Department of Pathology, Faculty of Medicine, Dokuz Eylül University, İnciraltı, İzmir - Turkey

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Characterization Of Berberine On Human Cancer Cells In Culture, Savio Szeto, Christine Miu Ngan Yow, Ka Wah Fung Jan 2002

Characterization Of Berberine On Human Cancer Cells In Culture, Savio Szeto, Christine Miu Ngan Yow, Ka Wah Fung

Turkish Journal of Medical Sciences

Berberine originates from a Chinese herbal medicine and possesses a wide variety of anti-cancer activities. In this study, the killing effect of berberine on nasopharyngeal carcinoma cells (NPC/HK1) was investigated. The trypan blue exclusion assay was used to assess the cytotoxic effect of berberine in this cell line. Berberine, at 5-200 µM, induced cell death in a dose-dependent manner. Treatment of cells with 200 µM berberine for 5 h yielded a lethal dose of 50% (LD50). The Comet Assay was employed to evaluate the extent of DNA damage and repair after berberine treatment (0 -100 µM). DNA damage was evident …

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A Comparative Study Of The Clinical Aspects And Relationship Between Fractures Of Mandibular Angle And The Presence Of A Lower Third Molar, Mehmet Yaltirik, Cem Rüştü Tanyel, Bülent Kati̇poğlu Jan 2002

A Comparative Study Of The Clinical Aspects And Relationship Between Fractures Of Mandibular Angle And The Presence Of A Lower Third Molar, Mehmet Yaltirik, Cem Rüştü Tanyel, Bülent Kati̇poğlu

Turkish Journal of Medical Sciences

Several authors have reported that the presence of teeth may be one of the determinants of mandibular fractures. Fracture of the jaw plays an important role in the practice of the oral surgeon. A number of factors contribute to the strength of the mandible. These include presence of active and strong musculature, the shape and thickness of the bone, and the presence or absence of teeth. The Deparment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Istanbul University, managed 100 patients with mandibular factures between 1991 and 1999. The male to female ratio was 5.25/1 and the majority of patients …

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Individual Cdr3 Regions As Targets For Detection Of Clonal Cells In Acute Lymphocytic Leukemia, Hakan Savli Jan 2002

Individual Cdr3 Regions As Targets For Detection Of Clonal Cells In Acute Lymphocytic Leukemia, Hakan Savli

Turkish Journal of Medical Sciences

VLI University of Helsinki Transplantation Laboratory, Bone Marrow Transplantation Research Team, Helsinki - FINLAND

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Rate-Dependent Effects Of Dofetilide On Epicardial Monophasic Action Potentials In Isolated Rabbit Heart With Atrial Pacing, Mustafa Özbek, Şule Gök Jan 2002

Rate-Dependent Effects Of Dofetilide On Epicardial Monophasic Action Potentials In Isolated Rabbit Heart With Atrial Pacing, Mustafa Özbek, Şule Gök

Turkish Journal of Medical Sciences

Dofetilide (UK 68,798), a new antiarrhythmic agent, blocks potassium channels selectively and acts primarily by prolonging repolarization duration. The aim of this study was to investigate rate-dependent repolarization changes due to dofetilide in a fast beating in-vitro heart model. The study was designed using Langendorff perfusion of rabbit hearts at the drug concentrations of 1 nM, 3 nM and 10 nM. The electrophysiological evaluations were performed using the recording of epicardial monophasic action potentials. Atrial pacing was set at the cycle length (ms) of 300, 325, 350, 375 and 400 so that repolarization duration could be measured in different heart …

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Colicinogeny, Lipopolysaccharide And Outer Membrane Protein Profiles Of Multi-Drug Resistant Salmonella Typhimurium Isolates From Turkey, Göksu Elpek, Bülent İçgen, Gülay Özcengi̇z Jan 2002

Colicinogeny, Lipopolysaccharide And Outer Membrane Protein Profiles Of Multi-Drug Resistant Salmonella Typhimurium Isolates From Turkey, Göksu Elpek, Bülent İçgen, Gülay Özcengi̇z

Turkish Journal of Medical Sciences

A total of 259 clinical isolates of non-repetitive non-typhi salmonellae (NTS) were previously examined for their antibiotic resistance patterns and plasmid contents. Multi-drug resistant strains comprised 19.3% (50/259) of the isolates and almost all were Salmonella typhimurium. In the present study, 35 of these multi-drug resistant S. typhimurium isolates were further characterized for colicinogeny, lipopolysaccharide (LPS) and outer membrane protein (OMP) profiles. Fourteen of the 35 (40%) isolates were found to be colicin producers. All isolates showed smooth-type LPS. In 26 of the (74.3%) isolates, OMPs of 30.6 and 34.6 kDa were observed whereas three (8.6%) of them were found …

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Clinical Evaluation Of The Fastplaquetb For The Rapid Diagnosis Of Pulmonary Tuberculosis, Cengi̇z Çavuşoğlu, Sevi̇nç Güneri̇, Mutay Suntur, Altinay Bi̇lgi̇ç Jan 2002

Clinical Evaluation Of The Fastplaquetb For The Rapid Diagnosis Of Pulmonary Tuberculosis, Cengi̇z Çavuşoğlu, Sevi̇nç Güneri̇, Mutay Suntur, Altinay Bi̇lgi̇ç

Turkish Journal of Medical Sciences

The reliability of the FASTPlaqueTB (FPTB) test (Biotec Ltd.) for the rapid diagnosis of pulmonary tuberculosis was evaluated and its diagnostic performance was compared with the Amplified Mycobacterium Tuberculosis Direct (MTD) test (Gen-Probe) by testing 80 sputum samples obtained from 77 patients. The results were compared to those of mycobacterial culture, smear and clinical course. After a chart review 14 culture-negative patients who had been on antituberculosis therapy before the study began were excluded from the final analysis. Of the remaining 63 patients, 33 were considered to have tuberculosis; 29 of them were both smear and culture positive, for whom …

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Penetrating Cardiac Injuries, Ahmet Özyazicioğlu, Azman Ateş, Münacetti̇n Cevi̇z, Sami̇ Karapolat, Engi̇n Bozkurt, Hi̇kmet Koçak Jan 2002

Penetrating Cardiac Injuries, Ahmet Özyazicioğlu, Azman Ateş, Münacetti̇n Cevi̇z, Sami̇ Karapolat, Engi̇n Bozkurt, Hi̇kmet Koçak

Turkish Journal of Medical Sciences

Objectives: To present our experience of penetrating cardiac injuries treated at Atatürk University hospital; in 17 years 38 patients were analyzed. Methods: Patients were classified into three groups: group A (stable), 12; group B (shock), 21; and group C (agonal), five. Five patients were treated by pericardial window and three by pericardiocentesis. Two patients in group C, 19 patients in group B and five patients in group A underwent median sternotomy or thoracotomy in the operating room. Emergency room thoracotomies were performed in four patients. Results: There were 12 patients in group A, of which 11 survived (92 %). Of …

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Maternal Serum 25-Hydroxycholecalciferol Levels In The Third Trimester Of Pregnancy, Şi̇nasi̇ Özsoylu Jan 2002

Maternal Serum 25-Hydroxycholecalciferol Levels In The Third Trimester Of Pregnancy, Şi̇nasi̇ Özsoylu

Turkish Journal of Medical Sciences

No abstract provided.

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Genes Encoding Several Poly (Adp-Ribose) Glycohydrolase (Parg) Enzymes, The Proteins And Fragments Thereof, And Antibodies Immnoreactive Therewith, Myron Jacobson, Elaine L. Jacobson, Jean-Christoph Amé, Winston Lin Dec 2001

Genes Encoding Several Poly (Adp-Ribose) Glycohydrolase (Parg) Enzymes, The Proteins And Fragments Thereof, And Antibodies Immnoreactive Therewith, Myron Jacobson, Elaine L. Jacobson, Jean-Christoph Amé, Winston Lin

Graduate Center for Nutritional Sciences Faculty Patents

The isolation and characterization of cDNAs encoding poly(ADP-ribose) glycohydrolase (PARG) enzymes and the amino acid sequences of PARGs from several species are described. PARG is involved in the cellular response to DNA damage and its proper function is associated with the body's response to neoplastic disorder inducing agents and oxidative stress. Expression vectors containing the cDNAs and cells transformed with the vectors are described. Probes and primers that hybridize with the cDNAs are described. Expression of the cDNA in E. coli results in an enzymatically active protein of about 111 kDa and an active fragment of about 59 kDa. Methods …

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Vdac-Dependent Permeabilization Of The Outer Mitochondrial Membrane By Superoxide Induces Rapid And Massive Cytochrome C Release., M Madesh, György Hajnóczky Dec 2001

Vdac-Dependent Permeabilization Of The Outer Mitochondrial Membrane By Superoxide Induces Rapid And Massive Cytochrome C Release., M Madesh, György Hajnóczky

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Enhanced formation of reactive oxygen species (ROS), superoxide (O2*-), and hydrogen peroxide (H2O2) may result in either apoptosis or other forms of cell death. Here, we studied the mechanisms underlying activation of the apoptotic machinery by ROS. Exposure of permeabilized HepG2 cells to O2*- elicited rapid and massive cytochrome c release (CCR), whereas H2O2 failed to induce any release. Both O2*- and H2O2 promoted activation of the mitochondrial permeability transition pore by Ca2+, but Ca2+-dependent pore opening was not required for O2*--induced CCR. Furthermore, O2*- alone evoked CCR without damage of the inner mitochondrial membrane barrier, as mitochondrial membrane potential …

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A Pdz-Binding Motif Is Essential But Not Sufficient To Localize The C Terminus Of Cftr To The Apical Membrane, Michal I. Milewski, John E. Mickle, John K. Forrest, Diane M. Stafford, Bryan D. Moyer, Jie Cheng, William B. Guggino, Bruce A. Stanton, Garry R. Cutting Dec 2001

A Pdz-Binding Motif Is Essential But Not Sufficient To Localize The C Terminus Of Cftr To The Apical Membrane, Michal I. Milewski, John E. Mickle, John K. Forrest, Diane M. Stafford, Bryan D. Moyer, Jie Cheng, William B. Guggino, Bruce A. Stanton, Garry R. Cutting

Dartmouth Scholarship

Localization of ion channels and transporters to the correct membrane of polarized epithelia is important for vectorial ion movement. Prior studies have shown that the cytoplasmic carboxyl terminus of the cystic fibrosis transmembrane conductance regulator (CFTR) is involved in the apical localization of this protein. Here we show that the C-terminal tail alone, or when fused to the green fluorescent protein (GFP), can localize to the apical plasma membrane, despite the absence of transmembrane domains. Co-expression of the C terminus with full-length CFTR results in redistribution of CFTR from apical to basolateral membranes, indicating that both proteins interact with the …

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Analysis Of Mitotic Microtubule-Associated Proteins Using Mass Spectrometry Identifies Astrin, A Spindle-Associated Protein, Gary J. Mack, Duane A. Compton Dec 2001

Analysis Of Mitotic Microtubule-Associated Proteins Using Mass Spectrometry Identifies Astrin, A Spindle-Associated Protein, Gary J. Mack, Duane A. Compton

Dartmouth Scholarship

We purified microtubules from a mammalian mitotic extract and obtained an amino acid sequence from each microtubule-associated protein by using mass spectrometry. Most of these proteins are known spindle-associated components with essential functional roles in spindle organization. We generated antibodies against a protein identified in this collection and refer to it as astrin because of its association with astral microtubule arrays assembled in vitro. Astrin is approximately 134 kDa, and except for a large predicted coiled-coil domain in its C-terminal region it lacks any known functional motifs. Astrin associates with spindle microtubules as early as prophase where it concentrates at …

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Genetic Dissection Of Behavioral And Neurogenomic Responses To Acute Ethanol, Aaron Wolen Dec 2001

Genetic Dissection Of Behavioral And Neurogenomic Responses To Acute Ethanol, Aaron Wolen

Theses and Dissertations

Individual differences in initial sensitivity to ethanol are strongly related to the heritable risk of alcoholism in humans. To elucidate key molecular networks that modulate ethanol sensitivity we performed a systems genetics analysis of ethanol-responsive gene expression in brain regions of the mesocorticolimbic reward circuit (prefrontal cortex, nucleus accumbens and ventral midbrain) across the BXD RI panel, a highly diverse family of isogenic mouse strains before and after treatment with ethanol. Acute ethanol altered the expression of ~2,750 genes in one or more regions and 400 transcripts were jointly modulated in all three. Ethanol-responsive gene networks were extracted with a …

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Inheritance Of Dorsal Fin Coloration In The Metriaclima Species Complex (Teleostei: Cichlidae) Of Lake Malawi, Paulette Reneau Dec 2001

Inheritance Of Dorsal Fin Coloration In The Metriaclima Species Complex (Teleostei: Cichlidae) Of Lake Malawi, Paulette Reneau

Masters Theses & Specialist Projects

The rock-dwelling cichlids (mbuna) of Lake Malawi have undergone an explosive evolution, giving rise to an assemblage of 300-500 species within the last one million years. Most widespread mbuna 'species' are characterized by the presence of local endemic populations, differing primarily in coloration and often of uncertain taxonomic rank. The recency and rapidity of speciation within the mbuna have led to difficulties in reconstructing an accurate species-level phylogeny, in turn limiting our ability to elucidate the evolutionary dynamics associated with divergence of coloration and other characters. Based on morphometric and meristic characters, Stauffer et al. (1997) erected a new genus …

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The Effect Of Lead Acetate On The Susceptibility Of C3heb/Fej Mice Infected With The Parasite Trypanosoma Cruzi, Savonna Warren Dec 2001

The Effect Of Lead Acetate On The Susceptibility Of C3heb/Fej Mice Infected With The Parasite Trypanosoma Cruzi, Savonna Warren

Masters Theses & Specialist Projects

Lead has been mined by man for centuries with evidence of its use dating back 6000 years. Chronic exposure to lead can result in encephalopathy, anemia, and nephropathy. Today, cases of lead poisoning are uncommon; however, lead continues to be incorporated into the body through subclinical exposures. These low dosages of lead have been shown to have a deleterious effect on the immune system. Experimental animals exposed to low levels of lead are unable to effectively respond to a number of bacterial and viral challenges. The present study focuses on the relationship between lead and parasitic infection. Parasitemia, mortality, serum …

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Expression Of Gus Gene In Tobacco (Nicotiana Tabacum) And Corn (Zea Mays) Using Dimboa-Resistant Agrobacterium Strains, Deepti Mohamalawari Dec 2001

Expression Of Gus Gene In Tobacco (Nicotiana Tabacum) And Corn (Zea Mays) Using Dimboa-Resistant Agrobacterium Strains, Deepti Mohamalawari

Masters Theses & Specialist Projects

This thesis evaluates the ability of Agrobacterium tumefaciens strains resistant to the compound DIMBOA [2, 4-dihydroxy-7-methoxy-2h-l,4- benzoxazin-3(4H)-one] to infect corn. DIMBOA is a secondary plant metabolite and is believed to have antimicrobial properties and provides resistance to the plant against microbial infection. Agrobacteriummediated genetic transformation technique can be employed to genetically alter most dicotyledonous plant species. However, such transformation has been limited in monocotyledonous plants, especially corn. One of the factors responsible for this recalcitrance is the presence of DIMBOA in corn shoots. In this study, we proposed the use of DIMBOA- resistant strains of Agrobacterium tumefaciens, bearing binary plasmids …

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Effects Of Antioxidant Supplementation With Vitamin E And Selenium On Cytokine Production In Mice Infected With Trypanosoma Cruzi, Dong Chen Dec 2001

Effects Of Antioxidant Supplementation With Vitamin E And Selenium On Cytokine Production In Mice Infected With Trypanosoma Cruzi, Dong Chen

Masters Theses & Specialist Projects

Dietary supplementation with the antioxidants vitamin E and selenium (Se) has been shown to be beneficial against the intracellular parasite Trypanosoma cruzi during experimental Chagas' disease. Supplementation of mice with vitamin E and selenium at levels well above the recommended daily allowance for these two substances results in significantly decreased parasitemia levels and increased longevity. However, the mechanistic role of the antioxidants in this process is not well understood. It is known that vitamin E and selenium can reduce oxidative stress and improve host immune responses. In addition, the synthesis of many regulatory cytokines is known to be influenced by …

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Can Meaningful Effective Connectivities Be Obtained Between Auditory Cortical Regions?, M S Gonçalves, D A Hall, Ingrid Johnsrude, M P Haggard Dec 2001

Can Meaningful Effective Connectivities Be Obtained Between Auditory Cortical Regions?, M S Gonçalves, D A Hall, Ingrid Johnsrude, M P Haggard

Brain and Mind Institute Researchers' Publications

Structural equation modeling (SEM) of neuroimaging data can be evaluated both for the goodness of fit of the model and for the strength of path coefficients (as an index of effective connectivity). SEM of auditory fMRI data is made difficult by the necessary sparse temporal sampling of the time series (to avoid contamination of auditory activation by the response to scanner noise) and by the paucity of well-defined anatomical information to constrain the functional model. We used SEM (i.e., a model incorporating latent variables) to investigate how well fMRI data in four adjacent cortical fields can be described as an …

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Dextran-Methylprednisolone Succinate As A Prodrug Of Methylprednisolone: Plasma And Tissue Disposition, Xiaoping Zhang, Reza Mehvar Dec 2001

Dextran-Methylprednisolone Succinate As A Prodrug Of Methylprednisolone: Plasma And Tissue Disposition, Xiaoping Zhang, Reza Mehvar

Pharmacy Faculty Articles and Research

Plasma and tissue disposition of a macromolecular prodrug of methylprednisolone (MP), dextran (70 kDa)–methylprednisolone succinate (DMP), was studied in rats. Single 5‐mg/kg doses of DMP or unconjugated MP were administered into the tail veins of different groups of rats (n  = 4/group/time point). Blood (cardiac puncture) and tissues (liver, spleen, kidney, heart, lung, thymus, and brain) were collected at various times after DMP (0–96 h) or MP (0–2 h) injections. Concentrations of DMP and MP in samples were analyzed by size‐exclusion chromatography (SEC) and reversed‐phase high‐performance liquid chromatography (HPLC), respectively. Conjugation of MP with 70‐kDa dextran resulted in 22‐, …

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Evaluation Of Cholera Vaccines Formulated With Toxin-Coregulated Pilin Peptide Plus Polymer Adjuvant In Mice, Jia-Yan Wu, William F. Wade, Ronald K. Taylor Dec 2001

Evaluation Of Cholera Vaccines Formulated With Toxin-Coregulated Pilin Peptide Plus Polymer Adjuvant In Mice, Jia-Yan Wu, William F. Wade, Ronald K. Taylor

Dartmouth Scholarship

Cholera is an acute diarrheal disease that is caused by the gram-negative bacterium Vibrio cholerae. The low efficacy of currently available killed-whole-cell vaccines and the reactinogenicity coupled with potential reversion of live vaccines have thus far precluded widespread vaccination for the control of cholera. Recent studies on the molecular nature of the virulence components that contribute to V. cholerae pathogenesis have provided insights into possible approaches for the development of a defined subunit cholera vaccine. Genetic analysis has demonstrated that the toxin-coregulated pilus (TCP) is the major factor that contributes to colonization of the human intestine by V. cholerae. In …

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Immune Response Genes Modulate Serologic Responses To Vibrio Cholerae Tcpa Pilin Peptides, Michael D. Meeks, Terri K. Wade, Ronald K. Taylor, William F. Wade Dec 2001

Immune Response Genes Modulate Serologic Responses To Vibrio Cholerae Tcpa Pilin Peptides, Michael D. Meeks, Terri K. Wade, Ronald K. Taylor, William F. Wade

Dartmouth Scholarship

Cholera is an enteric disease caused by Vibrio cholerae. Toxin-coregulated pilus (TCP), a type 4 pilus expressed by V. cholerae, is a cholera virulence factor that is required for host colonization. The TCP polymer is composed of subunits of TcpA pilin. Antibodies directed against TcpA are protective in animal models of cholera. While natural or recombinant forms of TcpA are difficult to purify to homogeneity, it is anticipated that synthesized TcpA peptides might serve as immunogens in a subunit vaccine. We wanted to assess the potential for effects of the immune response (Ir) gene that could complicate a peptide-based …

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