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Articles 41881 - 41910 of 45181

Full-Text Articles in Medicine and Health Sciences

Co-Existence Of Intrahepatic Bile Duct Adenoma And Colonic Adenocarcinoma, Gülen Akyol, Nüket Üzüm, Nusret Akyürek, Bülent Menteş Jan 2008

Co-Existence Of Intrahepatic Bile Duct Adenoma And Colonic Adenocarcinoma, Gülen Akyol, Nüket Üzüm, Nusret Akyürek, Bülent Menteş

Turkish Journal of Medical Sciences

Intrahepatic bile duct adenoma (BDA) is a rare benign tumor of the liver that is usually diagnosed by microscopic examination. Most cases are incidentally discovered during surgery or autopsy. Here, we report the co-existence of colonic adenocarcinoma and intrahepatic BDA mimicking metastasis in a 62-year-old man. The patient underwent metastasectomy because of the presence of colonic adenocarcinoma diagnosed at almost the same time. The diagnosis was benign in frozen sections intraoperatively and total colectomy was performed during the same operation. BDA should be included in the diseases to be differentiated from hepatic primary or metastatic tumors.

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Ductal Carcinoma Of The Parotid Gland Coexisting With Pleomorphic Adenoma, Bi̇rol Ci̇velek, Ercan Demi̇rbağ, Tayyar Selçuk, Uğur Çakmak, Seli̇m Çelebi̇oğlu Jan 2008

Ductal Carcinoma Of The Parotid Gland Coexisting With Pleomorphic Adenoma, Bi̇rol Ci̇velek, Ercan Demi̇rbağ, Tayyar Selçuk, Uğur Çakmak, Seli̇m Çelebi̇oğlu

Turkish Journal of Medical Sciences

Benign tumors of the parotid gland such as pleomorphic adenoma present as a painless mass and pose no difficulty in diagnosis. It is very rare to find a benign mass coexisting with a malignant entity in the parotid gland. We present a case of pleomorphic adenoma coexisting with ductal carcinoma.

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Acute Intoxication By Endosulfan: Any Role Of N-Acetylcysteine Therapy?, Ahmet Demi̇rcan, Eli̇f Çalidağ, Murat Özsaraç, Ayfer Keleş, Fi̇kret Bi̇ldi̇k Jan 2008

Acute Intoxication By Endosulfan: Any Role Of N-Acetylcysteine Therapy?, Ahmet Demi̇rcan, Eli̇f Çalidağ, Murat Özsaraç, Ayfer Keleş, Fi̇kret Bi̇ldi̇k

Turkish Journal of Medical Sciences

Reactive oxygen species may play a role in the mediation of acetaminophen (APAP) hepatotoxicity. N-acetylcysteine (NAC) is the standard therapy for treatment of the APAP overdose patient. The suspected mechanism of hepatic injury appears to be similar to that of APAP and the empiric use of NAC may be justified, especially in significant endosulfan poisoning. An 18-year-old male presented to the emergency department because of unconsciousness and seizure that developed after acute intentional ingestion of endosulfan. Severe diaphoresis was noted and he had a Glasgow Coma Score of 7 (E1M4V2). Within 8 hours of his arrival in the emergency department, …

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Purtscher´S Retinopathy: An Unusual Association With A Complicated Mandibular Fracture, Tongabay Cumurcu, Hüseyi̇n Yardim, Mehmet Güven, Raşi̇t Kiliç, Ni̇lüfer Özkan Jan 2008

Purtscher´S Retinopathy: An Unusual Association With A Complicated Mandibular Fracture, Tongabay Cumurcu, Hüseyi̇n Yardim, Mehmet Güven, Raşi̇t Kiliç, Ni̇lüfer Özkan

Turkish Journal of Medical Sciences

We present a case of unilateral traumatic retinal angiopathy following a mandibular fracture. An 11-year-old child involved in a bicycle accident developed Purtscher´s retinopathy in the left eye with retinal hemorrhages, cotton wool spots, and optic disc swelling on funduscopy. The visual acuity in this eye was counting fingers at one meter.

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Generalized Choreoathetosis In An Acquired Immune Deficiency Syndrome Patient With Cerebral Toxoplasmosis, İpek Mi̇di̇, Hari̇ka G. Çalişkan, Zafer Toktaş, Aydin Sav, Di̇lek İ. Günal Jan 2008

Generalized Choreoathetosis In An Acquired Immune Deficiency Syndrome Patient With Cerebral Toxoplasmosis, İpek Mi̇di̇, Hari̇ka G. Çalişkan, Zafer Toktaş, Aydin Sav, Di̇lek İ. Günal

Turkish Journal of Medical Sciences

Many hypokinetic and hyperkinetic movement disorders (e.g. parkinsonism, chorea, myoclonus, dystonia) are associated with acquired immune deficiency syndrome (AIDS) and may sometimes represent the initial manifestation of the illness. We described a 37-year-old human immunodeficiency virus (HIV)-infected patient with generalized choreoathetoid movements associated with AIDS. Cranial MRI revealed multiple cerebral and cerebellar abscesses. The diagnosis of toxoplasmosis was established by brain biopsy. Hemichorea and hemiballismus in AIDS patients are pathognomonic findings of cerebral toxoplasmosis. Generalized choreiform movement is a rare condition and related to the bilateral cerebral involvement in toxoplasma disease affecting the subcortical structures.

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Biliary Pseudolithiasis In A Neonate: A New Complication Of Total Parenteral Nutrition, Nurdan Uras, Zeynep İleri̇soy Yakut, Alparslan Tonbul, Ahmet Karadağ, Cüneyt Tayman, Semra Kara, Mustafa Mansur Tatli Jan 2008

Biliary Pseudolithiasis In A Neonate: A New Complication Of Total Parenteral Nutrition, Nurdan Uras, Zeynep İleri̇soy Yakut, Alparslan Tonbul, Ahmet Karadağ, Cüneyt Tayman, Semra Kara, Mustafa Mansur Tatli

Turkish Journal of Medical Sciences

No abstract provided.

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A Novel Method For The Production Of Potentially Therapeutic Human Monoclonal Antibodies In Vitro, Adria L. Bykowski Jan 2008

A Novel Method For The Production Of Potentially Therapeutic Human Monoclonal Antibodies In Vitro, Adria L. Bykowski

MUSC Theses and Dissertations

We have developed a novel approach for the production of potentially therapeutic human monoclonal antibodies in vitro. This method holds great promise for generating therapeutic antibodies against infectious disease, cancer, and inflammation. The complex nature of current methods for producing human monoclonal antibodies is a major impediment to large scale passive transfer immunotherapy. Our novel technique utilizes Epstein-Barr virus immortalized tonsil or peripheral blood B cells from healthy human volunteers. These B cells are forced to undergo non-specific differentiation to become mature IgG antibody producing plasma "like" cells that continuously proliferate in vitro. Using this method, millions of transformed B …

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Reduced Acute Inflammatory Responses To Microgel Conformal Coatings, Amanda W. Bridges, Neetu Singh, Kellie L. Burns, Julia E. Babensee, L. Andrew Lyon, Andrés J. García Jan 2008

Reduced Acute Inflammatory Responses To Microgel Conformal Coatings, Amanda W. Bridges, Neetu Singh, Kellie L. Burns, Julia E. Babensee, L. Andrew Lyon, Andrés J. García

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Implantation of synthetic materials into the body elicits inflammatory host responses that limit medical device integration and biological performance. This inflammatory cascade involves protein adsorption, leukocyte recruitment and activation, cytokine release, and fibrous encapsulation of the implant. We present a coating strategy based on thin films of poly(N-isopropylacrylamide) hydrogel microparticles (i.e. microgels) cross-linked with poly(ethylene glycol) diacrylate. These particles were grafted onto a clinically relevant polymeric material to generate conformal coatings that significantly reduced in vitro fibrinogen adsorption and primary human monocyte/macrophage adhesion and spreading. These microgel coatings also reduced leukocyte adhesion and expression of pro-inflammatory cytokines (TNF-alpha, IL-1 beta, …

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Evaluation Of Serological Tests For The Diagnosis Of Visceral Leishmaniasis, Selçuk Kiliç, Ayşegül Taylan Özkan, Cahi̇t Babür, Gönül Tanir, Henk Dfh Schallig Jan 2008

Evaluation Of Serological Tests For The Diagnosis Of Visceral Leishmaniasis, Selçuk Kiliç, Ayşegül Taylan Özkan, Cahi̇t Babür, Gönül Tanir, Henk Dfh Schallig

Turkish Journal of Medical Sciences

Aim: Visceral leishmaniasis (VL) is a zoonosis that affects both animals and man. VL is seen sporadically in the Aegean, Mediterranean, Black Sea and central Anatolian regions of Turkey. The aim of this study was to evaluate serological tests for the diagnosis of VL. Materials and Methods: The performance of two agglutination tests based on freeze-dried whole promastigote Leishmania antigen, i.e. Fast Agglutination Screening Test (FAST) and Direct Agglutination Test (DAT), an Indirect Immunofluorescent Antibody Test (IFAT), and an Enzyme-Linked Immunosorbent Assay (ELISA) using soluble antigen were compared to parasitological diagnosis in the serum specimens of 59 patients with the …

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The Impact Of Patient Education On Diabetes Empowerment Scale (Des) And Diabetes Attitude Scale (Das-3) In Patients With Type 2 Diabetes, Nazli Atak, Kenan Köse, Tanju Gürkan Jan 2008

The Impact Of Patient Education On Diabetes Empowerment Scale (Des) And Diabetes Attitude Scale (Das-3) In Patients With Type 2 Diabetes, Nazli Atak, Kenan Köse, Tanju Gürkan

Turkish Journal of Medical Sciences

Aim: This study was conducted to assess the impact of a brief, patient-centered education program on perceived self-efficacy and attitudes towards diabetes of patients with type 2 diabetes. Materials and Methods: A randomized controlled study was designed and conducted to assess the impact of education using the DES (Diabetes Empowerment Scale) and DAS-3 (Diabetes Attitude Questionnaire-3), which were administered using a pre- and post-test design. A patient-centered education program was developed on the basis of the data supplied from patients' responses to a knowledge pre-test and the ´´Teaching Letters`` prepared by the Diabetes Education Study Group (DESG) of the European …

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Highly Elevated Adenosine Deaminase Level In Brucellar Pleural Effusion, Mustafa Kasim Karahocagi̇l, Hayretti̇n Akdeni̇z, Azi̇z Dursun Kirikçi, Hasan Karsen, Bünyami̇n Sertoğullari Jan 2008

Highly Elevated Adenosine Deaminase Level In Brucellar Pleural Effusion, Mustafa Kasim Karahocagi̇l, Hayretti̇n Akdeni̇z, Azi̇z Dursun Kirikçi, Hasan Karsen, Bünyami̇n Sertoğullari

Turkish Journal of Medical Sciences

Pleural involvement is a rare presentation of brucellosis. There are only a few case reports in the literature presenting with pleural involvement due to brucellosis. In this report, we present a case with exudative pleural fluid first considered as tuberculous pleurisy due to lymphocyte predominance and elevated level of pleural adenosine deaminase, but later diagnosed as brucella pleurisy with positive serologic and microbiologic test results. In conclusion, in the differential diagnosis of pleurisies, routine serologic and bacteriologic methods appear to be more important than pleural adenosine deaminase elevation, especially in regions endemic for both tuberculosis and brucellosis.

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Seckel Syndrome With Spontaneous Chromosomal Instability, Abdulgani̇ Tatar, Zeynep Ocak, Hakan Döneray, Ergi̇n Işik, Ahmet Yeşi̇lyurt, Behzat Özkan, Sitki Öztaş Jan 2008

Seckel Syndrome With Spontaneous Chromosomal Instability, Abdulgani̇ Tatar, Zeynep Ocak, Hakan Döneray, Ergi̇n Işik, Ahmet Yeşi̇lyurt, Behzat Özkan, Sitki Öztaş

Turkish Journal of Medical Sciences

Seckel syndrome is an autosomal recessive disorder characterized by prenatal and postnatal growth retardation, bird-headed face and mild mental retardation. It is a disorder involving the DNA damage-response genes. Failure in the DNA damage response and repair process can cause chromosomal instability. In addition, it is possible that there are several loci responsible for this syndrome, and variety in the molecular pathogenesis is the cause of phenotypic heterogeneity. Three different loci have been reported thus far. The effect of the locus with mutation on phenotype may be used in the subgrouping of Seckel syndrome. We report a case with Seckel …

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A Personal Ethics Responsibility Example: The Relationship Between Child Development And Drugs Taken By Pregnant Mother, Çağatay Üstün, Özge Özgürler Jan 2008

A Personal Ethics Responsibility Example: The Relationship Between Child Development And Drugs Taken By Pregnant Mother, Çağatay Üstün, Özge Özgürler

Turkish Journal of Medical Sciences

Personal responsibility is an important ethical concept. The pregnant mother should regard this concept as of prime importance. The pregnant mother should take some precautions in order to protect her own health and that of her baby in order to provide for its normal development. In this communication, we address the general effects of medications or drugs ingested by a pregnant mother on the baby. Thus, we target refinement of the personal ethic responsibility of the mothers.

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Seminal Plasma Transforming Growth Factor-\Beta (Tgf-\Beta) And Epidermal Growth Factor (Egf) Levels In Patients With Varicocele, Üçler Kisa, M. Murad Başar, Mehmet Ferhat, Osman Çağlayan Jan 2008

Seminal Plasma Transforming Growth Factor-\Beta (Tgf-\Beta) And Epidermal Growth Factor (Egf) Levels In Patients With Varicocele, Üçler Kisa, M. Murad Başar, Mehmet Ferhat, Osman Çağlayan

Turkish Journal of Medical Sciences

Aims: The aim of this study was to analyze seminal plasma epidermal growth factor (EGF) and transforming growth factor-\beta (TGF-\beta) levels in infertile patients with varicocele and normal fertile cases, and to evaluate the relationships between seminal plasma EGF and TGF-\beta, seminal parameters and serum hormone levels. Materials and Methods: A total of 100 patients with varicocele were enrolled into the study. Semen analyses were performed after 2 and 5 days of sexual abstinence. These patients were divided into two groups based on the results of semen analysis as oligoasthenoteratozoospermia (Group 1) and normal semen analysis (Group 2). Additionally, 100 …

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Cisplatin Causes Oxidation In Rat Liver Tissues: Possible Protective Effects Of Antioxidant Food Supplementation, Aslihan Avci, Recep Çeti̇n, İmge B. Ergüder, Erdi̇nç Devri̇m, Bülent Kiliçoğlu, Özden Çandir, H. Serdar Öztürk, İlker Durak Jan 2008

Cisplatin Causes Oxidation In Rat Liver Tissues: Possible Protective Effects Of Antioxidant Food Supplementation, Aslihan Avci, Recep Çeti̇n, İmge B. Ergüder, Erdi̇nç Devri̇m, Bülent Kiliçoğlu, Özden Çandir, H. Serdar Öztürk, İlker Durak

Turkish Journal of Medical Sciences

Aims: In this study, we aimed to investigate the possible molecular mechanism of cisplatin hepatotoxicity and to establish whether some natural antioxidant foods, namely dried black grape and tomato, may provide protection against cisplatin hepatotoxicity. Materials and Methods: Twenty-eight rats were used throughout the study. Cisplatin was administered intraperitoneally (i.p.) in a single dose (10 mg/kg). Antioxidant food supplementation was started three days before cisplatin treatment. There were 7 animals in each group (control, cisplatin, cisplatin plus dried black grape and cisplatin plus tomato juice). Rats were sacrificed 72 h after the treatment. The livers were removed and prepared for …

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The Effects Of Intravenous Glutamine On Bacterial Translocation And Intestinal Morphology In Experimental Pancreatitis, Hüseyi̇n Berkem, Bülent C. Yüksel, Ruki̇ye Berkem, S. Yi̇ği̇t Yildiz, Kubi̇lay Gündoğdu, İ. Hakan Özel, Serdar Topaloğlu, Süleyman Hengi̇rmen Jan 2008

The Effects Of Intravenous Glutamine On Bacterial Translocation And Intestinal Morphology In Experimental Pancreatitis, Hüseyi̇n Berkem, Bülent C. Yüksel, Ruki̇ye Berkem, S. Yi̇ği̇t Yildiz, Kubi̇lay Gündoğdu, İ. Hakan Özel, Serdar Topaloğlu, Süleyman Hengi̇rmen

Turkish Journal of Medical Sciences

Aim: The aim of this study was to investigate the effects of intravenous glutamine administration on bacterial translocation and intestinal morphology in rats with induced acute pancreatitis. Materials and Methods: Forty-eight Wistar-Albino rats were divided into four groups (n = 12 for each group). Pancreatitis was induced with ligation of the main pancreatobiliary duct except in the sham group, in which only periportal dissection was performed. Rats in the sham and control groups were exposed to standard rat pellet. Total parenteral nutrition (TPN) was administered solely to the pancreatitis + TPN group and together with glutamine (Gln) to the pancreatitis …

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The Importance Of Serum Procalcitonin Levels In Patients With Chronic Obstructive Pulmonary Disease Exacerbations, Cantürk Taşçi, Arzu Balkan, Nuri̇ Karadurmuş, Satilmiş İnal, Seli̇m Kiliç, Meti̇n Özkan, Hayati̇ Bi̇lgi̇ç, Kudret Eki̇z Jan 2008

The Importance Of Serum Procalcitonin Levels In Patients With Chronic Obstructive Pulmonary Disease Exacerbations, Cantürk Taşçi, Arzu Balkan, Nuri̇ Karadurmuş, Satilmiş İnal, Seli̇m Kiliç, Meti̇n Özkan, Hayati̇ Bi̇lgi̇ç, Kudret Eki̇z

Turkish Journal of Medical Sciences

Aim: Chronic obstructive pulmonary disease (COPD) is a preventable and treatable, but progressive disease and hospital admissions of patients with COPD are frequently due to acute exacerbations. Acute phase reactants are capable of demonstrating the inflammation; however, they cannot be employed to make a difference between bacterial and nonbacterial causes of the inflammation. Recently, measurement of procalcitonin (PCT) levels appears to be useful in order to minimize this problem. The aim of this study was to examine whether the treatment arrangements based on serum PCT levels in patients presenting with COPD acute exacerbations will be appropriate or not. Materials and …

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Prevalence Of The Metabolic Syndrome In A Rural Turkish Population: Comparison And Concordance Of Two Diagnostic Criteria, Ayfer Gemalmaz, Serpi̇l Aydin, Okay Başak, Güzel Di̇şçi̇gi̇l, Aslihan Karul Jan 2008

Prevalence Of The Metabolic Syndrome In A Rural Turkish Population: Comparison And Concordance Of Two Diagnostic Criteria, Ayfer Gemalmaz, Serpi̇l Aydin, Okay Başak, Güzel Di̇şçi̇gi̇l, Aslihan Karul

Turkish Journal of Medical Sciences

Aim: This study was performed to compare the prevalence of the metabolic syndrome (MES) according to the International Diabetes Federation (IDF) and Adult Treatment Panel III (ATPIII) definitions in a population-based sample and to determine the concordance of the definitions. Materials and Methods: A total of 244 adults aged >=20 years (145 women and 99 men), selected systematically from household registration cards in a rural village in West Anatolia, were analyzed. Kappa test was done to examine the agreement between the definitions. Results: The mean age of the group was 46.9 ± 14.9 years. The prevalence of MES using ATPIII …

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Is Ghrelin A Natural Anti-Microbial Agent?, Süleyman Aydin, Hi̇kmet Geçki̇l, Nermi̇n Kiliç, Fazi̇let Erman, S. Sirri Kiliç, Özfer Yeşi̇lada Jan 2008

Is Ghrelin A Natural Anti-Microbial Agent?, Süleyman Aydin, Hi̇kmet Geçki̇l, Nermi̇n Kiliç, Fazi̇let Erman, S. Sirri Kiliç, Özfer Yeşi̇lada

Turkish Journal of Medical Sciences

No abstract provided.

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Gender Bias Of Cardiovascular Risk In Caucasian Type Ii Diabetics: A Haemostatic Explanation?, William Quirke Jan 2008

Gender Bias Of Cardiovascular Risk In Caucasian Type Ii Diabetics: A Haemostatic Explanation?, William Quirke

Theses

People with type II diabetes are disproportionately affected by cardiovascular disease compared to those without diabetes. The relative risk of cardiovascular disease caused by type II diabetes is higher in females than in males. This risk has not been fully explained by traditional risk factors and attention has turned to the possible role of haemostatic abnormalities in explaining the excess cardiovascular morbidity and mortality among diabetic females. We examined specific parameters of the coagulation (factor VII, factor VIII, von Willebrand factor, fibrinogen) and fibrinolytic (plasminogen activator inhibitor- 1, thrombin-activatable fibrinolysis inhibitor) system in 113 Irish Caucasian type II diabetics to …

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Sr-Bi Protects Against Endotoxemia In Mice Through Its Roles In Glucocorticoid Production And Hepatic Clearance, Lei Cai, Ailing Ji, Frederick C. De Beer, Lisa R. Tannock, Deneys R. Van Der Westhuyzen Jan 2008

Sr-Bi Protects Against Endotoxemia In Mice Through Its Roles In Glucocorticoid Production And Hepatic Clearance, Lei Cai, Ailing Ji, Frederick C. De Beer, Lisa R. Tannock, Deneys R. Van Der Westhuyzen

Internal Medicine Faculty Publications

Septic shock results from an uncontrolled inflammatory response, mediated primarily by LPS. Cholesterol transport plays an important role in the host response to LPS, as LPS is neutralized by lipoproteins and adrenal cholesterol uptake is required for antiinflammatory glucocorticoid synthesis. In this study, we show that scavenger receptor B-I (SR-BI), an HDL receptor that mediates HDL cholesterol ester uptake into cells, is required for the normal antiinflammatory response to LPS-induced endotoxic shock. Despite elevated plasma HDL levels, SR-BI–null mice displayed an uncontrollable inflammatory cytokine response and a markedly higher lethality rate than control mice in response to LPS. In addition, …

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Role Of Reactive Oxygen Species Peroxynitrite In Traumatic Spinal Cord Injury, Yiqin Xiong Jan 2008

Role Of Reactive Oxygen Species Peroxynitrite In Traumatic Spinal Cord Injury, Yiqin Xiong

University of Kentucky Doctoral Dissertations

Peroxynitrite (PN, ONOO-), formed by nitric oxide radical (•NO) and superoxide radical (O2•-), plays an important role in post-traumatic oxidative damage. In the early work, we determined the temporal characteristics of PN-derived oxidative damage in a rat spinal cord injury (SCI) model. Our results showed 3-nitrotyrosine (3-NT), a specific marker for PN, rapidly accumulated at early time points (1 hr, 3 hrs), after when it plateaued and the high level was sustained to 1 week post injury. The co-localization of 3-NT and lipid peroxidation derived-4-HNE observed in immunohistochemistry indicates PN is involved in lipid peroxidative as …

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The Underlying Mechanism(S) Of Fasting Induced Neuroprotection After Moderate Traumatic Brain Injury, Laurie Michelle Helene Davis Jan 2008

The Underlying Mechanism(S) Of Fasting Induced Neuroprotection After Moderate Traumatic Brain Injury, Laurie Michelle Helene Davis

University of Kentucky Doctoral Dissertations

Traumatic brain injury (TBI) is becoming a national epidemic, as it accounts for 1.5 million cases each year. This disorder affects primarily the young population and elderly. Currently, there is no treatment for TBI, which means that ~2% of the U.S. population is currently living with prolonged neurological damage and dysfunction. Recently, there have been many studies showing that TBI negatively impacts mitochondrial function. It has been proposed that in order to save the cell from destruction mitochondrial function must be preserved. The ketogenic diet, originally designed to mimic fasting physiology, is effective in treating epilepsy. Therefore, we have used …

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Analysis Of Hiv-1 Variable Loop 3-Specific Neutralizing Antibody Responses By Hiv-2/Hiv-1 Envelope Chimeras, Katie L. Davis Jan 2008

Analysis Of Hiv-1 Variable Loop 3-Specific Neutralizing Antibody Responses By Hiv-2/Hiv-1 Envelope Chimeras, Katie L. Davis

All ETDs from UAB

Defining the epitope specificities of the neutralizing antibody response to the HIV-1 envelope protein (Env) during natural human infection and in response to vaccination by HIV-1 immunogens could provide insight into the mechanisms of virus immune containment and facilitate vaccine design. Transplantation of discrete HIV-1 neutralizing epitopes into HIV-2 Env scaffolds may provide a sensitive, biologically functional context in which to quantify specific antibody reactivities in complex sera. Here we describe the development of a novel HIV-2 proviral scaffold (pHIV-2KR.X7) into which we have substituted the env V3 region of several laboratory and primary HIV-1 strains to yield a panel …

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The Role Of Tgfß Signaling In Skeletal Development, Hwa-Seon Seo Jan 2008

The Role Of Tgfß Signaling In Skeletal Development, Hwa-Seon Seo

All ETDs from UAB

skeletal element is essential for body movement along with the joints, muscles, tendons and ligaments. They also protect internal organs and serve as a reservoir for hematopoietic stem cells and minerals. To accomplish these multiple tasks, the size and shape of the skeletal elements need to be carefully designed during development of the embryo. Skeletal formation in vertebrae is a complex developmental processes controlled by dynamic and well-balanced interactions between a number of molecular signals. Intensive efforts in the past several decades have made substantial progress in understanding molecular and cellular mechanisms of skeletal development. Despite the fact that TGFß …

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The Developmental Functions Of Bdnf And Mecp2 On Dendritic And Synaptic Structure, Christopher A. Chapleau Jan 2008

The Developmental Functions Of Bdnf And Mecp2 On Dendritic And Synaptic Structure, Christopher A. Chapleau

All ETDs from UAB

Mutations in the transcriptional repressor MeCP2 cause Rett Syndrome (RTT), a mental retardation disease associated with reduced dendritic architecture of cortical pyramidal neurons, in addition to a decrease in the number of dendritic spines. I present the first quantification analysis of spine density in postmortem human brain tissue, demonstrating that hippocampal CA1 pyramidal neurons have reduced spine densities in RTT patients throughout their lives. One gene that MeCP2 regulates is BDNF, an important developmental factor that modulates synaptic transmission and plasticity, as well as spine formation and maturation. In immature cultured hippocampal neurons, cell-autonomous expression of BDNF accelerates the differentiation …

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Calmodulin Binding To Cellular Flice Like Inhibitory Protein Modulates Fas-Induced Signaling And Tumorigenesis In Cholangiocarcinoma, Pritish Subhash Pawar Jan 2008

Calmodulin Binding To Cellular Flice Like Inhibitory Protein Modulates Fas-Induced Signaling And Tumorigenesis In Cholangiocarcinoma, Pritish Subhash Pawar

All ETDs from UAB

Cholangiocarcinoma, a fatal tumor arising from biliary epithelium, has very poor 5-year survival rate due to lack of early diagnosis and effective therapies. Induction of the Fas-mediated apoptosis is a promising therapeutic target in this tumor. Studies from our group and others have indicated that Fas-expression correlates inversely with disease progression and that CaM-antagonists induce apoptosis in cholangiocarcinoma cells in a Fas related manner. Further, we reported a direct and dynamic interaction of CaM and Fas and that CaM is recruited into the Fas-stimulated death inducing signaling complex (DISC), suggesting a cross talk between Fas and CaM pathways. The studies …

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Solution Chemical Synthesis Of Nanostructured Thermoelectric Materials, Xiaohua Ji, Terry M. Tritt, Xinbing Zhao, Joe W. Kolis Jan 2008

Solution Chemical Synthesis Of Nanostructured Thermoelectric Materials, Xiaohua Ji, Terry M. Tritt, Xinbing Zhao, Joe W. Kolis

Journal of the South Carolina Academy of Science

No abstract provided.

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Role Of Variant Sialylation In Regulating Tumor Cell Behavior, Faheem M. Shaikh Jan 2008

Role Of Variant Sialylation In Regulating Tumor Cell Behavior, Faheem M. Shaikh

All ETDs from UAB

Many different tumors have been documented to have elevated levels of the enzyme ST6Gal I, a Golgi glycosyltransferase that adds α2-6 sialic acids to glycoproteins. Concurrently, upregulated ST6Gal I is associated with metastasis and poor patient prognosis. We initially showed that HD3 colonocytes made to express oncogenic-ras, a common mutation in colon carcinoma, have increased expression of ST6Gal I and elevated α2-6 sialylated integrins. Having established that ras regulates ST6Gal I expression in colon epithelial cells, we found that colonocytes carrying hyper α2-6 sialylated β1 integrins exhibit increased adhesion to and migration toward collagen I. Further, we found that β1 …

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Antioxidant Effect Of Melatonin In Systemic Circulation Of Rats After Unilateral Testicular Torsion, Fi̇kret Erdemi̇r, Beki̇r Suha Parlaktaş, Hüseyi̇n Özyurt, Özgür Boztepe, Ömer Atiş, Semsetti̇n Şahi̇n Jan 2008

Antioxidant Effect Of Melatonin In Systemic Circulation Of Rats After Unilateral Testicular Torsion, Fi̇kret Erdemi̇r, Beki̇r Suha Parlaktaş, Hüseyi̇n Özyurt, Özgür Boztepe, Ömer Atiş, Semsetti̇n Şahi̇n

Turkish Journal of Medical Sciences

Aim: To investigate the antioxidant effects of melatonin in the systemic circulation of rats after unilateral testicular torsion. Materials and Methods: After the approval of the study by the Local Ethical Committee, 30 male Wistar albino rats, 5.5-6 months old and weighing 250-300 g, were used in the study. The rats were randomly divided into three groups, each consisting of 10 rats. In group 1, the control group, the left testis was excised after sham operation. In group 2, the torsion group, torsion was created by rotating the left testis 720° in clockwise direction and maintained for 2 h. In …

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