Medicine and Health Sciences Commons^™

The Paraoxonase 1 (Pon1) Gene Polymorphisms In Coronary Artery Disease In The Southeastern Turkish Population, Abdussemet Hazar, Fuat Di̇lmeç, Mustafa Göz, Aydemi̇r Koçarslan, Mehmet Sali̇h Aydin, Abbas Heval Demi̇rkol

Turkish Journal of Medical Sciences

To investigate the association between the paraoxonase 1 (PON1) c.163T>A and c.575A>G polymorphisms and coronary artery disease (CAD), and whether specific polymorphisms in the PON1 gene are associated with CAD in the southeastern Turkish population. Many different genetic and clinical factors have been identified as causes or contributors to atherosclerosis. Complex diseases such as CAD, hypertension, and diabetes are usually caused by an individual’s susceptibility to various genes, environmental factors, and the interactions between them. The PON1 enzyme has been implicated in the pathogenesis of atherosclerosis and CAD. Materials and methods: Enrolled in this study were 61 patients …

The Seroprevalence Of Anaplasma Phagocytophilum In Humans From Two Different Climatic Regions Of Turkey And Its Co-Seroprevalence Rate With Borrelia Burgdorferi*, Turabi̇ Güneş, Ömer Poyraz, Mehmet Ataş, Nergi̇z Hacer Turgut

Turkish Journal of Medical Sciences

To investigate the seroprevalence of Anaplasma phagocytophilum in people living in 2 different climatic regions and to evaluate the co-seroprevalence rate of A. phagocytophilum with Borrelia burgdorferi. Sinop and Tokat provinces, both in the middle Black Sea region of Turkey, have distinct climatic features. Materials and methods: In 2006-2007, serum samples were collected from people living in rural areas of Tokat and Sivas, and anti-A. phagocytophilum IgG antibodies were explored by the IFA method. Positive samples were further investigated for the possible presence of B. burgdorferi IgG antibodies. Results: A. phagocytophilum seropositivity was found in 29 (10.62%) out of 273 …

Agreement Models For Multiraters, Tülay Saraçbaşi

Turkish Journal of Medical Sciences

Agreement between 2 or more independent raters evaluating the same items and same scale can be measured by kappa coefficient. In recent years, modeling agreement among raters rather than summarizing indices has been preferred. In this study, the disadvantages of kappa are reviewed. Agreement models are introduced and these models are applied to a real data set. Materials and methods: Three pathologists classified each of 118 slides in terms of carcinoma in situ of the uterine cervix, based on the most involved lesions. Using log-linear agreement models, agreement between 3 pathologists according to their evaluations was investigated. Results: Coefficient of …

Comparison Of Results In Two Acoustic Analysis Programs: Praat And Mdvp, Haldun Oğuz, Mehmet Aki̇f Kiliç, Mustafa Asim Şafak

Turkish Journal of Medical Sciences

To compare acoustic analysis results obtained by 2 computer programs, Praat and the Multi-Dimensional Voice Program (MDVP). Different voice analysis programs use similar descriptions to define voice perturbation measures. Materials and methods: A total of 47 voice samples reflecting a spectrum of normal and pathological voices were randomly selected from a database, and the same voice samples were used to obtain mean fundamental frequency, jitter, shimmer, and noise-to-harmonics ratio results from 2 acoustic analysis programs. Results: The results obtained for mean fundamental frequency and shimmer were not significantly different between the 2 computer programs. The results for jitter and noise-to-harmonics …

Gamma-Glutamyl Transferase Activity Increases In Prehypertensive Patients, Özlem Karakurt, Göksel Çağirci, Nesli̇han Ebru Eryaşar

Turkish Journal of Medical Sciences

To investigate the association between serum gamma-glutamyl transferase (gamma-glutamyl transpeptidase, GGT) levels and prehypertension in a nationally representative sample of Turkish adults. GGT is an enzyme present in serum and most cell surfaces. It is used as an oxidative stress marker. Increased serum GGT levels are implicated in increased blood pressure and the progression of hypertension. GGT may also have a role in the pathogenesis of cardiovascular disease, diabetes mellitus, obstructive sleep apnea syndrome, and metabolic syndrome. Materials and methods: Prehypertension was identified as systolic blood pressure ranging from 120 to 139 mmHg or diastolic blood pressure ranging from 80 …

Prognostic Role Of Tc-99m Pertechnetate Thyroid Scintigraphy Prior To Fixed-Dose Radioiodine Therapy Of Toxic Multinodular Goiters*, Doğangün Yüksel, Fatma Suna Kiraç, Olga Yaylali, Işil Demi̇ray Uğuz

Turkish Journal of Medical Sciences

To investigate the prognostic role of Tc-99m pertechnetate thyroid scintigraphy pretreatment in patients with toxic multinodular goiters (TMNG) who were then treated with fixed I-131 doses. Materials and methods: We retrospectively evaluated 28 patients (18 females and 10 males; mean ± SD = 63 ± 11 years) that were treated with 740 megabecquerels (MBq) of I-131 for TMNG. Information, including age, Tc-99m pertechnetate thyroid scintigraphy and ultrasonography findings, antithyroid medication, thyroid hormone profile, and clinical status before treatment, was recorded. The regions of interest were drawn over the hot nodules, salivary glands, and the background on the anterior thyroid images. …

Icsi Outcome In Severely Oligoasthenozoospermic Patients And Its Relationship To Prewash Progressive Sperm Motility*, Ni̇lgün Turhan, Aslihan Pekel, Ayli̇n Ayrim, Ömer Bayrak

Turkish Journal of Medical Sciences

To investigate the association between prewash progressive sperm motility and pregnancy rate in cases of severely oligoasthenozoospermic patients in intracytoplasmic sperm injection (ICSI) cycles. Materials and methods: The study included 80 infertile couples who were treated by ICSI due to severe oligoasthenozoospermia (

Long-Term Outcomes Of 23-Gauge Transconjunctival Sutureless Vitrectomy, Mehmet Çitirik, Coşar Batman, Tolga Bi̇çer, Arsen Akinci

Turkish Journal of Medical Sciences

To assess the long-term efficacy and safety of 23-gauge transconjunctival sutureless pars plana vitrectomy in the management of vitreoretinal diseases. Materials and methods: In this study, 53 eyes of patients who underwent 23-gauge transconjunctival sutureless pars plana vitrectomy were included. A complete ophthalmological examination was performed preoperatively and at day 1, week 1, and months 1, 3, 6, and 12 after the surgery. Results: The mean age of the patients was 56.3 years (range: 22-73). Overall, the mean preoperative best-corrected visual acuity was 20/800, and the final mean postoperative best-corrected visual acuity at the 12-month visit was 20/160. The overall …

Detection And Genotyping Of Cryptosporidium Spp. In Diarrheic Stools By Pcr/Rflp Analyses, Selma Usluca, Ümi̇t Aksoy

Turkish Journal of Medical Sciences

To compare microscopy and polymerase chain reaction (PCR) as methods for diagnosing Cryptosporidium spp. and identifying the genotype of the parasite in diarrheic stool. Materials and methods: Stool samples from diarrheic patients admitted to Dokuz Eylül University Medical Faculty were collected on a specific day of the week. Stool samples sent to our laboratory from patients affected by a diarrhea epidemic in İzmir were also included in the study. A total of 162 stool samples were examined by microscopic and molecular methods, and the validity of the molecular method was investigated. Results: Using Kinyoun acid-fast dye, Cryptosporidium spp. was found …

Incidence Of Subtypes Of The Suprapatellar Fold In Fetus And Their Clinical Relevance In Early Periods Of Life: A Preliminary Study*, Zeli̇ha Kurtoğlu, Mustafa Akteki̇n, Deni̇z Uzmansel

Turkish Journal of Medical Sciences

To determine whether the morphology and incidence of subtypes of the fetal suprapatellar fold are different from those of adults. Materials and methods: Suprapatellar folds of 30 fetal knees (6 male and 9 female fetuses, ages varying between 20 and 34 weeks of gestation) were classified according to their morphological features. Results: In 33.3% of the knees, the suprapatellar fold was forming an apparent barrier between the suprapatellar bursa and the main articular cavity. Vertical parts of the mediopatellar fold in 3 fetuses and lateral fold in 4 fetuses were coursing as the continuation of the suprapatellar folds. The suprapatellar …

Evaluation Of Dose-Related Genotoxicity Of Desflurane By Sce Human Lymphocytes, Bahar Aydinli, Ayşegül Özgök, Zeli̇ha Asli Demi̇r, Seyhan Yağar, Mehmet Ali̇ Ergün, Derya Karaer, Mustafa Necmi̇ İlhan

Turkish Journal of Medical Sciences

To evaluate dose-related genotoxicity of desflurane. In the literature, there are studies with equivocal data regarding the potential genotoxicity of inhalational anesthetics. However, it is important to know about the genotoxic safety of an anesthetic agent. Materials and methods: Two groups were enrolled into the study. The first group was maintained with a desflurane minimum alveolar concentration (MAC) of 0.5 and the second was maintained with 1 MAC of desflurane. Blood samples were obtained and studied at the baseline and after 3 h of anesthesia via sister chromatid exchange (SCE) assay. Results: In both groups, SCEs per cell were noted …

Attitudes To The Challenges Of Life Among Different Occupation Groups, Olgun Göktaş, Oğuz Teki̇n, İrfan Şencan

Turkish Journal of Medical Sciences

To determine the attitudes of some occupation groups towards challenges. Materials and methods: In the present study, data were collected by administering the Fatih-Bursa Scale of Attitude to Challenges (F.B.-SATC) to various occupation groups. The participants were divided into 6 occupation groups: healthcare workers, educators, technical staff (engineers, architects, etc.), self-employed people, security staff (police offices, military staff), and housewives. Data were assessed with a F.B.-SATC scoring system measuring attitudes towards challenges. The scale has 5 factors: Thoughts about Challenges (TAC), Outlook on Life (OL), Problem Solving (PS), Targets and Ideals (AI), and Social State (SS) factors. The tool included …

Nosocomial Candidemia: A Threat Beyond Nosocomial Bacterial Infections In Intensive Care Units, Emi̇ne Alp Meşe, Çi̇ğdem Ağkuş, Ramazan Coşkun, Gökhan Metan, Ayşe Nedret Koç, Murat Sungur, Mehmet Doğanay

Turkish Journal of Medical Sciences

There is no abstract

Left Main Coronary Calcification Mimicking Dissection: Multislice Computed Tomography Saves The Patient From Emergent Surgery, Tahi̇r Durmaz, Telat Keleş, Ni̇hal Akar Bayram, Meli̇ke Ruşen Meti̇n, Hüseyi̇n Ayhan, Engi̇n Bozkurt

Turkish Journal of Medical Sciences

Diagnosis of coronary artery dissection using multislice computed tomography (MSCT), particularly of the left main coronary artery (LMCA), has been rarely reported. Coronary anatomy and calcification can be evaluated with MSCT. Herein, we present a case with acute coronary syndrome and coronary artery calcification mimicking the LMCA dissection detected by MSCT.

Biomimetic Precipitation Of Uniaxially Grown Calcium Phosphate Crystals From Full-Length Human Amelogenin Sols, Vuk Uskoković, Wu Li, Stefan Habelitz

Pharmacy Faculty Articles and Research

Human dental enamel forms over a period of 2 – 4 years by substituting the enamel matrix, a protein gel mostly composed of a single protein, amelogenin with fibrous apatite nanocrystals. Self-assembly of a dense amelogenin matrix is presumed to direct the growth of apatite fibers and their organization into bundles that eventually comprise the mature enamel, the hardest tissue in the mammalian body. This work aims to establish the physicochemical and biochemical conditions for the synthesis of fibrous apatite crystals under the control of a recombinant fulllength human amelogenin matrix in combination with a programmable titration system. The growth …

Toward A Mechanistic Understanding Of Narcolepsy With Cataplexy, William Mccurdy

McNair Poster Presentations

Narcolepsy (hypersomnolence) is a disorder that affects 1 in 2000 individuals in the United States and it is characterized by excessive daytime sleepiness (EDS) and catalepsy, which is a sudden loss of muscle tone. As of relatively recent years, there has been a general consensus amongst the scientific community concerning the etiology of narcolepsy as numerous studies suggest that it is caused by the deficiency of neurotransmitters called orexin-A and orexin-B (or hypocretin-1 and hypocretin-2). Research suggests that deficiencies of these proteins are related to a mutation on chromosome 6 in the human leukocyte antigen (HLA) complex which is a …

Nigrostriatal Dopamine-Neuron Function From Neurotrophic-Like Peptide Treatment And Neurotrophic Factor Depletion, Ofelia Meagan Littrell

Theses and Dissertations--Neuroscience

Trophic factors have shown great promise in their potential to treat neurological disease. In particular, glial cell line-derived neurotrophic factor (GDNF) has been identified as a potent neurotrophic factor for midbrain dopamine (DA) neurons in the substantia nigra (SN), which lose function in Parkinson’s disease (PD). GDNF progressed to phase II clinical trials, which did not meet proposed endpoints. The large size and binding characteristics of GDNF have been suspected to contribute to some of the shortcomings of GDNF related to delivery to target brain regions. Smaller peptides derived from GDNF (Dopamine-Neuron Stimulating Peptides – DNSPs) have been recently investigated …

Lysophosphatidic Acid Production And Signaling In Platelets, Zachary Bennett Fulkerson

Theses and Dissertations--Physiology

Lysophosphatidic acid (LPA) belongs to a class of extracellular lipid signaling molecules. In the vasculature, LPA may regulate platelet activation and modulate endothelial and smooth muscle cell function. LPA has therefore been proposed as a mediator of cardiovascular disease.

The bulk of circulating LPA is produced from plasma lysophosphatidylcholine (LPC) by autotaxin (ATX), a secreted lysophospholipase D (lysoPLD). Early studies suggest that some of the production of circulating LPA is platelet-dependent. ATX possesses an N-terminal somatomedin B-like domain suggesting the hypothesis that ATX interacts with platelet integrins which may localize ATX to substrate in the membrane and/or alter the catalytic …

Effect Of Type 2 Diabetes On The Dynamic Response Characteristics Of Leg Vascular Conductance During Exercise, Oscar Mac Ananey, H Reilly, D O'Shea, M Egana, S Green

Articles

Abstract

In this study we tested the hypothesis that type 2 diabetes impairs the dynamic response of leg vascular conductance (LVC) during exercise. LVC (leg blood flow/mean arterial pressure) responses were studied during intermittent contractions of the calf muscle in subjects with type 2 diabetes (n = 9), heavy controls (n = 10) and lean controls (n = 8) using a biexponential function and an estimate of the mean response time (MRT). The time constant of the second phase of LVC was significantly greater in type 2 diabetes (66.4 ± 29.2 s) than the heavy (22.2 ± 13.4 s) and …

Evaluation Of The Tick Bites In A Crimean-Congo Haemorrhagic Fever (Cchf) Endemic Area In Turkey, Serpi̇l Erol, Ahmet Yeni̇solak, Göknur Yapar Toros, Ayşe Albayrak

Turkish Journal of Medical Sciences

After the first description of a CCHF outbreak in Turkey, tick bites became an increasing cause of visits to health-care facilities. In this study, we evaluated tick bites in a CCHF endemic region. Materials and methods: The study included cases of tick bites that were referred to 2 hospitals in Erzurum between June and October 2008. All cases were followed-up for 10 days for the results of CCHF. Results: During the study period, 161 patients were admitted for a tick bite. The majority (56.3%) were farmers and housewives. Children ≤ 13 years of age were bitten mostly on the head …

Effects Of Plasma Lipids And Smoking On Cognitive Function, Oğuz Teki̇n, Adem Özkara, Burcu Yanik, M. Ramazan Yi̇ği̇toğlu, Ati̇lla İlhan, Erkan Kibrisli, İrfan Şencan, Meti̇n Canbal

Turkish Journal of Medical Sciences

To research the relations between plasma lipids and smoking as they affect cognitive functions. Some studies have suggested a relationship between plasma cholesterol concentration, smoking, and the frequency of cognitive disturbances. Our hypothesis was that plasma lipids and smoking are related to cognitive impairment. Materials and methods: The plasma lipid profiles and cognitive functions of the subjects were measured and the relations among plasma lipid levels, smoking, and cognitive functions were observed. The study was performed on subjects with no history of chronic disease. Mental status was evaluated by the mini-mental state examination (MMSE) in patients over 40 years of …

A Pattern Of Lymphadenopathies Seen In A Tertiary Care Hospital In Lahore, Pakistan, Sobia Naseem, Saira Bilal, Maham Akhlaq, Nausheen Henna, Waqas Sami, Abdul Nagi, Muhammad Ashraf

Turkish Journal of Medical Sciences

This cross sectional study was conducted to assess various clinicopathological parameters in 1785 patients from various regions of Punjab. Materials and methods: These cases were collected from Gulab Devi Chest Hospital, Lahore, Pakistan. The data were collected from all patients during a period of 2 years, from June 2006 to June 2008. All the cases were diagnosed after routine hematoxylin and eosin staining. Results: Our observations revealed that the most prevalent lymphadenopathy in these patients was tuberculous lymphadenitis 53% (n = 946), and the most common group of lymph nodes involved is cervical lymph nodes. A significant association was observed …

Intramammarian Glomus Tumor: Radiologic And Pathological Findings, Eli̇f Aşik Kamberoğlu, Huban Si̇bel Orhun Yavuz, Aydin Kurt, Mehmet Gümüş, Ali̇ İpek, Asli Tanrivermi̇ş Sayit, Mustafa Karaoğlanoğlu

Turkish Journal of Medical Sciences

We aimed to describe a histopathologically proven intramammarian glomus tumor and presented mammographic and Doppler ultrasound findings. Glomus tumor is a relatively uncommon soft tissue tumor. It can occur at any age and anatomical site with a predilection for the subungual region. Usually there is no diagnostic difficulty for small, painful subungual nodules but it is more difficult in deep locations. The breast is a very uncommon location for a glomus tumor. Ultrasound characteristics of glomus tumors located in the hand region are known and published previously. With its slightly lobulated margins, lucent notch, and highly vascular nature, ultrasound characteristics …

The Relationship Of The Anatomical Dimensions Of The Sigmoid Colon With Sigmoid Volvulus, Sabri̇ Selçuk Atamanalp, Gürkan Öztürk, Bülent Aydinli, Durkaya Ören

Turkish Journal of Medical Sciences

To investigate the role of the anatomical dimensions of the sigmoid colon in the development of sigmoid volvulus (SV). Materials and methods: The present prospective study was performed with 447 patients who underwent abdominal surgery. The length of the sigmoid colon (SCL), the height of the sigmoid mesentery (SMH), the width of the sigmoid mesentery (SMW), and the width of the base of the sigmoid mesentery (SBW) were measured in the operation. Additionally, SCL/SBW, SMH/SBW, and SMH/SMW rates were calculated. Results: The mean SCL, SMH, SMW, and SBW values were 43.7 ± 8.9 cm, 19.3 ± 4.6 cm, 15.6 ± …

Free Amino Acid Concentration In Aqueous Humour Of Patients With Nuclear Or Cortical Cataract, Mevlüt Sai̇t Keleş, Sadullah Keleş, Destan Ni̇l Kulaçoğlu, Seyi̇than Taysi̇, Orhan Baykal, Ramazan Memi̇şoğullari, Yaşar Nuri̇ Şahi̇n

Turkish Journal of Medical Sciences

Since the free amino acids (a.a.) and derivated a.a. compounds in physiological fluids might reflect physiological or pathological conditions, some researchers have investigated the correlation of a.a. concentrations in physiological fluids with some clinical conditions, including ocular diseases. Here, we aimed to compare free and derivated a.a. in nuclear (generally a physiologic condition) and cortical (generally a pathologic condition) cataract. Materials and methods: Ten patients with nuclear and 10 with cortical cataract were included in this study. Aqueous humour a.a. and derivated a.a. compounds were determined by HPLC method (HP 1100) with Pickering post-column derivatization. Results: There was no significant …

First Trimester Maternal Serum Papp-A Levels And Macrosomia In Nondiabetic Mothers, Ebru Tarim, Servet Özden Haciveli̇oğlu, Tayfun Çok, Hali̇l Tayfun Bağiş

Turkish Journal of Medical Sciences

To determine whether or not there is a relationship between first-trimester maternal serum pregnancy-associated placental protein (PAPP-A) levels and fetal macrosomia in nondiabetic mothers. Materials and methods: In this study, 63 consecutive term macrosomic neonates (Group 1) (birth weight >= 4000 g) and 100 consecutive appropriate-for-gestational-age (AGA) term neonates (Group 2) were included. Transabdominal ultrasound examinations were performed to diagnose any major fetal defects and to measure crown-rump length (CRL) and fetal nuchal translucency (NT) thickness. Blood samples were drawn from each woman in order to obtain fasting blood glucose, PAPP-A, and free beta-human chorionic gonadotropin (beta-hCG) levels. Ultrasound measurements …

The Prenatal Diagnosis Of Familial Satellited Yq Chromosomes, Sezi̇n Yakut, Saffet Öztürk, Mehmet Şi̇mşek, İbrahi̇m İnanç Mendi̇lci̇oğlu, Güven Lüleci̇

Turkish Journal of Medical Sciences

To report a rare chromosomal abnormality, familial satellited Y chromosome (Yqs), in 3 Turkish prenatal cases. Material and methods: Metaphase chromosomes were prepared from amniocytes for prenatal cases and from lymphocytes for their fathers according to the standard methods. Results: In all cases, the analysis of all GTG-banded metaphases showed satellites on the long arms of chromosome Y as 46, XYqs karyotype. The indications for cytogenetic study were advanced maternal age and abnormal ultrasonographic findings with increased risk in the first trimester screening test. Cytogenetic studies of the fathers revealed that the Yqs were inherited. The satellites were positively stained …

Risk Factors Affecting Surgical Outcomes In Patients Undergoing Hypothermic Circulatory Arrest During Aortic Surgeries: A 10-Year Study, Bree Ann Young, James K. Wu, Martin E. Matsumura Md, Sanjay M. Mehta Md, Theodore G. Phillips Md, Michael F. Szwerc Md, Gary W. Szydlowski Md, Raymond L. Singer Md

Department of Medicine

No abstract provided.

Neo-Adjuvant Chemotherapy And Radiation Therapy In Patients With Stage Iiia (N2) Non-Small Cell Lung Cancer (Nsclc): A Retrospective Analysis With Lessons Learned, Eliot L. Friedman Md, Michael F. Szwerc Md, Charles Andrews Md, Robert Kruklitis Md, Kathleen A. Leies, Ferdy Santiago

Department of Medicine

No abstract provided.

Oral Fixed Drug Eruption Secondary To Isoniazid, Tanya Ermolovich Do, Tatyana Groysman Do

Department of Medicine

No abstract provided.