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Articles 39451 - 39480 of 45239

Full-Text Articles in Medicine and Health Sciences

Identification Of Amino Acid Residues Important For Anti-Ifn Activity Of Porcine Reproductive And Respiratory Syndrome Virus Non-Structural Protein 1, Lalit Beura, Sakthivel Subramaniam, Hiep Vu, Byungjoon Kwon, Asit K. Pattnaik, Fernando A. Osorio Jan 2012

Identification Of Amino Acid Residues Important For Anti-Ifn Activity Of Porcine Reproductive And Respiratory Syndrome Virus Non-Structural Protein 1, Lalit Beura, Sakthivel Subramaniam, Hiep Vu, Byungjoon Kwon, Asit K. Pattnaik, Fernando A. Osorio

School of Veterinary and Biomedical Sciences: Faculty Publications

The non-structural protein 1 (nsp1) of porcine reproductive and respiratory syndrome virus is partly responsible for inhibition of type I interferon (IFN) response by the infected host. By performing alanine-scanning mutagenesis, we have identified amino acid residues in nsp1α and nsp1β~ (the proteolytic products of nsp1) that when substituted with alanine(s) exhibited significant relief of IFNsuppression. A mutant virus (16-SA, in which residues 16-20 of nsp1β were substituted with alanines) encoding mutant nsp1β recovered from infectious cDNA clone was shown to be attenuated for growth in vitro and induced significantly higher amount of type I IFN transcripts in infected macrophages. …

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Glycosyl-Phosphatidylinositol (Gpi)-Anchored Membrane Association Of The Porcine Reproductive And Respiratory Syndrome Virus Gp4 Glycoprotein And Its Co-Localization With Cd163 In Lipid Rafts, Yijun Du, Asit K. Pattnaik, Cheng Song, Dongwan Yoo, Gang Li Jan 2012

Glycosyl-Phosphatidylinositol (Gpi)-Anchored Membrane Association Of The Porcine Reproductive And Respiratory Syndrome Virus Gp4 Glycoprotein And Its Co-Localization With Cd163 In Lipid Rafts, Yijun Du, Asit K. Pattnaik, Cheng Song, Dongwan Yoo, Gang Li

School of Veterinary and Biomedical Sciences: Faculty Publications

The porcine reproductive and respiratory syndrome virus (PRRSV) glycoprotein 4 (GP4) resembles a typical type I membrane protein in its structure but lacks a hydrophilic tail at the C-terminus, suggesting that GP4 may be a lipid-anchored membrane protein. Using the human decay-accelerating factor (DAF; CD55), a known glycosyl-phosphatidylinositol (GPI) lipid-anchored protein, chimeric constructs were made to substitute the GPI-anchor domain of DAF with the putative lipid-anchor domain of GP4, and their membrane association and lipase cleavage were determined in cells. The DAF-GP4 fusion protein was transported to the plasma membrane and was cleaved by phosphatidylinositol-specific phospholipase C (PI-PLC), indicating that …

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A Single Amino Acid Change Resulting In Loss Of Fluorescence Of Egfp In A Viral Fusion Protein Confers Fitness And Growth Advantage To The Recombinant Vesicular Stomatitis Virus, Phat X. Dinh, Debasis Panda, Phani B. Das, Subash C. Das, Anshuman Das, Asit K. Pattnaik Jan 2012

A Single Amino Acid Change Resulting In Loss Of Fluorescence Of Egfp In A Viral Fusion Protein Confers Fitness And Growth Advantage To The Recombinant Vesicular Stomatitis Virus, Phat X. Dinh, Debasis Panda, Phani B. Das, Subash C. Das, Anshuman Das, Asit K. Pattnaik

School of Veterinary and Biomedical Sciences: Faculty Publications

Using a recombinant vesicular stomatitis virus encoding eGFP fused in-frame with an essential viral replication protein, the phosphoprotein P, we show that during passage in culture, the virus mutates the nucleotide C289 within eGFP of the fusion protein PeGFP to A or T, resulting in R97S/C amino acid substitution and loss of fluorescence. The resultant non-fluorescent virus exhibits increased fitness and growth advantage over its fluorescent counterpart. The growth advantage of the non-fluorescent virus appears to be due to increased transcription and replication activities of the PeGFP protein carrying the R97S/C substitution. Further, our results show that the R97S/C mutation …

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Amino Acid Residues In The Non-Structural Protein 1 Of Porcine Reproductive And Respiratory Syndrome Virus Involved In Down-Regulation Of Tnf-Cx Expression In Vitro And Attenuation In Vivo, Sakthivel Subramaniam, Lalit Beura, Byungjoon Kwon, Asit K. Pattnaik, Fernando A. Osorio Jan 2012

Amino Acid Residues In The Non-Structural Protein 1 Of Porcine Reproductive And Respiratory Syndrome Virus Involved In Down-Regulation Of Tnf-Cx Expression In Vitro And Attenuation In Vivo, Sakthivel Subramaniam, Lalit Beura, Byungjoon Kwon, Asit K. Pattnaik, Fernando A. Osorio

School of Veterinary and Biomedical Sciences: Faculty Publications

Porcine reproductive and respiratory syndrome virus (PRRSV) suppresses tumor necrosis factor-alpha (TNF-α) production at both transcriptional and post-transcriptional levels by its non-structural proteins 1α and 1β (Nsp1α and Nsp1β). To identifY the amino acid residues responsible for this activity, we generated several alanine substitution mutants of Nsp1α and Nsp1β. Examination of the mutant proteins revealed that Nsp1α residues Gly90, Asn91 , Arg97, Argl 00 and Arg124 were necessary for TNF-α promoter suppression, whereas several amino acids spanning the entire Nsp1β ~ were found to be required for this activity. Two mutant viruses, with mutations at Nsp1α Gly90 or Nsp1β residues …

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Fusion Of A Fluorescent Protein To The Pul25 Minor Capsid Protein Of Pseudorabies Virus Allows Live-Cell Capsid Imaging With Negligible Impact On Infection, Kevin P. Bohannon, Patricia J. Sollars, Gary E. Pickard, Gregory A. Smith Jan 2012

Fusion Of A Fluorescent Protein To The Pul25 Minor Capsid Protein Of Pseudorabies Virus Allows Live-Cell Capsid Imaging With Negligible Impact On Infection, Kevin P. Bohannon, Patricia J. Sollars, Gary E. Pickard, Gregory A. Smith

School of Veterinary and Biomedical Sciences: Faculty Publications

In order to resolve the location and activity of submicroscopic viruses in living cells, viral proteins are often fused to fluorescent proteins (FPs) and visualized by microscopy. In this study, we describe the fusion of FPs to three proteins of pseudorabies virus (PRV) that allowed imaging of capsids in living cells. Included in this study are the first recombinant PRV strains expressing FP–pUL25 fusions based on a design applied to herpes simplex virus type 1 by Homa and colleagues. The properties of each reporter virus were compared in both in vitro and in vivo infection models. PRV strains expressing FP–pUL25 …

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Staphylococcal Response To Oxidative Stress, Rosmarie Gaupp, Nagender Ledala, Greg A. Somerville Jan 2012

Staphylococcal Response To Oxidative Stress, Rosmarie Gaupp, Nagender Ledala, Greg A. Somerville

School of Veterinary and Biomedical Sciences: Faculty Publications

Staphylococci are a versatile genus of bacteria that are capable of causing acute and chronic infections in diverse host species. The success of staphylococci as pathogens is due in part to their ability to mitigate endogenous and exogenous oxidative and nitrosative stress. Endogenous oxidative stress is a consequence of life in an aerobic environment; whereas, exogenous osidative and nitrosative stress are often due to the bacteria's interaction with host immune systems. To overcome the deleterious effects of oxidative and nitrosative stress, staphylococci have evolved protection, detoxification, and repair mechanisms that are controlled by a network of regulators. In this review, …

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Cross-Talk Between Nfkb And The Pi3-Kinase/Akt Pathway Can Be Targeted In Primary Effusion Lymphoma (Pel) Cell Lines For Efficient Apoptosis, Azhar Hussain, Saeeda O. Ahmed, Maqbool Ahmed, Omar S. Khan, Sally Al Abdul Mohsen, Leonidas C. Platanias, Khawla S. Al-Kuraya, Shahab Uddin Jan 2012

Cross-Talk Between Nfkb And The Pi3-Kinase/Akt Pathway Can Be Targeted In Primary Effusion Lymphoma (Pel) Cell Lines For Efficient Apoptosis, Azhar Hussain, Saeeda O. Ahmed, Maqbool Ahmed, Omar S. Khan, Sally Al Abdul Mohsen, Leonidas C. Platanias, Khawla S. Al-Kuraya, Shahab Uddin

Centre for Regenerative Medicine & Stem Cell Research

Background: A number of constitutively activated signaling pathways play critical roles in the survival and growth of primary effusion lymphoma cells (PELs) including NFkB and PI3/AKT kinase cascades. NFkBis constitutively activated in a number of malignancies, including multiple myeloma, Burkitt’s lymphoma and diffuse large cell B-cell lymphoma. However, its role in primary effusion lymphoma has not been fully explored.
Methodology/Principal Findings: We used pharmacological inhibition and gene silencing to define the role of NFkB in growth and survival of PEL cells. Inhibition of NFkB activity by Bay11-7085 resulted in decreased expression of p65 in the nuclear compartment as detected by …

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Feasibility Study Of Trans-Cranial Direct Current Stimulation In Presence Of Brain Tumor, Abhilash Nair Jan 2012

Feasibility Study Of Trans-Cranial Direct Current Stimulation In Presence Of Brain Tumor, Abhilash Nair

Dissertations and Theses

Trans-cranial Direct Current Stimulation has been shown to modulate cortical neuronal activity. Weak constant current is applied to the scalp using electrodes, leading to sub-threshold changes in neuronal membrane potential. Before actual clinical stimulation is performed, such systems are validated by simulating the stimulation and the resulting current flow patterns using finite element solvers. However, the reliability of such models depends upon the accuracy with which the underlying anatomy has been modeled [1]. In earlier studies it has been shown that the current flow patterns within the brain are altered due to the presence of lesioned brain tissues[2]. Here we …

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A Case Of Classic Kaposi’S Sarcoma Treated With Electron Beam Radiation Therapy, Luis A. Soro Do, Stephen M. Purcell Do, Lusia S. Yi Do, Ms Jan 2012

A Case Of Classic Kaposi’S Sarcoma Treated With Electron Beam Radiation Therapy, Luis A. Soro Do, Stephen M. Purcell Do, Lusia S. Yi Do, Ms

Department of Medicine

No abstract provided.

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Improving Sexual Function Using A Multidisciplinary Approach For A Breast Cancer Survivor: A Case Report, Karen Snowden Pt, Dpt, Wcs, Carole Moretz Psyd, Msn Jan 2012

Improving Sexual Function Using A Multidisciplinary Approach For A Breast Cancer Survivor: A Case Report, Karen Snowden Pt, Dpt, Wcs, Carole Moretz Psyd, Msn

Department of Medicine

No abstract provided.

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Evaluation Of The Relationship Between Obstructive Sleep Apnea Syndrome Severity And Cephalometric And Clinical Variables, Süleyman Hakan Tuna, Önder Öztürk, Muhammet Hakan Türkkahraman, Hüseyi̇n Alkiş, Hüseyi̇n Avni̇ Balcioğlu, Ahmet Akkaya Jan 2012

Evaluation Of The Relationship Between Obstructive Sleep Apnea Syndrome Severity And Cephalometric And Clinical Variables, Süleyman Hakan Tuna, Önder Öztürk, Muhammet Hakan Türkkahraman, Hüseyi̇n Alkiş, Hüseyi̇n Avni̇ Balcioğlu, Ahmet Akkaya

Turkish Journal of Medical Sciences

To evaluate the cephalometric features of patients with obstructive sleep apnea syndrome (OSAS) and to elucidate the relationship between the severity of OSAS and cephalometric and clinical variables. Materials and methods: Ninety-three patients (71M/22W) with OSAS were classified into 3 subgroups according to the apnea-hypopnea index (AHI). Various cephalometric and clinical measurements were carried out for all patients. Results: Inferior airway space (IAS), maximum soft palate thickness (MSPT), SNGoGn°, and distance of hyoid bone to mandibular plane (Hy-MPPerp) were found to be higher in severe OSAS for both sexes. Middle airway space, IAS, MSPT, and Hy-MPPerp were correlated positively with …

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Maternal Smoking During Pregnancy And Effects On Neonatal Anthropometry: A Prospective Study, Fati̇h Bolat, Özge Eren, Güher Bolat, Emrah Can, Serdar Cömert, Hasan Si̇nan Uslu, Asi̇ye Nuhoğlu Jan 2012

Maternal Smoking During Pregnancy And Effects On Neonatal Anthropometry: A Prospective Study, Fati̇h Bolat, Özge Eren, Güher Bolat, Emrah Can, Serdar Cömert, Hasan Si̇nan Uslu, Asi̇ye Nuhoğlu

Turkish Journal of Medical Sciences

To identify risk factors associated with cigarette smoking during pregnancy and to evaluate the effect of smoking on anthropometric measurements. Materials and methods: This study was carried out prospectively in selected women who gave birth to a healthy, term infant at Şişli Etfal Education and Research Hospital from January 2009 to January 2010. Smoking status during pregnancy was categorized into 3 groups: nonsmoker; smoker; passive smoker. Regression analysis was performed to compare risk factors with cigarette smoking. Results: A total of 1175 mothers were enrolled. Active and passive smoking rates were 14.9% and 32.3%, respectively. In univariate analysis, maternal active …

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Hyperactivation Of The Hypothalamo-Pituitary-Adrenocortical Axis In Streptozotocin Diabetic Rats: Effect Of Tinospora Cordifolia (Willd.) And Insulin Therapy, Nagaraja Puranik, Sheela Devi Devi, Kararshaha Kammar Jan 2012

Hyperactivation Of The Hypothalamo-Pituitary-Adrenocortical Axis In Streptozotocin Diabetic Rats: Effect Of Tinospora Cordifolia (Willd.) And Insulin Therapy, Nagaraja Puranik, Sheela Devi Devi, Kararshaha Kammar

Turkish Journal of Medical Sciences

In the present study, we investigated the extent to which changes in corticosterone level and food and water intake behavior occur in diabetes and explored the effect of Tinospora cordifolia extracts and insulin therapy in streptozotocin-induced diabetic rats. Materials and methods: Female albino rats of the inbred Wistar strain (body weight: 180-210 g) were used in this study. Experimental diabetes was induced by injecting freshly prepared streptozotocin once at the dose of 55 mg/kg body weight intravenously in 0.1 M citrate buffer, pH 4.5. The drug was administered orally for 10 days and 30 days in different groups containing 6 …

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Effectiveness Of An Original Vaginal Placation Of The Uterosacral Ligaments As Vault Prolapse Prevention, Vesna Antovska Jan 2012

Effectiveness Of An Original Vaginal Placation Of The Uterosacral Ligaments As Vault Prolapse Prevention, Vesna Antovska

Turkish Journal of Medical Sciences

The aim of this study was to evaluate the effectiveness of an original vaginal plication of the uterosacral ligaments as a preventive procedure for recurrent vault prolapse. Materials and methods: In total, 216 women with stage III/IV genital prolapse (POPQ system) underwent vaginal hysterectomy combined with uterosacral ligaments plication. First, the rectum was dissected from the posterior vaginal wall; next, 3 absorbable sutures were placed through both uterosacral ligaments; finally, a fourth suture was placed circularly through both uterosacral ligaments and the posterior vaginal margin. Statistical analysis made use of Student's paired test and Mantel-Haenszel's chi-square test. Results: At the …

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An Investigation Of The Relationship Between Clinical Features Of Amoebiasis And Entamoeba Histolytica Genotypes, Remzi̇ Engi̇n Araz, Özgür Koru, Mehmet Tanyüksel, Tuncer Özeki̇nci̇, Ali̇ Ceylan, Hati̇ce Zeynep Güçlü Kilbaş, Mutali̇p Çi̇çek Jan 2012

An Investigation Of The Relationship Between Clinical Features Of Amoebiasis And Entamoeba Histolytica Genotypes, Remzi̇ Engi̇n Araz, Özgür Koru, Mehmet Tanyüksel, Tuncer Özeki̇nci̇, Ali̇ Ceylan, Hati̇ce Zeynep Güçlü Kilbaş, Mutali̇p Çi̇çek

Turkish Journal of Medical Sciences

To determine the presence of Entamoeba histolytica/E. dispar and E. moshkovskii in stool samples, tRNA-based short tandem repeat gene polymorphism in E. histolytica isolates, and the relationship between amoeba load and clinical outcome in studies. Materials and methods: This study involved 840 stools samples of individuals having diarrhea/dysentery and individuals who were asymptomatic by using microscopy, culture, E. histolytica antigen ELISA, and conventional/real-time PCR methods. Results: Of the 840 samples analyzed, 4.3% (36/840), 2.6% (22/840), and 7.4% (62/840) of the stool samples were determined to be positive by E. histolytica antigen ELISA, and real-time PCR for E. histolytica and E. …

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Genotoxic Effects Of Banding Procedure With Different Orthodontic Cements On Human Oral Mucosa Cells, Firat Öztürk, Şengül Yüksel, Ebubeki̇r Toy, Elçi̇n Lati̇fe Kurtoğlu, Eyüp Burak Küçük Jan 2012

Genotoxic Effects Of Banding Procedure With Different Orthodontic Cements On Human Oral Mucosa Cells, Firat Öztürk, Şengül Yüksel, Ebubeki̇r Toy, Elçi̇n Lati̇fe Kurtoğlu, Eyüp Burak Küçük

Turkish Journal of Medical Sciences

To assess the genotoxic and cytotoxic effects of banding procedure with 5 different orthodontic cements on human oral buccal epithelium cells. Materials and methods: Fifty healthy volunteers (mean age: 14.54 ± 2.37 years) were randomly divided into 5 groups of 10. Preformed stainless steel molar bands (3M Unitek) were cemented to the upper and lower first molar teeth with 5 different orthodontic cements (Durelon, GC Fuji Ortho Band LC Paste Pak, Meron, Ultra Band Lok, and 3M Unitek Multi Cure) in each group. Genotoxic effects of the banding procedure for a 1-month period were evaluated using the micronucleus test (MNT). …

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Creating A Risk Model To Determine Paraaortic Lymph Node Involvement In Endometrial Carcinoma, Ahmet Taner Turan, Burcu Aykan Yildirim, Işin Üreyen, Deni̇z Hizli, Mustafa Alper Karalök, Ömer Lütfi̇ Tapisiz, Hakki Gökhan Tulunay, Nuretti̇n Boran, Nejat Özgül, Mehmet Faruk Köse Jan 2012

Creating A Risk Model To Determine Paraaortic Lymph Node Involvement In Endometrial Carcinoma, Ahmet Taner Turan, Burcu Aykan Yildirim, Işin Üreyen, Deni̇z Hizli, Mustafa Alper Karalök, Ömer Lütfi̇ Tapisiz, Hakki Gökhan Tulunay, Nuretti̇n Boran, Nejat Özgül, Mehmet Faruk Köse

Turkish Journal of Medical Sciences

To define a high-risk group for paraaortic (PA) lymph node metastasis among endometrial carcinoma patients. Materials and methods: Prognostic factors determining PA lymph node metastasis were defined. Using these factors in different combinations, 14 risk groups were formed. A patient with at least one of these factors was considered as high-risk for PA lymph node metastasis. Results: This study included 152 patients. Of these patients, 18 had tumors in the PA region. Lymphovascular space invasion (LVSI) and pelvic lymph node metastasis were independent prognostic factors for PA lymph node involvement. In the risk modeling system, pelvic lymph node metastasis was …

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Comparison Of Three Volumetric Techniques For Estimating Thyroid Gland Volume, Ümi̇t Erkan Vurdem, Ni̇yazi̇ Acer, Tolga Erteki̇n, Ahmet Savranlar, Ömer Topuz, Mustafa Keçeli̇ Jan 2012

Comparison Of Three Volumetric Techniques For Estimating Thyroid Gland Volume, Ümi̇t Erkan Vurdem, Ni̇yazi̇ Acer, Tolga Erteki̇n, Ahmet Savranlar, Ömer Topuz, Mustafa Keçeli̇

Turkish Journal of Medical Sciences

The aims of this study were to estimate the preoperative thyroid volume in patients with a multinodular goiter by the use of ultrasonography (USG) and magnetic resonance imaging (MRI), and then to compare these approaches with the postsurgical total volume measured by Archimedes' principle. Materials and methods: In this study, we compared 3 methods for the determination of thyroid volume: thyroid volume measured with ellipsoid formula via 2-dimensional ultrasonography (2D USG); the stereological (point-counting) method using MRI; and the postsurgical total volume determined by the fluid displacement technique as a gold standard. Results: Thyroid volumes were calculated in a total …

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Right Diaphragmatic Lipoma: Report Of Five Cases And Review Of The Literature, Yener Aydin, Mustafa Esat Yamaç, Ali̇ Bi̇lal Ulaş, Habi̇b Bi̇len, Ati̇la Eroğlu Jan 2012

Right Diaphragmatic Lipoma: Report Of Five Cases And Review Of The Literature, Yener Aydin, Mustafa Esat Yamaç, Ali̇ Bi̇lal Ulaş, Habi̇b Bi̇len, Ati̇la Eroğlu

Turkish Journal of Medical Sciences

Approximately 40 diaphragmatic lipoma cases have been reported in the literature to date. Diaphragmatic lipoma is 2 times more likely to appear on the left rather than the right side. In the present study, diaphragmatic lipoma was evaluated in patients who underwent surgical management in light of the literature data. Materials and methods: This study retrospectively evaluated 5 consecutive diaphragmatic lipoma patients who underwent surgical treatment at the Thoracic Surgery Clinic between January 2003 and April 2012. Results: Of the patients, 3 were female and 2 were male. The average age of the patients was 62.2 years (range: 54-77). All …

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Relation Of Total Homocysteine Level With Metabolic And Anthropometric Variables In Obese Children And Adolescents, Ayhan Abaci, Ahmet Zülfi̇kar Akelma, Osman Özdemi̇r, Şami̇l Hizli, Cem Hasan Razi, Kadi̇r Okhan Akin Jan 2012

Relation Of Total Homocysteine Level With Metabolic And Anthropometric Variables In Obese Children And Adolescents, Ayhan Abaci, Ahmet Zülfi̇kar Akelma, Osman Özdemi̇r, Şami̇l Hizli, Cem Hasan Razi, Kadi̇r Okhan Akin

Turkish Journal of Medical Sciences

To evaluate the total homocysteine (tHcy) level, a risk factor for atherosclerosis, atherothrombosis, and insulin resistance, for sex and pubertal state differences in obese children. Its relationship with metabolic and anthropometric parameters was also investigated. Materials and methods: The study involved obese children with a body mass index (BMI) above the 95th percentile who presented with the complaint of excessive weight gain, and healthy children with a BMI below the 85th percentile. Results: The study included 100 obese (mean age: 10.2 ± 2.7 years) and 71 healthy nonobese (mean age: 10.9 ± 2.6) children. A comparison of the data from …

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The Epidemiologic Characteristics Of Patients That Underwent Surgery For Hip Fracture, Mehmet Uğurlu, Serdar Yilmaz, Alper Deveci̇, Serhan Ünlü, Bi̇rol Tunç, Yusuf Üstü, Emrah Sayit, Seli̇m Yavuz Sani̇soğlu Jan 2012

The Epidemiologic Characteristics Of Patients That Underwent Surgery For Hip Fracture, Mehmet Uğurlu, Serdar Yilmaz, Alper Deveci̇, Serhan Ünlü, Bi̇rol Tunç, Yusuf Üstü, Emrah Sayit, Seli̇m Yavuz Sani̇soğlu

Turkish Journal of Medical Sciences

To retrospectively review the epidemiologic characteristics of patients who underwent surgery for hip fracture. Materials and methods: Patients who underwent surgery for hip fracture in our clinic between 2006 and 2010 were evaluated in terms of their age, sex, localization of fracture, and surgical procedure. Results: The mean age of 419 patients who underwent surgery for hip fracture was 74.18 ± 11.26 (50-106). Of the patients, 55.13% were operated on for intertrochanteric femur fractures, 33.41% for collum femoris fractures, and 11.46% for subtrochanteric femur fractures. The most frequent age range of patients who underwent surgery for hip fracture was found …

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The Evaluation Of The Results Of Adjuvant Chemoradiotherapy In Patients With Gastric Cancer: Results From A Single Center In Eastern Anatolia, Mehmet Bi̇li̇ci̇, Sali̇m Başol Teki̇n, Mustafa Kandaz, Keri̇m Çayir, Mustafa Vecdi̇ Erteki̇n, Hi̇lal Kiziltunç Özmen Jan 2012

The Evaluation Of The Results Of Adjuvant Chemoradiotherapy In Patients With Gastric Cancer: Results From A Single Center In Eastern Anatolia, Mehmet Bi̇li̇ci̇, Sali̇m Başol Teki̇n, Mustafa Kandaz, Keri̇m Çayir, Mustafa Vecdi̇ Erteki̇n, Hi̇lal Kiziltunç Özmen

Turkish Journal of Medical Sciences

To evaluate the results of postoperative chemoradiotherapy in patients with gastric cancer. Gastric cancer is an important public health problem in Turkey, especially in the eastern Anatolia region. Surgery is the primary modality for managing early-stage disease, but most patients who undergo a curative resection develop locoregional or distant recurrence. Therefore, the administration of adjuvant treatment in gastric cancer has great importance. Materials and methods: Operated patients with stage IB-IV (M0) gastric cancer were enrolled in this study. A total of 148 patients with gastric cancer who had completed adjuvant chemoradiotherapy were evaluated retrospectively. Total overall survival (OS), disease-free survival …

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What Is The Best Cut-Off Point For Screening Gestational Diabetes In Turkish Women?, Aydin Köşüş, Nermi̇n Köşüş, Ni̇lgün Turhan Jan 2012

What Is The Best Cut-Off Point For Screening Gestational Diabetes In Turkish Women?, Aydin Köşüş, Nermi̇n Köşüş, Ni̇lgün Turhan

Turkish Journal of Medical Sciences

To find an optimal threshold level with higher sensitivity and specificity for screening of gestational diabetes mellitus (GDM) in Turkish pregnant women. Materials and methods: This was a retrospective study. Screening for GDM was performed in all pregnant women between 24 and 28 weeks of gestation using the 1 h 50 g glucose challenge test (GCT) with a subsequent 3 h 100 g oral glucose tolerance test (OGTT) for confirmation if screened positive. The glucose values obtained were analyzed by both the Carpenter and Coustan (C&C criteria) and National Diabetes Data Group (NDDG) criteria. Results: There were 808 women meeting …

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Investigation Of The Results Of A Smoking Cessation Clinic And The Factors Associated With Success, Leyla Sağlam Jan 2012

Investigation Of The Results Of A Smoking Cessation Clinic And The Factors Associated With Success, Leyla Sağlam

Turkish Journal of Medical Sciences

To investigate the success rate and factors affecting success at a smoking cessation clinic. Materials and methods: In this study, 608 patients (397 male and 211 female) admitted to a smoking cessation clinic to quit smoking between 1 January 2006 and 1 June 2010 were investigated. Routine biochemical and hematological tests, pulmonary function tests, exhaled carbon monoxide levels, electrocardiographs, and chest X-rays were obtained from all of the patients. The questionnaire forms, including the Fagerström Test for Nicotine Dependence (FTND), were filled by all of the participants. At the end of months 6, 12, and 18, the smoking cessation success …

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Xeroderma Pigmentosum In Eastern Turkey: A Review Of 15 Cases, Necmetti̇n Akdeni̇z, Serap Güneş Bi̇lgi̇li̇, Ömer Çalka, Ayşe Serap Karadağ Jan 2012

Xeroderma Pigmentosum In Eastern Turkey: A Review Of 15 Cases, Necmetti̇n Akdeni̇z, Serap Güneş Bi̇lgi̇li̇, Ömer Çalka, Ayşe Serap Karadağ

Turkish Journal of Medical Sciences

Aim: To determine the demographic and clinical characteristics of xeroderma pigmentosum (XP). XP is a rare autosomal recessive disease that is characterized by cellular hypersensitivity to ultraviolet radiation, development of cancers at an early age, severe actinic changes, and photophobia. Materials and methods: In the dermatology clinic of Yüzüncü Yıl University, Van, Turkey, 15 patients who were diagnosed with XP were seen between April 2004 and May 2010. They were evaluated according to their age, sex, family history, parental relationships, age at onset of skin lesions, presence of cutaneous malignancy, and neurological and ophthalmologic involvement. Results: The patients consisted of …

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Cytotoxic Effect Of Cigarette Smoke Condensate On Mice And Rat Mesenchymal Stem Cells And Hela Cells, Aftab Ahmad, Abdul Rauf Shakoori Jan 2012

Cytotoxic Effect Of Cigarette Smoke Condensate On Mice And Rat Mesenchymal Stem Cells And Hela Cells, Aftab Ahmad, Abdul Rauf Shakoori

Turkish Journal of Medical Sciences

Aim: To study the effect of cigarette smoke condensate (CSC) on HeLa cells and mesenchymal stem cells (MSCs) of mice (mMSC) and rats (rMSC). Cigarette smoking results in the deaths of millions of people annually. The constituents of cigarette smoke produce oxidants in the cells that result in inflammation, carcinogenesis, and apoptosis. Materials and methods: CSC was collected on filter paper and dissolved in dimethyl sulfoxide, and 10-100 µg/mL was added to HeLa cells, mMSCs, and rMSCs in a 96-well plate. The cytotoxic effect of CSC was measured after 48 h using a neutral red uptake assay. Images of the …

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Improvement Of Monosymptomatic Enuresis After Adenotonsillectomy In Children With Obstructive Sleep Apnea Syndrome, Ahmet Gökçe, Sündüs Aslan, Fati̇h Rüştü Yalçinkaya, Mürsel Davarci, Yusuf Seli̇m Kaya, Nazan Savaş, Sadik Görür, Şafak Dağli, Ahmet Namik Ki̇per, Mevlana Derya Balbay Jan 2012

Improvement Of Monosymptomatic Enuresis After Adenotonsillectomy In Children With Obstructive Sleep Apnea Syndrome, Ahmet Gökçe, Sündüs Aslan, Fati̇h Rüştü Yalçinkaya, Mürsel Davarci, Yusuf Seli̇m Kaya, Nazan Savaş, Sadik Görür, Şafak Dağli, Ahmet Namik Ki̇per, Mevlana Derya Balbay

Turkish Journal of Medical Sciences

To investigate the prevalence of monosymptomatic enuresis (ME) in children diagnosed with obstructive sleep apnea syndrome (OSAS) and the rate of resolution or improvement in enuresis following adenotonsillectomy. Materials and methods: We retrospectively reviewed the charts of 541 consecutive patients who underwent adenotonsillectomy for OSAS secondary to adenotonsillar hypertrophy between January 2005 and January 2009. All of the charts for patients between 5 and 18 years of age at the time of surgery (n = 398) were included in the study. After reviewing the charts, the families were contacted by telephone. Those patients who had shown preoperative symptoms of enuresis …

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The Role Of Primary Cilia In Articular Cartilage And Growth Plate, Ching-Fang Chang Jan 2012

The Role Of Primary Cilia In Articular Cartilage And Growth Plate, Ching-Fang Chang

All ETDs from UAB

Primary cilia are now considered an important organelle required for many key steps during developmental processes including skeletal development. Articular cartilage and growth plate are two cartilage compartments whose functions are important postnatally. Articular cartilage is a think cartilage layer which serves as a cushion to protect the joint space, whereas growth plate is important for postnatal long bone growth. Both articular cartilage and growth plate need to be developed properly to ensure the normal bone function. Here, we show an important role of primary cilia in development of both articular cartilage and growth plate using genetic modified mouse model …

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Neuropharmacology Of The Α2a Adrenergic Receptor In Disorders Of Mood And Cognition, Christopher Cottingham Jan 2012

Neuropharmacology Of The Α2a Adrenergic Receptor In Disorders Of Mood And Cognition, Christopher Cottingham

All ETDs from UAB

Depressive disorders carry relatively high lifetime risks of greater than 10%, and the antidepressant drugs used in the pharmacotherapy of these mood/cognitive disorders are among the most-prescribed pharmacological agents. However, a detailed understanding of both depressive etiology and the pharmacological mechanisms of action for antidepressant drugs remain elusive. The overall goal of this dissertation research is to provide novel in-sights through a detailed study of the neuropharmacology of the α2A adrenergic receptor (AR). α2ARs, as key regulators of noradrenergic neurotransmission, have been broadly understood to have some ill-defined role in both the neurobiology and neuropharmacology of depressive disorders. The studies …

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Adhesion Molecule Interactions Influence The Implementation Of Immune Responses To Infection, Maureen Ann Cox Jan 2012

Adhesion Molecule Interactions Influence The Implementation Of Immune Responses To Infection, Maureen Ann Cox

All ETDs from UAB

Interactions mediated by intercellular adhesion molecule-1 (ICAM-1) enhance both the antigenic and cytokine signals that CD8 T cells perceive, and these interactions have been suggested to be required for the formation of memory CD8 T cells. Following acute lymphocytic choriomeningitis virus (LCMV) infection of ICAM-1-/- mice, we observe elevated numbers of "effector-phenotype" (CD127lo KLRG-1hi IL-2-) virus-specific CD8 T cells well into the memory phase, while the development of memory-phenotype CD8 T cells (CD127hi KLRG-1lo IL-2 producing) is not impaired. The enhanced maintenance of effector-phenotype cells is due to ICAM-1 deficiency on non-T cell subsets, suggesting a role for ICAM-1 mediated …

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