Medicine and Health Sciences Commons^™

Exposure To Urban Air Pollution And Bone Health In Clinically Healthy Six-Year-Old Children, Lilian Calderón-Garcidueñas, Antonieta Mora-Tiscareño, Maricela Franco-Lira, Ricardo Torres-Jardon, Bernardo Pena-Cruz, Carolina Palacios-López, Hongtu Zhu, Linglong Kong, Nicolas Mendoza-Mendoza, Hortencia Montesinoscorrea, Lina Romero, Gildardo Valencia-Salazar, Michael Kavanaugh, Silvestre Frenk

Biomedical and Pharmaceutical Sciences Faculty Publications

Air pollution induces systemic inflammation, as well as respiratory, myocardial and brain inflammation in children. Peak bone mass is influenced by environmental factors. We tested the hypothesis that six-year-olds with lifetime exposures to urban air pollution will have alterations in inflammatory markers and bone mineral density (BMD) as opposed to low-polluted city residents when matched for BMI, breast feeding history, skin phototype, age, sex and socioeconomic status. This pilot study included 20 children from Mexico City (MC) (6.17 years ± 0.63 years) and 15 controls (6.27 years ± 0.76 years). We performed full paediatric examinations, a history of outdoor exposures, …

Novel Dicarboxylate Selectivity In An Insect Glutamate Transporter Homolog, Hui Wang, Avi M. Rascoe, David Charles Holley, Eric Gouaux, Michael Kavanaugh

Biomedical and Pharmaceutical Sciences Faculty Publications

Mammals express seven transporters from the SLC1 (solute carrier 1) gene family, including five acidic amino acid transporters (EAAT1-5) and two neutral amino acid transporters (ASCT1-2). In contrast, insects of the order Diptera possess only two SLC1 genes. In this work we show that in the mosquito Culex quinquefasciatus, a carrier of West Nile virus, one of its two SLC1 EAAT-like genes encodes a transporter that displays an unusual selectivity for dicarboxylic acids over acidic amino acids. In eukaryotes, dicarboxylic acid uptake has been previously thought to be mediated exclusively by transporters outside the SLC1 family. The dicarboxylate selectivity was …

Brain Immune Interactions And Air Pollution: Macrophage Inhibitory Factor (Mif), Prion Cellular Protein (Prpc), Interleukin-6 (Il-6), Interleukin 1 Receptor Antagonist (Il-1ra), And Interleukin-2 (Il-2) In Cerebrospinal Fluid And Mif In Serum Differentiate Urban Children Exposed To Severe Vs. Low Air Pollution, Lilian Calderón-Garcidueñas, Janet V. Cross, Maricela Franco-Lira, Mariana Aragón-Flores, Michael Kavanaugh, Ricardo Torres-Jardon, Chih-Kai Chao, Charles Thompson, Jing Chang, Hongtu Zhu, Amedeo D'Angiulli

Biomedical and Pharmaceutical Sciences Faculty Publications

Mexico City Metropolitan Area children chronically exposed to high concentrations of air pollutants exhibit an early brain imbalance in genes involved in oxidative stress, inflammation, innate and adaptive immune responses along with accumulation of misfolded proteins observed in the early stages of Alzheimer and Parkinson's diseases. A complex modulation of serum cytokines and chemokines influences children's brain structural and gray/white matter volumetric responses to air pollution. The search for biomarkers associating systemic and CNS inflammation to brain growth and cognitive deficits in the short term and neurodegeneration in the long-term is our principal aim. We explored and compared a profile …

Comparison Of Latanoprost, Brimonidine Tartrate, And Bimatoprost Plus Timolol Maleate In Fixed Combinations, Güli̇z Fatma Yavaş, Tuncay Küsbeci̇, Onur Polat, Mahmut Karadaş, Sitki Samet Ermi̇ş, Ümi̇t Übeyt İnan

Turkish Journal of Medical Sciences

To compare the intraocular pressure (IOP)-lowering efficacy of fixed-combination antiglaucoma agents, and to evaluate the effect of these drugs on the visual field and optic disk morphology. Materials and methods: Included in this retrospective study were 17 eyes receiving latanoprost 0.005% + timolol maleate 0.5% fixed combination (group 1), 18 eyes receiving brimonidine tartrate 0.2% + timolol maleate 0.5% fixed combination (group 2), and 16 eyes receiving bimatoprost 0.03% + timolol maleate 0.5% fixed combination (group 3), all with the diagnosis of primary open-angle glaucoma or ocular hypertension. Intraocular pressure was measured by Goldmann applanation tonometer, a visual field test …

Analysis Of 161 Adult Patients With Brucellosis, Bi̇rcan Kayaaslan, Esragül Akinci, Ali̇ye Baştuğ, Seli̇m Sirri Eren, Pinar Öngürü, Ayşe But, Meltem Arzu Yetki̇n, Hurrem Bodur

Turkish Journal of Medical Sciences

To evaluate the epidemiology, clinical features, and complications of brucellosis. Materials and methods: Between January 2005 and December 2008, 161 patients with brucellosis who were admitted to our clinic were evaluated prospectively. Results: Of the patients, 97 (60.2%) were male, and the mean age was 47 ± 17 years (range: 16-79). There were 99 patients (61.5%) classified as acute, 36 (22.4%) classified as subacute, and 6 (3.7%) classified as having a chronic infection. Relapse or reinfection was observed in 20 (12.4%) patients. Blood culture positivity rates were 60.7% and 44.8% among acute and subacute cases, respectively (P = 0.008). In …

Special Issue On Medical Simulation, Michel Audette, Hanif M. Ladak

Computational Modeling & Simulation Engineering Faculty Publications

We would like to welcome you to this Special Issue on Medical Simulation, the first of its kind not only for SIMULATION: Transactions of The Society for Modeling and Simulation International, but for any technical journal. Our respective backgrounds are an indication of the technical and clinical breadth of medical simulation, as we approach the subject as primarily medical image analysis and biomechanics experts respectively, each with a variety of clinical interests spanning virtual reality (VR)–based neuro-, orthopedic and ear-nose-and-throat surgery. Moreover, we believe that the breadth of the papers that comprise this issue reflects an even broader perspective. After …

Lipopolysaccharide-Induced Neuronal Activation In The Paraventricular And Dorsomedial Hypothalamus Depends On Ambient Temperature, Samuel P. Wanner, Kyoko Yoshida, Vladimir A. Kulchitsky, Andrei I. Ivanov, Kazuyuki Kanosue, Andrej A. Romanovsky

Human and Molecular Genetics Publications

Systemic inflammatory response syndrome is associated with either fever or hypothermia, but the mechanisms responsible for switching from one to the other are unknown. In experimental animals, systemic inflammation is often induced by bacterial lipopolysaccharide (LPS). To identify the diencephalic and brainstem structures involved in the fever-hypothermia switch, we studied the expression of c-Fos protein, a marker of neuronal activation, in rats treated with the same high dose of LPS (0.5 mg/kg, intravenously) either in a thermoneutral (30°C) or cool (24°C) environment. At 30°C, LPS caused fever; at 24°C, the same dose caused profound hypothermia. Both fever and hypothermia were …

Parallel Changes In Intracellular Water Volume And Ph Induced By Nh3/Nh4+ Exposure In Single Neuroblastoma Cells, Victor M. Blanco, Martín S. Márquez, Francisco J. Alvarez-Leefmans

Pharmacology and Toxicology Faculty Publications

BACKGROUND:

Increased blood levels of ammonia (NH3) and ammonium (NH4(+)), i.e. hyperammonemia, leads to cellular brain edema in humans with acute liver failure. The pathophysiology of this edema is poorly understood. This is partly due to incomplete understanding of the osmotic effects of the pair NH3/NH4(+) at the cellular and molecular levels. Cell exposure to solutions containing NH3/NH4(+) elicits changes in intracellular pH (pHi), which can in turn affect cell water volume (CWV) by activating transport mechanisms that produce net gain or loss of solutes and water. The occurrence of CWV changes caused by NH3/NH4(+) has long been suspected, but …

Plasma Soluble Thrombomodulin And Soluble Endothelial Protein C Receptor Levels In Colorectal Cancer Patients, Serap Ünal Ti̇lki̇, Hüseyi̇n Engi̇n, Ayla Gökmen, Cemi̇l Bi̇li̇r, Yücel Üstündağ

Turkish Journal of Medical Sciences

Thrombomodulin (TM) and endothelial protein C receptor (EPCR) are 2 transmembrane proteins that are thought to play an important role in cancer. We aimed to discover whether these 2 proteins are prognostic indicators in colorectal cancer. Materials and methods: Plasma TM and EPCR levels were measured using the ELISA method in 50 patients in different tumor stages that had been recently diagnosed with colorectal cancer and in a healthy control group of 50 people. Results: In colorectal cancer patients, higher plasma TM (21.3 ± 22.8 ng/mL, 13.2 ± 16.2 ng/mL, P = 0.010) and plasma EPCR levels (149.9 ± 79.6, …

Demonstration Of Mutations Conferring Resistance To Lamivudine In Liver Tissue Of Chronic Hepatitis B Patients Under Lamivudine Therapy, İsmai̇l Yaşar Avci, Can Polat Eyi̇gün, Emi̇ne Günal, Ayhan Kubar, Hanefi̇ Cem Gül, Ömer Coşkun, Hakan Erdem, Levent Görenek, Bülent Ahmet Beşi̇rbelli̇oğlu

Turkish Journal of Medical Sciences

To demonstrate the genotypic lamivudine resistance in liver tissue of patients with negative serum hepatitis B virus (HBV) DNA under long-term lamivudine therapy. Materials and methods: Fourteen patients (10 patients with elevated alanine aminotransferase and 4 patients under long-term lamivudine therapy for severe liver disease) with undetected serum HBV DNA were included in the study. A liver biopsy was performed for each patient, and HBV DNA extracted from liver tissue was analyzed with TaqMan real-time polymerase chain reaction. Results: Mutations conferring lamivudine resistance were shown for all 14 patients in their liver tissue-extracted HBV DNA. One patient had rtM204V, 4 …

Compliance To Treatment And Reaching Of Metabolic Goals Are Better In Oad-Treated Diabetics Than Insulin-Treated Diabetics In The Turkish Population, Sema Uçak, Emi̇ne Şatir, Okcan Basat, Yüksel Altuntaş

Turkish Journal of Medical Sciences

We assessed the success rates of reaching glycated haemoglobin (HbA1c) goals in different treatment groups. Materials and methods: This was a single-centre, retrospective study including 2995 patients. The proportion of patients reaching their HbA1c goals, according to the International Diabetes Federation (IDF), American Association of Clinical Endocrinologists (AACE), and American Diabetes Association (ADA), were determined. Results: There were 4 different treatment groups: 1) diet group (n = 140), 2) oral antidiabetic drug (OAD) group (n = 1238), 3) insulin group (n = 765), and 4) insulin + OAD group (n = 812). According to the IDF and AACE criteria, the …

Comparison Of The Efficacies Of I-Gel^{Tm} And Lma-Proseal^{Tm} For Airway Management In Pediatric Patients, Orhan Tokgöz, Adnan Tüfek, Serbülent Gökhan Beyaz, Mustafa Uğur Yüksel, Feyzi̇ Çeli̇k, İlker Öngüç Aycan, Abdulmenap Güzel

Turkish Journal of Medical Sciences

The present study was performed to compare the performance of I-gel^{TM} with LMA-ProSeal^{TM} in children undergoing anesthesia. Materials and methods: A total of 185 patients who were scheduled for elective surgery in Dicle University's hospital were randomly divided into 2 groups: the I-gel^{TM} group (Group-I, n = 95) and the p-LMA^{TM} group (Group-P, n = 90). Airway leakage pressure, insertion time, fiberoptic laryngeal image scores, ease of insertion, and possible complications were compared between these groups. Results: The airway leakage pressure of Group-I was significantly higher than that of Group-P (means ± SD: 28 ± 5 vs. 20 ± 4 …

Polymorphisms In Abc Transporters (Abca1 And Abcc8) In Metabolic Syndrome, Orhan Değer, Yunus Emre Yandi, Mi̇hri̇ban Ayvaz, Ci̇hangi̇r Erem, Ari̇f Bayram Hacihasanoğlu

Turkish Journal of Medical Sciences

To identify important single nucleotide polymorphisms (SNPs) in the ABCA1 and ABCC8 (SUR1) genes and determine if they are associated with metabolic syndorome (MetS). Materials and methods: Fifty-eight subjects fulfilling all 5 MetS criteria were chosen from 4809 subjects who participated in our screening study (Trabzon MetS study). Forty-three subjects who did not fulfill any MetS criteria were chosen as the control group. Genotyping of the samples after DNA isolation was performed by direct sequencing. For SNP analysis, exons 7, 15, 19, 36, 41, and 49 for ABCA1 and exons 16 and 18 for ABCC8 were selected. Results: The most …

Comparison Of The Effects Of Intraarticular Hyaluronic Acid And Antiinflammatory Drug Treatments On The Surgical Intervention Rates In Patients With Gonarthrosis, Murat Korkmaz, Yalçin Erdoğan, Ayli̇n Okur, Ayşe Yeşi̇m Göçmen, İlhan Günaydin

Turkish Journal of Medical Sciences

The aim of this study was to compare the frequencies of surgical interventions between patients receiving intraarticular hyaluronic acid (IAHA) injection and those receiving only oral antiinflammatory drug treatment at the end of a 1-year follow-up period. Materials and methods: A total of 705 patients diagnosed with knee osteoarthritis (OA) between 2007 and 2009 were included in this study. Their records were investigated retrospectively. We divided 218 of the patients into 3 groups according to the Kellgren–Lawrence criteria, and they received sodium hyaluronate once a week for 3 weeks. Another 487 patients with gonarthrosis served as group 2 and were …

Clinical Manifestations Of 16 Oropharyngeal Tularemia Patients: Experience Of A Referral Hospital In The City Of Konya, Turkey, Mesut Sabri̇ Tezer, Gülteki̇n Övet, Necat Alataş, Mehmet Hakan Görgülü, Ersen Koç, Mehmet Aki̇f Öztürk

Turkish Journal of Medical Sciences

In recent years, tularemia's importance has been reemerging in Turkey. However, the majority of tularemia cases were reported in the northern cities of Turkey. In this study, we report 16 oropharyngeal tularemia patients living in rural areas of the city of Konya, which is located in the southern zone of the Central Anatolia Region of Turkey. Materials and methods: Sixteen patients (12 males, 4 females; mean age: 33.7 years, range: 10–73 years) were included in this study. All patients were admitted to our clinic for the evaluation of intractable cervical mass lesions. The diagnosis of tularemia was made after exclusion …

Dexmedetomidine Infusion Prevents Postoperative Shivering In Patients Undergoing Gynecologic Laparoscopic Surgery, Semra Karaman, İlkben Günüşen, Mustafa Arda Ceylan, Yücel Karaman, Esra Nur Çeti̇n, Abdurrahi̇m Derbent, Ahmet Mete Ergenoğlu

Turkish Journal of Medical Sciences

This placebo-controlled, randomized study was performed to evaluate the efficacy of dexmedetomidine in preventing postoperative shivering. Materials and methods: Sixty patients undergoing gynecologic laparoscopic surgery were assigned randomly to 2 groups to be administered either dexmedetomidine as a loading of 1 µg kg^{-1} for 10 min followed by a maintenance infusion of 0.5 µg kg^{-1} h^{-1} (Group D, n = 30), or a normal saline infusion (Group S, n = 30). Results: Postoperative shivering was observed in 14 patients in Group S and in 3 patients in Group D (P = 0.001). The sedation scores were higher in the dexmedetomidine …

Alfacalcidol Suppresses Α-Receptor–Mediated Vasoconstriction Via An Endothelium Dependent Mechanism, İsmai̇l Ün, Aki̇f Hakan Kurt, Ali̇ Batuş, Kansu Büyükafşar

Turkish Journal of Medical Sciences

Vitamin D level could be related to blood pressure and cardiovascular health. However, the direct suppressor effect of vitamin D on vascular contraction has not yet been explored. Therefore, the effects of alfacalcidol (1\alpha-hydroxyvitamin D_3) and calcitriol (1\alpha,25-dihydroxyvitamin D_3) on contractions induced by phenylephrine (10^{-8} to 10^{-5} M) in mice aorta were investigated. Materials and methods: Arterial rings were suspended in isolated organ chambers filled with Krebs bicarbonate solution gassed with 95% O_2 and 5% CO_2 maintained at 37 °C. Tissue responses were recorded isometrically with a force transducer and displayed on an acquisition system. Alfacalcidol and calcitriol were applied …

The Effect Of Combined Treatment Of Alpha-Tocopherol, Ascorbic Acid, And Pyridoxine With Nmda Blocker Memantine On Penicillin-Induced Epileptiform Activity In Rats, Duygu Aydin, Mehmet Yildirim, Mustafa Ayyildiz, Erdal Ağar

Turkish Journal of Medical Sciences

To evaluate the effects of coadministration of vitamins alpha-tocopherol, ascorbic acid, and pyridoxine with memantine on a penicillin-induced experimental epilepsy model in rats so as to clarify the eventual interaction between these vitamins and the N-methyl-D-aspartate (NMDA) system. Materials and methods: The epileptic focus was produced by intracortical penicillin G potassium injection. The effects of intraperitoneal injections of memantine, memantine + alpha-tocopherol, memantine + ascorbic acid, and memantine + pyridoxine combinations on epileptiform activity were evaluated in electrocorticogram recordings. Results: The antiepileptiform effects appeared earlier in all memantine and vitamin coadministrated groups compared to the memantine-alone group, but the difference …

The Outcomes Of The Pregnancies Of Lactating Women, Özlem Şengül, Ahmet Akin Si̇vaslioğlu, Mahmut Kuntay Kokanali, Işik Üstüner, Ayşe Fi̇li̇z Avşar

Turkish Journal of Medical Sciences

To evaluate the outcomes of pregnancies occurring during lactation. Materials and methods: Sixty-one women who had interpregnancy intervals of 2 years were evaluated. Group 1 included 39 pregnancies of lactating women. Group 2 included 22 pregnancies of women who ceased lactation before conception. The groups were compared for gestational weight gain, birth weight, and obstetric complications. Results: The birth weights of the subsequent pregnancies of the first group were statistically lower than the second group (3086.6 ± 379.2 versus 3386.8 ± 388.1 g, P = 0.006). There was no statistically significant difference in obstetric complications observed between the 2 groups …

Lung Abscess: Analysis Of The Results As Community-Acquired Or Nosocomial, Nuri̇ Tutar, Fatma Sema Oymak, Asi̇ye Kanbay, Hakan Büyükoğlan, Afra Yildirim, İnsu Yilmaz, Suat Ali̇ Doğan, İnci̇ Gülmez, Ramazan Demi̇r

Turkish Journal of Medical Sciences

To assess the etiology, underlying disease, treatment procedures, and mortality rate of lung abscesses by dividing the patients into community-acquired lung abscess (CALA) and nosocomial lung abscess (NLA) subgroups. Materials and methods: We reviewed and analyzed data on 62 adult cases of CALA and NLA treated during 2000-2011 at a tertiary university hospital in Turkey. Results: Of these 62 patients, 44 had CALA and 18 had NLA. Etiologic microorganisms were isolated in 20 of the 44 patients (45.4%) in the CALA group and in 15 of the 18 patients (83.3%) in the NLA group. Among these patients, Staphylococcus aureus (20.0%) …

Is Placement Of Pelvic Drain Indispensable After Radical Cystectomy, Extended Lymph Node Dissection, And Orthotopic Neobladder Substitution?, Ahmet Tunç Özdemi̇r, Serkan Altinova, Ege Can Şerefoğlu, Ali̇ Fuat Atmaca, Mevlana Derya Balbay

Turkish Journal of Medical Sciences

To evaluate the necessity of leaving a pelvic drain after open radical cystectomy. Materials and methods: Between January 2007 and January 2010, 58 patients with muscle-invasive bladder carcinoma were included. All patients underwent radical cystectomy, extended lymph node dissection, and orthotopic bladder (Studer pouch) substitution. Patients were randomized to have a pelvic drain catheter (Group 1, n = 22) or not (Group 2, n = 36). Ureteral catheters were removed at postoperative days 7 and 8. The pelvic drain catheters in Group 1 were removed when daily production was

Decreasing Blood Loss And The Need For Transfusion After Cabg Surgery: A Double-Blind Randomized Clinical Trial Of Topical Tranexamic Acid, Mahmoud Nouraei, Afshin Gholipour Baradari, Rahman Ghafari, Mohammad Reza Habibi, Amir Emami Zeydi, Narges Sharifi

Turkish Journal of Medical Sciences

Reopening sternotomy to control bleeding after coronary artery bypass grafting surgery (CABG) has been reported in 2%-7% of cases. Platelet dysfunction and activation of fibrinolytic cascade are the common causes of bleeding after on-pump CABG. Different antifibrinolytic drugs have been used to reduce bleeding. In this study, we aimed to investigate the efficacy of topical tranexamic acid in reducing postoperative mediastinal bleeding after CABG. Materials and methods: This was a double-blind placebo-controlled randomized clinical trial on 40 patients as the control and another 40 patients as the study group. On completion of CABG before sternotomy wound closure, tranexamic acid (2 …

Impact Of Acute Sleep Deprivation On Aortic Elastic Properties In Healthy Workers, İlyas Akdemi̇r, Gökhan Altunbaş, Süleyman Ercan, Selve Arslan, Vedat Davutoğlu

Turkish Journal of Medical Sciences

People are more frequently exposed to acute sleep loss nowadays due to extensive working. Epidemiologic studies suggest that sleep deprivation (SD) increases the risk of cardiovascular events. Aortic stiffness is also shown to predict cardiovascular events, stroke, and death even in healthy populations. The association between SD and aortic stiffness remains unknown. We sought to determine the impact of acute SD on aortic elastic properties in healthy workers. Materials and methods: The study population consisted of 34 healthy medical personnel working in shifts (17 men and 17 women). Less than half of the mean daily sleep time, or less than …

Evaluation Of The Relationship Between Dental Erosion And Scintigraphically Detected Gastroesophageal Reflux In Patients With Cerebral Palsy, Zülfi̇kar Polat, Özlem Marti Akgün, İlker Turan, Günseli̇ Güven Polat, Ceyhan Altun

Turkish Journal of Medical Sciences

To evaluate the relationship between dental erosion (DE) and scintigraphically detected gastroesophageal reflux disease (GERD) in patients with cerebral palsy (CP). Materials and methods: Included in the study were 21 CP patients with dental erosion and a control group consisting of 16 CP patients without dental erosion (total of 37 children; 19 male, 18 female; mean age: 12.1 ± 2.8 years). The severity of DE was scored and all patients underwent gastroesophageal reflux scintigraphy. Results: The prevalence of GERD in patients with DE (78.9%) was found to be significantly higher than that in patients without DE (21.1%). The number of …

Anterior Segment Morphometry And Intraocular Pressure Change After Uneventful Phacoemulsification, Tamer Takmaz, Pinar Kösekahya, Pi̇raye Zeynep Kürkçüoğlu

Turkish Journal of Medical Sciences

To evaluate the changes in anterior segment morphometry and intraocular pressure (IOP) with 3D rotating Scheimpflug camera-topography system after uneventful phacoemulsification. Materials and methods: In 56 eyes of 54 patients, anterior chamber depth (ACD), anterior chamber volume (ACV), anterior chamber angle (ACA), and central corneal thickness (CCT) were measured with the Sirius 3D Rotating Scheimpflug camera-topography system preoperatively and 1 month after surgery. IOP was measured with applanation tonometer. The preoperative and postoperative results were compared. Results: Preoperative and postoperative anterior segment parameters were as follows: ACD 2.7 ± 0.4 and 3.5 ± 0.3 mm, ACV 143.6 ± 48.8 and …

Intraarticular Hydraulic Distension With Steroids In The Management Of Hemiplegic Shoulder, Asuman Doğan, Refi̇ka Demi̇rtaş, Neşe Özgi̇rgi̇n

Turkish Journal of Medical Sciences

The aim of this study is to compare intraarticular steroid administration and steroid administration with hydraulic distention of the glenohumeral joint in hemiplegic patients who had developed shoulder pain and limitation. Materials and methods: The study consisted of 60 patients attending an inpatient rehabilitation program following a stroke. Each patient had shoulder pain and shoulder limitations . The patients were divided into 3 groups consisting of 20 patients each, according to their order of admission. Conventional physical treatment and rehabilitation (PTR) methods were applied to the patients in Group 1 (control group), conventional PTR and an intraarticular steroid were applied …

Evaluation Of Nonneoplastic Findings On Vaginal Smears With Comparison Of Intrauterine Devices And Oral Contraceptive Pill Effects, Rahi̇me Bedi̇r Findik, Servet Güreşci̇, Ayşe Nurcan Ünlüer, Jale Karakaya

Turkish Journal of Medical Sciences

Although the Pap smear is a common screening test for cervical cancer and its precursors, it can detect some benign conditions as well. In this study, the aim was to evaluate smear results with regard to nonneoplastic findings and to compare them to the detectable effects of intrauterine devices (IUDs) and oral contraceptive pills (OPs). Materials and methods: In this retrospective study, the hospital records and cytopathology reports of 4248 patients were recorded. Smear results were evaluated according to the 2001 Bethesda System and were evaluated according to age groups, menopausal/menstrual status, physical examination findings, and contraceptive method usage. Results: …

New Risk Scoring System For Femoral Pseudoaneurysm Formation After Cardiac Catheterization (Ateş Scoring System), Mehmet Ateş, Mehmet Beşi̇r Akpinar, Fai̇k Fevzi̇ Okur, Ahmet Feyzi̇ Abacilar, Veysel Şahi̇n, İhsan Sami̇ Uyar, Emi̇n Alp Alayunt

Turkish Journal of Medical Sciences

To create a new scoring system for femoral pseudoaneurysm (FPA) formation after diagnostic or interventional cardiac catheterization. Materials and methods: We evaluated 41,322 transfemoral catheterization procedures performed in our center within 7 years. Among all procedures, 630 FPAs developed that required surgical repair. Eighty-five cases were managed by compression with duplex guidance. As a case-control group, 1260 patients were selected from the patients who had been catheterized during the same time period but did not develop FPA. We created the risk scoring system according to body mass index, hypertension, diabetes mellitus, catheter diameter, coronary artery disease, atherosclerosis, and number of …

The Effects Of Acetyl Shikonin Isolated From Onosma Armeniacum On Oxidative Stress In Ethanol-Induced Ulcer Model Of Rats, Aysun Toker, Fati̇h Akçay, Hülya Aksoy, Hali̇s Süleyman, Ufuk Özgen, Havva Erdem

Turkish Journal of Medical Sciences

We investigated the effects of acetyl shikonin isolated from Onosma armeniacum on ethanol-induced gastric injury (ulcer) and on oxidant-antioxidant parameters in the gastric tissue of rats. Materials and methods: Eighteen albino Wistar male rats were divided into 3 different experimental groups. Group 1 (n = 6) was the control group, group 2 (n = 6) was the ethanol group, and group 3 (n = 6) was the acetyl shikonin + ethanol group. The animals in group 3 were given ethanol (1 mL, 50% v/v) 30 min after acetyl shikonin (40 mg/kg) administration by orogastric tube. Results: The lowest mean nitric …

Serum Lipoprotein(A) And High Sensitivity C Reactive Protein Levels In Saudi Patients With Type 2 Diabetes Mellitus And Their Relationship With Glycemic Control, Syed Shahid Habib

Turkish Journal of Medical Sciences

To study serum lipoprotein(a) [Lp(a)] and high sensitivity C reactive protein (hsCRP) levels in Saudi patients with type 2 diabetes mellitus (DM) and their relationship with glycemic control. Materials and methods: A total of 201 subjects were selected for the study. The final selection included 103 patients with type 2 DM (64 males and 39 females) and 98 healthy control subjects (58 males and 40 females). Fasting venous blood samples were analyzed for glucose, glycosylated hemoglobin (HbA1c), lipids, Lp(a), and hsCRP levels. Results: Subjects with poor glycemic control showed significantly higher levels of fasting blood glucose levels (10.29 ± 3.56 …