Medicine and Health Sciences Commons^™

Ultrastructure And Chemical Composition Of Microconidial Walls Of Trichophyton Mentagrophytes, Christine Da-Ruh Wu

Dissertations

No abstract provided.

Chemicals And Food: An Account About Additives, Wayland E. Noland

Journal of the Minnesota Academy of Science

Food additives are listed by functional category and discussed in terms of the scale of their use and relative risks in terms of long-term human toxicity. The greatest risks appear to lie with the antimicrobial preservative agents, and food colors (which serve only a cosmetic purpose); these and the synthetic sweeteners are discussed in relatively greater detail.

Chlorofluorocarbon Effects On Cardiac, Pulmonary, And Respiratory Patients, Mildred E. Olson

Journal of the Minnesota Academy of Science

Research results from studies of the physiological effects of aerosal propellants on animals and people are summarized. The papers selected for this summary were published between 1968 and 1975. Effects of the 15 chlorofluorocarbons used as propellants have been recorded on the cardiac, pulmonary and respiratory functions of a number of animal species as well as man. The fifteen propellants have been classified into four groups on the basis of their degree of toxicity. Fluorocarbon 11, the most frequently used propellant, is in group 1, the most toxic. The relative toxicity of each of the 14 other propellants compared with …

Measurement Of Permeability Of The Cell Membrane To Water, Richard Moore, Frederick Thornburgh, Donggyu Jin

Journal of the Minnesota Academy of Science

The water permeability was measured for blood cells from normal subjects and for blood cells from patients with leukemia. The method of measurement of the kinetics of water influx employed a stopped flow apparatus. The method of calculation of results was based on irreversible thermodynamics. The measurements and calculations were both performed with the assistance of a computer. The water permeability of the leukemic cells was decreased from normal, and the values were more variable than normal. Leukemia changes the structure of the cell membrane.

Similarities In Analgesia Produced By Cervical Probing And Intracranial Stimulation To The Mesencephalic Grey Matter, Kathleen Casey Westlake

Dissertations, Theses, and Masters Projects

No abstract provided.

Stereospecific Opiate Binding In Human Erythrocyte Membranes And Changes In Heroin Addicts, Leo G. Abood, Holly G. Atkinson, Mary Macneil

Publications and Research

Stereospecific opiate binding has been demonstrated in human erythrocyte membranes, having a Kd of 9-10(-9) M. In most respects the binding characteristics resemble those of synaptic membranes. These included the correlation of binding affinity and pharmacological potency of opiates; competition by naloxone; inhibition by Ca2+ and Na+; and sensitivity to phospholipases and trypsin. A comparison of stereospecific opiate binding in control human subjects and heroin addicts revealed a 43% increase in the addict group.

An Analysis Of Blood Cortisol Levels In Oral Surgery Patients Under Various Levels Of Intravenous Medication, Fred L. Bunch

Loma Linda University Electronic Theses, Dissertations & Projects

This study was designed to objectively evaluate each pharmacological component of the Loma Linda intravenous sedation technique. The results were evaluated as a function of stress as measured by plasma cortisol levels.

The study was conducted on fifty patients in groups of ten. Blood samples were taken at set procedure intervals during dental extraction of third molar teeth. A component of the Loma Linda technique was deleted from each of the groups to ascertain its role in sedation and relief of stress.

Results show a trend toward reduction of plasma cortisol levels as the procedure progresses, indicating a measure of …

Bibliography Of Secondary Sources On The History Of Dermatology Ii. Obituaries And Biographies In English Before 1973, Lawrence Charles Parish, M.D., John Thorne Crissey, M.D., Jennifer L. Parish, M.D., Daniel H. Parish, J.D.

Department of Dermatology and Cutaneous Biology Faculty Papers

Bibliography of Secondary Sources on the History of Dermatology

II. Obituaries and Biographies in English before 1973

The Effect Of A Pufa Diet On Human Red Blood Cell Levels Of 2, 3-Dpg, Sandra A. Dassenko

Loma Linda University Electronic Theses, Dissertations & Projects

Fasting blood was collected at weekly intervals and the level of 2,3-DPG of the red blood cell was determined in 15 male subjects age 28 to 57 with serum cholesterol levels greater than 250 mg%. A lactovegetarian diet containing no cholesterol, a high level of dietary fiber and a P/S ratio of 4.0 was provided for 28 days.

During the course of the experimental period the 2,3-DPG increased by an average of 0.83> «moles/ml red blood cell which was highly significant (p^.001). This significant increase of 2,3-DPG which relates to an increased oxygen delivery capability of the red blood cells …

A Descriptive Study Of Women's Attitudes Towards Obtaining Or Not Obtaining Papanicolaou Smears, Linda J. Shults

Loma Linda University Electronic Theses, Dissertations & Projects

It was the purpose of this study to identify the attitudes of a selected group of women which influenced their participation in Papanicolaou testing. These attitudes were inferred from the reasons women gave for obtaining the test. The subjects were randomly selected from the telephone book of a medium-sized town in Southern California. The 135 women who participated in the telephone interview were considered to be the respondents in the study.

A review of the literature revealed that through the annual use of the Papanicolaou smear, approximately 11,000 deaths every year from uterine and cervical cancer could be prevented, Attitudes …

An Evaluation Of The Cytotoxicity Of Root Canal Filling Materials On Tissue Culture Cells In Vitro: Grossman's Sealer, N2 Permanent, Rickert's Sealer, And Cavit, Donald D. Antrim

Loma Linda University Electronic Theses, Dissertations & Projects

An in vitro study using radioactively-labeled tissue culture cells was conducted over a seven-month period on Grossman's sealer, Rickert's sealer, N₂ Permanent, and Cavit to determine the lasting and relative tissue toxicity of these materials.

From this study it was observed that all materials possess lasting tissue toxicity. When relative toxicity is considered, Grossman's is the most toxic, followed by N₂, Rickert's and Cavit in descending order of toxicity. Both Grossman's and N₂ would be considered highly toxic, with Rickert's displaying moderate toxicity. Cavit would be considered mild to moderate in toxicity.

The use of radioactively-labeled …

Lethatlity Of And Elicitation Of Protective Antibody By Vibrio Parahaemolyticus Attc 17803, Richard Carlucci

Masters Theses & Specialist Projects

The LD₅₀ of Vibrio parahaemolyticus ATCC 17803 for 13- to 18-g male mice, strain ICR, as determined by the 50% endpoint method, was found to be an estimated 7 x 10⁷ CFU, when administered intraperitoneally in 0.5 ml of 24-h broth culture, O. D. 0.5 at 650 nm, diluted to 10^-0.72.

The elicitation of protective antibody by this bacterium in male New Zealand White rabbits was demonstrated by testing control, baseline, and hyperimmune rabbit sera for their protective effect against 2 LD₅₀ of the bacterium administered intraperitoneally in 13- to 18-g male mice, strain ICR. …

Anatomical And Phenological Variation Of Liquidambar Styraciflua L. Under Controlled Environmental Conditions, William Randel

Masters Theses & Specialist Projects

A large degree of variation in fiber tracheid length, vood specific gravity, and time of apical bud formation existed vithin two populations of Liquidambar styraciflua L. from south central Kentucky. The variation exhibited by these populations may be attributed to the self-sterility of Liquidaribar and the variable environment of south central Kentucky. Variation of fiber tracheid length and wood specific gravity within the two populations was significant. Fiber tracheid length was dependent on temperature and photoperiod while wood specific gravity was primarily dependent on temperature. A significant level of variation was also evident between the two populations regarding tracheid length. …

The Relationship Of Alcohol Consumption In Rats To Morphine And Codeine Intake And The Metabolism Of Dopamine, Hsiu Fen Liu

Loma Linda University Electronic Theses, Dissertations & Projects

The effects of morphine and codeine free-choice alcohol consumption in male Sprague-Dawley rats were studied. Intakes of a 10% alcohol solution in milliliters per 100 gm. of body weight were on recorded weekly. No difference was found in the alcohol intake of rats given either a morphine-supplemented diet (0.01% of the diet) or daily injection of morphine sulfate (2 mg./kg.); however, there was a significant lower intake of water (p < .05) in those rats fed the diet with morphine. Total fluid consumption of both groups given the morphine-supplemented diet and daily injection of morphine sulfate was decreased (p < .05). It was found that morphine did not affect the percentage of total fluid consumed as alcohol or the weight gain.

Two levels of codeine phosphate (10 mg./kg. and 20 mg./kg.) were injected subcutaneously into rats twice a day. It was observed that the codeine significantly decreased alcohol intake in rats …

The Xyy Syndrome And The Judicial System, Paul Cheverie

North Carolina Central Law Review

No abstract provided.

The Effect Of Diet On Neutrophilic Phagocytosis, Linda L. Hoover

Loma Linda University Electronic Theses, Dissertations & Projects

Two series of experiments were conducted in order to determine the effects of diet on neutrophilic phagocytosis. The first series was designed to determine the effects of varying amounts of oral glucose on phagocytosis. Blood samples from 6 to 8 subjects were drawn at fasting, and at various time periods following ingestion of 12.5, 25, 50, 75, and 100 grams of glucose. In the second series of experiments, blood samples were taken from 11 subjects after an overnight fast and 2 hours following ingestion of one of 4 different liquid diets, which included the following: the meal (I), consisting of …

Effect Of Speed Of Muscle Contraction On Strength Improvement, Terry Alan Dieckhoff

Masters Theses

No abstract provided.

Chlorophyll Levels And Leaf Chlorplast Ultrastructure As Ecotypic Characters In Xanthium Strumarium L., Farag Abdulrahman

Masters Theses & Specialist Projects

The major objective of the work was to clarify some of the adaptive mechanisms that a common widespread species would show as a possible requirement for survival in its natural habitats. Analysis of various populations of Xanthium (cocklebur) indicated differences in chlorophyll levels and leaf chloroplasts ultrastructure between populations. The study also revealed some insight into intrapopulational variation in dark requirements for flowering of selected populations. In addition, caloric values of dried leaf material of cocklebur were analyzed for interpopulational differences. It was evident that higher chlorophyll levels are correlated with increase in latitude of origin and a corresponding decrease …

The Catabolism Of Thiamine By Phycomyces Blakesleeanus, Cheryl Lowe

Masters Theses & Specialist Projects

none

Regulation Of The Secondary Antibody Response In Vitro. Ii. Chemical Properties Of An Antibody Inhibitory Material (Aim) Produced In Antigen-Stimulated Rabbit Lymph Node Organ Culture, Charles T. Ambrose

Charles T. Ambrose

We have previously described an inhibitor of antibody synthesis found in serum-free medium of rabbit lymph node organ cultures undergoing a secondary response (1). This present paper concerns some chemical properties of this antibody inhibitory material (AIM), 1 notably its sensitivity to ribonuclease. The implications of this latter observation on the isolation of AIM are explored. Other experiments described here indicate that the inhibition of antibody synthesis by AIM is reversible and most pronounced during the productive phase in vitro. Crucial to these studies has been the preparation of media and the recognition of spurious inhibitory effects, particularly those relating …

Seasonal And Spatial Distribution Of The Plankton Of Barren Lake, Kentucky, With Special Reference To The Phytoplankton Community, John Wright

Masters Theses & Specialist Projects

A study of the seasonal and spatial distribution of phytoplankters in relation to physio-chemical parameters and discharge regime was conducted in Barren Lake, Kentucky, a flood control reservoir with a dam equipped with a multilevel outlet, from February, 1970, through January, 1971. Paired samples were collected every two weeks from April through October and every three weeks from November through March. Samples were obtained from eight depths in the main pool area of the reservoir and from the tailwater. Reservoir discharge was primarily from the upper 3 m from April through September. At other times, discharge incorporated lower levels to …

Pneumotachograph, Louis Diamond, William T. Lipscomb

Pharmacology and Nutritional Sciences Faculty Patents

A pneumotachograph suitable for measuring flow rates of respiratory gases in small animals and comprising essentially a flow-resisting element which can be placed in series with a subject''s airway. The pressure drop across the resistive element is proportional to the rate of airflow and is linear over the range of flows which one normally would expect to encounter in small animals (0-2 liters/min.).

X-Ray-Induced Specific-Locus Mutation Rates In Newborn And Young Mice, Paul Bruce Selby

Doctoral Dissertations

The specific-locus mutation frequency resulting from 300 R of acute X irradiation has been determined for the germ cells present in male mice at 0, 2, 4, 6, 8, 10, 14, 21, 28, and 35 days of age and also for female mice at 0 days of age, Sample size was much larger for the males irradiated on day 0 than for other age groups but in all groups it was large enough to insure that an extremely high rate would be noticed. At 35 days of age the testis is histologically similar to that of the adult. It was …

Partial Purification And Properties Of Nicotinamide Adenine Dinucleotide Phosphate-Specific Isocitrate Dehydorgenase Of Phycomyces Blakesleeanus, Adrienne Shanler

Masters Theses & Specialist Projects

none

Value Of Oxygen With Innovar And Methohexital For Outpatient Oral Surgery, Andrew D. Harsany

Loma Linda University Electronic Theses, Dissertations & Projects

This paper demonstrates the value of oxygen in maintaining arterial blood gas in an adequate range during outpatient oral surgery. Dental extractions were completed on ten patients under an anesthetic technique utilizing Innovar and methohexital with supplemental nasal oxygen. Blood gas samples were drawn at five stages during the procedure.

The mean of the PaO₂ samples drawn with the patient at the point of deepest sedation was approximately three times the normal value.

Oxygen for pulmonary ventilation provides a reservoir in the lungs, saturation of hemoglobin, and increased oxygen in the plasma which provides a margin of safety if …

The Effect Of Glucose On The Food Intake Of Goldthioglucose Injected Mice, Janet Lahti

Dissertations and Theses

Jean Mayer has postulated the presence of glucoreceptors located primarily in the ventromedial hypothalamic nuclei of the brain which are activated by glucose in the measure that they utilize it. According to Mayer, hunger occurs when glucose is not available for metabolic purposes and satiation supervenes when glucose is made available. Control of this mechanism rests with the glucoreceptors. These receptors are believed to be destroyed when an injection of the compound goldthioglucose is given to mice. These animals subsequently become obese and are found to have gold deposits and lesions in the ventromedial area and also in other parts …

Mathematical Model Of Placental Oxygen And Carbon Dioxide Exchange, Ester P. Hill

Loma Linda University Electronic Theses, Dissertations & Projects

This model of placental CO₂ and O₂ exchange calculates the time course of changes in P_^CO2, [HCO₃^-], and [H⁺] in each of four "compartments" of placental exchange vessels: maternal erythrocytes, maternal plasma, fetal plasma and fetal erythrocytes. The changes in hemoglobin-bound CO₂ (carbamate) and oxyhemoglobin contents within the erythrocytes are also calculated, permitting consideration of the Haldane and Bohr effects. Equations were written to represent one-dimensional steady state CO₂ and O₂ diffusion between concurrent maternal and fetal capillaries and the subsequent hydration, carbamino and oxyhemoglobin reactions. The equations …

Effect Of Lateral Positioning On Central Venous Pressure, Romelda C. Jereos

Loma Linda University Electronic Theses, Dissertations & Projects

This experimental study was conducted to investigate the effects of lateral positioning on central venous pressure. It was hypothesized that lateral positioning would not significantly change the central venous pressure so long as the subjects were placed on the same horizontal plane for both supine and lateral measurements. It was also hypothesized that the length of time spent in the lateral position would not alter the pressure.

It is recognized that several factors do indeed play important roles in the maintenance of central venous pressure. The effect of one particular influencing factor, gravity, was central to this study. The difference …

The Duration Of The Effect Of Different Carbohydrates On Neutrophilic Phagocytosis, Judy L. Reeser

Loma Linda University Electronic Theses, Dissertations & Projects

In order to determine the duration of the effect of glucose, fructose, sucrose, honey, starch, and orange juice on neutrophilic phagocytosis, 10 subjects underwent a complete series of carbohydrate tolerance tests. Blood samples were drawn at specific time periods following ingestion of 100 grams of each carbohydrate. Blood was then analyzed for glucose and phagocytic index (the mean number of bacteria engulfed per leukocyte); a red blood cell and white blood cell count and differential white cell count were done also on about 1/2 of the samples. In addition, 7 other subjects participated in a fasting study in which no …

Cardioregulatory Role Of The Abdominal Ganglion Of Aplysia Californica, George Maeda

Loma Linda University Electronic Theses, Dissertations & Projects

An isolated heart-abdominal ganglion preparation of this mollusc was developed and used to study the cardioregulatory function of the ganglion and nerves. The heart was perfused with artificial sea water through an atrial cannula and the gastro-esophageal artery was catheterized for blood pressure monitoring. The presence and cardioregulatory effects of axons in the nerves was investigated by electrical stimulation. Fine-tipped glass microelectrodes inserted into ganglionic neurons were used to determine the relationship between the neuronal and cardiac activities.

The principal results are listed below.

1. Primarily inhibitory responses are obtained from both right and left connective stimulation, with some evidence for …