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Medical Sciences

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2019

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Articles 331 - 360 of 371

Full-Text Articles in Medicine and Health Sciences

Do Pd-1 And Pd-L2 Expressions Have Prognostic Impact In Hematologic Malignancies?, Serdal Korkmaz, Selahatti̇n Erdem, Ebru Akay, Erdem Arzu Taşdemi̇r, Hati̇ce Karaman, Muzaffer Kekli̇k Jan 2019

Do Pd-1 And Pd-L2 Expressions Have Prognostic Impact In Hematologic Malignancies?, Serdal Korkmaz, Selahatti̇n Erdem, Ebru Akay, Erdem Arzu Taşdemi̇r, Hati̇ce Karaman, Muzaffer Kekli̇k

Turkish Journal of Medical Sciences

Background/aim: PD-1 (programmed death-1) is an immune checkpoint receptor that modulates T-cell activity in peripheral tissues via interaction with its ligands, PD-L1 (programmed death-ligand 1) and PD-L2 (programmed death-ligand 2). Tumor cells upregulate PD-L1 or PD-L2 to inhibit this T lymphocyte attack. Our goal was to determine the PD-1 and PD-L2 expression rates of various hematologic malignancies, and evaluate whether PD-1 and PD-L2 expressions have an impact on prognosis. Materials and methods: For this purpose, pretreatment bone marrow biopsy specimens of 83 patients [42 multiple myeloma (MM), 21 acute leukemia, and 20 chronic lymphocytic leukemia (CLL)] were stained with monoclonal …

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Evaluation Of The Retinal Nerve Fiber Layer And Ganglion Cell Complex Thicknesses In Patients With Exfoliation Syndrome, Cem Alay, Oya Tekeli̇, Özge Yanik Odabaş, Feyza Çaliş Karanfi̇l Jan 2019

Evaluation Of The Retinal Nerve Fiber Layer And Ganglion Cell Complex Thicknesses In Patients With Exfoliation Syndrome, Cem Alay, Oya Tekeli̇, Özge Yanik Odabaş, Feyza Çaliş Karanfi̇l

Turkish Journal of Medical Sciences

Background/aim: This study aimed to evaluate retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thicknesses using spectral domain optical coherence tomography (SD-OCT) in both unilateral and bilateral exfoliation syndrome (XFS) patients.Materials and methods: Twenty-four patients with unilateral XFS, 20 patients with bilateral XFS, and 23 healthy subjects were enrolled in this study. Eyes with XFS were compared with both fellow eyes and age-matched control subject eyes in terms of mean and segmental RNFL thickness and minimum, mean, and segmental GCC thickness. Results: In the bilateral XFS group, minimum GCC of the right eye (75.80 ± 11.6 μm) was …

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External Validation Of Anastomotic Leakage Risk Analysis System In Patients Who Underwent Colorectal Resection, Sadetti̇n Er, Sabri̇ Özden, Faruk Koca, Bariş Doğu Yildiz, Bülent Cavi̇t Yüksel, Mesut Tez Jan 2019

External Validation Of Anastomotic Leakage Risk Analysis System In Patients Who Underwent Colorectal Resection, Sadetti̇n Er, Sabri̇ Özden, Faruk Koca, Bariş Doğu Yildiz, Bülent Cavi̇t Yüksel, Mesut Tez

Turkish Journal of Medical Sciences

Background/aim: One of the most feared complications after colon resection for carcinoma is anastomotic leakage. Prediction of anastomotic leakage can alter pre- and perioperative management of patients. This study validates an anastomotic leakage prediction system. Materials and methods: Ninety-five patients who underwent colonic resection between 1 January 2016 and 30 January 2017 were included in the study. Patient records and electronic charting system data were used to calculate anastomotic leakage risk on the http://www.anastomoticleak.com/ website.Results: Fifty-six (58.9%) patients were male and thirty-nine (41.1%) were female. The mean age was 61.7 (min: 33, max: 90). Six (6.3%) patients had anastomotic leakage. …

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Branch Retinal Vein Occlusion Associated With Platelet Activation, Emrullah Beyazyildiz, Mehmet Çitirik, Mert Şi̇mşek, Özlem Beyazyildiz, İbrahi̇m Celaletti̇n Haznedaroğlu Jan 2019

Branch Retinal Vein Occlusion Associated With Platelet Activation, Emrullah Beyazyildiz, Mehmet Çitirik, Mert Şi̇mşek, Özlem Beyazyildiz, İbrahi̇m Celaletti̇n Haznedaroğlu

Turkish Journal of Medical Sciences

Background/aim: The aim of this study is to study subclinical platelet activation by detecting three important platelet activation parameters of mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) in patients with branch retinal vein occlusion (BRVO) in comparison to those in healthy control subjects.Materials and methods: This prospective study included 43 patients with BRVO (Group 1)and 40 control subjects (Group 2). The levels of MPV, PDW, and PCT were measured in both of the studied groups.Results: The mean serum level of MPV value was 7.64 ± 0.64 in Group 1 and 7.39 ± 0.42 in Group 2. …

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Prevalence Of Multiple Sclerosis In An Urban Population Of Sivas Province In Turkey, Şeyda Fi̇gül Gökçe, Burhanetti̇n Çi̇ğdem, Sanem Nemmezi̇ Karaca, Asli Bolayir, Özlem Kayim Yildiz, Ahmet Suat Topaktaş, Hati̇ce Balaban Jan 2019

Prevalence Of Multiple Sclerosis In An Urban Population Of Sivas Province In Turkey, Şeyda Fi̇gül Gökçe, Burhanetti̇n Çi̇ğdem, Sanem Nemmezi̇ Karaca, Asli Bolayir, Özlem Kayim Yildiz, Ahmet Suat Topaktaş, Hati̇ce Balaban

Turkish Journal of Medical Sciences

Background/aim: Multiple sclerosis (MS) is a common neurological disorder that can be a leading cause of nontraumatic disability in several countries. Recent reports have indicated a moderate to high risk of MS in European countries. In this study, we examined the prevalence of MS in a well-defined urban population of provincial center in Sivas Province in Turkey.Materials and methods: This study sampled all registered residents of urban areas of provincial center in Sivas Province in April 2017 and 2018 January. All the included patients met the McDonald 2010 criteria. Medical records were reviewed, including all available previously acquired magnetic resonance …

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Factors Associated With Glomerular Filtration Rate Variation In Primary Hyperparathyroidism After Parathyroidectomy, Mustafa Çalişkan, Muhammed Kizilgül, Selvi̇han Beysel, Beki̇r Uçan, Fati̇h Alper Akcan, Mümtaz Takir, Mustafa Özbek, Erman Çakal Jan 2019

Factors Associated With Glomerular Filtration Rate Variation In Primary Hyperparathyroidism After Parathyroidectomy, Mustafa Çalişkan, Muhammed Kizilgül, Selvi̇han Beysel, Beki̇r Uçan, Fati̇h Alper Akcan, Mümtaz Takir, Mustafa Özbek, Erman Çakal

Turkish Journal of Medical Sciences

Background/aim: Prolonged hypercalcemia impairs renal function, and a reduced glomerular filtration rate (GFR) is typical in advanced primary hyperparathyroidism (PHPT). There are scarce data related to predictors of renal impairment in patients with PHPT. Hence, we aimed to evaluate changes in kidney function in PHPT patients after parathyroidectomy (PTX) and identify factors associated with GFR variation in these patients.Materials and methods: One hundred and twenty-five patients with PHPT who underwent surgery between 2012 and 2014 were enrolled in the study. Patients were divided into two groups according to GFR values: patients whose GFR was lower than 60 mL/min/1.73 m2 and …

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Comparison Of Ga-68 Psma Positron Emission Tomography/Computerized Tomography With Tc-99m Mdp Bone Scan In Prostate Cancer Patients, Rabi̇a Lebri̇z Uslu Beşli̇, Muhammet Sai̇t Sağer, Eli̇fe Akgün, Sertaç Asa, Onur Erdem Şahi̇n, Çeti̇n Demi̇rdağ, Ekrem Güner, Seyedbaresh Razavi̇khosroshahi̇, Emre Karayel, Hüseyi̇n Pehli̇vanoğlu, Aslan Aygün, İlhami̇ Uslu, Zübeyr Talat, Keri̇m Sönmezoğlu Jan 2019

Comparison Of Ga-68 Psma Positron Emission Tomography/Computerized Tomography With Tc-99m Mdp Bone Scan In Prostate Cancer Patients, Rabi̇a Lebri̇z Uslu Beşli̇, Muhammet Sai̇t Sağer, Eli̇fe Akgün, Sertaç Asa, Onur Erdem Şahi̇n, Çeti̇n Demi̇rdağ, Ekrem Güner, Seyedbaresh Razavi̇khosroshahi̇, Emre Karayel, Hüseyi̇n Pehli̇vanoğlu, Aslan Aygün, İlhami̇ Uslu, Zübeyr Talat, Keri̇m Sönmezoğlu

Turkish Journal of Medical Sciences

Background/aim: The aim of our study was to compare Tc-99m MDP bone scan and Ga-68 PSMA PET/CT in terms of detection of bone metastasis in prostate cancer patients. Materials and methods: A total of 28 prostate cancer patients with bone scan and PSMA PET/CT performed within 90 days were retrospectively included in our analysis. All bone lesions were scored as negative (score-0), positive (score-1), or suspicious (score-2) for metastasis by two experienced nuclear medicine physicians. Both patient-based and region-based analyses were made for all osseous lesions. Results: On per-patient analysis; sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), …

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Does Chest Compression During Cardiopulmonary Resuscitation Provide Sufficient Cerebral Oxygenation?, Mehmet Aki̇f Yazar, Mehmet Bariş Açikgöz, Adnan Bayram Jan 2019

Does Chest Compression During Cardiopulmonary Resuscitation Provide Sufficient Cerebral Oxygenation?, Mehmet Aki̇f Yazar, Mehmet Bariş Açikgöz, Adnan Bayram

Turkish Journal of Medical Sciences

Background/aim: Some of the patients suffering from cardiac arrest (CA) remain in a chronic unconscious state in intensive care units (ICUs). The primary aim of this study was to evaluate the efficacy of chest compression (CC) on cerebral oxygenation during cardiopulmonary resuscitation (CPR). As a secondary goal, we attempted to determine the effects of regional cerebral oxygen saturation (rSO2) values on consciousness and the survival rate using the Full Outline of Unresponsiveness (FOUR) scoring method.Materials and methods: This observational preliminary study was carried out with 20 patients with CA who were hospitalized in ICUs. The rSO2 values measured by near-infrared …

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The Effects Of Early Neurodevelopmental Bobath Approach And Mobilization On Quadriceps Muscle Thickness In Stroke Patients, Arzu Güçlü Gündüz, Gökhan Yazici, Çağla Özkul, Hami̇t Küçük, Hale Zeynep Batur Çağlayan, Bi̇jen Nazliel Jan 2019

The Effects Of Early Neurodevelopmental Bobath Approach And Mobilization On Quadriceps Muscle Thickness In Stroke Patients, Arzu Güçlü Gündüz, Gökhan Yazici, Çağla Özkul, Hami̇t Küçük, Hale Zeynep Batur Çağlayan, Bi̇jen Nazliel

Turkish Journal of Medical Sciences

Background/aim: Following stroke, damage to the central nervous system and adaptive changes in muscle tissue are factors responsible for the loss of muscle strength. Even though it is suggested that early physiotherapy and mobilization prevent structural adaptive changes in muscle tissue, studies regarding this issue are insufficient. The aim of this study is to investigate the effects of early physiotherapy and mobilization on quadriceps muscle thickness (QMT) in stroke patients.Materials and methods: Twelve stroke patients who were admitted to the neurology intensive care unit and 13 healthy controls were included in the study. QMT was examined at admission and discharge …

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Serum Fetuin-A Is Associated With The Components Of Miac(Malnutrition, Inflammation, Atherosclerosis, Calcification) Syndrome In Different Stages, Rüya Mutluay, Ceyla Konca Değerteki̇n, Emel Işiktaş Sayilar, Ülver Deri̇ci̇, Serap Gülteki̇n, Sevi̇m Gönen, Seli̇m Turgay Arinsoy, Mahmut Şükrü Si̇ndel Jan 2019

Serum Fetuin-A Is Associated With The Components Of Miac(Malnutrition, Inflammation, Atherosclerosis, Calcification) Syndrome In Different Stages, Rüya Mutluay, Ceyla Konca Değerteki̇n, Emel Işiktaş Sayilar, Ülver Deri̇ci̇, Serap Gülteki̇n, Sevi̇m Gönen, Seli̇m Turgay Arinsoy, Mahmut Şükrü Si̇ndel

Turkish Journal of Medical Sciences

Background/aim: Fetuin-A, a circulating inhibitor of calcification, is a marker of inflammatory-nutritional state. We evaluated the association between serum fetuin-A levels and vascular calcification, intima-media thickness, and nutritional and inflammatory markers in different stages of chronic kidney disease (CKD). Materials and methods: CKD patients were sampled for calcium-phosphate parameters and nutritional and inflammatory markers [highly sensitive C-reactive protein (hs-CRP)], and serum fetuin-A levels. Intima-media thicknesses of the common carotid arteries (CIMT) were measured. Peripheral artery calcification scores were obtained.Results: A total of 238 patients were included in the study. Fetuin-A levels in patients with end-stage renal disease were significantly lower …

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Evaluation Of Measles Immunity In Turkey: Is It Still A Threat?, Selda Karaayvaz, Melahat Melek Oğuz, Ufuk Beyazova, Fatma Gülay Korukluoğlu, Yasemi̇n Coşgun, Zeli̇ha Güzelküçük, Fatma Nur Baran Aksakal, Fi̇gen Şahi̇n Dağli Jan 2019

Evaluation Of Measles Immunity In Turkey: Is It Still A Threat?, Selda Karaayvaz, Melahat Melek Oğuz, Ufuk Beyazova, Fatma Gülay Korukluoğlu, Yasemi̇n Coşgun, Zeli̇ha Güzelküçük, Fatma Nur Baran Aksakal, Fi̇gen Şahi̇n Dağli

Turkish Journal of Medical Sciences

Background/aim: Measles is one of the important vaccine-preventable diseases with many complications in childhood. This study presents cross-sectional seroepidemiological data, beginning from neonatal cord blood in infants to children under 6 years of age, about waning of measles antibody and tries to suggest the proper time for measles immunization.Materials and methods: A total of 564 blood samples consisting of neonatal cord blood and samples taken from infants and children at ages of 6, 9, 24-48, and 49-72 months were analyzed for measles seropositivity in a period of 6 months. Results: Measles seropositivity rate was 72.5% in 109 cord blood samples, …

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Risk Factors For Rectal Colonization Of Carbapenem-Resistant Enterobacteriaceae In A Tertiary Care Hospital: A Case-Control Study From Turkey, Fatma Eser, Gülruhsar Yilmaz, Hati̇ce Rahmet Güner, İmran Hasanoğlu, Fatma Yekta Ürkmez Korkmaz, Zi̇yaci̇bali̇ Açikgöz, Mehmet Akin Taşyaran Jan 2019

Risk Factors For Rectal Colonization Of Carbapenem-Resistant Enterobacteriaceae In A Tertiary Care Hospital: A Case-Control Study From Turkey, Fatma Eser, Gülruhsar Yilmaz, Hati̇ce Rahmet Güner, İmran Hasanoğlu, Fatma Yekta Ürkmez Korkmaz, Zi̇yaci̇bali̇ Açikgöz, Mehmet Akin Taşyaran

Turkish Journal of Medical Sciences

Background/aim: This study aimed to evaluate the risk factors of patients colonized with carbapenem-resistant Enterobacteriaceae (CRE).Materials and methods: The study was conducted between January 2010 and March 2016. The colonized group consisted of patients who had a CRE strain in their rectal swab cultures, whereas patients with negative rectal surveillance cultures for CRE who were concurrently hospitalized in the same units with the colonized group patients were included in the control group.Results: The number of patients in the colonized and the control group was 71 and 120, respectively. Both groups were evaluated for demographic and healthcare-associated characteristics. Isolated microorganisms in …

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Effects Of Ankaferd Hemostat On Helicobacter Pylori Strains And Antibiotic Resistance, Rafi̇ye Çi̇ftçi̇ler, Ahmet Koluman, İbrahi̇m Celaletti̇n Haznedaroğlu, Nejat Akar Jan 2019

Effects Of Ankaferd Hemostat On Helicobacter Pylori Strains And Antibiotic Resistance, Rafi̇ye Çi̇ftçi̇ler, Ahmet Koluman, İbrahi̇m Celaletti̇n Haznedaroğlu, Nejat Akar

Turkish Journal of Medical Sciences

Background/aim: Ankaferd hemostat (ABS; Ankaferd blood stopper, İstanbul, Turkey) is a folkloric medicinal plant extract. The aim of this study was to determine the effect of Ankaferd hemostat (ABS) on the fate of Helicobacter pylori strains. The study also aims to determine alterations in the antimicrobial resistance of three different H. pylori strains in response to ABS exposure.Materials and methods: H. pylori Strain 1 was obtained from the culture collection ATCC 43504 and passaged three times for viability. Strain 2 was isolated from a gastric ulcer patient and Strain 3 was isolated from a gastritis patient. 1% of ABS was …

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Virulence Factors And Antimicrobial Resistance In Uropathogenic Escherichiacoli Strains Isolated From Cystitis And Pyelonephritis, Hosseinali Ghazvini, Keyvan Taheri, Elahe Edalati, Ali Miri, Mansour Sedighi, Shiva Mirkalantari Jan 2019

Virulence Factors And Antimicrobial Resistance In Uropathogenic Escherichiacoli Strains Isolated From Cystitis And Pyelonephritis, Hosseinali Ghazvini, Keyvan Taheri, Elahe Edalati, Ali Miri, Mansour Sedighi, Shiva Mirkalantari

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to investigate the prevalence of virulence genes as well as patterns of antibiotic resistance in cystitis and pyelonephritis uropathogenic Escherichia coli (UPEC) isolates. Materials and methods: Two hundred UPEC isolates were collected from hospitalized patients with pyelonephritis (n = 50) and cystitis (n = 150) in Shafa Hospital in Iran. Antimicrobial susceptibility and ESBL production were determined with confirmatory tests. Polymerase chain reaction assay was performed to determine the prevalence of virulence genes in UPEC strains. Results: Of a total 200 UPEC isolates, the highest and lowest resistance rates to antibiotics were for …

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Effects Of Ankaferd Hemostat On Red Blood Cell Aggregation: A Hemorheological Study, Rafi̇ye Çi̇ftçi̇ler, Sali̇h Aksu, Nesli̇han Hacer Di̇kmenoğlu Falkmarken, İbrahi̇m Celaletti̇n Haznedaroğlu Jan 2019

Effects Of Ankaferd Hemostat On Red Blood Cell Aggregation: A Hemorheological Study, Rafi̇ye Çi̇ftçi̇ler, Sali̇h Aksu, Nesli̇han Hacer Di̇kmenoğlu Falkmarken, İbrahi̇m Celaletti̇n Haznedaroğlu

Turkish Journal of Medical Sciences

Background/aim:Ankaferd hemostat (ABS; Ankaferd blood stopper, İstanbul, Turkey) is a prohemostatic agent affecting erythrocytes. The hemostatic action of ABS depends upon fibrinogen gamma chain, prothrombin, and red blood cells. The aim of this study was to assess the effects of ABS on erythrocyte aggregation via hemorheological analyses.Materials and methods: To measure erythrocyte aggregation, blood samples were obtained from healthy, nonsmoker volunteers who had not taken any medication in the previous 10 days. One mL of blood was placed into the laser-assisted optical rotational cell analyzer (LORCA), into the chamber formed by the gap between two concentric glass cylinders. The solution …

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In Silico Design And In Vitro Development Of A Highly Accurate Test To Detect Brucella Species, Hosein Safari, Setareh Shahnazari, Maysam Mard-Soltani, Somayeh Tavakoli, Bahman Khalesi Jan 2019

In Silico Design And In Vitro Development Of A Highly Accurate Test To Detect Brucella Species, Hosein Safari, Setareh Shahnazari, Maysam Mard-Soltani, Somayeh Tavakoli, Bahman Khalesi

Turkish Journal of Medical Sciences

Background: Conventionalmethods of detecting Brucella spp. suffer from technical and biological complications. Besides, newly characterized species of the genus Brucella could be neglected by previously designed polymerase chain reaction (PCR) tests. Therefore, a more accurate PCR-based test seems to be imminently needed. Materials and methods: Blood samples were collected from 39 patients diagnosed with brucellosis and 25 healthy controls. Multiple sequence alignments (MSA) were performed on 500 Omp2-related protein and gene sequences. Thereafter, specific primers were designed and synthesized for the regions with highest conservancy. The collected samples were assessed by PCR test. To overcome the cross-reactivity issue, PCR thermal …

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Anticandidal Activities Of Lactic Acid Bacteria Isolated From The Vagina, Sevda Er, Ayşe İstanbullu Tosun, Gi̇zem Arik Berk, Meri̇h Kivanç Jan 2019

Anticandidal Activities Of Lactic Acid Bacteria Isolated From The Vagina, Sevda Er, Ayşe İstanbullu Tosun, Gi̇zem Arik Berk, Meri̇h Kivanç

Turkish Journal of Medical Sciences

Background/aim: Lactic acid bacteria prevent the overgrowth of pathogenic agents and opportunistic pathogens in the vagina. Moreover, lactic acid bacteria contribute to the preservation of vaginal microbiota by producing antimicrobial agents. Previous studies showed that some lactic acid bacteria exhibited antimicrobial activity against Candida species causing yeast vaginosis as well as many bacterial pathogens.Materials and methods: The antifungal activities of various lactic acid bacteria isolated from the vagina of healthy women on some Candida species isolated from the vagina were investigated by agar diffusion technique. Results: Most of the lactic acid bacteria that belong to the species of Lactobacillus crispatus, …

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Retracted Article: Prevalence And Antimicrobial Susceptibility Pattern Of Toxigenic Clostridium Difficilestrains Isolated In Iran, Maryam Mohammadbeigi, Zahra Safayi Delouyi, Nima Mohammadzadeh, Arash Ala'almohadesin, Keyvan Taheri, Elahe Edalati, Mansour Sedighi, Abed Zahedi Bialvaei Jan 2019

Retracted Article: Prevalence And Antimicrobial Susceptibility Pattern Of Toxigenic Clostridium Difficilestrains Isolated In Iran, Maryam Mohammadbeigi, Zahra Safayi Delouyi, Nima Mohammadzadeh, Arash Ala'almohadesin, Keyvan Taheri, Elahe Edalati, Mansour Sedighi, Abed Zahedi Bialvaei

Turkish Journal of Medical Sciences

No abstract provided.

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Cloning And Molecular Characterization Of Thiol-Specific Antioxidant Gene Of Leishmania Tropica Turkey Isolate, Hamza Özavci, Mustafa Kaplan Jan 2019

Cloning And Molecular Characterization Of Thiol-Specific Antioxidant Gene Of Leishmania Tropica Turkey Isolate, Hamza Özavci, Mustafa Kaplan

Turkish Journal of Medical Sciences

Background/aim: Thiol-specific antioxidant (TSA) protein is one of the most promising molecules among candidates for vaccine against cutaneous leishmaniasis. It was found to be significantly protective against different Leishmania species. In this study, cloning and molecular characterization of thiol-specific antioxidant gene of L. tropica Turkey isolate (LtTSA) were aimed. Materials and methods: LtTSA was amplified by PCR using the specific primers of TSA gene and cloned into the pcDNA3.1 vector. The cloning was confirmed by PCR screening, restriction enzyme reactions, and DNA sequence analysis. Finally, three-dimensional structure and antigenic properties of the protein encoded by the LtTSA were determined.Results: Six …

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Determining The Insulin Secretion Potential For Certain Specific G-Protein Coupled Receptors In Min6 Pancreatic Beta Cells, Hasan Gençoğlu, Kazi̇m Şahi̇n, Peter M. Jones Jan 2019

Determining The Insulin Secretion Potential For Certain Specific G-Protein Coupled Receptors In Min6 Pancreatic Beta Cells, Hasan Gençoğlu, Kazi̇m Şahi̇n, Peter M. Jones

Turkish Journal of Medical Sciences

Background/aim: The polypeptide hormone insulin is essential for the maintenance of whole-body fuel homeostasis, and defects in insulin secretion and/or action are associated with the development of type 1 and type 2 diabetes. The aim of this study was to assess the role of some G-protein coupled receptors (GPCRs), GPR54, GPR56, and GPR75, and cannabinoid receptors CB1R and CB2R, in the regulation of pancreatic ß-cell function.Materials and methods: Insulin secretion from mouse insulinoma ß-cell line (MIN6) monolayers was assessed via insulin radioimmu-noassay (RIA). Reverse transcription-polymerase chain reaction (RT-PCR) was used to assess the expression of some specific GPCRs and the …

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S1pr2 Deficiency Enhances Neuropathic Pain Induced By Partial Sciatic Nerve Ligation, Qiang Gu, Jin Chao Hou, Xiang Ming Fang Jan 2019

S1pr2 Deficiency Enhances Neuropathic Pain Induced By Partial Sciatic Nerve Ligation, Qiang Gu, Jin Chao Hou, Xiang Ming Fang

Turkish Journal of Medical Sciences

Background/aim: Sphingosine 1-phosphate receptor 2 (S1PR2), a member of the seven-transmembrane receptor family, can be activated by its natural ligand sphingosine 1-phosphate (S1P) to initiate signal transduction and is involved in a wide range of biological effects such as immune cell migration and vascular permeability. Its relationship with neuropathic pain (NP) has not been reported. In this study, the effects of S1PR2 on the development of NP were studied.Materials and methods: We generated a model of NP by partial sciatic nerve ligation (pSNL). The 50% paw withdrawal threshold of the wild-type (WT) group and the S1PR2 deficiency group were measured …

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Mir-33 And Rip140 Participate In Lps-Induced Acute Lung Injury, Hua Li, Huan Hou, Shuang Liu, Yangyang Feng, Wansi Zhong, Xiaojuan Hu, Nianlong Yan Jan 2019

Mir-33 And Rip140 Participate In Lps-Induced Acute Lung Injury, Hua Li, Huan Hou, Shuang Liu, Yangyang Feng, Wansi Zhong, Xiaojuan Hu, Nianlong Yan

Turkish Journal of Medical Sciences

Background/aim: Pulmonary microvascular endothelial cells (PMVECs) play a pivotal role in the process of acute lung injury (ALI), which can be induced by lipopolysaccharide (LPS). Numerous reports have indicated that both miR-33 and RIP140 are involved in the inflammatory response in macrophages. In this study, we sought to investigate whether miR-33 and RIP140 participate in ALI induced by LPS.Materials and methods: First, we isolated and identified PMVECs from BALB/c mice. Subsequently, both PMVECs and BALB/c mice were treated with PBS, LPS, or pyrrolidine dithiocarbamate (PDTC) plus LPS and divided into three groups: control (PBS), LPS (LPS), and L+P (LPS plus …

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Antinociceptive Effect Of Liposomal Bupivacaine Formulations After Intrathecal Administration In Rats, İlker Yi̇ği̇t, Berri̇n Günaydin, Ömer Hakan Emmez, Meci̇t Orhan Uludağ, Nur Banu Bal, İsmai̇l Tuncer Deği̇m Jan 2019

Antinociceptive Effect Of Liposomal Bupivacaine Formulations After Intrathecal Administration In Rats, İlker Yi̇ği̇t, Berri̇n Günaydin, Ömer Hakan Emmez, Meci̇t Orhan Uludağ, Nur Banu Bal, İsmai̇l Tuncer Deği̇m

Turkish Journal of Medical Sciences

Background/aim: Based on our previous in vitro study with multilamellar liposomal bupivacaine (MLB) versus bupivacaine alone in artificial cerebrospinal fluid, we aimed to investigate in vivo antinociceptive effect of intrathecal MLB by determining tail flick latency (TFL) time after thermal stimulation in rats. Materials and methods: After preparing MLB and high-yield drug entrapment in liposome (HYDEL) bupivacaine, 18 female Wistar rats were assigned to 3 groups as control (bupivacaine) and study groups (MLB and HYDEL bupivacaine) including 6 rats in each group to administer these drugs intrathecally. Antinociceptive activity was determined in terms of TFL time after thermal stimulation. Maximum …

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Comparison Of Venous Repair Results Using Either Arterial Or Vein Grafts In A Crush-Avulsion Injury Model, Selami̇ Serhat Şi̇rvan, Işil Akgün Demi̇r, Fati̇h Irmak, Dağhan Dağdelen, Kamuran Zeynep Sevi̇m, Ayşe Ayşi̇m Özağari, Ayşi̇n Karasoy Yeşi̇lada Jan 2019

Comparison Of Venous Repair Results Using Either Arterial Or Vein Grafts In A Crush-Avulsion Injury Model, Selami̇ Serhat Şi̇rvan, Işil Akgün Demi̇r, Fati̇h Irmak, Dağhan Dağdelen, Kamuran Zeynep Sevi̇m, Ayşe Ayşi̇m Özağari, Ayşi̇n Karasoy Yeşi̇lada

Turkish Journal of Medical Sciences

Background/aim: Venous insufficiency after replantation or revascularization is one of the most common causes of limb loss in either the short or the long term. The aim of this study was to evaluate the results of a new technique to overcome venous insufficiency.Materials and Methods: A crush-avulsion type of injury was formed in the femoral veins of rats of 3 separate groups. In the control group, primary repair was applied to the damaged veins and the remaining 2 groups were repaired with either an arterial graft or a vein graft. The success rates of anastomosis were then compared.Results: In the …

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A Comparative Biomechanical Analysis Of Suprapectineal And Infrapectineal Fixation On Acetabular Anterior Column Fracture By Finite Element Modeling, Mehmet Yücens, Kadi̇r Bahadir Alemdaroğlu, Ahmet Özmeri̇ç, Serkan İltar, Ahmet Özgür Yildirim, Nevres Hürri̇yet Aydoğan Jan 2019

A Comparative Biomechanical Analysis Of Suprapectineal And Infrapectineal Fixation On Acetabular Anterior Column Fracture By Finite Element Modeling, Mehmet Yücens, Kadi̇r Bahadir Alemdaroğlu, Ahmet Özmeri̇ç, Serkan İltar, Ahmet Özgür Yildirim, Nevres Hürri̇yet Aydoğan

Turkish Journal of Medical Sciences

Background/aim: The aim of this study is to compare the stability and implant stresses of suprapectineal plate with infrapectineal plate in three subconfigurations of the screw types. Materials and methods: The stabilities of different fixation methods were compared by finite element analysis on six models. Three infrapectineal and three suprapectineal models each with locked, unlocked, or combined screws were employed. Three-dimensional finite element stress analysis was performed by using isotropic materials with a load of 2.3 kN applied at standing positions. Motion at the fracture line was measured on four different points located on the pubic and iliac sides of …

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About "Efficacy Of Bispectral Index Monitoring For Prevention Of Anesthetic Awareness And Complications During Oocyte Pick-Up Procedure", Ayşe Çi̇ğdem Tütüncü Jan 2019

About "Efficacy Of Bispectral Index Monitoring For Prevention Of Anesthetic Awareness And Complications During Oocyte Pick-Up Procedure", Ayşe Çi̇ğdem Tütüncü

Turkish Journal of Medical Sciences

No abstract provided.

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Tenofovir Disoproxil Fumarate May Not Cause Renal And Bone Toxicity In Chronic Hepatitis B Patients: A Retrospective Cross-Sectional Study, Hati̇ce Rahmet Güner, Zeli̇ha Koçak Tufan, Gülruhsar Yilmaz, Mehmet Akin Taşyaran Jan 2019

Tenofovir Disoproxil Fumarate May Not Cause Renal And Bone Toxicity In Chronic Hepatitis B Patients: A Retrospective Cross-Sectional Study, Hati̇ce Rahmet Güner, Zeli̇ha Koçak Tufan, Gülruhsar Yilmaz, Mehmet Akin Taşyaran

Turkish Journal of Medical Sciences

No abstract provided.

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Characterization And Haplotype Study Of 6 Novel Str Markers Related To The Kcnq1 Gene In Heterogeneous Cardiovascular Disorders In The Iranian Population, Azam Amirian, Zahra Zafari, Zohre Sharifi, Alireza Kordafshari, Morteza Karimipoor, Sirous Zeinali Jan 2019

Characterization And Haplotype Study Of 6 Novel Str Markers Related To The Kcnq1 Gene In Heterogeneous Cardiovascular Disorders In The Iranian Population, Azam Amirian, Zahra Zafari, Zohre Sharifi, Alireza Kordafshari, Morteza Karimipoor, Sirous Zeinali

Turkish Journal of Medical Sciences

No abstract provided.

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Urinary Phytate Concentration And Risk Of Fracture Determined By The Frax Index In A Group Of Postmenopausal Women, Angel Arturo Lopez Gonzalez, Felix Grases, Bartolome Mari, Matias Tomas-Salva, Adrian Rodriguez Jan 2019

Urinary Phytate Concentration And Risk Of Fracture Determined By The Frax Index In A Group Of Postmenopausal Women, Angel Arturo Lopez Gonzalez, Felix Grases, Bartolome Mari, Matias Tomas-Salva, Adrian Rodriguez

Turkish Journal of Medical Sciences

Background/aim: This study was designed to evaluate the relationship between urinary phytate concentration and risk of fracture at 10 years, determined by using the FRAX model, in women who had undergone menopause within 5 years of the time of enrollment. Materials and methods: Of the 212 postmenopausal women evaluated, 69 were excluded because they had urinary phytate concentrations between 0.51 and 0.99 mg/L. Of the remaining 143 women, 91 had low (≤0.50 mg/L) and 52 had high (≥1.0 mg/L) urinary phytate concentrations. The 10-year risk of fracture was calculated by using the FRAX model.Results: The risks of major osteoporotic fracture …

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Long-Term Monitoring Of Graves' Disease In Children And Adolescents: A Single-Center Experience, Selma Tunç, Özge Köprülü, Hati̇ce Ortaç, Özlem Nalbantoğlu, Ceyhun Di̇zdarer, Korcan Demi̇r, Behzat Özkan Jan 2019

Long-Term Monitoring Of Graves' Disease In Children And Adolescents: A Single-Center Experience, Selma Tunç, Özge Köprülü, Hati̇ce Ortaç, Özlem Nalbantoğlu, Ceyhun Di̇zdarer, Korcan Demi̇r, Behzat Özkan

Turkish Journal of Medical Sciences

Background/aim: Graves' disease (GD) is more severe, requires a more complex treatment, and has a lower probability of achieving remission in children than in adults. There is no consensus on the appropriate duration of antithyroid drug (ATD) treatment. Surgical or radioactive iodine (RAI) treatments are not definitive and generally result in permanent hypothyroidism.This study's goal was examining the effectiveness of ATD treatment in children and adolescents withGD and determining the risk factors of remission and relapse.Materials and methods: This retrospective study included 45 patients (36 females and 9 males, median age 12.5 years) aged 4-18 who were diagnosed with GD …

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