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Full-Text Articles in Medicine and Health Sciences
Histological Changes In The Rat Thoracic Aorta After Chronic Nitric Oxide Synthase Inhibition, Ni̇gar Vardi, Feral Öztürk, Ersi̇n Fadillioğlu, Ali̇ Otlu, Murat Yağmurca
Histological Changes In The Rat Thoracic Aorta After Chronic Nitric Oxide Synthase Inhibition, Ni̇gar Vardi, Feral Öztürk, Ersi̇n Fadillioğlu, Ali̇ Otlu, Murat Yağmurca
Turkish Journal of Medical Sciences
The objective of this study was to determine the morphological effects of chronic nitric oxide (NO) inhibition on the thoracic aorta of Wistar rats. Fifteen male Wistar Albino rats were divided into three groups. Group I rats (control group, n = 5) received tap water, group II rats (n = 5) recieved 100 mg/kg L-NAME (moderate NO inhibiton) and group III rats (n = 5) received 500 mg/kg L-NAME, in drinking water (severe NO inhibition) for 15 days. At the end of 15 days, the carotid arteries of the rats were cannulated and their blood pressure was measured. The rats …
Hemodynamic Changes After Aortopulmonary Separation, Ersi̇n Fadillioğlu, M. Kemal Irmak, Murat Yağmurca, Hasan Erdoğan
Hemodynamic Changes After Aortopulmonary Separation, Ersi̇n Fadillioğlu, M. Kemal Irmak, Murat Yağmurca, Hasan Erdoğan
Turkish Journal of Medical Sciences
The neural crest origin of the aortopulmonary septum has led us to investigate the septum. We designed the present study to assess the hemodynamic changes following aortopulmonary separation in the rat. We freed the ascending aorta from the pulmonary artery by blunt dissection and placed aluminium foil between them in anesthetized, ventilated, open-chest animals and found that the procedure resulted in a slight but significant increase in systolic and diastolic blood pressure and in an insignificant elevation of the heart rate. The hemodynamic deterioration observed after the separation process might be a result of a possible function of the aortopulmonary …