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Articles 1 - 30 of 70
Full-Text Articles in Medicine and Health Sciences
Investigating Toxic Effects Of The Hiv-Rt Inhibitor 2-Phenoxymethyl-5-Chloro-Benzimidazole On Rat Liver, Yeşi̇m Uğur, Ayşegül Akbay Yarpuzlu, Ayşegül Nazi̇koğlu, Esi̇n Aşan, İlkay Yildiz, Şükrü Keleş
Investigating Toxic Effects Of The Hiv-Rt Inhibitor 2-Phenoxymethyl-5-Chloro-Benzimidazole On Rat Liver, Yeşi̇m Uğur, Ayşegül Akbay Yarpuzlu, Ayşegül Nazi̇koğlu, Esi̇n Aşan, İlkay Yildiz, Şükrü Keleş
Turkish Journal of Medical Sciences
The aim of this study was to investigate the toxic effects of the human immunodeficiency virus- reverse transcriptase (HIV-RT) inhibitor 2-phenoxymethyl-5-chlorobenzimidazole on rat liver at the light microscopic level to gain an insight into possible effects in human subjects. To do this, an animal experimental model was constructed and rats were divided into single injected rat (SIR) and multiple injected rat (MIR) groups, as well as single and multiple solvent dimethylsulfoxide (DMSO) injected controls and an untreated control. Cellular heterogeneity was observed in a non-prominent way in the SIR group (prominent in only one area) and very prominently in the …
Transient Silent Ischemia After Ptca Manifested With A Bizarre Ecg, Hakan Özhan, Ramazan Akdemi̇r, Sadik Duran, Mehmet Yazici, Hüseyi̇n Arinç, Hüseyi̇n Gündüz, Ci̇hangi̇r Uyan
Transient Silent Ischemia After Ptca Manifested With A Bizarre Ecg, Hakan Özhan, Ramazan Akdemi̇r, Sadik Duran, Mehmet Yazici, Hüseyi̇n Arinç, Hüseyi̇n Gündüz, Ci̇hangi̇r Uyan
Turkish Journal of Medical Sciences
HAN^1, Ramazan AKDEMİR^1, Sadık DURAN^1, Mehmet YAZICI^1, Hüseyin ARINÇ^2, Hüseyin GÜNDÜZ^2, Cihangir UYAN^2 ^1Department of Cardiology, Düzce Faculty of Medicine, Abant İzzet Baysal University, Düzce - Turkey ^2Department of Cardiology, İzzet Baysal Faculty of Medicine, Abant İzzet Baysal University, Bolu - Turkey
Fatal Liver Failure Secondary To Chemotherapy Induced Hepatitis-B Virus Reactivation In A Patient With Acute Myeloid Leukemia, Zülal Özkurt, Mustafa Ertek, Ayten Kadanali, Serpi̇l Erol, Mehmet Parlak
Fatal Liver Failure Secondary To Chemotherapy Induced Hepatitis-B Virus Reactivation In A Patient With Acute Myeloid Leukemia, Zülal Özkurt, Mustafa Ertek, Ayten Kadanali, Serpi̇l Erol, Mehmet Parlak
Turkish Journal of Medical Sciences
KURT, Mustafa ERTEK, Ayten KADANALI, Serpil EROL, Mehmet PARLAK Department of Clinical Bacteriology and Infectious Diseases, Faculty of Medicine, Atatürk University, Erzurum - Turkey
Importance Of Calcium, Beri̇van Tandoğan, N. Nuray Ulusu
Importance Of Calcium, Beri̇van Tandoğan, N. Nuray Ulusu
Turkish Journal of Medical Sciences
Calcium is the most abundant mineral in the body. Calcium regulates many cellular processes and has important structural roles in living organisms. Skeletal muscle structure and function, polymerisation of fibrin and the conduction of impulses in the nervous system are regulated by calcium. Calcium is an important intracellular messenger in protozoa, plants, and animals. Calcium-transporting systems which are located in the plasma membrane and in the organelles, regulate the ionic concentration of calcium in various compartments according to the different demands of the physiological cycle and these systems upregulate calcium entry by the action of several hormones and calcium binding …
Prenatal Diagnosis Of B-Thalassemia In The Antalya Province, İbrahi̇m Keser, Esra Manguoğlu, Özlem Güzeloğlu Kayişli, Fatma Kurt, İnanç Mendi̇lci̇oğlu, Mehmet Şi̇mşek, Gülseren Bağci, Güven Lüleci̇
Prenatal Diagnosis Of B-Thalassemia In The Antalya Province, İbrahi̇m Keser, Esra Manguoğlu, Özlem Güzeloğlu Kayişli, Fatma Kurt, İnanç Mendi̇lci̇oğlu, Mehmet Şi̇mşek, Gülseren Bağci, Güven Lüleci̇
Turkish Journal of Medical Sciences
Beta-thalassemia and Sickle cell anemia are serious health problems in the Antalya Province of Turkey as well as World Wide. We aimed to summarize data obtained from the prenatal diagnosis for beta-thalassemia and sickle cell anemia of 103 fetuses. All samples were cytogenetically and molecular genetically examined during a period of 4 years. Molecular testing using RDBH and direct DNA sequencing was performed by using amplified DNA from chorionic villi samples at 9-14 weeks of gestation, while mutations in the parents were determined in advance. Cytogenetic analysis was carried out from a primary culture set up. Of the 103 fetuses, …
Sjögren's Syndrome: A Study Of Salivary Electrophoresis, Mehmet Yaltirik, Hülya Koçak Berberoğlu, Kivanç Ergen, Bariş Aydil
Sjögren's Syndrome: A Study Of Salivary Electrophoresis, Mehmet Yaltirik, Hülya Koçak Berberoğlu, Kivanç Ergen, Bariş Aydil
Turkish Journal of Medical Sciences
Many diagnostic tests exist to assess the salivary and lacrimal involvement in Sjögren's syndrome (SS), but there is still disagreement. The purpose of this study was to examine salivary proteins in patients with primary Sjögren's syndrome and healthy control subjects by the polyacrylamide gel electrophoresis, as well as the applicability of the method. The polyacrylamide gel electrophoresis, applied in our examinations, is a simple and rapid method, requiring only a minute amount of saliva for the analysis. Saliva were collected from patients suffering from primary Sjögren's syndrome (n = 10) and a control group (n = 10). All saliva samples …
Ebola: A Significant Threat As An Infectious Disease, And As A Potential Bioterrorism Agent, Çağatay Üstün, Özge Özgürler
Ebola: A Significant Threat As An Infectious Disease, And As A Potential Bioterrorism Agent, Çağatay Üstün, Özge Özgürler
Turkish Journal of Medical Sciences
No abstract provided.
Multiple Aneurysms Of The Left External Jugular Vein, Sami̇ Karapolat, Bi̇lgehan Erkut, Yahya Ünlü
Multiple Aneurysms Of The Left External Jugular Vein, Sami̇ Karapolat, Bi̇lgehan Erkut, Yahya Ünlü
Turkish Journal of Medical Sciences
APOLAT, Bilgehan ERKUT, Yahya ÜNLÜ Department of Cardiovascular Surgery, Faculty of Medicine, Atatürk University, Erzurum - Turkey
Additional Distinct Findings In Three Cases With Wolfram Syndrome, Ni̇met Kabakuş, A. Neşe Çitak Kurt, Abdullah Kurt, Hani̇fi̇ Yildirim, Turgut Yilmaz, Saadet Akarsu
Additional Distinct Findings In Three Cases With Wolfram Syndrome, Ni̇met Kabakuş, A. Neşe Çitak Kurt, Abdullah Kurt, Hani̇fi̇ Yildirim, Turgut Yilmaz, Saadet Akarsu
Turkish Journal of Medical Sciences
No abstract provided.
The Effect Of Glutathione S-Transferase M1 Genotype On Benzo[A]Pyrene-Induced Sister Chromatid Exchanges And Chromosomal Aberrations In Peripheral Blood Lymphocytes, Gülgün S. Güven, Mehmet Güven, İlhan Onaran, Turgut Uluti̇n, Seni̇ha Hacihanefi̇oğlu
The Effect Of Glutathione S-Transferase M1 Genotype On Benzo[A]Pyrene-Induced Sister Chromatid Exchanges And Chromosomal Aberrations In Peripheral Blood Lymphocytes, Gülgün S. Güven, Mehmet Güven, İlhan Onaran, Turgut Uluti̇n, Seni̇ha Hacihanefi̇oğlu
Turkish Journal of Medical Sciences
Sister chromatid exchange (SCE) and chromosomal aberration (CA) in peripheral lymphocytes have been widely used in assessing exposure to mutagens and carcinogens. One of the extensively studied genotoxins is benzo[a]pyrene (BaP). The aim of the present study was to examine the ability of BaP to induce different individual cytogenetic response measured by SCE and CA frequency. The possible influence of genetic polymorphism was also taken into account, by including donors representing positive or null glutathione S-transferase M1 (GSTM1) genotypes. SCEs and CAs were analyzed from 72-h whole-blood lymphocyte cultures of 16 GSTM1 positive and 15 GSTM1 null donors after treatment …
Prevalence Of Brucellozis In The Rural Area Of Kayseri, Central Anatolia, Turkey, Fevzi̇ye Çeti̇nkaya, Meli̇s Naçar, Ayşe Nedret Koç, Selma Gökahmetoğlu, Tülay Aydin
Prevalence Of Brucellozis In The Rural Area Of Kayseri, Central Anatolia, Turkey, Fevzi̇ye Çeti̇nkaya, Meli̇s Naçar, Ayşe Nedret Koç, Selma Gökahmetoğlu, Tülay Aydin
Turkish Journal of Medical Sciences
This study was planned in order to make good the lack of information about population-based data on the prevalence of brucellosis in the Kayseri region. This cross-sectional research was performed on 1850 individuals living in the rural regionaround Kayseri. People aged 15-85 in 9 districts in this rural areas were interviewed and blood samples were screened using the Rose Bengal Agglutination test. The overall prevalence of brucellosis was 3.4%. Although the rate was higher in females (3.7%) than in males (2.9%), there was no significant difference. The lowest prevalence (2.0%) was observed in the 25-34 age group, and the highest …
Quality Control Studies On Conventional Carbamazepine Tablets Available On The Turkish Drug Market, Tansel Çomoğlu, Nurşi̇n Gönül
Quality Control Studies On Conventional Carbamazepine Tablets Available On The Turkish Drug Market, Tansel Çomoğlu, Nurşi̇n Gönül
Turkish Journal of Medical Sciences
Carbamazepine (CBZ) is a widely used antiepileptic drug. It is used to control grandmal seizure as well as in the treatment of neuralgia. The drug is characterised by slow and irregular gastrointestinal absorption due to its low water solubility. In clinics, for conventional dosage forms of CBZ, single daily dosing is insufficient; effective CBZ level is provided by multiple drug administration. Multiplicity of dosage causes inconsistent plasma CBZ levels leading to side effects because of narrow therapeutic and toxic levels. In this study, quality controls of different conventional CBZ tablets which are commercially available on the Turkish drug market were …
Lipid Profile And Lipid Peroxidation Pattern Pre And Post Exercise In Coronary Artery Disease, Hedef D. El-Yassin, Nabil M. A. Hasso, Hassan A. Al-Rubayi
Lipid Profile And Lipid Peroxidation Pattern Pre And Post Exercise In Coronary Artery Disease, Hedef D. El-Yassin, Nabil M. A. Hasso, Hassan A. Al-Rubayi
Turkish Journal of Medical Sciences
Increased aerobic metabolism during exercise is a potential source of oxidative stress, which plays an important role in the development of atherosclerotic disease, while antioxidants delay or prevent various steps in atherosclerosis. The aim of this study was to identify the effect of oxidative stress induced by the TMT (Treadmill exercise Test) and the lipid peroxidation level as and lipid profile in blood, which may help in confirming the diagnosis of CAD (Coronary Artery Disease) in borderline cases of TMT results. This may help in future for early detection and possible prevention of atherosclerosis especially in people with a family …
Lymphocyte Subpopulations In Patients With Acute Brucellosis, İlhami̇ Çeli̇k, H. Handan Akbulut
Lymphocyte Subpopulations In Patients With Acute Brucellosis, İlhami̇ Çeli̇k, H. Handan Akbulut
Turkish Journal of Medical Sciences
The aim of this work was to evaluate changes in lymphocyte subpopulations, especially helper and cytotoxic T cells, in acute brucellosis patients undergoing treatment. Forty-three acute brucellosis patients were included in the study. Twenty healthy subjects served as controls. Total lymphocytes and the CD3^+, CD4^+, CD8^+, CD19^+ and CD (16+56)^+ subpopulations were counted by two-color flow cytometric analysis. The CD4+ counts in patients before and after treatment were not statistically different (p = 0.7), but healthy subjects had significantly more of these cells (p = 0.001 and p = 0.001 compared to pre- and post-treatment patients, respectively). The CD8^+ counts …
Juvenile Dermatomyositis Resistant To Steroids, Muzaffer Polat, İpek Akil, Tarkan İki̇zoğlu, Seli̇m Serter, Mi̇ne Özkol, Özge Yilmaz İki̇zoğlu, Şenol Coşkun
Juvenile Dermatomyositis Resistant To Steroids, Muzaffer Polat, İpek Akil, Tarkan İki̇zoğlu, Seli̇m Serter, Mi̇ne Özkol, Özge Yilmaz İki̇zoğlu, Şenol Coşkun
Turkish Journal of Medical Sciences
POLAT^1, İpek AKIL^1, Tarkan İKİZOĞLU^1, Selim SERTER^2, Mine ÖZKOL^2, Özge YILMAZ İKİZOĞLU^1, Şenol COŞKUN^1 ^1Department of Pediatrics, Faculty of Medicine Celal Bayar University, Manisa - Turkey ^2Department of Radiology, Faculty of Medicine Celal Bayar University, Manisa - Turkey
A Comparison Of Three High Performance Liquid Chromatographic (Hplc) Methods For Measurement Of Plasma Total Homocysteine, Emi̇n Özgür Akgül, Erdi̇nç Çakir, Ömer Özcan, Hali̇l Yaman, Cumhur Bi̇lgi̇, Mehmet Kemal Erbi̇l
A Comparison Of Three High Performance Liquid Chromatographic (Hplc) Methods For Measurement Of Plasma Total Homocysteine, Emi̇n Özgür Akgül, Erdi̇nç Çakir, Ömer Özcan, Hali̇l Yaman, Cumhur Bi̇lgi̇, Mehmet Kemal Erbi̇l
Turkish Journal of Medical Sciences
Homocysteine (tHcy) has been in routine use in many centers after this amino acid was reported as an independent risk factor for cardiovascular, cerebrovascular and peripheral vascular diseases. Many high-performance liquid chromatographic (HPLC) methods including a commercially available kit (Chromsystems) were reported for measuring tHcy in biologic samples. Although the commercial kits are believed to have higher precision, sensitivity and accuracy as well as practical and fast, it may cause high prices by increased test ordering. In this study we aimed to compare two different low-cost methods which had similar advantages with commercial kit as a reference method. In the …
Effects Of Ace Inhibition And At1 Receptor Blockade On Cardiac Ischaemia-Reperfusion Induced Mortality And Cardiac Markers In Rats, Mustafa Iraz, Şemsetti̇n Şahi̇n, Ercüment Ölmez, Ahmet Acet
Effects Of Ace Inhibition And At1 Receptor Blockade On Cardiac Ischaemia-Reperfusion Induced Mortality And Cardiac Markers In Rats, Mustafa Iraz, Şemsetti̇n Şahi̇n, Ercüment Ölmez, Ahmet Acet
Turkish Journal of Medical Sciences
Many studies have established the therapeutic benefits of angiotensin-converting enzyme (ACE) inhibitors such as reducing reperfusion arrhythmias, and angiotensin II type 1 (AT1) blocker may have similar effects to ACE inhibitors. In this study, it was aimed to compare the effects of an ACE inhibitor captopril and AT1 receptor blocker losartan on death from arrhythmias and biochemical markers such as cardiac troponin T and I (cTnT, cTnI), myoglobin, creatin kinase (CK), creatine kinase-MB isoenzyme (CK-MB) and aspartate aminotransferase (AST) after cardiac ischemia/reperfusion in an in vivo rat model. Study design and methods: sixty four male rats were divided into four …
Pelvic Aspergillosis In A Renal Transplant Patient, Mustafa Sofi̇keri̇m, Yeşi̇m Çeti̇nkaya, Fuad Guli̇yev, Banu Sancak, Ender Özden, İlhan Erkan, Mehmet Bakkaloğlu
Pelvic Aspergillosis In A Renal Transplant Patient, Mustafa Sofi̇keri̇m, Yeşi̇m Çeti̇nkaya, Fuad Guli̇yev, Banu Sancak, Ender Özden, İlhan Erkan, Mehmet Bakkaloğlu
Turkish Journal of Medical Sciences
SOFİKERİM^1, Yeşim ÇETİNKAYA^2, Fuad GULİYEV^1, Banu SANCAK3, Ender ÖZDEN^1, İlhan ERKAN^1, Mehmet BAKKALOĞLU^1 ^1Department of Urology, Faculty of Medicine, Hacettepe University, Ankara - Turkey ^2Department of Internal Medicine, Section of Infectious Diseases, Faculty of Medicine, Hacettepe University, Ankara - Turkey ^3Department of Microbiology and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
A New Diagnostic System In Cancer Research: Bioluminescent Imaging (Bli), Z. Günnur Di̇kmen, Ginelle Gellert, Paki̇ze Doğan, Ralph Mason, Peter Antich, Edmond Richer, Woodring E. Wright, Jerry W. Shay
A New Diagnostic System In Cancer Research: Bioluminescent Imaging (Bli), Z. Günnur Di̇kmen, Ginelle Gellert, Paki̇ze Doğan, Ralph Mason, Peter Antich, Edmond Richer, Woodring E. Wright, Jerry W. Shay
Turkish Journal of Medical Sciences
Bioluminescent imaging (BLI) is particularly well suited for imaging small animals, and it can be readily used by scientists who are already routinely using the luciferase gene as a reporter in cell-based assays. This strategy relies on ATP and an O_2 dependent photochemical reaction between luciferin and luciferase, resulting in the release of photons from only live cells. In BLI, the intensity of the light detected by the device is proportional to the intensity of light emitted and the relationship is quantitative. This study was performed to determine the sensitivity of BLI for the imaging of lung metastasis and breast …
Remifentanil Infusion And Paracervical Block Combination For Transvaginal Ultrasound Guided Oocyte Retrieval, Kadi̇r Kaya, Ertan Öztürk, Bi̇lge Tuncer, Berri̇n Günaydin
Remifentanil Infusion And Paracervical Block Combination For Transvaginal Ultrasound Guided Oocyte Retrieval, Kadi̇r Kaya, Ertan Öztürk, Bi̇lge Tuncer, Berri̇n Günaydin
Turkish Journal of Medical Sciences
The optimal anesthetic technique for transvaginal ultrasound guided oocyte retrieval (TUGOR) is not known. We present a case series of patients having TUGOR under intravenous remifentanil infusion and paracervical block (PCB). One hundred four unpremedicated patients were included in our study. After monitoring heart rate (HR), mean arterial pressure (MAP), peripheral oxygen saturation (SpO_2) and end tidal CO_2 (ETCO_2), a remifentanil infusion of 0.25 µg kg^{-1} min^{-1} was started. PCB (10 ml 1% lidocaine) was performed under remifentanil infusion. As soon as the patient felt dizzy, the remifentanil infusion was decreased to 0.15 µg kg^{-1} min^{-1}. Sedation was evaluated according …
Patients' Knowledge Of The Intravenous Contrast Materials And Their Risks: A Cross-Sectional Survey, Ayli̇n Yücel, Bumi̇n Deği̇rmenci̇, Murat Acar, Hülya Elli̇dokuz, Ramazan Albayrak, Alpay Haktanir
Patients' Knowledge Of The Intravenous Contrast Materials And Their Risks: A Cross-Sectional Survey, Ayli̇n Yücel, Bumi̇n Deği̇rmenci̇, Murat Acar, Hülya Elli̇dokuz, Ramazan Albayrak, Alpay Haktanir
Turkish Journal of Medical Sciences
The aim of this study was to determine the level of knowledge about the intravenous contrast materials (IVCMs) and their risks in patients in an Anatolian city. The study included 156 outpatients who applied for radiographic studies requiring the use of IVCMs. The data were obtained by face-to-face interviews before the radiographic examination. The questionnaire was designed specifically for this study and the respondent was given a total score of 100 points for all correct answers. Patients' information about the IVCMs, their risks, and their role in the diagnosis of some diseases were investigated with this survey. ANOVA, t-test and …
Alternate Approaches To Infertility - Are They Safe?, Srinivasa Jayachandra
Alternate Approaches To Infertility - Are They Safe?, Srinivasa Jayachandra
Turkish Journal of Medical Sciences
No abstract provided.
Plasma Procalcitonin Levels In Chronic Haemodialysis Patients, H. Handan Akbulut, İlhami̇ Çeli̇k, Mehmet Özden, Ayhan Doğukan, Vedat Bulut
Plasma Procalcitonin Levels In Chronic Haemodialysis Patients, H. Handan Akbulut, İlhami̇ Çeli̇k, Mehmet Özden, Ayhan Doğukan, Vedat Bulut
Turkish Journal of Medical Sciences
The objective of our study was to assess procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations in end-stage renal disease (ESRD) patients undergoing haemodialysis sessions and the effect of intermittent haemodialysis on PCT levels. We measured plasma PCT and CRP levels in 43 ESRD patients without evidence of systemic infection at the beginning of haemodialysis and 4 hours later. Control group consisted of 40 volunteers with no complaints. Venous blood samples were collected from the patient before and after hemodialysis and the control groups. PCT was assayed by immunoluminometry. The mean plasma concentration of PCT (2.13 ± 0.7 ng/mL) and …
An Overview Of Keratinocyte Carcinoma And Prospective Study On The Accuracy Of The Surgeon’S Diagnosis Of Keratinocyte Carcinoma, Nesri̇n Tan Başer, Nurten Yavuz, Ahmet Terzi̇oğlu, Gürcan Aslan
An Overview Of Keratinocyte Carcinoma And Prospective Study On The Accuracy Of The Surgeon’S Diagnosis Of Keratinocyte Carcinoma, Nesri̇n Tan Başer, Nurten Yavuz, Ahmet Terzi̇oğlu, Gürcan Aslan
Turkish Journal of Medical Sciences
This article concerning the rate of accurate diagnosis of keratinocyte carcinoma is reported by experienced surgeons. Keratinocyte carcinoma (KC) has been recently used in order to define basal cell carcinoma and squamous cell carcinoma. Although an histopathologic analysis is standard for diagnosis, clinical diagnosis is still important for the choice of proper treatment. In this prospective study, 204 lesions were excised following clinical pre-diagnosis of keratinocyte carcinoma. The lesions were excised from the proper surgical limit for clinical diagnosis and sent for histopathologic examination. We have seen that we frequently confuse BCC s and SCC s with actinic keratosis. According …
Benign Solitary Colonic Ulceration Mimicking Lipoma Of The Colon, Murat Acar, Osman Nuri̇ Di̇lek, Fatma Hüsni̇ye Di̇lek, Dursun Ali̇ Şahi̇n, İhsan Uslan
Benign Solitary Colonic Ulceration Mimicking Lipoma Of The Colon, Murat Acar, Osman Nuri̇ Di̇lek, Fatma Hüsni̇ye Di̇lek, Dursun Ali̇ Şahi̇n, İhsan Uslan
Turkish Journal of Medical Sciences
AR^1, Osman Nuri DİLEK^2, Fatma Hüsniye DİLEK^3, Dursun Ali ŞAHİN^2, İhsan USLAN^4 ^1Department of Radiology, Faculty of Medicine, Afyon Kocatepe University, Afyon - Turkey ^2Department of Surgery, Faculty of Medicine, Afyon Kocatepe University, Afyon - Turkey ^3Department of Pathology, Faculty of Medicine, Afyon Kocatepe University, Afyon - Turkey ^4Department of Internal Medicine, Faculty of Medicine, Afyon Kocatepe University, Afyon - Turkey
Evaluation Of Plasma Protein C Antigen, Protein C Activity And Thrombomodulin Levels In Type 2 Diabetic Patients, Berna Aslan, Nezaket Eren, Şebnem Ci̇ğerli̇, Fatma Müldür, Ni̇hal Yücel
Evaluation Of Plasma Protein C Antigen, Protein C Activity And Thrombomodulin Levels In Type 2 Diabetic Patients, Berna Aslan, Nezaket Eren, Şebnem Ci̇ğerli̇, Fatma Müldür, Ni̇hal Yücel
Turkish Journal of Medical Sciences
The imbalance between coagulation and fibrinolysis leads to vascular complications in diabetics. In our study, we have investigated the effects of the protein C-thrombomodulin system as a cause of diabetic vascular complications. Whereas PC-Ag levels were lower, thrombomodulin (TM) levels of diabetics were higher than that of the controls (P < 0.001, P < 0.001 respectively). Furthermore, patients were divided into three groups according to their urinary albumin excretion (UAE). Group 1, 2 and 3 consisted of 27 patients with UAC £ 30 µg/ml, 16 patients with UAC in range 30-140 µg/ml, 3 patients with UAC >140 µg/ml, respectively. Plasma PC-Ag levels were significantly decreased in group 1 and 2 with respect to controls (P < 0.01, P < 0.01). Plasma TM concentrations were significantly increased in group 1, 2 and 3 compared with the control group (P < 0.001, P < 0.01, P < 0.01). Patients were also divided into two groups according to the duration of their illness; patients whose diabetic age < 10 years (Group A) and whose diabetic age > 10 years (Group B). In both groups, PC-Ag levels were lower and TM levels higher than that of the control group (P < 0.01, P < 0.01; P < 0.001, P < 0.001 respectively). There was no significant difference between group A and B in PC-Ag levels (P > 0.50) but a significant difference in TM levels (P < 0.001).
Salivary Malondialdehyde Levels In Patients With Oral Leukoplakia, Yegane Güven, Meral Ünür, Kivanç Bektaş, Ezel Uslu, Ahmet Belce, Erdi̇nç Demi̇rez, Şule Can
Salivary Malondialdehyde Levels In Patients With Oral Leukoplakia, Yegane Güven, Meral Ünür, Kivanç Bektaş, Ezel Uslu, Ahmet Belce, Erdi̇nç Demi̇rez, Şule Can
Turkish Journal of Medical Sciences
Since leukoplakia is a premalignant condition, it is evident that an effective means of control would contribute to reducing the mortality and morbidity of oral cancer. The reactivity of free radicals and singlet oxygen is believed to be an important factor in the pathogenesis of many degenerative diseases including carcinogenesis. Reactive free radicals may damage cells by induction of lipid peroxidation of the polyunsaturated fatty acids. Buege and Aust's method was used for lipid peroxidation analysis. One way of estimating free radical activity and lipid peroxidation is to determine the concentration of malondialdehyde (MDA) in the body fluids. MDA concentration …
Amputated Tuba-Ovarian Torsion In A Newborn, Mi̇ne Özkol, Gülgün Yilmaz Ovali, Özüm Tunçyürek, Aydin Şencan, Yüksel Pabuşçu
Amputated Tuba-Ovarian Torsion In A Newborn, Mi̇ne Özkol, Gülgün Yilmaz Ovali, Özüm Tunçyürek, Aydin Şencan, Yüksel Pabuşçu
Turkish Journal of Medical Sciences
OL^1, Gülgün Yılmaz OVALI^1, Özüm TUNÇYÜREK^1, Aydın ŞENCAN^2, Yüksel PABUŞÇU^1 ^1Department of Radiology, Faculty of Medicine, Celal Bayar University, Manisa - Turkey ^2Department of Pediatric Surgery, Faculty of Medicine, Celal Bayar University, Manisa - Turkey
A Large Odontogenic Keratocyst Containing A Third Molar Tooth In The Maxillary Antrum, Keri̇m Ortakoğlu, Berkay Tolga Süer, Meti̇n Şençi̇men
A Large Odontogenic Keratocyst Containing A Third Molar Tooth In The Maxillary Antrum, Keri̇m Ortakoğlu, Berkay Tolga Süer, Meti̇n Şençi̇men
Turkish Journal of Medical Sciences
TAKOĞLU, Berkay Tolga SÜER, Metin ŞENÇİMEN Department of Oral and Maxillofacial Surgery, Gülhane Military Medical Academy, Ankara - Turkey
Peripheral Facial Paralysis And Apoptosis Induced By Herpes Simplex Type I Virus: A Rat Study, Ni̇met Kabakuş, H. Cengi̇z Alpay, Ahmet Gödekmerdan, Üzeyi̇r Gök, Nusret Akpolat
Peripheral Facial Paralysis And Apoptosis Induced By Herpes Simplex Type I Virus: A Rat Study, Ni̇met Kabakuş, H. Cengi̇z Alpay, Ahmet Gödekmerdan, Üzeyi̇r Gök, Nusret Akpolat
Turkish Journal of Medical Sciences
Different results have been reported concerning the impact of agents used in the treatment of idiopathic facial nerve paralysis (FNP) generated by HSV type I (HSV-I) on the apoptotic process. We aimed at investigating the effects of different agents (steroids, acyclovir and interferon) used in the treatment of idiopathic FNP on the apoptotic process in animals in whom experimental FNP has been produced by HSV-I. After cleaning the auricles of 113 animals, linear injuries were produced, and then 25 micromole KOS HSV-I was inoculated with the solution containing 1.7 x 107 virus per milliliter. On the 6th day after the …