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Investigating Toxic Effects Of The Hiv-Rt Inhibitor 2-Phenoxymethyl-5-Chloro-Benzimidazole On Rat Liver, Yeşi̇m Uğur, Ayşegül Akbay Yarpuzlu, Ayşegül Nazi̇koğlu, Esi̇n Aşan, İlkay Yildiz, Şükrü Keleş
Investigating Toxic Effects Of The Hiv-Rt Inhibitor 2-Phenoxymethyl-5-Chloro-Benzimidazole On Rat Liver, Yeşi̇m Uğur, Ayşegül Akbay Yarpuzlu, Ayşegül Nazi̇koğlu, Esi̇n Aşan, İlkay Yildiz, Şükrü Keleş
Turkish Journal of Medical Sciences
The aim of this study was to investigate the toxic effects of the human immunodeficiency virus- reverse transcriptase (HIV-RT) inhibitor 2-phenoxymethyl-5-chlorobenzimidazole on rat liver at the light microscopic level to gain an insight into possible effects in human subjects. To do this, an animal experimental model was constructed and rats were divided into single injected rat (SIR) and multiple injected rat (MIR) groups, as well as single and multiple solvent dimethylsulfoxide (DMSO) injected controls and an untreated control. Cellular heterogeneity was observed in a non-prominent way in the SIR group (prominent in only one area) and very prominently in the …