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Full-Text Articles in Medicine and Health Sciences
Effects Of Ramadan Fasting On Stroke, Selçuk Çomoğlu, Ahmet Temi̇zhan, Emel Peşi̇nci̇, İzzet Tandoğan, Şenay Özbakir
Effects Of Ramadan Fasting On Stroke, Selçuk Çomoğlu, Ahmet Temi̇zhan, Emel Peşi̇nci̇, İzzet Tandoğan, Şenay Özbakir
Turkish Journal of Medical Sciences
The effects of fasting on humans have not been adequately investigated. Ramadan fasting is a great opportunity for scientific research due to its peculiar nature. With this in mind, we conducted research on the effects of Ramadan on stroke, which is one of the most common causes of death in adults. Patients hospitalized solely for ischemic stroke and intracerebral hemorrhage were evaluated retrospectively. The ratio of these cases to other patients hospitalized in the neurology department was determined. The in-hospital clinical course and mortality rates of the patients with stroke were evaluated. Within the entire cohort, the most frequently encountered …
A Cell Protective Mechanism In A Murine Model Of Parkinson's Disease, Emi̇n Öztaş, Turgut Topal
A Cell Protective Mechanism In A Murine Model Of Parkinson's Disease, Emi̇n Öztaş, Turgut Topal
Turkish Journal of Medical Sciences
Parkinson's disease is characterized by progressive degeneration of the dopaminergic (DA) neurons in the substantia nigra (SN). However, the mechanism underlying DA cell death remains unclear. While apoptotic cell death has been implicated in DA cell death in Parkinson's disease, autophagy - a regulated cellular process for degrading intracellular proteins and organelles under stress - in Parkinson's disease is not known. Here, we report evidence of autophagy in DA neurons of the SN in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of Parkinson's disease. Mice were treated with saline or MPTP (40 mg/kg) and sacrificed after 7 days, and brain tissue samples were …