Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Antifungal activity (2)
- ELISA (2)
- Gingival crevicular fluid (2)
- Immunohistochemistry (2)
- Immunohistochemistry. (2)
-
- L-glutamine (2)
- Laxative (2)
- Oxidative stress (2)
- P53 (2)
- Rat. (2)
- Susceptibility (2)
- Toxocara canis (2)
- ATM (1)
- Abdominal wall closure (1)
- Absence epilepsy (1)
- Acute Pancreatitis (1)
- Acute pancreatitis (1)
- After-potentials (1)
- AgNOR (1)
- Ageing (1)
- Aging (1)
- Alcian Blue (1)
- Allele frequencies (1)
- Allopurinol and Stress-induced ulcer (1)
- Alzheimer's disease (1)
- Anionic sites (1)
- Antifreeze glycoproteins (1)
- Antioxidant activity (1)
- Antioxidants (1)
- Aortopulmonary window (1)
Articles 1 - 30 of 108
Full-Text Articles in Medicine and Health Sciences
Sandwich-Type Enzyme Immunoassay For Amyloid A4 Protein In Cerebrospinal Fluid From Patients With Head Trauma, İbrahi̇m Pi̇ri̇m
Sandwich-Type Enzyme Immunoassay For Amyloid A4 Protein In Cerebrospinal Fluid From Patients With Head Trauma, İbrahi̇m Pi̇ri̇m
Turkish Journal of Medical Sciences
The aim of this study was to design a simple method for detecting the amyloid A4 protein in the cerebrospinal fluid (CSF) of patients who had severe brain trauma caused by traffic or other accidents and to evaluate its diagnostic and prognostic value. For this purpose, a sandwich type ELISA assay was used. A4, a 4kDa protein of 39-43 amino acids, is a metabolic product of a membrane-spanning, 695-770 aa, precursor molecule, the b-amyloid precursor protein (b-APP). The polyclonal rabbit antibody against synthetic A4 protein (1-40 residues) was used as an immobilized antibody. A mouse monoclonal antibody against synthetic A4 …
Are Inflammatory Cytokines Potential Mediators Of Phenytoin-Induced Gingival Overgrowth?, Nurcan Buduneli̇, Gül Ati̇lla, Neci̇l Kütükçüler
Are Inflammatory Cytokines Potential Mediators Of Phenytoin-Induced Gingival Overgrowth?, Nurcan Buduneli̇, Gül Ati̇lla, Neci̇l Kütükçüler
Turkish Journal of Medical Sciences
The levels of interleukin-1beta, tumour necrosis factor-alpha, and interleukin 6 in gingival crevicular fluid of phenytoin-treated patients (from sites exhibiting overgrowth and sites not exhibiting overgrowth) and control subjects were investigated. Six epileptic patients exhibiting severe phenytoin-induced gingival overgrowth, 12 patients with chronic gingivitis and 11 subjects with clinically healthy periodontium were included in the study. The cytokine levels were analysed by enzyme-linked immunosorbent assay and expressed as ng/2 sites. Wilcoxon signed-rank test, Kruskall-Wallis, Mann-Whitney U test and Spearman rank correlation were used for statistical analysis of the data. Overgrown sites showed significantly higher levels of interleukin-1beta compared to the …
Pulmonary Infections Due To Legionella Pneumophila In Immunocompromised Patients, Demet Kaya, Si̇nan Ergi̇nel, Muzaffer Meti̇ntaş, Zeki̇ Üstüner, İrfan Uçgun, Necla Özdemi̇r
Pulmonary Infections Due To Legionella Pneumophila In Immunocompromised Patients, Demet Kaya, Si̇nan Ergi̇nel, Muzaffer Meti̇ntaş, Zeki̇ Üstüner, İrfan Uçgun, Necla Özdemi̇r
Turkish Journal of Medical Sciences
The numbers of immunocom-promised individuals increase as programmes for organ transplantation and chemotherapy of malignant disease advance. Pulmonary infections, which progress rapidly, are one of the major clinical problems in these groups. This study was designed to evaluate the microbiology of pneumonia in immunocompromised patients and to determine the role of Legionella pneumophila. Immunocompromised patients receiving antineoplastic chemotherapy, diagnosed as pneumonia with clinical and radiographic findings and routine laboratory tests were included in the study. For microbiological diagnosis, expectorated sputum was cultured for L. pneumophila. In addition to standard bacterial, fungal and mycobacterial media, specimens were examined microscopically. Direct flourescent …
The Effect Of Sulfur Dioxide On T-Butyl Hydroperoxide Induced Oxidative Stress In Lung Tissues Of Rats, Saadet Gümüşlü, Di̇jle Ki̇pmen Korgun, Süreyya Bi̇lmen, Gülteki̇n Yücel, Pi̇raye Yargiçoğlu, Aysel Ağar
The Effect Of Sulfur Dioxide On T-Butyl Hydroperoxide Induced Oxidative Stress In Lung Tissues Of Rats, Saadet Gümüşlü, Di̇jle Ki̇pmen Korgun, Süreyya Bi̇lmen, Gülteki̇n Yücel, Pi̇raye Yargiçoğlu, Aysel Ağar
Turkish Journal of Medical Sciences
In this study, the effects of sulfur dioxide (SO_2) ,a common pollutant in urban air, on t-butyl hydroperoxide-induced oxidative stress in rat lung tissues were examined. Ten young rats and 10 adult rats were exposed to SO_2 while another 10 young rats and 10 adult rats made up the control groups. Ten ppm SO_2 was administered to the animals of the SO_2 groups in an exposure chamber for one hour a day every day for 6 weeks. The control groups were exposed to filtered air in the same chamber for the same period. At the end of the experimental period, …
Effects Of The Use Of Hypochlorite As A Cleaning Substance On Pulmonary Functions, Rezan Demi̇ralay
Effects Of The Use Of Hypochlorite As A Cleaning Substance On Pulmonary Functions, Rezan Demi̇ralay
Turkish Journal of Medical Sciences
This study was carried out to investigate the effects of a low hypochlorite concentration as a cleaning substance on pulmonary functions. For this purpose, 23 cleaning workers from the Faculty of Medicine of Suleyman Demirel University were selected as the study group and 14 people from technical personnel as the control group. The study group consisted of 17 females and 6 males with a mean age of 26.4±5.6 years and the mean duration of exposure to the substance in question was 10.3±10.7 months without any atopy history. The control group consisted of 12 females and 2 males with a mean …
Smooth Muscle Actin (Sma) Immunoreactivity In Primary Glomerulonephritis (Gn), Duygu Düşmez, Gülfi̇li̇z Gönlüşen, Emel Akoğlu, Sevgi̇ Küllü, İlhan Tuncer
Smooth Muscle Actin (Sma) Immunoreactivity In Primary Glomerulonephritis (Gn), Duygu Düşmez, Gülfi̇li̇z Gönlüşen, Emel Akoğlu, Sevgi̇ Küllü, İlhan Tuncer
Turkish Journal of Medical Sciences
The aims of this study were to determine the role of interstitial and glomerular myofibroblasts in the progression of various glomerulonephritis, and to assess the value of myofibroblasts in determining long-term renal outcome. The biopsy specimens of 42 primary glomerulonephritis cases were reviewed and stained immunohistochemically with alpha smooth muscle actin antibody. The serum creatine level was compared to the pathological changes. The interstitial alpha smooth muscle actin staining correlated with the serum creatine level at the time of biopsy. The glomerular staining, conversely, did not show any relation with renal function. Interstitial myofibroblasts play a role in the development …
Apolipoprotein-E Genotyping In Patients With Coronary Heart Disease, İbrahi̇m Pi̇ri̇m, Muhammet Fevzi̇ Polat, Ersi̇n Akarsu, Yaşar Nuri̇ Şahi̇n, Engi̇n Bozkurt
Apolipoprotein-E Genotyping In Patients With Coronary Heart Disease, İbrahi̇m Pi̇ri̇m, Muhammet Fevzi̇ Polat, Ersi̇n Akarsu, Yaşar Nuri̇ Şahi̇n, Engi̇n Bozkurt
Turkish Journal of Medical Sciences
The aim of the study was to establish apolipoprotein E genotype in the patients with coronary heart disease (CHD) who are inhabitants of the north-east of Turkey. The study involved 106 patients (70 male, 36 female; ages ranging from 37 to 69 years) who are local people and were angiocardiographically diagnosed for CHD. The risk factors such as smoking, alcohol and obesity were determined and serum triglyceride, total cholesterol, LDL and HDL were measured in the subjects. Each patient sample was apolipoprotein E genotyped, which was achieved by PCR amplification of the 227 bp region followed by Cfo I digestion …
Diabetic Osteopathy: Who Is At Risk?, Serap Demi̇r, Ayşi̇n Öge, Selma Karaahmetoğlu, Osman Müftüoğlu, Seni̇ha Naldöken
Diabetic Osteopathy: Who Is At Risk?, Serap Demi̇r, Ayşi̇n Öge, Selma Karaahmetoğlu, Osman Müftüoğlu, Seni̇ha Naldöken
Turkish Journal of Medical Sciences
This study was designed to determine the prevalence of osteopathy in diabetic patients, who are at risk of developing osteopathy, and clarify the relationship between osteopathy and other complications of diabetes mellitus. Thirty-four type I and 66 type II diabetic patients admitted to the endocrinology clinic between 1996 and 1997 and 30 nondiabetic subjects as a control group were studied. Bone scintigraphy (Tc 99m methylene diphosphonate) was used for the diagnosis of osteopathy. The body mass index (BMI) of each patient was calculated. Polyneuropathy was assessed by electromyography and the patients, for each of whom BMI was calculated, were asked …
The Type And Frequency Of Infections Occurring In Collagen Tissue Diseases, Refi̇k Ali̇ Sari, Mehmet Şahi̇n, Göksal Keski̇n, İlhami̇ Ki̇ki̇, Murat Turgay
The Type And Frequency Of Infections Occurring In Collagen Tissue Diseases, Refi̇k Ali̇ Sari, Mehmet Şahi̇n, Göksal Keski̇n, İlhami̇ Ki̇ki̇, Murat Turgay
Turkish Journal of Medical Sciences
Corticosteroids, widely used in the treatment of collagen tissue diseases, increase the number of neutrophils and decrease the total numbers of lymphocytes, monocytes, eosinophils and basophils. In addition, corticosteroids alter important functional activities of both lymphocytes and monocytes. They suppress the bactericidial activities of phagocytes. In this manner, the resistance to infections is reduced. Cytotoxic drugs can have profound effects on the production and function of both phagocyte cells and lymphocytes. We followed up 115 patients with collagen tissue disease for two years and 22 of them had infections. Eight of these 22 patients had urinary tract infection, six had …
In Vivo Interaction Between Cadmium And Essential Trace Elements Copper And Zinc In Rats, H. Hakan Aydin, Canan Çoker, Bi̇ltan Ersöz
In Vivo Interaction Between Cadmium And Essential Trace Elements Copper And Zinc In Rats, H. Hakan Aydin, Canan Çoker, Bi̇ltan Ersöz
Turkish Journal of Medical Sciences
The complex in vivo interaction between Cd, a toxic metal and essential trace elements, mainly Zn and Cu, has not been elucidated yet. The objective being the elucidation of this interrelationship, Cd was subcutaneously administered as CdCI_2 (1 mg/kg/day) for 5 consecutive days to Swiss albino male rats (n=10). After 5 days, the rats were decapitated. Cd, Zn and Cu levels were estimated in hepatic, renal, cardiac and skeletal muscle specimens. Cd was found to be significantly elevated in all tissues (p< 0.001). Zn was increased in hepatic and renal tissues (p< 0.001 and p< 0.05) compared to the controls. Cu was also significantly increased in these tissues. Myocardial and skeletal muscle tissues also manifested a significant increase in Cu and Zn in this group. It is concluded that Cd administration alters the Zn and Cu status in vivo. However, the mechanism underlying the interactions between toxic and essential elements should be further investigated.
Determination Of The Absorption Of Zn By Preterm Infants, Using 70zn Enriched Tracer, Ulvi̇ Ulusoy, John E. Whitley
Determination Of The Absorption Of Zn By Preterm Infants, Using 70zn Enriched Tracer, Ulvi̇ Ulusoy, John E. Whitley
Turkish Journal of Medical Sciences
Absorption of zinc by preterm infants from a synthetic milk labelled extrinsically with 70Zn tracer was determined by faecal monitoring. Six male preterm babies with a mean gestational age of 31±2.9 weeks and a mean birth weight of 1.23±0.24 kg were studied for three balance periods of 72 h with intervals ranging from 6 to 30 days. The babies were fed with the milk containing zinc with added 70Zn tracer. The net (NA) and true (TA) absorption, and endogenous loss (EL) of zinc were determined by the classical (chemical) balance and isotopic approaches. The mean TA, NA and EL were …
Lateral Periodontal Cyst, Işil Saygun, Ati̇lla Özdemi̇r, Mükerrem Safali
Lateral Periodontal Cyst, Işil Saygun, Ati̇lla Özdemi̇r, Mükerrem Safali
Turkish Journal of Medical Sciences
No abstract provided.
Thalamic Hemorrhage (Presentation And Prognosis Of Hemorrhages), Şule Bi̇len, Selçuk Çomoğlu, Yaşar Şahi̇n, Şenay Özbakir
Thalamic Hemorrhage (Presentation And Prognosis Of Hemorrhages), Şule Bi̇len, Selçuk Çomoğlu, Yaşar Şahi̇n, Şenay Özbakir
Turkish Journal of Medical Sciences
The thalamus is one of the most vulnerable areas for intracerebral hemorrhages. In this study, we investigated the parameters of thalamic hemorrhage such as risk factors, initial complaints, neurologic findings and the prognostic effects of the presence or absence of ventricular penetration, as well as the volume and size of hematoma. A total of 57 patients with thalamic hemorrhage, whose diagnosis was confirmed by cranial computerized tomography, were evaluated. The most significant risk factor was hypertension, while the most common initial clinic symptom was incontinence. Those patients who had small hemorrhagic size of low volume and the presence of ventricular …
Molecular Genetics Of Breast Cancer, Emel Ergül, Ali̇ Sazci
Molecular Genetics Of Breast Cancer, Emel Ergül, Ali̇ Sazci
Turkish Journal of Medical Sciences
Recent advances in molecular biology enable researchers to understand the basis of breast cancer much better and show that hereditery breast cancer may result from mutations on several specific gene loci including BRCA1, BRCA2, p53, ATM and PTEN. These genes are tumor supressor genes and although their functions are different, they are all involved in the maintenance of genomic stability after DNA damage. Mutations that impair the function of these genes may adversely affect the manner in which DNA damage is processed. It is likely that the risk of breast cancer development is increased through this mechanism. Moreover, there are …
Difficulties Associated With The Study Of Action Potential After-Potentials In Rat Cultured Sensory Neurones, Ahmet Ayar, Roderick H. Scott
Difficulties Associated With The Study Of Action Potential After-Potentials In Rat Cultured Sensory Neurones, Ahmet Ayar, Roderick H. Scott
Turkish Journal of Medical Sciences
We investigated the properties of action potential after-potentials in cultured dorsal root ganglion neurones from neonatal rats using the whole cell patch clamp technique. The aims of this study were to characterize after-potentials and investigate the possible influences of Ca^{2+}-induced Ca^{2+}release (CICR) on neuronal excitability. The reversal potentials of action potential after-depolarizations and after-hyperpolarizations were estimated. Although evidence for both Ca^{2+}-activated chloride and potassium conductances was obtained, the data indicated that the after-potentials were contaminatied by a variety of distinct ionic events. Apamin was used to attenuate potassium conductances and appeared to enhance the after-depolarizations due to Ca^{2+}-activated chloride conductances. …
A Relation Between The Apolipoprotein E Genotypes And Microalbuminuria In Type 2 Diabetes Mellitus, Ersi̇n Akarsu, İbrahi̇m Pi̇ri̇m, İlyas Çapoğlu, Hasan Kaya, Güngör Akçay, Necdet Ünüvar
A Relation Between The Apolipoprotein E Genotypes And Microalbuminuria In Type 2 Diabetes Mellitus, Ersi̇n Akarsu, İbrahi̇m Pi̇ri̇m, İlyas Çapoğlu, Hasan Kaya, Güngör Akçay, Necdet Ünüvar
Turkish Journal of Medical Sciences
Various relations between apolipoprotein E (apo E) and diabetic nephropathy have been reported. In this study, the question of whether there is any relation between apo E genotypes and microalbuminuria in patients with type-2 diabetes mellitus was examined. Twenty-one male and 25 female patients, with ages the range of 37-62 years (mean 51.7±7.5) with type-2 diabetes mellitus were studied. The apo E genotypes were determined by PCR amplification of the 227 bp region followed by CfoI digestion to release specific band patterns. While 24 patients had microalbuminuria (microalbuminuria group), 22 patients had normoalbuminuria (normoalbuminuria group). The patients with microalbuminuria had …
Biochemical Bone Markers In Prostate Cancer Patients With Local And Advanced Bone Metastates, Hülya Aksoy, Yilmaz Aksoy, Fati̇h Akçay, İsa Özbey
Biochemical Bone Markers In Prostate Cancer Patients With Local And Advanced Bone Metastates, Hülya Aksoy, Yilmaz Aksoy, Fati̇h Akçay, İsa Özbey
Turkish Journal of Medical Sciences
In the present study involving patients with bone metastases arising from prostate cancer, we measured urinary deoxypyridinoline (DPD) as a marker of collagen breakdown activity, serum total and bone-specific alkaline phosphatase activities and serum prostate specific antigen (PSA). This study included 20 patients with benign prostate hyperplasia (BPH) and 23 patients with carcinoma, 11 of had with bone metastases. DPD excretion in urine was significantly greater in prostate cancer patients with bone metastasis than in those with localised prostate cancer or BPH (p0.05). The serum markers of bone formation [total alkaline phosphatase (T-ALP) and bone ALP (B-ALP)] displayed higher mean …
Perioperative Oral Supplement With Immunonutrients In Gastrointestinal Cancer Patients, Ni̇hal Zeki̇ye Erdem, İ. Hakan Kulaçoğlu, Mehtap Akci̇l Temel, Ahmet Çinar Yasti, Nuri̇ Aydin Kama, Nazan Bozkurt
Perioperative Oral Supplement With Immunonutrients In Gastrointestinal Cancer Patients, Ni̇hal Zeki̇ye Erdem, İ. Hakan Kulaçoğlu, Mehtap Akci̇l Temel, Ahmet Çinar Yasti, Nuri̇ Aydin Kama, Nazan Bozkurt
Turkish Journal of Medical Sciences
Significant benefits have been gained with pre or peri-operative nutritional support in surgical patients with malnutrition. Recent studies have also shown that some enteral formulas including certain nutrients like glutamine could provide more benefit than the standard formulas. In this prospective-randomized study, the effects of perioperative oral supplement with enteral formulas containing glutamine in comparison with a standard enteral formula in patients who were operated on for GI malignancies were examined. Thirty-two patients were divided into two groups: the study group was given oral supplement with an elemental diet (Alitraq®) for 7 days preoperatively and 10 days postoperatively as 30-35% …
Unusual Presentation Of A Chondromyxoid Fibroma Of The Temporal Bone, Asuman Ni̇han Haberal, Banu Bi̇lezi̇kçi̇, Mehmet Coşkun, Nur Altinörs, Beyhan Demi̇rhan
Unusual Presentation Of A Chondromyxoid Fibroma Of The Temporal Bone, Asuman Ni̇han Haberal, Banu Bi̇lezi̇kçi̇, Mehmet Coşkun, Nur Altinörs, Beyhan Demi̇rhan
Turkish Journal of Medical Sciences
No abstract provided.
Immunohistochemical Expression Of C-Erb-B2, Steroid Receptors And Cathepsin-D In Breast Carcinomas: A Clinicopathologic Trial, Hadi̇ce Eli̇f Peştereli̇, Okan Erdoğan, Bahar Kiliçarslan, Taner Çolak, Evren Tercan, Mustafa Akaydin, Şeyda Karaveli̇
Immunohistochemical Expression Of C-Erb-B2, Steroid Receptors And Cathepsin-D In Breast Carcinomas: A Clinicopathologic Trial, Hadi̇ce Eli̇f Peştereli̇, Okan Erdoğan, Bahar Kiliçarslan, Taner Çolak, Evren Tercan, Mustafa Akaydin, Şeyda Karaveli̇
Turkish Journal of Medical Sciences
Aim: We investigated the role of c-erb-B2, hormone receptors and cathepsin D in breast carcinoma progression and their correlation with each other. Methods: Forty-six breast carcinoma patients, operated on in the deparment of surgery and diagnosed in the pathology department, were classified according to their histopathological characteristics; the results of immunostaining with estrogen and progesterone receptors, c-erb-B2 and cathepsin-D were correlated with the stage and the disease-free survival of the patients. Results: Nuclear positivity was observed in 23 (50 %) cases for estrogen receptor and in 16 (34.8 %) cases for progesterone receptor. There was membranous staining with c-erb-B2 in …
The Short-Term Results Of Intensive Insulin Therapy In Preadolescent Children With Type-1 Diabetes, Ayşenur Ökten, Gülay Kaya, Mukaddes Doğan Kalyoncu, Gamze Çan
The Short-Term Results Of Intensive Insulin Therapy In Preadolescent Children With Type-1 Diabetes, Ayşenur Ökten, Gülay Kaya, Mukaddes Doğan Kalyoncu, Gamze Çan
Turkish Journal of Medical Sciences
Purpose: The aim of this study was to observe the effects of and compliance with an intensive insulin regimen in preadolescent children with type-1 diabetes. Patients and methods: Eleven insulin-dependent diabetic patients, five girls and six boys aged 8 - 11 years (mean 9 years 3 months) with a mean±SD diabetes duration of 2±1.07 years, participated in this study. The results of the intensive insulin regimen were evaluated after one-year follow-up in 11 patients, and in 8 patients at 18 months. In the first year of this study we aimed to bring about higher blood glucose than is generally advised, …
Lung Functions In Workers Exposed To Tobacco Dust, Ahmet Tevfi̇k Sünter, Faruk Bağirici, Ci̇had Dündar, Abdullah Marangoz, Yildiz Pekşen
Lung Functions In Workers Exposed To Tobacco Dust, Ahmet Tevfi̇k Sünter, Faruk Bağirici, Ci̇had Dündar, Abdullah Marangoz, Yildiz Pekşen
Turkish Journal of Medical Sciences
Workers in the tobacco industry are exposed to tobacco dust, which has allergenic and irritative effects on airways. In this study, our aim was to determine whether tobacco dust has any effect on lung functions and volumes. A questionnaire about working conditions was applied to 448 workers, some of which had been exposed to tobacco dust while others had not, and all workers underwent measurements of spirometric flow and volume. Of the study group, 126 workers were exposed to tobacco dust for more than 10 years and 55 were not. All of these 181 workers were also nonsmokers. There were …
A Cadaveric Study Of The Anatomic Variations Of The Brachial Plexus Nerves In The Axillar Region And Arm, Z. Asli Aktan, Lokman Öztürk, Okan Bi̇lge, Mehmet Asim Özer, Yelda Atamaz Pinar
A Cadaveric Study Of The Anatomic Variations Of The Brachial Plexus Nerves In The Axillar Region And Arm, Z. Asli Aktan, Lokman Öztürk, Okan Bi̇lge, Mehmet Asim Özer, Yelda Atamaz Pinar
Turkish Journal of Medical Sciences
Forty-eight upper limbs were dissected in order to study the courses and relations of the brachial plexus nerves in the axilla. Connections between the musculocutaneous and median nerves were found in five arms. There was a suprascapular nerve arising from the union of C4 and C5 directly in one cadaver. A branch from the median nerve extending to the brachial artery was determined. In one of the cadavers the radial nerve arose only from the union of posterior divisions of the inferior and middle trunks.
Fetal 45,X/46,Xy Mosaicism, Cytogenetic And Morphologic Findings In Pregnancy, Murat Derbent, Banu Bi̇lezi̇kçi̇, İdi̇l Alpas, Volkan Baltaci
Fetal 45,X/46,Xy Mosaicism, Cytogenetic And Morphologic Findings In Pregnancy, Murat Derbent, Banu Bi̇lezi̇kçi̇, İdi̇l Alpas, Volkan Baltaci
Turkish Journal of Medical Sciences
No abstract provided.
Irreversible Blindness: An Unusual Complication Of The Caldwell-Luc Operation, Gülhanim Haciyakupoğlu, Müsli̇me Yalaz, Altan Atakan Özcan, Erol Aksungur
Irreversible Blindness: An Unusual Complication Of The Caldwell-Luc Operation, Gülhanim Haciyakupoğlu, Müsli̇me Yalaz, Altan Atakan Özcan, Erol Aksungur
Turkish Journal of Medical Sciences
No abstract provided.
A Case Of Malignant Hyperthermia During Sevoflurane Anesthesia, Si̇bel Bariş, Deni̇z Karakaya, Fuat Güldoğuş, Bi̇nnur Sarihasan, Ati̇lla Tekat
A Case Of Malignant Hyperthermia During Sevoflurane Anesthesia, Si̇bel Bariş, Deni̇z Karakaya, Fuat Güldoğuş, Bi̇nnur Sarihasan, Ati̇lla Tekat
Turkish Journal of Medical Sciences
No abstract provided.
Sialolithiasis (Salivary Stone), Mehmet Dalkiz, Necdet Doğan, Bedri̇ Beydemi̇r
Sialolithiasis (Salivary Stone), Mehmet Dalkiz, Necdet Doğan, Bedri̇ Beydemi̇r
Turkish Journal of Medical Sciences
No abstract provided.
Flow Cytometric Analysis Of The Effects Of Methotrexate And Vepesid On The Hep-2 Cell Cycle, Ni̇zami̇ Duran, Adi̇l M. Allahverdi̇yev, Sali̇h Çeti̇ner
Flow Cytometric Analysis Of The Effects Of Methotrexate And Vepesid On The Hep-2 Cell Cycle, Ni̇zami̇ Duran, Adi̇l M. Allahverdi̇yev, Sali̇h Çeti̇ner
Turkish Journal of Medical Sciences
Objective: To determine the mechanism of action of Methotrexate and Vepesid on the HEp-2 cells isolated from human laryngeal cancer cells morphologically and flow cytometrically (G1, G2, S and PI). Materials and Methods: The HEp-2 continuous cell line was used. Cultivation of the cells was realized in EMEM medium with 10% fetal bovine serum at an atmosphere of 37ºC with 5% CO_2. Six different concentrations of Vepesid and Methotrexate were prepared by diluting with deionized water (5 µg/ml, 50 mg/ml, 500 µg/ml). The morphological and cell cycle parameters of HEp-2 cells were determined by inverted microscope and flow cytometer respectively. …
The Effects Of Benzo(A) Pyrene Doxorubicin And Paclitaxel On P170 Glycoprotein, Di̇dem Turgut Coşan, Ayşe Başaran
The Effects Of Benzo(A) Pyrene Doxorubicin And Paclitaxel On P170 Glycoprotein, Di̇dem Turgut Coşan, Ayşe Başaran
Turkish Journal of Medical Sciences
B(a)P is a mutagenic, carcinogenic and teratogenic substance. Paclitaxel and doxorubicin are antineoplastic drugs widely used in cancer treatment. The purpose of this study is to observe the effects of doxorubicin and paclitaxel on p170 glycoprotein in rat liver and kidney tissue after administration of B(a)P. As is well known, p170 glycoprotein is an indicator of drug resistance. We hypothesized that a combination of these antineoplastic drugs would cause lower p170 levels and thus would have a stronger effect than single drug administration. For confirmation, a combination of drugs was used to prevent the development of drug resistance. In this …
In Vitro Mic Determination Of Haemophilus Influenzae Strains Using E-Test, Ni̇lay Çöplü, Orhan Cem Aktepe, Selda Uluutku, Engi̇n Güvener
In Vitro Mic Determination Of Haemophilus Influenzae Strains Using E-Test, Ni̇lay Çöplü, Orhan Cem Aktepe, Selda Uluutku, Engi̇n Güvener
Turkish Journal of Medical Sciences
H. influenzae is a fastidious bacteria, so the selection of a reliable method for in-vitro susceptibility tests is particularly important. The E-test is a practical method for detecting in-vitro antimicrobial susceptibility of antibiotics by MIC values. This study was performed using the E-test for direct patient management and in order to obtain epidemiological data on H. influenzae. The detection of antimicrobial agent resistance among fifty-seven H. influenzae isolates from lower respiratory tract infections in childhood was studied by the E-test. The E-test was performed on HTM agar according to the instruction manual recommendations. The susceptibility ratios and the MIC90 values …