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Are Inflammatory Cytokines Potential Mediators Of Phenytoin-Induced Gingival Overgrowth?, Nurcan Buduneli̇, Gül Ati̇lla, Neci̇l Kütükçüler
Are Inflammatory Cytokines Potential Mediators Of Phenytoin-Induced Gingival Overgrowth?, Nurcan Buduneli̇, Gül Ati̇lla, Neci̇l Kütükçüler
Turkish Journal of Medical Sciences
The levels of interleukin-1beta, tumour necrosis factor-alpha, and interleukin 6 in gingival crevicular fluid of phenytoin-treated patients (from sites exhibiting overgrowth and sites not exhibiting overgrowth) and control subjects were investigated. Six epileptic patients exhibiting severe phenytoin-induced gingival overgrowth, 12 patients with chronic gingivitis and 11 subjects with clinically healthy periodontium were included in the study. The cytokine levels were analysed by enzyme-linked immunosorbent assay and expressed as ng/2 sites. Wilcoxon signed-rank test, Kruskall-Wallis, Mann-Whitney U test and Spearman rank correlation were used for statistical analysis of the data. Overgrown sites showed significantly higher levels of interleukin-1beta compared to the …
The Effect Of Fixed Restoration Materials On The Il-1\Beta Content Of Gingival Crevicular Fluid, Jüli̇de Özen, Bedri̇ Beydemi̇r, Muhi̇tti̇n A. Serdar, Mehmet Dalkiz, Işil Saygun, Ati̇lla Özdemi̇r
The Effect Of Fixed Restoration Materials On The Il-1\Beta Content Of Gingival Crevicular Fluid, Jüli̇de Özen, Bedri̇ Beydemi̇r, Muhi̇tti̇n A. Serdar, Mehmet Dalkiz, Işil Saygun, Ati̇lla Özdemi̇r
Turkish Journal of Medical Sciences
Cast alloys used in dentistry come into close and prolonged contact with the gingiva and the oral mucosa, and certain alloys have been claimed to cause inflammation of gingival and periodontal tissues. However, only little information is available on the molecules mediating the mechanism of such an effect. For this reason, the aims of this study were to determine 1L-1\beta levels in the gingival crevicular fluid (GCF) before and after the placement of base, high-noble metal-ceramic and all-ceramic crowns. Thirty patients requiring an artificial crown for a maxillary second premolar were suitable for the present study; 18 were male and …