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Articles 7531 - 7560 of 42137
Full-Text Articles in Medicine and Health Sciences
Unraveling Etc Complex I Function In Ferroptosis Reveals A Potential Ferroptosis-Inducing Therapeutic Strategy For Lkb1-Deficient Cancers, Chao Mao, Guang Lei, Amber Horbath, Min Wang, Zhengze Lu, Yuelong Yan, Xiaoguang Liu, Lavanya Kondiparthi, Xiong Chen, Jun Cheng, Qidong Li, Zhihao Xu, Li Zhuang, Bingliang Fang, Joseph R Marszalek, Masha V Poyurovsky, Kellen Olszewski, Boyi Gan
Unraveling Etc Complex I Function In Ferroptosis Reveals A Potential Ferroptosis-Inducing Therapeutic Strategy For Lkb1-Deficient Cancers, Chao Mao, Guang Lei, Amber Horbath, Min Wang, Zhengze Lu, Yuelong Yan, Xiaoguang Liu, Lavanya Kondiparthi, Xiong Chen, Jun Cheng, Qidong Li, Zhihao Xu, Li Zhuang, Bingliang Fang, Joseph R Marszalek, Masha V Poyurovsky, Kellen Olszewski, Boyi Gan
Faculty, Staff and Student Publications
The role of the mitochondrial electron transport chain (ETC) in regulating ferroptosis is not fully elucidated. Here, we reveal that pharmacological inhibition of the ETC complex I reduces ubiquinol levels while decreasing ATP levels and activating AMP-activated protein kinase (AMPK), the two effects known for their roles in promoting and suppressing ferroptosis, respectively. Consequently, the impact of complex I inhibitors on ferroptosis induced by glutathione peroxidase 4 (GPX4) inhibition is limited. The pharmacological inhibition of complex I in LKB1-AMPK-inactivated cells, or genetic ablation of complex I (which does not trigger apparent AMPK activation), abrogates the AMPK-mediated ferroptosis-suppressive effect and sensitizes …
Enhancer Switching In Cell Lineage Priming Is Linked To Erna, Brg1’S At-Hook, And Swi/Snf Recruitment, Dhurjhoti Saha, Srinivas Animireddy, Junwoo Lee, Anna Thommen, Mckenzie M Murvin, Yue Lu, J Mauro Calabrese, Blaine Bartholomew
Enhancer Switching In Cell Lineage Priming Is Linked To Erna, Brg1’S At-Hook, And Swi/Snf Recruitment, Dhurjhoti Saha, Srinivas Animireddy, Junwoo Lee, Anna Thommen, Mckenzie M Murvin, Yue Lu, J Mauro Calabrese, Blaine Bartholomew
Faculty, Staff and Student Publications
RNA transcribed from enhancers, i.e., eRNA, has been suggested to directly activate transcription by recruiting transcription factors and co-activators. Although there have been specific examples of eRNA functioning in this way, it is not clear how general this may be. We find that the AT-hook of SWI/SNF preferentially binds RNA and, as part of the esBAF complex, associates with eRNA transcribed from intronic and intergenic regions. Our data suggest that SWI/SNF is globally recruited in cis by eRNA to cell-type-specific enhancers, representative of two distinct stages that mimic early mammalian development, and not at enhancers that are shared between the …
Parkinson's Disease - Association With Anxiety, Depression, And Sleep Disorders, Isabella J. Boroje
Parkinson's Disease - Association With Anxiety, Depression, And Sleep Disorders, Isabella J. Boroje
Doctoral Dissertations and Projects
Parkinson’s disease (PD) is a progressive neurological disorder presenting with motor symptoms, such as tremors at rest, bradykinesia, rigidity, and gait instability, and non-motor symptoms, such as anxiety, depression, excessive daytime sleepiness (EDS), and REM Sleep Behavior Disorder (RBD). The purpose of this study was to examine the associations of anxiety, depression, and EDS scores with being Prodromal (PPD) - at risk of developing the disease (PPD), having been diagnosed with PD, or being a Healthy Control (HC) using a multinomial logistic regression model. Additional analysis examined RBD scores and their difference across PPD, PD, and HC cohorts. The study …
Brg1/Brm Inhibitor Targets Aml Stem Cells And Exerts Superior Preclinical Efficacy Combined With Bet Or Menin Inhibitor, Warren Fiskus, Jessica Piel, Mike Collins, Murphy Hentemann, Branko Cuglievan, Christopher P Mill, Christine E Birdwell, Kaberi Das, John A Davis, Hanxi Hou, Antrix Jain, Anna Malovannaya, Tapan M Kadia, Naval Daver, Koji Sasaki, Koichi Takahashi, Danielle Hammond, Patrick K Reville, Jian Wang, Sanam Loghavi, Rwik Sen, Xinjia Ruan, Xiaoping Su, Lauren B Flores, Courtney D Dinardo, Kapil N Bhalla
Brg1/Brm Inhibitor Targets Aml Stem Cells And Exerts Superior Preclinical Efficacy Combined With Bet Or Menin Inhibitor, Warren Fiskus, Jessica Piel, Mike Collins, Murphy Hentemann, Branko Cuglievan, Christopher P Mill, Christine E Birdwell, Kaberi Das, John A Davis, Hanxi Hou, Antrix Jain, Anna Malovannaya, Tapan M Kadia, Naval Daver, Koji Sasaki, Koichi Takahashi, Danielle Hammond, Patrick K Reville, Jian Wang, Sanam Loghavi, Rwik Sen, Xinjia Ruan, Xiaoping Su, Lauren B Flores, Courtney D Dinardo, Kapil N Bhalla
Faculty, Staff and Student Publications
BRG1 (SMARCA4) and BRM (SMARCA2) are the mutually exclusive core ATPases of the chromatin remodeling BAF (BRG1/BRM-associated factor) complexes. They enable transcription factors/cofactors to access enhancers/promoter and modulate gene expressions responsible for cell growth and differentiation of acute myeloid leukemia (AML) stem/progenitor cells. In AML with MLL1 rearrangement (MLL1r) or mutant NPM1 (mtNPM1), although menin inhibitor (MI) treatment induces clinical remissions, most patients either fail to respond or relapse, some harboring menin mutations. FHD-286 is an orally bioavailable, selective inhibitor of BRG1/BRM under clinical development in AML. Present studies show that FHD-286 induces differentiation and lethality in AML cells with …
Chemoattractant Distribution In The Drosophila Egg Chamber, Lara Scott
Chemoattractant Distribution In The Drosophila Egg Chamber, Lara Scott
Biology and Medicine Through Mathematics Conference
No abstract provided.
Graphing The Curve: A Mathematical Expedition Into Social Distancing's Role In The South African Covid-19 Narrative, Chidozie Williams Chukwu
Graphing The Curve: A Mathematical Expedition Into Social Distancing's Role In The South African Covid-19 Narrative, Chidozie Williams Chukwu
Biology and Medicine Through Mathematics Conference
No abstract provided.
An Algorithm Of Aesthetics: The Mathematical Beauty Of Type-B Turing Pattern Development In Monkeyflowers, Clara A. Rinker, Emily S.G. Simmons, Joshua R. Puzey, Gregory D. Conradi Smith
An Algorithm Of Aesthetics: The Mathematical Beauty Of Type-B Turing Pattern Development In Monkeyflowers, Clara A. Rinker, Emily S.G. Simmons, Joshua R. Puzey, Gregory D. Conradi Smith
Biology and Medicine Through Mathematics Conference
No abstract provided.
Unraveling Gut Microbiota And Mucus Dynamics In Response To Polyethylene Glycol (Peg), Shaikh Obaidullah
Unraveling Gut Microbiota And Mucus Dynamics In Response To Polyethylene Glycol (Peg), Shaikh Obaidullah
Biology and Medicine Through Mathematics Conference
No abstract provided.
Sperm-Egg Interaction For Fertilization Success, Prajakta P. Bedekar
Sperm-Egg Interaction For Fertilization Success, Prajakta P. Bedekar
Biology and Medicine Through Mathematics Conference
No abstract provided.
Stage Structured Model For Oyster Restoration With Larval Transport, Sarah Brownstein
Stage Structured Model For Oyster Restoration With Larval Transport, Sarah Brownstein
Biology and Medicine Through Mathematics Conference
No abstract provided.
A Random Differential Equation Model To Estimate Treatment Sensitivity In Synthetic And In Vitro Tumor Growth Data, Natalie Meacham
A Random Differential Equation Model To Estimate Treatment Sensitivity In Synthetic And In Vitro Tumor Growth Data, Natalie Meacham
Biology and Medicine Through Mathematics Conference
No abstract provided.
Modeling Interactions Between Platelet-Like Particles And Fibrin Matrix During Polymerization And Ultrasound Stimulation In Wound Healing Applications, Julia Sanger, Ashley C. Brown, Marie Muller, Mansoor A. Haider
Modeling Interactions Between Platelet-Like Particles And Fibrin Matrix During Polymerization And Ultrasound Stimulation In Wound Healing Applications, Julia Sanger, Ashley C. Brown, Marie Muller, Mansoor A. Haider
Biology and Medicine Through Mathematics Conference
No abstract provided.
Modeling Synergistic Effects Of Integrin And Tgf-Beta Signaling In Epithelial Mesenchymal Transition, Prerak Thakkar
Modeling Synergistic Effects Of Integrin And Tgf-Beta Signaling In Epithelial Mesenchymal Transition, Prerak Thakkar
Biology and Medicine Through Mathematics Conference
No abstract provided.
Assessing The Pre- And Post-Synaptic Effects Of Opioids On Inspiratory Rhythmogenesis, Diego F. Morandi Zerpa, Jingzhi Zhao
Assessing The Pre- And Post-Synaptic Effects Of Opioids On Inspiratory Rhythmogenesis, Diego F. Morandi Zerpa, Jingzhi Zhao
Biology and Medicine Through Mathematics Conference
No abstract provided.
Understanding Cardiovascular Dynamics: Insights From Data Driven Nonlinear Hyperelastic Wall Modeling In Pulmonary Arteries, Md Arifuzzaman, Mette S. Olufsen, Mansoor A. Haider
Understanding Cardiovascular Dynamics: Insights From Data Driven Nonlinear Hyperelastic Wall Modeling In Pulmonary Arteries, Md Arifuzzaman, Mette S. Olufsen, Mansoor A. Haider
Biology and Medicine Through Mathematics Conference
No abstract provided.
Stokes Flow Around Beating Microorganisms, Mckenna A. Witt
Stokes Flow Around Beating Microorganisms, Mckenna A. Witt
Biology and Medicine Through Mathematics Conference
No abstract provided.
A Comparative Analysis Of Source Identification Algorithms, Pablo A. Curiel
A Comparative Analysis Of Source Identification Algorithms, Pablo A. Curiel
Biology and Medicine Through Mathematics Conference
No abstract provided.
Mathematical Modeling Of Immune Response To Sars-Cov-2, Hwayeon Ryu
Mathematical Modeling Of Immune Response To Sars-Cov-2, Hwayeon Ryu
Biology and Medicine Through Mathematics Conference
No abstract provided.
Incorporating Awareness, Misinformation And Optimal Control In A Model Of Sars-Cov-2, Eric Numfor
Incorporating Awareness, Misinformation And Optimal Control In A Model Of Sars-Cov-2, Eric Numfor
Biology and Medicine Through Mathematics Conference
No abstract provided.
Information Feedback Delays Within Epidemic Models And Their Effect On Model Dynamics., Maria K. Bouka, Christopher Strickland Dr
Information Feedback Delays Within Epidemic Models And Their Effect On Model Dynamics., Maria K. Bouka, Christopher Strickland Dr
Biology and Medicine Through Mathematics Conference
No abstract provided.
Optimizing Immunotherapies For Improved Cancer Treatment, Anne Talkington, Anthony Kearsley
Optimizing Immunotherapies For Improved Cancer Treatment, Anne Talkington, Anthony Kearsley
Biology and Medicine Through Mathematics Conference
No abstract provided.
Topological Data Analysis Of Molecular Dynamics Simulations Of Monoclonal Antibodies, Melinda Kleczynski, Christina Bergonzo, Anthony Kearsley
Topological Data Analysis Of Molecular Dynamics Simulations Of Monoclonal Antibodies, Melinda Kleczynski, Christina Bergonzo, Anthony Kearsley
Biology and Medicine Through Mathematics Conference
No abstract provided.
A Stochastic Multi-Host Model For West Nile Virus: Determining The Probability Of Disease Extinction!, Suzanne Robertson
A Stochastic Multi-Host Model For West Nile Virus: Determining The Probability Of Disease Extinction!, Suzanne Robertson
Biology and Medicine Through Mathematics Conference
No abstract provided.
Stochastic Immunology Model And Its Analysis, Rahnuma Islam, David Swigon
Stochastic Immunology Model And Its Analysis, Rahnuma Islam, David Swigon
Biology and Medicine Through Mathematics Conference
No abstract provided.
Clustering Using Self Organizing Maps In Biology, Olcay Akman
Clustering Using Self Organizing Maps In Biology, Olcay Akman
Biology and Medicine Through Mathematics Conference
No abstract provided.
Decoding Immune Cell Navigation: Integrating Artificial Life Modeling With Tumor Microenvironment Dynamics, Sadegh Marzban
Decoding Immune Cell Navigation: Integrating Artificial Life Modeling With Tumor Microenvironment Dynamics, Sadegh Marzban
Biology and Medicine Through Mathematics Conference
No abstract provided.
Plenary: Mathematics Of Malaria Transmission Dynamics: The Renewed Quest For Eradication, Abba Gumel
Plenary: Mathematics Of Malaria Transmission Dynamics: The Renewed Quest For Eradication, Abba Gumel
Biology and Medicine Through Mathematics Conference
No abstract provided.
Explaining The Staircase Gelb Illusion, Simultaneous Contrast, And Perceptual Fading Of Stabilized Images With A Neural Model Driven By Fixational Eye Movements, Michael E. Rudd
MODVIS Workshop
A neural model of lightness computation driven by fixational eye movements is described and used to simulate various lightness phenomenon, including the Staircase Gelb illusion and its variants, simultaneous contrast, the Chevreul illusion, and perceptual fading of stabilized images. The model provides a precise account of the lightness matches from several experiments, with an overall error of only 1.5%. In the model, spatial maps of transient ON and OFF cell activations—produced as the eyes traverse the visual scene—are sorted by eye movement direction in visual cortex. At a subsequent processing stage, the activations within these maps are summed across space …
Plenary: Insights Into Depression: Mathematical Approaches, Janet Best
Plenary: Insights Into Depression: Mathematical Approaches, Janet Best
Biology and Medicine Through Mathematics Conference
No abstract provided.
The Palestinian Feature Film "200 Meters" Addresses The Issue Of The Apartheid Wall, Samar Abd Al Karim Farahat
The Palestinian Feature Film "200 Meters" Addresses The Issue Of The Apartheid Wall, Samar Abd Al Karim Farahat
Middle East Journal of Communication Studies
This study aimed to explain the methods of processing the Palestinian feature film" 200 meters " to the issue of the apartheid wall, using sub-objectives highlighting political, social and psychological issues and topics in addition to the characters and cinematic elements, to identify the form of processing carried out by the film in an integrated manner. Given the nature of this study, which aimed to find out how the 200-meter film dealt with the issue of the apartheid wall, the researcher adopted the most appropriate approach to studying this type of phenomena, which is the analytical approach. The results of …