Medicine and Health Sciences Commons^™

A Combined Nasolabial And Infra-Nasal Bi-Lobe Flap Design With Double Transposition For Reconstruction Of The Ipsilateral Upper And Lower Lips Associated With The Commissure Defect, Nyimi Bushabu Fidele, Yifang Zhao, Wu Tianfu, Yanfang Sun, Bing Liu

BioMedicine

Several classical flap variations have been designed to reconstruct lip and commissure defects. Although most of these variations maybe the best option for repairing defects, there is an increasing risk of anatomic distortion and functional disability, mostly in older persons. Herein, we present a combined nasolabial and infra-nasal bi-lobe flap design with double transposition, which was used to concomitantly close the upper and lower lips associated with commissure defects.

Pulmonary Alveolar Microlithiasis And Interstitial Pneumonitis: A Case Report Of The West Of Iran, Mazaher Ramezani, Zahra Aminparast, Masoud Sadeghi

BioMedicine

Pulmonary alveolar microlithiasis (PAM) is a rare disease with autosomal recessive inheritance. Herein, a 20-year-old lady referred to the hospital with a dry cough for two years. The chest X-ray findings were bilateral reticulonodular opacities in both lungs and honeycomb appearance suspicious for miliary tuberculosis and idiopathic pulmonary fibrosis. A wedge biopsy of lung showed that there were several intraalveolar laminated concretions in the pathology report compatible with pulmonary alveolar microlithiasis and interstitial infiltration of lymphocytes and neutrophils compatible with interstitial pneumonitis. PAM is a rare progressive disease with the production of microliths in pulmonary alveoli. The pathologist, radiologist, and …

Curcumin Reduces Malondialdehyde And Improves Antioxidants In Humans With Diseased Conditions: A Comprehensive Meta-Analysis Of Randomized Controlled Trials, Mohammad Alizadeh, Sorayya Kheirouri

BioMedicine

Objective: This systematic review and meta-analysis was conducted to collate the effects of curcumin on MDA and antioxidant markers in individuals with diseased conditions. In this study the research question was “does curcumin supplementation improves oxidative stress and antioxidant defense enzymes in human subjects compared to a group without curcumin supplementation?

Methods: This research included randomized controlled trials published in English in any year, in which intervention with curcumin was compared to either placebo, or standard of care or no intervention. Pubmed, Embase, Cochrane Central, Scopus and Google Scholar were searched. Meta-analysis was performed using RevMan (version 5.3), with standardized …

Epigenetic Profiling Of Mutyh, Klf6, Wnt1 And Klf4 Genes In Carcinogenesis And Tumorigenesis Of Colorectal Cancer, Kosar Babaei, Roya Khaksar, Tahereh Zeinali, Hossein Hemmati, Ahmadreza Bandegi, Pirouz Samidoust, Mohammad Taghi Ashoobi, Hooman Hashemian, Kourosh Delpasand, Fereshteh Talebinasab, Hoora Naebi, Seyed Hossein Mirpour, Arman Keymoradzadeh, Seyedeh Elham Norollahi

BioMedicine

Colorectal cancer (CRC) is distinguished by epigenetic elements like DNA methylation, histone modification, histone acetylation and RNA remodeling which is related with genomic instability and tumor initiation. Correspondingly, as a main epigenetic regulation, DNA methylation has an impressive ability in order to be used in CRC targeted therapy. Meaningly, DNA methylation is identified as one of most important epigenetic regulators in gene expression and is considered as a notable potential driver in tumorigenesis and carcinogenesis through gene-silencing of tumor suppressors genes. Abnormal methylation situation, even in the level of promoter regions, does not essentially change the gene expression levels, particularly …

The Rna Degradation Pathway Is Involved In Pparα-Modulated Anti-Oral Tumorigenesis, Nai-Wen Chang, Yi-Ping Huang

BioMedicine

Background: The activation of peroxisome proliferator-activated receptor alpha (PPARα) has been shown to reprogram tumor metabolism and exhibits great potential for treating anti-oral tumorigenesis.

Methods: In this study, we used a pathway-based strategy to explore possible functional pathways involved in the anticancer activity of PPARα in oral cancer cells through next-generation sequencing (NGS) and bioinformatic approaches.

Results: We found that 3919 genes were upregulated and 1060 genes were downregulated through PPARα activation. These genes were mainly involved in the proteasomal, mRNA surveillance, spliceosomal, RNA transport, and RNA degradation pathways, as indicated by GO and KEGG enrichment analysis. Importantly, a total …

Oral Acute And Sub-Acute Toxic Effects Of HydroalcoholicTerminalia ChebulaRetz AndAchillea WilhelmsiiExtracts In Balb/C Mice, Mahnaz Jafari, Kourosh Manochehri Naeini, Zahra Lorigooini, Rasool Namjoo

BioMedicine

Background: This study examined the acute and sub-acute toxic effects ofTerminalia chebulaandAchillea wilhelmsiiextracts on the murine model.

Methods: In both phases, mice were assigned to intervention and control groups. At the end of study, the liver, kidney, and heart tissues were collected for histopathological studies.

Results: In the acute phase of the study, the safe dose was ≤5000 mg/kg for both extracts. In sub-acute phase, LD50 (95% CI) ofAchillea wilhelmsiiextract was determined ≥5000 mg/kg and that ofTerminalia chebulaextract 2754.436 (2438-3114) mg/kg. The highest dose ofT. chebulaextract induced few histopathological changes.

Conclusion: It will be useful to gain information on the …

The Potential Therapeutic Effect For Melatonin And Mesenchymal Stem Cells On Hepatocellular Carcinoma, Yasser Mohamed, Mohamed A. Basyony, Nabila I. El-Desouki, Walied S. Abdo, Mohammed A. El-Magd

BioMedicine

Background/aim: Herein, we investigated the potential therapeutic effect of Melatonin (Mel) and/or mesenchymal stem cells (MSCs) on rat model of HCC.

Materials and Methods: Female mature rats were divided into 5 groups (n= 10/group): normal (Nor), HCC group intraperitoneally injected with 200 mg/kg DEN, and 3 treated groups; HCC + Mel (Mel) group given Mel intraperitoneally 20 mg/kg, twice a week, HCC + MSCs (MSCs) group intravenously injected by 1 × 10⁶ cells, and HCC + MSCs (Mel +MSCs) group.

Results: Rats in HCC group showed most deteriorated effect in form of increased mortality and relative liver weight, elevated …

Immunohistochemical Expression Of P53, Ki-67, And Cd34 In Psoriasis And Psoriasiform Dermatitis, Mazaher Ramezani, Atefeh Shamshiri, Elisa Zavattaro, Sedigheh Khazaei, Mansour Rezaei, Rozhano Mahmoodi, Masoud Sadeghi

BioMedicine

Background: Psoriasis is the prime example of psoriasiform tissue pattern and should be differentiated from other psoriasiform dermatoses both clinically and histopathologically.

Aim: To evaluate immunohistochemical expression of P53, Ki-67, and CD34 in psoriasis and psoriasiform dermatitis for diagnostic purposes.

Methods: An analytical cross-sectional study was performed on the paraffin blocks of 60 psoriasis and 31 psoriasiform dermatitis patients between 2014 and 2017. The selected formalin-fixed paraffin-embedded tissues from each biopsy specimen were cut into 4-micron sections. Initial sections were stained by hematoxylin and eosin staining. Primary antihuman antibodies against P53, Ki-67, and CD34 were applied. Positive control samples for …

The Judet Quadricepsplasty For Elderly Traumatic Knee Extension Contracture: A Case Report And Review Of The Literature, Benjamin Tze Keong Ding, Suheal Ali Khan

BioMedicine

Traumatic injuries to the knee are frequently complicated by extension contractures. The Judet Quadricepsplasty allows for controlled, sequential release of extrinsic and intrinsic knee contracture components while reducing the potential for iatrogenic quadriceps rupture. We document our institutions experience with this procedure and a systematic review of the current literature. We followed up on an elderly patient with posttraumatic flexion contracture that failed conservative management and underwent Judet Quadricepsplasty. Her knee range of motion improve dramatically from 20 degrees of flexion to 100 degrees of flexion. There was a residual extension lag of 5 degrees which did not impede on …

Cohort Study Of Microelement Status In “Healthy” Population Of Russian Megapolis, Andrew K. Martusevich, Konstantin A. Karuzin

BioMedicine

The aim of the study was at the cohort assessment of microelement status in large city residents classified as “apparently healthy people”. The population study included 2,025 randomly selected middle-aged (2045 years) persons without chronic diseases or acute infectious pathologies. The set of subjects was standardized by age and gender. A blood sample was taken once from each person to determine concentrations of microelements. The level of peripheral blood microelements were determined by atomic absorption spectrometry using «Shimadzu AA7000» device (Japan). The study of a large population of city residents demonstrated inhomogeneity in their microelement status. Deficit conditions were found …

Awareness On Breast Cancer Screening In Malaysia: A Cross Sectional Study, Mun-Seng Lee, Choiriyatul ‘Azmiyaty Amar Ma’ Ruf, Dayang Puteri Nadhirah Izhar, Sayyida Nafisah Ishak, Wan Syazana Wan Jamaluddin, Syafiqah Nadiah Mohd Ya’Acob, Muhammad Nazrullah Kamaluddin

BioMedicine

Introduction: The increasing rate of breast cancer (BC) incidence in Malaysia hints a lack of awareness among Malaysians. One (1) woman out of nineteen (19) is at risk with BC and almost up to fifty percent (50%) of women diagnosed with BC were reported to be under the age of fifty (50). Our main concern is to study the level of awareness among the women on risk factors, clinical manifestations, diagnosis, preventions and treatments.

Method: A cross-sectional study was conducted exclusively among women in the public with total sample of three hundred and forty six (346), questionnaires were distributed using …

Evaluation Of The Serum Β2 Microglobulin Level In Patients With Systemic Lupus Erythematosus And Its Correlation With Disease Activity, Miramir Aghdashi, Simak Salami, Ahmad Nezhadisalami

BioMedicine

Background: Designation of disease activity is serious for the management of systemic lupus erythematosus (SLE). Serum level of β2 microglobulin (β2M) may be associated with illness activity in SLE disease. Since the role of β2M for assessing of illness activity in SLE is not completely clear, the current study aimed to discern evaluation of β2M in patients with SLE and its correlation with sickness activity.

Materials and Methods: In this case-control study, 50 patients with SLE disease and 25 healthy individuals were selected in Imam Khomeini Hospital in central of Urmia.

Blood samples were collected safely from patients, serum was …

The Effect Of NigellaSativaOil On The Prevention Of Phlebitis Induced By Chemotherapy: A Clinical Trial, Niaz Behnamfar, Zohreh Parsa Yekta, Faraz Mojab, Seyyed Mohammad Kazem Naeini

BioMedicine

Introduction: Phlebitis, that disrupts chemotherapy, is the inflammation of the vein and the most common complication of intravenous injection of chemotherapy drugs.

Aim: the aim was determine the effect of topical application of N.sativaoil on the prevention of phlebitis caused by chemotherapy.

Methods: This single-blind clinical trial was conducted on 60 cancer patients. In the intervention group, five drops of N.sativaoil was applied on the distal area of the catheter, two times per day and every 12 hours from the first day of chemotherapy to the third day; no intervention was conducted for the subjects in the control group.

Results: …

The Prevalence Of Post-Traumatic Stress Disorder Among Emergency Nurses: A Cross Sectional Study In Northern Iran, Seyed Mohammad Hosseininejad, Fatemeh Jahanian, Forouzan Elyasi, Hossein Mokhtari, Mohammad Eslami Koulaei, Seyedeh Masoumeh Pashaei

BioMedicine

Background and objective: Posttraumatic stress disorder (PTSD) is one of the anxiety disorders which occurs in response to facing events and accidents accompanied by fear, frustration, and terror. Nurses who worked in the emergency departments witness unpleasant accidents and are exposed to stress and violence more than others. The aim of this study was to investigate the prevalence of PTSD among Iranian nurses working in the emergency department.

Materials and Methods: In this cross-sectional study, all nurses working in the emergency department of educational hospitals affiliated with Mazandaran University of Medical Sciences were included through census method (n = 131). …

Development Of Broad Spectrum Mycosporine Loaded Sunscreen Formulation From Ulva Fasciata Delile, Saurabh Bhatia, Satish Sardana, Ajay Sharma, Celia Bertha Vargas De La Cruz, Bhupal Chaugule, Laleh Khodaie

BioMedicine

Ba.ckground: Sunscreen formulations primarily offer protection against UV induced damages however nowadays it also maintains skin natural physiological conditions. Current global market is flooded with numerous sunscreen products which offer protection to skin against several UV induced damages. However most of these sunscreen formulations offers narrow spectrum protection against UV and also suffer from stability as well as toxicity related issues.

Methods: Present work aims to isolate mycosporine amino acid (Mgy) from green alga namelyUlva fasciata (U. fasciata)and study its sunscreen potential against widely used domestic marketed formulation. Stability evaluations were also performed for almost 90 days.

Results: Results demonstrated …

Fascioliasis Mimicking Malignancy In An Old Patient, Mazaher Ramezani, Farhad Amirian, Masoud Sadeghi

BioMedicine

No abstract provided.

Protective Effect OfGlycyrrhiza GlabraRoots Extract On Bone Mineral Density Of Ovariectomized Rats, Dimitrios Galanis, Konstantinos Soultanis, Pavlos Lelovas, Alexandros Zervas, Panagiotis Papadopoulos, Antonis Galanos, Katerina Argyropoulou, Maria Makropoulou, Anastasia Patsaki, Christina Passali, Anastasia Tsingotjidou, Stavros Kourkoulis, Sofia Mitakou, Ismene Dontas

BioMedicine

Objective: The aim of this study was to evaluate the potential effect of the methanolic extract of plantGlycyrrhiza glabraroots on bone mineral density and femoral bone strength of ovariectomized rats.

Methods: Thirty 10-month-old Wistar rats were randomly separated into three groups of ten, Control, Ovariectomy and Ovariectomy-plus-Glycyrrhiza in their drinking water. Total and proximal tibial bone mineral density was measured in all groups before ovariectomy (baseline) and after 3 and 6 months post ovariectomy. Three-point-bending of the femurs and uterine weight and histology were examined at the end of the study.

Results: No significant difference was noted in bone density …

Ossification Of The Yellow Ligament In The Cervical Spine – An Unusual Location, Jacob Yoong-Leong Oh, Victor Tzong-Jing Wang, Timothy Wei Wen Teo, Arun-Kumar Kaliya-Perumal, Hwan Tak Hee

BioMedicine

Ossification of the yellow ligament (OYL) or ligamentum flavum, usually occurs in the thoracic spine. Focal OYL occurring in the cervical spine is considered rare and is sparsely reported in the literature. We came across a 30-year-old male patient with progressive left upper limb and bilateral lower limb weakness over a period of 3 months, associated with an unsteady gait. Clinical examination revealed bilateral generalized hyper-reflexia in both upper and lower limbs, inverted supinator jerk, Hoffman’s sign and clonus. Myelopathy due to cord compression was suspected and further investigations were done. MRI and CT scans revealed a bony mass in …

In Vivo Microdialysis And In Vitro Hplc Analysis Of The Impact Of Paeoniflorin On The Monoamine Levels And Their Metabolites In The Rodent Brain, Yuh-Tzy Lin, Wei-Shih Huang, Huei-Yann Tsai, Min-Min Lee, Yuh-Fung Chen

BioMedicine

Background: Paeoniflorin (PF) possesses several effects such as analgesic, the anti-spasmodic effect on smooth muscle. It protects the cardiovascular system and reveals the neuroprotective effect on cerebral ischemia. Monoamine system has been identified to have complex regulatory effects in pain signaling. There are no reports regarding the impact of PF on monoamine levels in the rodent brain by microdialysis. In this study, the effects of PF on monoamines and their metabolites in the rodent brain usingin vivomicrodialysis andin vitrohigh performance liquid chromatography (HPLC) analysis.

Methods: Male S.D. rats were anesthetized, fixed onto the stereotaxic instrument to identify the positions of …

Gynura BicolorAqueous Extract Attenuated H2O2Induced Injury In Pc12 Cells, Ya-Chen Yang, Wen-Tzu Wu, Mei-Chin Mong, Zhi-Hong Wang

BioMedicine

Background: Protective effects ofGynura bicoloraqueous extract (GAE) at three concentrations upon nerve growth factor (NGF) differentiated-PC12 cells against H₂O₂induced injury were examined.

Methods: NGF differentiated-PC12 cells were treated with GAE at 0.25%, 0.5% or 1%. 100 μM H₂O₂was used to treat cells with GAE pre-treatments. After incubating at 37 °C for 12 hr, experimental analyses were processed.

Results: H₂O₂exposure decreased cell viability, increased plasma membrane damage, suppressed Bcl-2 mRNA expression and enhanced Bax mRNA expression. GAE pre-treatments reversed these changes. H₂O₂exposure reduced mitochondrial membrane …

Applying Wcacg Modified Process Is Beneficial On Reduced Door-To-Balloon Time Of Acute Stemi Patients, Qiao-Wen Li, Xiao-Jian Liu, Jin-Hua Li, Guo-Qi Zhang, Su-Min Chen, Chao-Long Huang, Min Qiu, Yue-Liang Li, Peng Duan, Yi-Jiun Weng, Xiao-Yong Zhang, Chih-Yang Huang

BioMedicine

Background: Various systems have employed with the objective to reduce the time from emergency medical services contact to balloon inflammation for ST-elevation myocardial infraction (STEMI) patients. The WCACG message system was used to an alternative communication platform to improve confirmation of the diagnosis and movement to treatment, resulted in shorten the door-to-balloon (D-to-B) time for STEMI patients.

Methods: We collected 366 STEMI patients admitted at the Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People’s Hospital, Department of Cardiology, during the period from June 2013 to October 2015. The patients were divided into two groups one underwent the current GC …

Monomicrobial Non-Neutrocytic Bacterascites Caused By Aeromonas Hydrophila In A Patient With Liver Cirrhosis, Chen-Sheng Lin, Cheng-Wen Lin

BioMedicine

Aeromonas peritonitis is a rare, but serious infection, as associated with spontaneous bacterial peritonitis, peritonitis in chronic ambulatory peritoneal dialysis, and intestinal perforation. Here, we reported a case of monomicrobial non-neutrocytic bacterascites caused by Aeromonas hydrophila (A. hydrophila). The patient, a 57-year-old man who had a history of alcoholic liver disease and chronic hepatitis C-related Child- Pugh class C liver cirrhosis, was admitted to our hospital with fever, dyspnea and a localized wound pain over left ankle. Ascitic fluid analysis demonstrated that ascitic polymorphonuclear cell count was 30 cells/ mm³. Empirical antimicrobial treatment with a combination of ceftriaxone …

Comparative Study Of The Effect Of Thymus Daenensis Gel 5% And Diclofenac In Patients With Knee Osteoarthritis, Morteza Dehghan, Shirin Asgharian, Elena Khalesi, Ali Ahmadi, Zahra Lorigooini

BioMedicine

Background: Osteoarthritis is a syndrome characterized by joint pain and reduced performance and efficien- cy in patient.Thymus daenensishas been used since old times for the treatment of bone and joint deformities and pain in traditional medicine.

Purpose: This study was conducted to examine traditional usages and pharmacological features ofT. daen- ensiswith respect to the effect of the plant in patients with osteoarthritis.

Methods: 120 patients with osteoarthritis were divided into 3 groups. Patients in each group were treated by 5%Thymus daenensisgel, 1% diclofenac gel, or placebo for 6 weeks, along with oral celecoxib capsules. Patients were assessed in different intervals, …

The Relationship Between Body Mass Index (Bmi) And Quality Of Life In Iranian Primary School Students In Tehran, Iran, Mostafa Farajpour. Kh, Mohadeseh Pishgahroodsari, Hamid Salehiniya, Fahimeh Soheilipour

BioMedicine

No abstract provided.

Alabama Agricultural Producers’ Experiences With Wild Pigs (Sus Scrofa) And Their Preferences Concerning Wild Pig Management, Hailey E. Ellis, Luren M. Jaebker, Alan D. Bright, Mark D. Smith, Keith M. Carlisle

United States Department of Agriculture Wildlife Services: Staff Publications

Government agencies and landowners use a variety of lethal methods to reduce invasive wild pig populations and resulting agricultural damages. To provide decision-makers with information regarding Alabama farmers’ experiences with wild pigs and their preferences for management actions, we surveyed Alabama Farmers Federation members in 2020. We found that wild pigs were commonly present on livestock, timber, and crop production acreage, but wild pig damages and costs were much more common among crop producers. Respondents' wildlife acceptance capacity for wild pigs was low and all lethal control methods were considered aceptable by most reposndents, particularly those performed by landowners. While …

The Effect Of Exercise Type On Working Memory, Ariana Gonzalez, William R. Kochen

Journal for Sports Neuroscience

Martial arts encompass a wide range of sports and techniques that have been practiced for self-defense and combat for thousands of years. It has expanded to include various styles such as Brazilian Jiu-Jitsu, Taekwondo, judo, and karate. It has also been practiced as a form of exercise and entertainment. Martial arts have been associated to discipline, integrity, improved stamina, and increased mental and problem-solving capabilities. Unlike other exercise methods, most martial arts require focus, skill, and technique, which have been hypothesized to improve memory. The purpose of the study was to determine if there was a significant improvement in the …

Systematic Review Of Immune Checkpoint Inhibitor-Related Gastrointestinal, Hepatobiliary, And Pancreatic Adverse Events, Malek Shatila, Hao Chi Zhang, Anusha Shirwaikar Thomas, Antonio Pizuorno Machado, Sidra Naz, Nitish Mittal, Christine Catinis, Krishnavathana Varatharajalu, Carolina Colli Cruz, Eric Lu, Deanna Wu, Julie R Brahmer, Franck Carbonnel, Stephen B Hanauer, Bret Lashner, Bryan Schneider, John A Thompson, Michel Obeid, David P Farris, Yinghong Wang

Faculty, Staff and Student Publications

Gastrointestinal immune-related adverse events (GI irAEs) are common manifestations of immune checkpoint inhibitor (ICI) toxicity. We present a comprehensive systematic review of the incidence, management, and clinical course of irAEs across the entire GI system, including the luminal GI tract, liver, and pancreas. MEDLINE, Embase, Web of Science Core Collection, and Cochrane Library were used to conduct this review. All studies pertaining to GI irAEs were included. Both abstracts and full manuscripts were eligible if they included human subjects and were written in the English language. Articles not available in English, animal studies, or research not specific to GI toxicity …

Oncolytic Virotherapies And Adjuvant Gut Microbiome Therapeutics To Enhance Efficacy Against Malignant Gliomas, Natalie M Meléndez-Vázquez, Candelaria Gomez-Manzano, Filipa Godoy-Vitorino

Faculty, Staff and Student Publications

Glioblastoma (GBM) is the most prevalent malignant brain tumor. Current standard-of-care treatments offer limited benefits for patient survival. Virotherapy is emerging as a novel strategy to use oncolytic viruses (OVs) for the treatment of GBM. These engineered and non-engineered viruses infect and lyse cancer cells, causing tumor destruction without harming healthy cells. Recent advances in genetic modifications to OVs have helped improve their targeting capabilities and introduce therapeutic genes, broadening the therapeutic window and minimizing potential side effects. The efficacy of oncolytic virotherapy can be enhanced by combining it with other treatments such as immunotherapy, chemotherapy, or radiation. Recent studies …

Use Of Electrical Bone Growth Stimulators In High-Risk Patients Following Spinal Fusion, Soumya Malhotra, Khavir Sharieff

HCA-NSU MD Research Day

Title: Use of Electrical Bone Growth Stimulators in High-Risk Patients Following Spinal Fusion Authors: Soumya Malhotra, BA., MS1 & Khavir Sharieff, DO, MBA2 1Class of 2027, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, FL 2Assistant Professor of Surgery, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Tampa Bay, FLNova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine Objective: This study aimed to elucidate the advantages of EBGSs following high-risk spinal fusions. Background: Pseudarthrosis is a condition where bones fail to fuse after an injury or surgery. It causes significant …

Hans Holbein's Portrait Of Henry Viii: England's Own Personal Jesus, Amy Pitsor

Best Integrated Writing

Pitsor explores the possibility that Holbein’s late-stage change in the composition of the portrait from a three-quarter view of Henry to a frontal view held a motive to present Henry as the head of the newly established Church of England and as equal to the pope, and possibly to Christ himself.