Medicine and Health Sciences Commons^™

Treating Chronic Low Back Pain And Plantar Fasciitis With Myokinesthetic System: A Case Study, Sadie Buboltz-Dubs, Russell Baker

Clinical Practice in Athletic Training

The purpose of this case study was to report the effects of the MyoKinesthetic (MYK) System on the pain and function of a collegiate softball player previously diagnosed with chronic non-specific low back pain and foot pain. The patient had been experiencing bilateral foot pain since childhood and conservative treatment options had failed to resolve her pain long term. Additionally, the patient had been experiencing persistent back tightness and soreness. Upon arrival at the university, the patient was evaluated using the MYK postural analysis to identify if a primary nerve root dysfunction could be the cause of her pain. The …

Supporting Mental Wellness In Transgender Athletes, Abaigeal C. Fields, Zachary K. Winkelmann

Clinical Practice in Athletic Training

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A Review Of Automated External Defibrillator Considerations In Athletic Training, Bryana M. Mammana, Susan W. Yeargin, Zachary K. Winkelmann

Clinical Practice in Athletic Training

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Correlation Between Pre-Season Single-Leg Hop Testing Data And Lower Extremity Injuries In Collegiate Soccer Players, Ashley Kuchenbuch, Justin M. Stanek

Clinical Practice in Athletic Training

Lower extremity injuries are very common in collegiate soccer athletes and often lead to long-term rehabilitation programs and a decline in the athlete’s overall quality of life. Using single leg hop tests to identify “at-risk” athletes before the competitive season begins could allow medical staff to implement injury prevention programs that could help reduce the incidence of lower extremity injuries throughout the season. The purpose of this study was to determine if data taken from single leg hop (SLH) testing could help predict lower extremity injuries in female collegiate soccer players. A convenience sample of twenty-one participants were chosen to …

College Student-Athlete Perceptions Of Characterizations And Interpersonal Trust In Their Athletic Trainer: A Point-Of-Care Research Study, Ryan N. Moran, Deidre Leaver-Dunn, Jeff Allen, Jessica Wallace

Clinical Practice in Athletic Training

Patient-centered care is essential in athletic training with limited research examining the relationship between patient and clinician. Previous theory has identified constructs of quality athletic trainers (ATs); however, it remains unknown how current athletes perceive these theorized constructs in the ATs providing them medical care. The purpose of this study was to determine the perceptions of characterizations of a quality athletic trainer and interpersonal trust between the student-athlete and AT in the collegiate setting and establish reliability of these surveys. A second aim was to explore differences between sex, previous exposure to an AT, and having had access to an …

The Impact Of Video-Assisted Education On Knowledge And Retention Compared To Paper Education Material, Keiona M. Nance, Matthew J. Drescher, Lindsey E. Eberman, Matthew J. Rivera

Clinical Practice in Athletic Training

When educating patients, clinicians must be effective to assure patients understand their treatment plan and abide by such to achieve optimal outcomes. Teaching methods that stimulate numerous senses more positively impact learning outcomes. The purpose of this study is to compare paper and video-assisted education at the point-of-care with the aim of changing patient education and local practice in a system for individuals undergoing total hip arthroplasties (THAs). We used a randomized cohort design to explore patient knowledge and retention and educational method at the point-of-care. We compared the current education method (paper) to video-assisted materials using pre and post-education …

Exploratory Clinical Assessment And Treatment Of Autonomic Nervous System Dysregulation Post Concussion: A Case Study, Megan Coker, James May

Clinical Practice in Athletic Training

The physiological alterations in autonomic nervous system (ANS) function due to concussion are suggested to play a role in persistent post-concussion symptoms (PPCS). Currently, there are few objective and clinically feasible measurements to assess ANS vitality in patients experiencing PPCS. The following case study details an assessment and treatment protocol targeted towards regulating the ANS in an adolescent female suffering from PPCS one month after injury. Pre-intervention, patient-reported outcome measures (PROMs) used to assess perceived pain, anxiety, stress, and breathing function were administered as well as a physical assessment performed for breath function and vagus nerve integrity. The patient was …

Comparing Mental Health Between Ncaa Division Iii Student-Athletes Competing In Team- And Individual-Sports, Autumn Presley, Tiffany Franklin, Jeffrey Williams

Clinical Practice in Athletic Training

Mental health is a topic that has gained attention in recent years, but few studies have examined NCAA Division III student-athletes. Division III student-athletes are known to experience high levels of distress, and previous literature indicates there may be a significant psychological difference between student-athletes who compete in individual-sports compared to those who participate in team-sports. The purpose of this study was to explore mental health challenges (levels of depression, stress, and anxiety symptoms) among Division III student-athletes, particularly between those participating in team- and individual-sports. A cross-sectional survey design was used. The independent variable was group (team-sport athletes and …

Medical Disqualification As A Barrier To Healthcare In Military Service Members, Kaitlyn A. Jones, Joshua R. Jaime, Zachary K. Winkelmann

Clinical Practice in Athletic Training

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Disruption Of Distal Appendage Protein Cep164 Causes Skeletal Malformation In Mice, Hiroyuki Yamaguchi, Megumi Kitami, Margaret Li, Sowmya Swaminathan, Radbod Darabi, Ken-Ichi Takemaru, Yoshihiro Komatsu

Faculty, Staff and Student Publications

The primary cilium is a cellular antenna to orchestrate cell growth and differentiation. Deficient or dysfunctional cilia are frequently linked to skeletal abnormalities. Previous research demonstrated that ciliary proteins regulating axoneme elongation are essential for skeletogenesis. However, the role of the ciliary proteins responsible for initiating cilium assembly in skeletal development remains unknown. Here, we investigate the function of centrosomal protein of 164 kDa (CEP164), a key ciliogenesis regulator that localizes at the distal appendages of the mother centriole, during skeletal development in mice. Interestingly, the mesodermal cell-specific Cep164 deletion resulted in severe bone defects and osteoblast-specific deletion of Cep164 …

A Bayesian Pharmacokinetics Integrated Phase I-Ii Design To Optimize Dose-Schedule Regimes, Mengyi Lu, Ying Yuan, Suyu Liu

Faculty, Staff and Student Publications

The schedule of administering a drug has profound impact on the toxicity and efficacy profiles of the drug through changing its pharmacokinetics (PK). PK is an innate and indispensable component of the dose-schedule optimization. Motivated by this, we propose a Bayesian PK integrated dose-schedule finding (PKIDS) design to identify the optimal dose-schedule regime by integrating PK, toxicity, and efficacy data. Based on the causal pathway that dose and schedule affect PK, which in turn affects efficacy and toxicity, we jointly model the three endpoints by first specifying a Bayesian hierarchical model for the marginal distribution of the longitudinal dose-concentration process. …

Neurofilament Light Chain In Serum Of Cancer Patients With Acute Neurological Complications, Amulya Gottiparthy, Keng Lam, Suprateek Kundu, Zixi Yang, Ivo Tremont-Lukats, Sudhakar Tummala

Faculty, Staff and Student Publications

Aim: Neurofilament light chain (NfL) is a nonspecific sensitive biomarker of axonal damage.

Methods: This case series identified cancer patients with neurological complications who had serum NfL measurements and paired these results to outcomes.

Results: NfL serum levels were available in 15 patients with hematological malignancies or solid tumors. The neurological complications studied were immune effector cell-associated neurotoxicity syndrome, immune checkpoint inhibitor-related encephalopathy, anoxic brain injury, Guillain-Barre syndrome, hemophagocytic lymphohistiocytosis, transverse myelitis, paraneoplastic syndrome, central nervous system demyelinating disorder and chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids. All patients but one with serum NfL >900 pg/ml died …

Predicting Kidney Graft Function And Failure Among Kidney Transplant Recipients, Yi Yao, Brad C Astor, Wei Yang, Tom Greene, Liang Li

Faculty, Staff and Student Publications

Background: Graft loss is a major health concern for kidney transplant (KTx) recipients. It is of clinical interest to develop a prognostic model for both graft function, quantified by estimated glomerular filtration rate (eGFR), and the risk of graft failure. Additionally, the model should be dynamic in the sense that it adapts to accumulating longitudinal information, including time-varying at-risk population, predictor-outcome association, and clinical history. Finally, the model should also properly account for the competing risk by death with a functioning graft. A model with the features above is not yet available in the literature and is the focus of …

Implementation Of Patient Care Documentation Standard For Athletic Training Staff In Intercolle, Lucas Bianco, Maria Popek, Bri Durics, Christian Miles

Clinical Practice in Athletic Training

Documentation is a professional standard for all health care professions. As part of a relatively young profession, athletic trainers have had to adjust to the expectations around documentation to stay at the same level as other health care providers. Documentation is often a highly discussed topic with more and more education sessions and resources being provided by NATA, BOC and NATA Research Education Foundation. The need for Continuous Quality Improvement projects and subsequent studies has continued to grow. Projects with a focus on documentation can be completed then disseminated to determine the most effective ways to improve documentation across our …

Harnessing Natural Medicine As A Resource For Socioeconomic Development, Eneojo Ogu, Martins Emeje, Munira Abdullahi

Journal of Bioresource Management

Natural medicine is currently gaining global acceptance among the developed and developing countries of the world due to its low toxicity, high efficacy and cost effectiveness. Developed countries are devising medicinal systems that require the use of medicinal plant products and resources. Thus, a marked increase in world demand for medicinal plant resources has emerged in the recent years and that has provided a great opportunity for medicinal plants exporting nations to expand their economy shares in this sector. Despite the Nigeria immense socio-economic promise, the country is in critical need following the fact that the multidimensional poverty rate is …

A Review On Wolbachia- A Viable Alternative To Control Aedes-Born Arboviral Diseases, Fatima Khizar, Iqra Mushtaq, Hafsa Masud, Muhammad Sajjad Sarwar

Journal of Bioresource Management

The endemic geographic ranges of mosquitoes are expanding due to various anthropogenic activities including rapid international travel and trade, urbanization, deforestation, and global warming. Hence, Aedes-borne arboviral diseases like dengue, chikungunya, yellow fever, or Zika infections would cause severe future outbreaks in non-endemic regions of the world. This threat to global public health highlights an urgent need for the development of efficient and effective mosquito control strategies. To date, a large number of mosquito vector-control strategies have been developed. Each of them has its strengths and weaknesses but the use of intracellular, endosymbiotic reproductive parasitic bacteria named Wolbachia pipientis …

Approved Car-T Therapies Have Reproducible Efficacy And Safety In Clinical Practice, Daniel Goyco Vera, Hiral Waghela, Mohamed Nuh, Jonathan Pan, Premal Lulla

Faculty, Staff and Students Publications

CAR-T cell therapy has established itself as a highly effective treatment for hematological malignancies. There are currently six commercial CAR-T products that have been FDA approved for diseases such as B-ALL, LBCL, MCL, FL, MM, and CLL/SLL. "Real-world" studies allow us to evaluate outcomes from the general population to determine their efficacy and safety compared to those who were included in the original trials. Based on several well conducted "Real-world" studies that represent diverse populations, we report that outcomes from the original trials that led to the approval of these therapies are comparable to those in practice.

Addressing Unprofessional Behaviors In The Clinical Learning Environment: Lessons From A Multi-Year Virtual, Intergenerational, Interdisciplinary Workshop, Stacey Rose, Anita Kusnoor, Phuong Huynh, Jocelyn Greely, Yesenia Rojas-Khalil, Doris Kung, Anne Gill, Nadia Ismail, Nital Appelbaum

Faculty, Staff and Students Publications

INTRODUCTION: Optimizing the clinical learning environment (CLE) is a medical education priority nationwide.

MATERIALS AND METHODS: We developed a virtual, one-hour workshop engaging students, housestaff and faculty in small-group discussions of five case scenarios adapted from reported unprofessional behaviors in the CLE, plus didactics regarding mistreatment, microaggressions and bystander interventions.

RESULTS: Over two sessions (2021-2022), we engaged 340 students and 73 faculty/housestaff facilitators. Post-session surveys showed significant improvement in participants' ability to recognize and respond to challenges in the CLE.

DISCUSSION: Our innovative workshop, including scenarios derived from institutional reports of unprofessional behaviors, advanced participants' knowledge and commitment to improve …

Faktor Determinan Kasus Diabetes Mellitus Tipe 2 Di Kabupaten Administrasi Kepulauan Seribu Provinsi Dki Jakarta Tahun 2023, Ulinuha Setya Darmawanti

Jurnal Epidemiologi Kesehatan Indonesia

Kepulauan Seribu Administrative District has the highest Diabetes Mellitus Incidence Rate compared to other areas in the DKI Jakarta Province, which is 317.4 per 10,000 residents. The purpose of this research is to identify the determinant factors that most influence cases of Type 2 Diabetes Mellitus in the Kepulauan Seribu in 2023, based on the relationship between factors such as Age, Gender, Occupation, History of Diabetes Mellitus, Body Mass Index (BMI), Excessive Sugar Consumption, Excessive Salt Consumption, Excessive Fat Consumption, Insufficient Fruit and Vegetable Intake, and Lack of Physical Activity. This research employs an analytical observational study method with a …

The Correlation Of Covid-19 Vaccination With Covid-19 Patient Mortality In Depok City, Indonesia, Dian Nugrahari, Asri Adisasmita Prof, Nurhanifah Hamdah

Jurnal Epidemiologi Kesehatan Indonesia

Vaccination is a disease prevention method recommended by the WHO as it will reduce disease severity, mortality rate and risks. The objective of this study is to discover the impact of COVID-19 vaccination against COVID-19 mortality rate in Indonesia. This was a retrospective cohort research on the data from the NAR COVID-19 database and the KPCPEN COVID-19 Dashboard of the Depok City Health Department from May 2020-February 2023. We performed a Cox proportional hazard analysis to obtain the risk for death. We discovered that COVID-19 vaccination reduced the mortality until it was less than 10% of unvaccinated population (0,24% for …

Asosiasi Antara Indeks Massa Tubuh Dan Mortalitas Pada Pasien Gagal Ginjal Kronis Yang Menjalankan Hemodialisa Reguler: Meta-Analisis Dari Studi Kohort, Joue Abraham Trixie Latupeirissa, Mondastri Korib Sudaryo, Dorothy Gabriella Ms., Benedikta Suryandari Ms., Vine Aprilianita Sri Indah Putri Ms.

Jurnal Epidemiologi Kesehatan Indonesia

Chronic kidney failure patients must undergo hemodialysis for life, therefore it is important to maximize hemodialysis services in every health facility. Accordingly, factors related to survival rates must be addressed. One of them is low Body Mass Index (BMI). This study assessed the relationship between low BMI and mortality in the patients. The study design used was meta-analysis. The articles involved were in the period 2012 - 2024. There are three literature sources: medical databases, previous studies, and ongoing research. Overall, 26 articles were obtained. Data analysis showed that BMI

The Impact Of Smoking Degree On One Year Survival Of Non-Small Cell Lung Cancer (Nsclc) At Persahabatan Hospital, Arief Wicaksono, Asri C. Adisasmita, Andika Chandra Putra

Jurnal Epidemiologi Kesehatan Indonesia

Lung cancer is a major global mortality problem with the worst prognosis compared to other types of cancer. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer and smoking is one of the main factors causing lung cancer. This study aims to determine the one-year survival of NSCLC patients with smoking levels and to determine what factors affect survival. This study is an observational study with a retrospective method, looking at medical record data of NSCLC patients both inpatients and outpatients at Persahabatan Hospital between January 2023 and December 2023 and then followed up until September …

Hubungan Gangguan Mental Emosional Dan Obesitas Sentral: Literature Review, Dwi Rahmawati, Ratna Djuwita

Jurnal Epidemiologi Kesehatan Indonesia

The prevalence of central obesity, both globally and in Indonesia, continues to increase. Mental and emotional disorders are one of the contributing factors to central obesity. In previous studies, it was known that the relationship between emotional mental disorders and obesity can occur in bidirections, where emotional mental disorders can cause central obesity or vice versa. This literature review aims to find out more about the relationship between emotional mental disorders and central obesity from various countries. The searching for articles used 4 databases (Scopus, Science Direct, Proquest, and Pubmed) with the Preferred Reporting Items for Systematic Review and Meta-Analysis …

Factors Affecting The Adoption Of Malaria Interventions For Pregnant Women In Tanzania: Tanzania Demographic Health Survey 2022, Melisa Nyamukondiwa, Asri C. Adisasmita, Renti Mahkota, Same Betera

Jurnal Epidemiologi Kesehatan Indonesia

Tanzania is endemic to malaria and pregnant women due to their vulnerability are among the high-risk groups. The adoption of malaria interventions targeted to pregnant women is affected by a number of factors. A cross-sectional study using secondary data from Tanzania Demographic Health Survey (TDHS) for 2022 was used. A logistic regression was used for bivariate analysis to identify factors affecting the adoption of malaria interventions during pregnancy in Tanzania. Data from pregnant women between 15 to 49 years (N=1408) were analyzed in this study. Insecticide treated nets (ITNs) and intermittent preventive therapy in pregnancy using sulfadoxine-pyrimethamine (IPTp-SP) were the …

Food For Thought: A Qualitative Assessment Of Medical Trainee And Faculty Perceptions Of Nutrition Education, Olivia Kunitsky, Mahdi Taye, Karla Feeley, Hugh Johnson, Abigail Glynn, Avery Stivale, Matthew Hamers, Alexis Notarianni, Sireesha Mamillapalli, Gabi Waite, Sonia Lobo

Department of Neurology Faculty Papers

BACKGROUND: The American Society of Clinical Nutrition recommends 37 to 44 h of undergraduate medical nutrition education. The Total Health Curriculum at Geisinger Commonwealth School of Medicine (GCSOM) contains 14 h of objective-based nutritional instruction. This study aimed to examine the perceptions of key stakeholders regarding the role of nutrition in medicine and to identify barriers, opportunities for improvement, and roles/responsibilities for innovative implementation of nutrition education.

METHODS: This exploratory, qualitative study employed a phenomenological approach and inductive coding process. Purposive sampling recruited medical students, undergraduate medical education (UME) faculty, physicians, and other healthcare professionals at GCSOM and affiliated clinical …

The Win Ratio Approach In Bayesian Monitoring For Two-Arm Phase Ii Clinical Trial Designs With Multiple Time-To-Event Endpoints, Xinran Huang, Jian Wang, Jing Ning

Faculty, Staff and Student Publications

To assess the preliminary therapeutic impact of a novel treatment, futility monitoring is commonly employed in Phase II clinical trials to facilitate informed decisions regarding the early termination of trials. Given the rapid evolution in cancer treatment development, particularly with new agents like immunotherapeutic agents, the focus has often shifted from objective response to time-to-event endpoints. In trials involving multiple time-to-event endpoints, existing monitoring designs typically select one as the primary endpoint or employ a composite endpoint as the time to the first occurrence of any event. However, relying on a single efficacy endpoint may not adequately evaluate an experimental …

Nos Inhibition Sensitizes Metaplastic Breast Cancer To Pi3k Inhibition And Taxane Therapy Via C-Jun Repression, Tejaswini Reddy, Akshjot Puri, Liliana Guzman-Rojas, Christoforos Thomas, Wei Qian, Jianying Zhou, Hong Zhao, Bijan Mahboubi, Adrian Oo, Young-Jae Cho, Baek Kim, Jose Thaiparambil, Roberto Rosato, Karina Ortega Martinez, Maria Florencia Chervo, Camila Ayerbe, Noah Giese, David Wink, Stephen Lockett, Stephen Wong, Jeffrey Chang, Savitri Krishnamurthy, Clinton Yam, Stacy Moulder, Helen Piwnica-Worms, Funda Meric-Bernstam, Jenny Chang

Faculty, Staff and Student Publications

Metaplastic breast cancer (MpBC) is a highly chemoresistant subtype of breast cancer with no standardized therapy options. A clinical study in anthracycline-refractory MpBC patients suggested that nitric oxide synthase (NOS) inhibitor NG-monomethyl-l-arginine (L-NMMA) may augment anti-tumor efficacy of taxane. We report that NOS blockade potentiated response of human MpBC cell lines and tumors to phosphoinositide 3-kinase (PI3K) inhibitor alpelisib and taxane. Mechanistically, NOS blockade leads to a decrease in the S-nitrosylation of c-Jun NH

Bayesian Nonparametric Model For Heterogeneous Treatment Effects With Zero-Inflated Data, Chanmin Kim, Yisheng Li, Ting Xu, Zhongxing Liao

Faculty, Staff and Student Publications

One goal of precision medicine is to develop effective treatments for patients by tailoring to their individual demographic, clinical, and/or genetic characteristics. To achieve this goal, statistical models must be developed that can identify and evaluate potentially heterogeneous treatment effects in a robust manner. The oft-cited existing methods for assessing treatment effect heterogeneity are based upon parametric models with interactions or conditioning on covariate values, the performance of which is sensitive to the omission of important covariates and/or the choice of their values. We propose a new Bayesian nonparametric (BNP) method for estimating heterogeneous causal effects in studies with zero-inflated …

Orthogonal And Multiplexable Genetic Perturbations With An Engineered Prime Editor And A Diverse Rna Array, Qichen Yuan, Hongzhi Zeng, Tyler C Daniel, Qingzhuo Liu, Yongjie Yang, Emmanuel C Osikpa, Qiaochu Yang, Advaith Peddi, Liliana M Abramson, Boyang Zhang, Yong Xu, Xue Gao

Faculty, Staff and Students Publications

Programmable and modular systems capable of orthogonal genomic and transcriptomic perturbations are crucial for biological research and treating human genetic diseases. Here, we present the minimal versatile genetic perturbation technology (mvGPT), a flexible toolkit designed for simultaneous and orthogonal gene editing, activation, and repression in human cells. The mvGPT combines an engineered compact prime editor (PE), a fusion activator MS2-p65-HSF1 (MPH), and a drive-and-process multiplex array that produces RNAs tailored to different types of genetic perturbation. mvGPT can precisely edit human genome via PE coupled with a prime editing guide RNA and a nicking guide RNA, activate endogenous gene expression …

Parp Inhibition Radiosensitizes Brca1 Wildtype And Mutated Breast Cancer To Proton Therapy, Mariam Ben Kacem, Scott J Bright, Emma Moran, David B Flint, David K J Martinus, Broderick X Turner, Ilsa Qureshi, Rishab Kolachina, Mandira Manandhar, Poliana C Marinello, Simona F Shaitelman, Gabriel O Sawakuchi

Faculty, Staff and Student Publications

Aggressive breast cancers often fail or acquire resistance to radiotherapy. To develop new strategies to improve the outcome of aggressive breast cancer patients, we studied how PARP inhibition radiosensitizes breast cancer models to proton therapy, which is a radiotherapy modality that generates more DNA damage in the tumor than standard radiotherapy using photons. Two human BRCA1-mutated breast cancer cell lines and their isogenic BRCA1-recovered pairs were treated with a PARP inhibitor and irradiated with photons or protons. Protons (9.9 and 3.85 keV/µm) induced higher cell kill independent of BRCA1 status. PARP inhibition amplified the cell kill effect to both photons …