Medicine and Health Sciences Commons^™

Multisociety Guidance For Infection Prevention And Control In Nursing Homes, Lona Mody, Sonali D. Advani, Muhammad Salman Ashraf, Allison H. Bartlett, Suzanne F. Bradley, Deborah P. Burdsall, Jennifer A. Hanrahan, Susan S. Huang, Robert L.P. Jump, Lindsay Nicolle, Mary-Claire Roghmann, Patricia Stone, Rekha K. Murthy

Department of Medicine Faculty Publications

This multisociety guidance was endorsed by SHEA, APIC, IDSA, PALTmed, and AGS. It provides recommendations for infection prevention and control (IPC) in the context of the complexity of nursing home care in the United States: increased medical acuity of residents, the spread of multidrug-resistant organisms, and the threat of emerging pathogens. Recommendations and implementation suggestions address IPC leadership, staffing, and resources, healthcare personnel and residents‘ adherence to precautions and effective hand hygiene, outbreak preparedness, training, occupational health, cleaning and disinfection in the care environment, and the involvement of IPC in the facility. The guidance also addresses the challenges of maintaining …

Leukocyte Infiltration Profiles At The Site Of Intradermal Injection Of Silikon-1000 In Scleroderma-Prone Ucd200/206 And Healthy White Leghorn Chickens, Katee L. Johnson, Jossie M. Santamaria, Chrysta N. Beck, Gisela F. Erf

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

Intradermal injections of silicone-based fillers for the face and body may cause chronic inflammation and fibrotic reactions in some individuals. Chickens from the UCD 200/206 White Leghorn (WL) line spontaneously develop a fibrotic autoimmune disease known as scleroderma/systemic sclerosis (SSc). Using the SSc-prone UCD and healthy WL chickens, a longitudinal study was conducted to examine the cellular inflammatory responses to intradermal (i.d.) injections of sterile SILIKON-1000. Specifically, the pulp (a skin derivative) of growing feathers (GFs) was i.d. injected with sterile SILIKON-1000 or phosphate-buffered saline (PBS) as injection control (8 and 3 birds/line, respectively; 10 µL/GF; 20 GFs/bird). Two GFs …

Parental Sources Of Nutrition Information And Their Knowledge, Attitudes, And Behaviors: Impact On Children's Dietary Intake In Ages 2-5 – A Cross-Sectional Study, Mara O. Fiorio

UNF Graduate Theses and Dissertations

Objectives: Nutrition in early childhood is critical to long-term health outcomes and parents play a key role in shaping children’s eating habits. This study examined where U.S. parents of children aged 2–5 obtain nutrition information, source credibility, and how parental nutrition knowledge, attitudes, and behaviors (KAB) relate to children’s dietary intake.

Methods: A cross-sectional online survey was completed by 126 parents, recruited via social media and community networks using convenience sampling. The survey assessed parental sources of nutrition information, perceived trustworthiness, nutrition knowledge, feeding attitudes and behaviors, and child dietary intake. Descriptive statistics summarized demographic characteristics and source utilization. Chi-square …

Polygenic Risk Scores Of Grip Strength In Men And Women With Or At Risk For Hiv, Sreevidya Sadananda Sadasiva Rao

Electronic Theses & Dissertations (2024 - present)

Background: Adequate hand function among older adults is necessary for the successful completion of activities of daily living and can affect whether an older adult is able to live independently. Current research highlights grip strength, the strength people have in their hands, as a robust predictor of morbidity and mortality, and explores the decline in grip strength over time. A person’s family history and genes (DNA) affect how much grip strength they have. Previous studies have identified genes that affect grip strength, mainly in European ancestry populations. In this study, we examined whether these genetic elements predict grip strength in …

Cardiac Timing Effects On Response Speed Are Modulated By Blood Pressure But Not Heart Rate Variability In Healthy Young Adults, Xiao Yang, Catalina Roldan, Michael Gazzanigo, Yasmine Nabulsi, Fang Fang

Research and Infrastructure Service Enterprise (RISE) Faculty Publications

Cardiac timing effects reflect the dynamic interplay between interoceptive and exteroceptive processes. Human information processing tends to be facilitated during cardiac diastole and inhibited during systole, reflecting autonomic regulation and the neuromodulation by baroreceptor afferents. Thus, blood pressure (BP) and vagally-mediated heart rate variability (vmHRV) are potential modulators of those effects. Additionally, cognitive control appears to play a critical role in the processes. However, whether cardiac timing effects are influenced by those factors remains unclear. The present study aimed to clarify these relationships. Fifty-one healthy young adults completed three experimental sessions to assess BP, short-term HRV, and cardiac timing effects. …

Loneliness Associates With Endothelial Dysfunction In A Community-Based Cohort: A Pilot Study And Translational Approach, Yvonne Baumer, Brian A. Tirado, Lola R. Ortiz-Whittingham, Andrew S. Baez, Cristhian A. Gutierrez-Huerta, Laurel G. Mendelsohn, Abhinav Saurabh, Joshua A. Jacobs, Marcus R. Andrews, Valerie M. Mitchell, Billy S. Collins, Antwan Jones, Danielle M. Schwartz, Anca D. Dobrian, Michael V. Stanton, Tiffany M. Powell-Wiley

Department of Biomedical and Translational Sciences Faculty Publications

Loneliness is known to be an important contributor to cardiovascular disease (CVD). However, little is known about the impact of loneliness on endothelial barrier integrity, a crucial hallmark of CVD development and progression. In this study, we aimed to investigate how loneliness might impact the endothelium. We found greater perceived loneliness associated with the product of circulating epinephrine and TNFα (E/T), which, in turn, associated with lower VE-cadherin on endothelial cells in an ex vivo experiment. Additionally, circulating plasma levels of soluble VE-cadherin were associated significantly with subclinical CVD. To explore the mechanistic aspects of these associations, we measured the …

Consumption Of The Food Groups With The Revised Benefits In The New Wic Food Package: A Scoping Review, Qi Zhang, Priyanka T. Patel, Bidusha Neupane, Caitlin M. Lowery, Futun Alkhalifah, Faezeh Mahdavi, Esther May Sarino

Epidemiology, Biostatistics, & Environmental Health Faculty Publications

Background: On 18 April 2024, the United States Department of Agriculture (USDA) published the first food package changes to the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) in over a decade, which reduced some food benefits (juice, milk, canned fish, and infant fruits and vegetables) and offered substitutes (cash-value vouchers (CVVs) or cash-value benefits (CVBs) to redeem for fruits and vegetables, cheese, soymilk, or other dairy products). Methods: To assess the impact of the changes on the consumption and redemption of these food groups, a systematic search was conducted, identifying 23 peer-reviewed publications between 2010 and 2024. …

Effects Of Cross-Sex Hormone Therapy (Csht) On Aortic Reactivity And Metabolic Parameters In Gonadectomized Male And Female Rats, Rifat Ara Islam

University of the Pacific Theses and Dissertations

With the rising awareness, the number of individuals identifying themselves as transgender in the US is increasing over the years. Cross-sex hormone therapy (CSHT) may alter cardiometabolic parameters leading to the increased risk of cardiovascular diseases (CVD) in transgender population. However, the underlying mechanisms of impaired cardiovascular functions in transgender female (male to female, MtF) or transgender male (female to male, FtM) individuals are not well documented. This study was undertaken to examine the effects of 17β-estradiol (E2)- and testosterone propionate (Tes)-treatment on key cardiometabolic parameters and aortic reactivity in castrated (CAS) male and ovariectomized (OVX) female Sprague Dawley (SD) …

Characterization Of The Overexpression Of Reca Homologs Rad51 And Dmc1 In Tetrahymena Thermophila, Jianna M. Cox

Graduate Theses/Dissertations

RecA homologs, Dmc1 and Rad51, work to repair DNA double-strand breaks (DSBs) within the cell through the recombination of homologous sections of DNA. Dmc1 works to repair programmed DSBs through meiotic recombination, while Rad51 functions to repair both meiotic and non-meiotic DSBs, the latter repaired through the process of homologous recombination repair (HHR). Chemotherapeutics, exogenous agents, work to form DSBs in cancer cells, attempting to inhibit the cell’s growth. A hyper recombinant phenotype is often seen in cancer cells due to the overexpression of RAD51, leading to drug resistance, the persistence of cancers, and an overall poor patient outcome. …

A Serum Biomarker Panel And Miniarray Detection System For Tracking Disease Activity And Flare Risk In Lupus Nephritis, Chenling Tang, Gongjun Tan, Aygun Teymur, Jiechang Guo, Arturo Haces-Garcia, Weihang Zhu, Richard Williams, Jing Ning, Ramesh Saxena, Tianfu Wu

Faculty, Staff and Student Publications

Introduction: Lupus nephritis (LN) leads to end stage renal disease (ESRD), and early diagnosis and disease monitoring of LN could significantly reduce the risk. however, there is not such a system clinically. In this study we aim to develop a biomarker-panel based point-of-care system for LN.

Methods: Immunoassay screening combined with genomic expression databases and machine learning techniques was used to identify a biomarker panel of LN. A quantitative biomarker-panel mini-array (BPMA) system was developed and the sensitivity, specificity, reproducibility, and stability of the were examined. The performance of BPMA in disease monitoring was validated with machine models using a …

Effect Of Digital Health Coaching On Self-Efficacy And Patient-Reported Outcomes In Individuals With Acute Myeloid And Chronic Lymphocytic Leukemia: A Pilot Randomized Controlled Trial, Jennifer Marvin-Peek, Valerie Shelton, Kelly Brassil, Bryan Fellman, Austin Barr, Kelly Sharon Chien, Danielle Hammond, Mahesh Swaminathan, Nitin Jain, William Wierda, Alessandra Ferrajoli, Courtney Dinardo

Faculty, Staff and Student Publications

Introduction: Promotion of self-efficacy can enhance engagement with health care and treatment adherence in patients with cancer. We report the outcomes of a pilot trial of a digital health coach intervention in patients with leukemia with the aim of improving self-efficacy.

Methods: Adult patients with newly diagnosed acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL) were randomized 1:1 to a digital health coach intervention or standard of care. The primary outcome of self-efficacy was measured by the Cancer Behavior Inventory (CBI) score.

Results: A total of 147 patients (37 AML, 110 CLL) were enrolled from July 2020 to December …

Short-Term Effect Of Water-Soluble Iodinated Contrast “Urografin” Used For Hysterosalpingography On Thyroid Profile, Mohamed Roshdi, Ahmed Mahmoud El Menayyer, Aya Mohamed Elbialy

Mansoura Medical Journal

Background: Lipiodol is one of the most used oil-soluble contrast media (OSCM) for hysterosalpingography (HSG). Particularly concerning are its long t1/2 in tissue (50 days) and high iodine concentration (480 mg/ml). Such high iodine content can cause either Wolff-Chaikoff effect (WCE) or hyperthyroidism (Jod-Basedow phenomena (JBP)), in particular in those who have pre-existing Graves' disease or multinodular goiter. Urografin is an ionic water-soluble contrast medium (WSCM) having lower iodine concentration (300 mg/ml). Our study aimed to evaluate the short-term influence of Urografin for HSG on thyroid function. Patients and Methods: Our study is a prospective one enrolling 49 women over …

Clinical Features And Prognosis Of Acute Kidney Injury In Hospital-Admitted Patients With Covid-19 In Egypt: A Single-Center Experience, Hoda M. M. Abdulaziz, Aya Ahmed Mohamed Elsayed, Elshahat A. Yousef

Mansoura Medical Journal

Background While COVID-19 primarily manifests clinically as a respiratory disease, it can also impact other organs, such as the kidneys. Acute kidney injury (AKI) is frequently seen in hospital-admitted patients with COVID-19 and is linked to poorer outcomes. This research sought to explore the rate, contributing elements, and consequences of AKI in individuals with COVID-19. Methods Data from 236 COVID-19-infected patients hospitalized at wards and intensive care units (ICUs) dedicated to isolation between September 2020 and February 2021 were analyzed. Comparisons between patients with and without AKI were done using statistical tests as appropriate. Binary logistic regression analyses were performed …

Split-Dose Versus Single-Dose Bowel Preparation For Colonoscopy: A Single Center Study, Mohamed Adel, Seham Seif, Hany Shabana, Asmaa Gameel

Mansoura Medical Journal

Background Colonscopy is now the gold standard for colorectal screening. Colon preparation is an important parameter for adequate bowel examination. Detection of small colorectal polyps which are precusors for colorectal adenocarcinoma needs effective bowel cleansing. Aim we performed a prospective randomized controlled trail to compare bowel cleanliness, compliance, tolerability, and patient satisfaction of a single regimen versus a split regimen for colonoscopy. Results The number of detected polyps was statistically significantly higher in the split method group as compared to the single method group (p= 0.040).Also, the prevalence features of ulcerative colitis was statistically significantly higher in the split method …

Effect Of Preoperative Stripsils Lozenges On Incidence Of Post-Extubation Sore Throat, Cough And Hoarseness After Endoscopic Retrograde Cholangiopancreatography Procedures: A Randomized Controlled Trial., Tarek Habeeb Ramadan, Waleed M R Elsarraf, Ahmed Refaat Abourezk, Mohamed Aly Eloraby

Mansoura Medical Journal

Background Sore throats are frequently experienced by patients following upper endoscopy procedures such as endoscopic retrograde cholangiopancreatography (ERCP). Cough and hoarseness of voice are other related complications. Aim of the work The current study evaluated whether pre-procedural oral Strepsils lozenges administration could reduce sore throat incidence and severity following ERCP procedures. Methods Sixty patients posted for elective ERCP under general anesthesia (GA) with endotracheal intubation were evenly allocated in a random manner to receive Strepsils lozenges (S group) or identical-looking placebo tablets (C group) 45 minutes before the procedure. Results The Strepsils group experienced a significantly lower incidence of both …

Impacts Of Age And Androgen Level On Albino Rat Meibomian Gland: Light & Electron Microscopic Study, Amira A. Hamid, Nawal A. Hasanin, Hanaa A. Khalaf, Walaa H. E. Hamed

Mansoura Medical Journal

Background: Histological changes in albino rats meibomian glands in relation to age and androgen level. Aim of the work: The current research attempted to assess the impact of age and androgen level on histological structure of meibomian gland . Material and methods: Three groups of adult male albino rats were used ,each group comprised ten rats, group I: six months, group II: one year and group III : two years, Each animal at proper age was weighed , anaesthetized and blood samples were collected for estimation of dehydro-epiandrosterone (DHEA) hormone . The eyelids of each rat were dissected and prepared …

Bipolar Radiofrequency Ablation Of The Genicular Nerve Versus Intra-Articular Botox Injection For Knee Osteoarthritis-Related Pain: A Randomized Controlled Study, Elsayed Elemam, Samah Elkenany Gouda, Abdelrahman Mamdouh Elnaggar, Ibrahim Abdelbaser, Ahmed Refaat Abourezk

Mansoura Medical Journal

Background Knee osteoarthritis (OA) is accompanied by considerable pain and impairment. Chronic knee OA pain and functional loss can be effectively managed with this minimally invasive method. Methods Sixty patients with persistent knee OA were evenly allocated in a random manner to receive either bipolar radiofrequency ablation of the genicular nerve (BRF) or intraarticular Botox injection. Results There was a significant decrease in the visual analog score (VAS) in the BRF group compared with the baseline score at the 4, 12, and 24-week follow-ups; however, the score significantly dropped in the Botox group only at the 4 and 12-week follow-ups …

Role Of Magnetic Resonance Diffusion Tensor Imaging In Differentiating Osteomyelitis From Osteoarthropathy In Diabetic Foot, Mona Mohamed Hamid Ibrahim Barakat, Saher Ebrahim Taman, Samer Abdelhamid Regal, Ahmed Galal Sadek

Mansoura Medical Journal

Background: Diabetic foot ulcer (DFU) represents a major cause of preventable morbidity among adults with diabetes mellitus (DM). Diabetic foot osteomyelitis (DFO) frequently arises through contiguous spread of soft tissue infection to the underlying bone. Diffusion tensor imaging (DTI) is an advanced magnetic resonance imaging (MRI) technique that enables quantitative evaluation of tissue microstructure. Aim: To assess the diagnostic value of magnetic resonance DTI in differentiating osteomyelitis from acute osteoarthropathy in patients with diabetic foot complications. Methods: This prospective study included 28 diabetic patients presenting with clinically suspected foot complications. According to the final diagnosis, patients were classified into two …

Pattern Integration And Differentiation: Dual Process Model Of Episodic Memory, Hallvard Røe Evensmoen, Lars M. Rimol, Henning Stople Rise, Tor Ivar Hansen, Hamed Nili, Anderson M. Winkler, Asta K. Håberg

Human Genetics Publications

The role of precise timing in episodic memory remains obscure. We showed 139 participants episodes consisting of objects, and tested subsequent memory for the precise timing and order of the objects and episodes. Temporal compression of the episode enhanced memory for relative but not absolute timing of the objects’ presentation and their order. Conversely, temporal expansion between neighboring episodes was associated with successful memory for episode order. fMRI in 36 participants revealed that temporal compression of the episode was associated with more similar activation patterns within episodes in several brain regions including the posterior hippocampus. However, the activation pattern in …

Developing A Prognostic Panel In Hormone Receptor Positive Breast Cancer; An Immunohistochemical Study With Clinicopathological Correlation, Shaimaa M Yussif, Reham Naguib, Nahed Soliman

Mansoura Medical Journal

Introduction

Breast cancer is a heterogeneous disease with a wide range of clinical, histological, and molecular characteristics. Various diagnostic methods have been used to ascertain prognosis by evaluating various clinicopathological data, such as tumor size, nodal stage, hormone receptor status, and human epidermal growth factor 2 (HER2) status, metastasis, tumor grade and lymphovascular emboli. Accurate substratification of prognostic groups with varying clinical outcomes is needed. This is particularly valid for cases of hormone receptor-positive breast cancer. The purpose of this study is to examine the immunohistochemical expression of a set of markers in hormone positive breast carcinoma cases and test …

Improvement Of Back Pain After Intraoperative Sacroiliac Injection During L5-S1 Fixation: A Randomized Controlled Retrospective Study, Mohamed Ali Abbas, Ahmed Zaghlol, Ayman M Ismail, Hamdy Nabwi, Mohamed Ismail, Ahmed Sameh Nada, Mona Mokhtar, Ahmed Shaker Elakhras

Mansoura Medical Journal

Background: Sacroiliac joint (SIJ) pain is a common complication following lumbar spinal fusion. The purpose of this research was to determine how effective intraoperative SIJ injection in preventing low back pain after L5-S1 fixation procedures. Methods: This randomized controlled retrospective study was performed on 70 individuals who underwent L5-S1 fixation and were classified equally into two groups: Group A intraoperative SIJ injection was performed, while Group B did not. Pain incidence, Oswestry Disability Index (ODI) scores, and failed back surgery syndrome (FBSS) rates were assessed preoperatively and at 2 weeks, 1, 3, and 6 months postsurgery. Results: At 6 months, …

Study Of Prevalence Of Toxoplasmosis In Some Renal ‎Diseases In Children: Is There An Association?‎, Rowida Mokhtar Abdoullah, Sherine M. Elzeiny, Nora I. Aboulfotouh, Ayman M. Hammad

Mansoura Medical Journal

Background: Toxoplasmosis, a widespread protozoal disease caused by the obligatory intracellular Toxoplasma gondii (TG). Chronic kidney disease (CKD) is a disease characterized by progressive damage and loss in kidney functions. End stage renal disease (ESRD) is known as CKD with GFR less than 15ml/min. Nephrotic syndrome (NS) is defined as heavy proteinuria that ultimately ends in hypoalbuminemia, hyperlipidemia and generalized edema. Patients with CKD and ESRD are immune compromised so more liable to increased incidence of infections, especially opportunistic infections. Nephrotic syndrome ,90% of cases, is of unknown etiology but some papers suggest toxoplasmosis as a cause. Aim: To evaluate …

Urinary Kidney Injury Molecule-1 As A Biomarker For Detection Of Albuminuria And Retinopathy Among Patients With Type 2 Diabetes Mellitus, Amr Y. El Feky, Yehia M. Ghanem, Talaat A. Abdelaaty, Magdy M. Elbordeny, Rabab H. Neanaa

Mansoura Medical Journal

Background: Diabetic retinopathy (DR) and diabetic kidney disease (DKD) are prevalent microvascular complications of type 2 diabetes mellitus (T2DM). The objective of this study was to examine the potential relevance of urinary kidney injury molecule-1 (uKIM-1) as a marker of DKD and DR in cases who have T2DM. Methods: A cross-sectional study has been performed among 60 cases with T2DM. They were subdivided into 30 patients with albuminuria and 30 patients without albuminuria. Sociodemographic data, fundus examination, laboratory investigations involving fasting blood glucose (FBG), fasting insulin, HbA1c, HOMA-IR, lipid profile, creatinine, and urinary albumin to creatinine ratio (ACR) have been …

Thyroid Peroxidase Antibody (Tpo Ab) Can Be Used As A Marker For Persistence Of Symptoms Of Hypothyroidism In Patients With Primary Hypothyroidism Despite Normal Tsh Level: Cross-Sectional Study, Gehad Mohamed Aldamsisy, Mohamed Ghoniem Mohamed, Mohammed Mofreh, Ahmed Albehairy

Mansoura Medical Journal

Background Primary hypothyroidism is one of the most prevalent endocrine conditions. Some hypothyroid patients treated with an acceptable dose of levothyroxine report continuing symptoms including fatigue, depression, and weight gain, despite having a TSH level in the lower half of the normal range. Aim to evaluate why some hypothyroid patients on levothyroxine continue to have residual symptoms despite apparently adequate replacement& laboratory euthyroid status? Patients and methods 111 Adult male and female ranging from (18-65) years with primary hypothyroidism and normal TSH taking adequate levothyroxine dose were divided into 2 groups. Group1: Hypothyroid patients with persistent symptoms despite normal TSH …

Dexmedetomidine Versus Nalbuphine As An Adjuvant To Intrathecal Bupivacaine In Lower Extremity Surgeries, Mohamed Aly El Oraby, Amira Hafez, Hazem E Moawad, Gihan A Trabea, Maha Ahmed Abo-Zeid Salim

Mansoura Medical Journal

Background: Numerous medications have been added to spinal anesthetic over the years in order to speed up its onset, shorten the time until the surgical incision, increase its duration, and offer sufficient postoperative analgesia. Objective: This study suggests that dexmedetomidine is superior than nalbuphine as an adjuvant to intrathecal local anesthetic for the duration of post-operative analgesia in lower extremity orthopedic surgical procedures. Patients and Methods: 60 patients underwent orthopedic lower extremity procedures were split into one of three groups at random: Bupivacaine, Bupivacaine- Dexmedetomidine (BD), or Bupivacaine-Nalbuphine (BN). The principal outcome was the duration of post-operative analgesia. The secondary …

Direct-Acting Antivirals For Chronic Hepatitis C Virus Infection In Children With Malignancy: A Review Of Current Evidence And Clinical Insights, Ashrakat Galal Aboelfotoh, Ahmad Darwish Mohamad, Ahmed Megahed Hassan

Mansoura Medical Journal

In children, hepatitis C virus (HCV) remains a serious health concern, especially those receiving cancer treatment, where repeated blood transfusions and immunosuppression significantly increase the risk of infection. The use of direct-acting antivirals (DAAs) represents a turning point in HCV management, delivering high cure rates with fewer side effects than previous therapies. In this review, we explore the latest insights into HCV epidemiology, transmission, and pathophysiology in pediatric patients, with particular attention to those facing malignancy. We will discuss the mechanisms of action, approved treatment regimens, and safety profiles of DAAs, focusing on combinations like sofosbuvir/ledipasvir in the oncology setting. …

Pulsed Radiofrequency Of Suprascapular Nerve Versus Radiofrequency Ablation Of Articular Branches Of The Shoulder For Intractable Shoulder Pain: A Randomized Controlled Study, Elsayed M. Elemam, Mahmoud M. Alseoudy, Ahmed R. Abourezk

Mansoura Medical Journal

BackgroundChronic shoulder pain is frequent in the community and can cause considerable functional impairment. The suprascapular nerve (SSN) is responsible for approximately 70% of the sensory innervation to the shoulder joint.Objectives: This randomized controlled trial aimed to compare the efficacy of pulsed radiofrequency treatment of the SSN with thermal radiofrequency ablation of the articular branches of the shoulder among patients with persistent shoulder pain.Methods 82 patients were randomly allocated into two equal groups; group PRF included patients who underwent pulsed radiofrequency of the suprascapular nerve, and group TRF included patients who underwent thermal radiofrequency ablation of articular terminal branches of …

Relationship Between Serum Micro-Rna 192 And 29c And Kidney Disease In Subjects With Type 2 Diabetes Mellitus, Amr Y. El Feky, Talaat A. Abdelaaty, Azza A. Ismail, Rania M. Elsharkawy, Mohamed F. Amara, Shimaa M. Elrahmany

Mansoura Medical Journal

Background Diabetic kidney disease (DKD) is a frequent and serious complication of type 2 diabetes mellitus (T2DM). This study aimed to assess the relationship between micro- RNA (miRNA)-192 and miRNA-29c expression and DKD in patients with T2DM. Patients and methods A case-control study was conducted with 160 participants: 40 T2DM patients with DKD, 40 T2DM patients without DKD, and 80 healthy controls. Plasma levels of miRNA-192 and miRNA-29c were quantified using quantitative reverse transcription PCR. Diagnostic accuracy was assessed via ROC curve analysis. Multivariate logistic regression identified predictors of DKD. Results Micro RNA-192 expression was significantly elevated while miRNA-29c expression …

Predictive Value Of Procalcitonin In Patients With Hepatitis C Virus Related Liver Cirrhosis And Sepsis, Omar Abdallah, Elshimaa Saad Eleraky, Doaa A. A. Abdeldayem, Mohamed Hossam El-Dein Zaghloul, Mohamed El-Saadany

Mansoura Medical Journal

Infection is a major source of morbidity and mortality in patients with liver cirrhosis. In about 30% of patients, bacterial infection is present on admission or develop during hospitalisation. Early detection of bacterial infection in patients with decompensated cirrhosis remain a major challenge, where time plays a crucial role. This study was conducted aiming to find the prognostic value of PCT in the patients with liver cirrhosis presenting with sepsis. During the period from June 2021 to December 2021, 75 subjects were enrolled. 50 patients with Hepatitis-C Virus (HCV) cirrhosis with sepsis. 25 patients had compensated cirrhosis while the other …

The Effect Of Parathyroidectomy Compared To Pharmacological Treatment On Biochemical Markers And Quality Of Life Among Maintenance Hemodialysis Patients With Secondary Hyperparathyroidism, Ahmed Bahie, Dina Abd El Halim Shahin, Magdy Elsaid Abd Elmagid Samour, Elshahat Ali Ahmed Mohamed Yousef

Mansoura Medical Journal

Background One-third of maintenance hemodialysis (HD) patients develop severe secondary hyperparathyroidism (SHPT). Parathyroidectomy (PTx) is recommended for resistant SHPT, but calcimimetics have reduced the need for surgery. Aim of the work: to compare biochemical and QoL parameters in HD patients with SHPT who underwent PTx to those treated medically. Subject and methods in a cross-sectional study, 200 maintenance HD patients in two equal groups: A (patients on medical treatment) and B (PTx patients). In Group A, 32 patients received Cinacalcet. A thorough history, anthropometrics, clinical examination, Electrocardiography and full laboratory tests including serum calcium (sCa), phosphorus (sPhos), intact parathormone (iPTH) …