Medicine and Health Sciences Commons^™

Santa Clara Magazine, Volume 26 Number 8, Summer 1984, Santa Clara University

Santa Clara Magazine

2 - ALBEE'S ST. GEORGE AND THE DRAGON By Michael Tueth, S.J. Some principles of archetypal criticism are applied to Albee's Who's Afraid of Virginia Woolf?

7 - NUCLEAR ADDICTION Edmund G. Brown Jr. The United States and the Soviet Union are engaged in an addictive and ultimately lethal process. Neither will break out of the curse of assured mutual destruction.

9 - GIVE US THIS DAY OUR DAILY BREAD By Charles E. French. There are good reasons today to hope for a solution to world hunger, one that will occur in our time.

13 - TRAITS OF A HEALTHY …

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Infectious Diseases And The Persisting Microbial Challenge, Louis D. Saravolatz

Henry Ford Hospital Medical Journal

No abstract provided.

Prospects For The Medical Use Of Interferon In 1984, Bosko Postic, Julio C. Arroyo

Henry Ford Hospital Medical Journal

Interferon, a natural and wide spectrum antiviral polypeptide that was discovered in 1957, has been extensively described. In addition to its antiviral effect, interferon has been found to suppress tumor growth and modulate the immune response. Until 1980, interferon was primarily prepared for clinical trials in human leukocytes derived from the buffy coat of whole blood. A major breakthrough occurred in the late 1970s when human interferon was produced by DNA recombinant methods in such heterologous cells as bacteria (genetic engineering). Interferon is not commercially available in 1984, but it may, based on clinical trials in humans, become part of …

Congenital Seminal Vesicle Cyst: A Specific Diagnosis By Computed Tomography, Leo Drolshagen, Michael A. Sandler

Henry Ford Hospital Medical Journal

Computed tomography (CT) has been shown to be of great value in the assessment of the urinary tract. However, this modality has been primarily used in the evaluation of renal masses and the staging of urinary tract carcinomas. It may also be useful in less common abnormalities, such as mesonephric duct anomalies including congenital seminal vesicle cysts. These lesions are associated with renal agenesis and may produce urinary tract symptoms, or be discovered incidentally. We present a case of a congenital vesicle cyst associated with ipsilateral renal agenesis with characteristic CT findings allowing for a specific diagnosis.

A Case Of Ige Myeloma: Methodology And Review Of The Literature, Pat A. Allevato, Michael J. Deegan, Jau-Wen Chu, Mary B. Perry, Carolyn L. Barth

Henry Ford Hospital Medical Journal

A 56-year-old man presented with a one-year history of progressive weakness predominantly affecting his extremities and persistent low back pain. Ouchterlony immunodiffusion of the concentrated urine detected a marked increase in lambda light chains. A sternal bone marrow documented a diagnosis of multiple myeloma. Screening high resolution agarose gel electrophoresis revealed diffuse hypogammaglobulinemia and, retrospectively, an equivocal, faint band which migrated in the fast gamma region. By using a combination of Immunoelectrophoresis and immunofixation electrophoresis, this questionable band was determined to represent an IgE lambda monoclonal protein. Radioimmunoassay for IgE documented a serum concentration of 50.6 mg/dl. No intact IgE …

Rapidly Progressive Pancytopenia, Hepatomegaly, And Abnormal Lung Uptake Of Colloid In Systemic Lupus Erythematosus: Possible Saturation Of Reticuloendothelial System With Blood Elements, Tetsushi Sakurai, Kiyoshi Fukuda, Ichiro Kono, Teizo Kabashima, Kazuhide Yamane, Heihachiro Kashiwagi

Henry Ford Hospital Medical Journal

A patient with systemic lupus erythematosus developed severe abdominal pain and tender hepatomegaly associated with progressive pancytopenia and elevated serum levels of circulating immune complexes. Liver scintigram demonstrated extreme hepatomegaly with poor colloid uptake and splenomegaly with increased colloid uptake. An unusual accumulation of colloid in the lungs was also noted. Subsequent clinical and laboratory studies raised the possibility of saturation of the reticuloendothelial system in the liver by circulating immune complexes and blood cells, a condition demonstrated in experimental animals, but not hitherto well documented in the human immune complex disorder.

Tubal Lavage In The Management Of Ectopic Pregnancy, Samuel A. Motanya, William H. Pfeffer, Emile Sandelin, C. James Chuong

Henry Ford Hospital Medical Journal

No abstract provided.

Clinical Trials: I. Design And Ethical Issues, Barbara Tilley

Henry Ford Hospital Medical Journal

No abstract provided.

Editorial, Raymond C. Mellinger

Henry Ford Hospital Medical Journal

No abstract provided.

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

The Effects Of Maternal Administration Of Methadone On Beta-Endorphin Content In The Brain And Pituitary Of The Rat Progeny, Randall L. Braun

Loma Linda University Electronic Theses, Dissertations & Projects

Methadone is often used in the maintenance and detoxification of opioid-dependent pregnant women. This use of methadone during pregnancy is known to be associated with teratogenic effects observed in the progeny. The present study is an attempt to gain insight into possible pathophysiologic mechanism(s) responsible for these teratogenic effects: specifically, a relationship between maternal methadone administration and the content of the endogenous opioid peptide, beta-endorphin, in the brain and pituitary of the rat progeny.

In brief, nulliparous mature female Sprague-Dawley rats received daily injections (5 mg./kg.) of methadone hydrochloride (methadone-treated) or a similar volume of physiological saline (controls), treatment started …

The Effect Of Dietary Alpha - Linolenic Acid On Apparent Risk Factors Of Cardiovascular Disease, Kelvin D. Lindbeck

Loma Linda University Electronic Theses, Dissertations & Projects

Eight healthy male lacto-ovo-vegetarian subjects averaging 28.0 ± 3.6 years of age (22 to 53 years) were fed a diet rich in α-linolenic acid (18:3 ω 3) for four weeks. Arterial blood pressure and body weight were recorded each week. Plasma 6-keto-prostaglandin F_1α (6-keto- PGF_1α ), thromboxane B₂ (TXB₂), total cholesterol, triglyceride, and total phospholipid fatty acid composition were analyzed at 0, 2 and 4 weeks.

Systolic blood pressure increased significantly between weeks 0 and 1 (106.5 ± 2.7 mmHg to 114.0 ± 3.7 mmHg; p < 0.003), but decreased to 107.3 t 2.6 mrHg (p < 0.02) at week 2. There was an insignificant increase in both systolic and diastolic blood pressures after four weeks. There was no significant change in either total cholesterol or triglyceride levels during the four weeks.

Plasma 6-keto-PGF_1α levels increased significantly from 60.13 ± …

Detailed Description And Nomenclature Of High Resolution G-Banded Horse Chromosomes And Cytogenetic Analysis Of Hereditary Multiple Exostosis In Horses, Alma Maciulis

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

A reliable technique for obtaining late prophase, prometaphase and greater numbers of metaphase chromosomes is presented. The increased number of mitoses and high resolution chromosomes were obtained using a modification of the typical three-day blood culture technique in which the cell cycle was temporarily blocked at the G₁-s border with methotrexate. A high resolution G-band idiogram is presented using a system similar to the standardization of human chromosomes. The use of this technique and system of nomenclature will facilitate routine analyses of horse chromosomes and provide a basis for the identification and recording of chromosome aberrations in this …

Distribution Of The Shoshone Scuplin (Cottus Greenei: Cottidae) In The Hagerman Valley Of South Central Idaho, Richard L. Wallace, J. S. Griffith Jr., D. M. Daley, Patrick J. Connolly, G. B. Beckham

Great Basin Naturalist

Cottus greenei, a potentially threatened species endemic to Idaho, was collected from 49 localities in 25 springs/streams in south central Idaho. Most localities were along the north bank of the Snake River in waters of the Thousand Springs formation, Gooding County. One population was found in a spring in the main Snake River. Another sculpin, Cottus bairdi, was collected with C. greenei at 23 locations in 16 springs/streams. Confusion concerning the type locality of Cottus greenei is discussed.>

Investigation Of The Coenzyme Binding Site Of Lactate Dehydrogenase From Chicken Muscle, Jia-Hwei Lin

Chemistry & Biochemistry Theses & Dissertations

Investigation of the coenzyme binding site of lactate dehydrogenase was approached by using coenzyme analogs. Inhibition studies of this enzyme using n-alkylphosphates as coenzyme analogs were performed with a fluorometric method. The results showed that all of the n-alkylphosphates were competitive inhibitors with respect to NAD⁺.

The n-alkyl-ADPs were synthesized from AMP and dicycloheaylammonium salts of n-alkylphosphates. The synthetic compounds were subjected to NMR spectroscopic studies, thin layer chromatography and determination of the ratio of adenosine moiety to phosphate groups. The results indicated that the synthetic compounds were n-alkyl-ADPs.

These synthetic compounds were used as coenzyme analogs in …

A Method For The Comparison Of Hdl Containing Apoprotein E And Hdl Cholesterol, Steven A. Knizner

Chemistry & Biochemistry Theses & Dissertations

Human serum high density lipoproteins (HDL) were isolated by preparative salt density gradient ultracentrifugation and analyzed further by heparin-sepharose affinity chromatography. Separation of the major classes of serum lipoproteins was achieved after a single ultracentrifugation on a salt density gradient at 272,000 x g for 36 hours in a swinging bucket rotor. After isolation, the total HDL was subdivided into HDL containing apoprotein E and HDL without this apoprotein by heparin-sepharose affinity chromatography. Relative amounts of these subclasses were then calculated.

HDL-cholesterol was measured after precipitation of LDL and VLDL by phosphotungstic acid and magnesium. The statistical relationship between HDL …

Screening Of Patients At High Risk For Cancer, Robert M. O'Bryan

Henry Ford Hospital Medical Journal

A cancer other than non-melanoma skin cancer will occur in one of every seven persons. Individuals with higher risks for cancer are those with increasing age, hereditary disorders, and a family history of cancer. Lifestyle, especially the use of tobacco and alcohol, diet, and perhaps behavioral patterns influence the risk. Less well understood but clearly pertinent risk factors include environmental and occupational exposures. The risk factors specific for breast cancer include a positive family history of breast cancer, history of mastopathy, age at first pregnancy greater than 35 years, early menarche with late menopause, and history of carcinoma of the …

Brief Communication: Streptokinase For Deep Venous Thrombosis, Barry Lesser, Maria A. Sawdyk

Henry Ford Hospital Medical Journal

No abstract provided.

Pericardial Tamponade In Acute Myeloid Leukemia, R. P. Warrier, K. R. Kini, R. Singh, K. Maeda, I. Barr, F. M. Jara

Henry Ford Hospital Medical Journal

We are reporting a case of acute myeloid leukemia in a child with pericardial effusion and cardiac tamponade, with a review of the literature. Morphologic and cytochemical evidence was used to diagnose acute myeloid leukemia, and radiologic, electrocardiographic, echocardiographic, cytologic, and histologic evidence confirmed the diagnosis of tamponade and pericardial leukemic involvement. Pericardiotomy and pericardial window drainage successfully relieved the tamponade, and conventional chemotherapy was used to induce a remission.

Cushing's Disease Due To Pituitary Carcinoma, M. Saeed Zafar, R. C. Mellinger, J. L. Chason

Henry Ford Hospital Medical Journal

Criteria for the diagnosis of pituitary carcinoma are subject to controversy. Some authors do not accept the demonstration of cellular anaplasia alone as sufficient to establish the diagnosis but require evidence of metastatic disease in order to label a pituitary tumor as malignant. However, pituitary tumors can metastasize even in the absence of anaplasia. The present case of Cushing's disease and pituitary carcinoma had no clinical evidence of metastases when first reported. Partial surgical removal of the tumor followed by irradiation resulted in clinical remission of the Cushing's syndrome, but two years later progressive uncontrollable recurrence of the disease ended …

Peritoneal Lavage Red Blood Cell And White Blood Cell Count: A Prospective Comparison Of Usefulness, Eugene Meyer, James C. Gruenberg

Henry Ford Hospital Medical Journal

Prospectively, 637 patients with blunt or penetrating trauma to the lower chest or abdomen had quantitative peritoneal lavage red blood cell (RBC) and white blood cell (WBC) counts as part of their initial diagnostic evaluation. Statistically, the lavage RBC count (error rate: 6.8%) was a superior test to the lavage WBC count (error rate: 9.7%) (chi sq=9.2564, p=0.0024). See Appendix. When the lavage RBC and WBC tests agreed, the predictive value was high: 94% (46/49) when both were positive and 95% (521/549) when both were negative. When the lavage RBC test was positive and the lavage WBC test was negative, …

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Why Cancer?, Angelos A. Kambouris

Henry Ford Hospital Medical Journal

No abstract provided.

Family History As A Marker For Increased Risk Of Breast Cancer And Colon Cancer, Robert A. Norum

Henry Ford Hospital Medical Journal

Cancer of the breast and colon are well known to occur with high frequency in families with certain inherited cancer syndromes. These cancers also occur with increased frequency in families which do not have a recognizable genetic cancer syndrome. The fact of familial occurrence can be used to identify people with increased risk of cancer. In high-risk people methods for early detection can be developed which may reduce morbidity and mortality from these cancers, as has been done for certain inherited cancer syndromes.

External Beam Treatment Of Inoperable Non-Small Cell Carcinoma Of The Lung, H. Gunter Seydel

Henry Ford Hospital Medical Journal

External beam radiation therapy for unresectable non-small cell carcinoma of the lung has produced significant survival in patients with disease limited to one hemithorax. New approaches to improve the results of radiation treatment of these patients include interstitial implantation, the use of hypoxic cell sensitizers, biologic response modifiers, as well as changes in the technique of radiation therapy. This includes the use of modern computerized tomographic scanning technology for better definition of tumor volume as well as the use of two fractions per day in the treatment of non-small cell carcinoma of the lung. Initial results of these studies are …

The Spectrum Of B Cell Neoplasia, Michael J. Deegan

Henry Ford Hospital Medical Journal

Recent progress in our understanding of the immune system and the development of new techniques that permit the precise identification of lymphocytes have permitted a reexamination of lymphoid neoplasms. Most of the non-Hodgkin's lymphomas and lymphocytic leukemias have been characterized as T or B cell neoplasms and have been shown to possess features similar to those expressed by normal lymphoid cells at different stages of maturation. The clinical significance and therapeutic implications of these discoveries are now being explored. This paper presents a concise overview of the differentiation of human B lymphocytes, the surface and cytoplasmic markers that permit their …

Preoperative Chemotherapy And Irradiation In The Treatment Of Soft Tissue Sarcomas Of The Lower Extremities: Preliminary Report Of Experience At Henry Ford Hospital, S. David Nathanson

Henry Ford Hospital Medical Journal

The development of effective chemotherapy and improved techniques of radiation therapy offer the possibility of managing soft tissue sarcomas so that surgery may need to be less radical than in the past and amputation can be avoided. The low rates of local-regional and systemic recurrence that have resulted from using innovative combinations of chemotherapy, radiation therapy, and conservative surgery encouraged us to use preoperative intraarterial adriamycin (doxorubicin) with or without radiation therapy for three cases of soft tissue sarcomas of the lower extremities. The rationale for this therapy is also discussed.

The Current Controversies In Surgical Management Of Early Breast Cancer, Angelos A. Kambouris

Henry Ford Hospital Medical Journal

No abstract provided.

Elevated Serum Transaminase As A Presenting Clue For Precirrhotic Hemochromatosis, Lester P. Kobylak

Henry Ford Hospital Medical Journal

For patients in whom unexplained elevations in SGOT and SGPT concentrations are found, determination of the serum iron level is recommended to screen for asymptomatic precirrhotic hemochromatosis. Care must be taken to differentiate between hereditary hemochromatosis and secondary iron accumulation due to liver disease.