Medicine and Health Sciences Commons^™

Donald Bailey Oral History, Donald Bailey

Oral History Collection

Susan Metrhens' Note:

Regarded by many of his peers at Jax as one of the most intuitive, prescient and creative scientists at the Lab, Bailey was a very reflective narrator. While he provides one anecdote of c.c. Little1s sartorial habits, this tape is largely devoid of anecdotal material, and is more a reminiscence by a scientist who was at Jax in the early '50's, who left and returned in 1967. I tried, through a variety of questions, to probe the synergy between Bailey and the Lab, the degree to which his prescience and creativity might be due to the freedom …

Priscilla "Skippy" Lane Oral History, Skippy Lane

Oral History Collection

Susan Mehrtens' Note:

We have in this tape the recollections of one of the most prolific authors in the field of mouse mutants, an indefatigable co-worker of Margaret Dickey, Margaret Green and currently, Muriel Davison. Full of scientific terms, this tape reveals clearly Lane's thorough absorption in the field to which she has devoted nearly the last forty years of her life. Toward the end of this tape, Lane alludes to Earl Green's sexist attitude, which other women have also mentioned to me on and off tape. Lane also waxes eloquently here about her efforts to establish a hiera'rchy within …

Prevalence Of Sensitivity To Sulfiting Agents In Asthmatic Patients, Robert K. Bush, Steve L. Taylor, Karen Holden, Julie A. Nordlee, William S. Busse

Department of Food Science and Technology: Faculty Publications

Ingestion of sulfiting agents can induce wheezing in some asthmatic patients. However, neither the prevalence of sulfite sensitivity nor the clinical characteristics of the affected asthmatic population are known. In a prospective single-blind screening study, 120 non-steroid-dependent and 83 steroid-dependent asthmatic patients underwent challenge with oral capsules of potassium metabisulfite. Five non-steroid-dependent and 16 steroid-dependent asthmatic patients experienced a greater than 20 percent reduction in their one-second forced expiratory volume within 30 minutes following the oral challenge. Twelve of these sulfite reactors were rechallenged with metabisulfite capsules in a double-blind protocol. Under these conditions, only three of seven steroid-dependent patients …

The Case For The Use Of Animals In Biomedical Research, Carl Cohen

Morality and Ethics of Animal Experimentation Collection

No abstract provided.

Santa Clara Magazine, Volume 29 Number 1, Fall 1986, Santa Clara University

Santa Clara Magazine

10 - IS SANTA CLARA STILL JESUIT? Declining vocations prompt this recurring question. Some of the faculty discuss what makes Santa Clara Jesuit to them. By Peg Major

16 - DON'T CALL ME MR. MOM Taking over the day care of his two tiny daughters while his wife worked provided this alumnus new insight on fatherhood. By Jim Craven

21 - PERSPECTIVES OF A PATRIARCH The spotlight is on Tom Bannan, class of '23, who started the procession of Bannans to Santa Clara. BY Paul Hennessy

26 - HOW NOT TO MAKE MONEY ON THE STOCK MARKET A guide to …

A Spray Programme For Table Grape Production In Western Australia, I. J. Cameron, P. Wood, A. Sproul

Viticulture published reports

This bulletin details the main sprays that can be used in table grape vineyards in Western Australia. Growers are advised to refer to the manufacturer's label for detailed recommendations since rates vary according to formulation. New chemicals are continually being marketed and any omissions are regretted and no preferences for any material or supplier is implied.

Genetic Characterization Of Human C-Rel Sequences, Elise Brownell, Stephen J. O'Brien, William Nash, Nancy Rice

Biology Faculty Articles

We isolated and sequenced a human genomic-DNA segment that is homologous to a portion of v-rel, the transforming gene of reticuloendotheliosis virus (strain T). We also localized the human rel sequences to human chromosome 2 by screening a panel of rodent x human somatic-cell hybrids with the newly described human rel segment.

The Synthesis And Evaluation Of The Cardiovascular Activity Of Novel Imidazole Ring Systems, Joseph E. De Los Angeles

Chemistry & Biochemistry Theses & Dissertations

An investigation was undertaken to synthesize and evaluate the cardiovascular activity of two imidazole ring systems. Imidazoles with hypotensive activity would provide novel potential antihypertensive drugs. These novel structures may also find use as chemical probes in the study of the cardiovascular system and as prototypes for other potential cardiovascular agents.

The histamine derivative, 7,7-dipyridyl-4,5,6,7-tetrahydroimidazo-[4,5-c]pyridine (ligand l), was demonstrated to possess significant hypotensive activity in laboratory rats. A 15 mg/Kg dose of ligand 1 produces a statistically significant decrease in blood pressure when injected IP. This hypotensive effect is also associated with marked increase in heart rate. Although compound 1 …

Thomas Roderick Oral History, Thomas Roderick

Oral History Collection

Susan Metrhens' Note:

Roderick has been a scientist at Jax for thirty years, working in no other place. He was hired just as Earl Green replaced C.C. Little and Roderick worked with and for Green for some dozen years before moving into his own lab, on his own grants. Roderick is both perceptive and analytical and this tape is valuable for his willingness to reflect on trends and personalities. He also has a philosopher's willingness to consider the values that drive the lab. Roderick was forthcoming with anecdotes, including a most telling one of Rich Prehn showing the courage of …

Barium Granuloma Mimicking Rectal Carcinoma, Freda L. Arlow, Diane M. D'Angelo

Henry Ford Hospital Medical Journal

No abstract provided.

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Restrictive Cardiomyopathy, Remigio Garcia, Mohsin Alam

Henry Ford Hospital Medical Journal

Restrictive obliterative cardiomyopathy, with emphasis on amyloid infiltration of the heart, is discussed. The presence of right-sided failure associated with low-voltage electrocardiographic complexes may simulate constrictive pericarditis. Intractable congestive heart failure is the most frequent presentation of amyloid heart disease, and the average survival from diagnosis is 14 months. Digitalis sensitivity and fatal arrhythmias are notoriously common. Other important, although less common, restrictive cardiomyopathies include 1) hemochromatosis, which is the only reversible cause of heart failure in this group: and 2) endomyocardial fibrosis, which is rarely seen in temperate zones but which is amenable to surgical palliation. Many questions regarding …

Potassium And Heart Failure, Howard S. Rosman, Mihai Gheorghiade, Sidney Goldstein

Henry Ford Hospital Medical Journal

No abstract provided.

Beta-Adrenergic Blocking Agents In Congestive Heart Failure, Sidney Goldstein

Henry Ford Hospital Medical Journal

Although recent physiologic studies suggest that increased catecholamine release in humans may in the long run represent an adverse homeostatic mechanism, this catecholamine release is acutely important in permitting human response to stress. Clinical interventions with beta-adrenergic blocking agents have showed a salutary effect on cardiac function in patients with severe heart failure: in patients with heart failure associated with myocardial infarction, these agents may help improve mortality rates. These studies indicate that the drugs are well tolerated when used carefully in these high-risk patients.

New Positive Inotropic Agents, Syed M. Jafri, James A. Bristol

Henry Ford Hospital Medical Journal

Current therapy for heart failure remains inadequate. New positive inotropic agents that augment myocardial contractility have been introduced. The positive inotropic effects of these nonglycoside, nonsympathomimetic agents are due, at least in part, to inhibition of cardiac phosphodiesterase activity and hence to an increase in myocardial cyclic AMP levels. These agents also have vasodilator properties through their effects on the enzyme phosphodiesterase in the vascular smooth muscle. Recent developments in the preclinical pharmacology, mechanism of action, and clinical experience with these new inotrope vasodilators are presented in this review. The role these drugs will play in revising our therapeutic strategy …

Azathioprine-Lnduced Reversible Severe Dyserythropoiesis As A Cause Of Anemia, Sundara B. K. Raman, Joseph P. Abraham, Sheikh M. Saeed, Maria Sawdyk

Henry Ford Hospital Medical Journal

A 43-year-old woman with a 20-year history of systemic lupus erythematosus was treated with azathioprine for progressive complications of the disease. She developed pancytopenia within four weeks after starting azathioprine therapy. Bone marrow examination showed marked dyserythropoiesis and varying degrees of marrow hypoplasia. Changes seen in normoblasts consisted of nuclear buds, multinucleation, Howell-Jolly bodies, and abnormal mitoses. Azathioprine was discontinued. Peripheral blood counts improved in the next four weeks. A progress bone marrow examination six weeks later showed marked improvement in red blood cell abnormalities. An additional bone marrow examination performed four months after discontinuation of azathioprine showed complete disappearance …

Bilateral Dislocation Of The Crystalline Lens In A Patient With Presumed Syphilitic Uveitis, Jeffrey S. Rapkin, David D. Bogorad

Henry Ford Hospital Medical Journal

Dislocation of the crystalline lens has been described in association with numerous systemic disorders and as a complication of ocular trauma. We present a case of bilateral lens dislocation in a patient with presumed syphilitic uveitis. The mechanism of lens dislocation is related to humoral and cellular effects of inflammation, although the role of trauma cannot be ignored. Persistent uveitis should be considered as a sign of active infection.

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Heart Failure: New Questions And Insights About An Old Foe, Jeffrey B. Lakier

Henry Ford Hospital Medical Journal

No abstract provided.

Indications For Acute And Chronic Digitalis Administration In Heart Failure, Mihai Gheorghiade

Henry Ford Hospital Medical Journal

No abstract provided.

Pathophysiology Of Heart Failure, Mihai Gheorghiade, Jeffrey B. Lakier

Henry Ford Hospital Medical Journal

Heart failure occurs when the heart is unable to maintain a cardiac output sufficient to satisfy the oxygen requirements of the body despite adequate blood volume and hemoglobin content. Regardless of the initial cause of heart failure and in spite of compensatory mechanisms, patients often follow a course of worsening heart failure that is characterized by a low cardiac output, high filling pressures, and increased peripheral vascular resistance. In addition to persistence of the initiating event, cardiac deterioration may be caused or aggravated by a variety of factors including depletion of cardiac norepinephrine stores, down-regulation of myocardial beta-adrenergic receptors, microvascular …

Altered Platelet Function In Patients With Severe Congestive Heart Failure, Syed M. Jafri, Jeanne M. Riddle, Sundara B. K. Raman, Sidney Goldstein

Henry Ford Hospital Medical Journal

Platelet function was assessed in 15 patients with severe congestive heart failure (CHF) and in 26 control subjects of similar ages. The platelet count (mm³), surface reactivity, aggregometry studies, release factors, and circulating aggregates were investigated. The mean number of circulating platelets was normal, but a hyperactive platelet response was found in 53% of the CHF patients. CHF patients had a 42% mean for the spread type platelet, and the average number of aggregates was 64: control subjects had a 12% mean for the spread type platelet, and the average number of aggregates was 40 (p < 0.05). Aggregation with all of the inducers was normal, although 27% of CHF patients showed spontaneous aggregation. The mean plasma levels of both platelet factor 4 and betathromboglobulin were abnormally elevated. No circulating platelet aggregates were detected. Our studies indicate that platelet function is abnormal in patients with CHF. The abnormal platelet reactivity found might contribute to the increased incidence of thromboembolic events observed in CHF patients.

"Congestion": An Infrequent Feature In Patients With Chronic Heart Failure On Therapy, Syed M. Jafri, Jeffrey B. Lakier, Howard S. Rosman, Sidney Goldstein

Henry Ford Hospital Medical Journal

The clinical presentation of chronic heart failure has changed with advances in therapy, and the physical findings of congestion are now inconsistently present. To determine the clinical signs of congestion, we studied the clinical findings of 44 patients who had chronic heart failure and abnormal left ventricular ejection fractions (23 ± 10%). Signs of pulmonary edema manifested as rales were absent in all patients in New York Heart Association (NYHA) classes I and II, in 66% of patients in NYHA class III, and in 14% of patients in NYHA class IV. Signs of right heart failure manifested as elevated jugular …

Echocardiographic Evaluation Of Patients With Congestive Heart Failure, Mohsin Alam

Henry Ford Hospital Medical Journal

Echocardiography is a useful noninvasive test for evaluating patients with suspected heart failure and enlarged cardiac silhouette. This test can obtain the dimensions and wall thickness of all four cardiac chambers and can evaluate left ventricular function. The test results are reproducible, and in many instances the etiology of heart failure can be determined.

The Effect Of Aortic Valve Replacement On Left Ventricular Function In Patients With Aortic Valvular Disease, Tennyson Lee, Cathy L. Glick, Jeffrey B. Lakier, Sidney Goldstein

Henry Ford Hospital Medical Journal

Despite improved surgical techniques and survival in patients following aortic valve replacement for aortic stenosis and aortic insufficiency, the proper timing for surgery remains controversial. The incomplete reversibility of left ventricular dysfunction remains a concern, and postoperative improvement of left ventricular function is not consistently demonstrated. We studied 11 patients with aortic stenosis and nine patients with aortic insufficiency using angiographic and radioisotope assessment of left ventricular function preoperatively. Postoperative left ventricular function was assessed over nine to 13 months by radioisotope multiple-gated acquisition (MUGA) scan. All patients with impaired left ventricular function preoperatively showed slow but significant recovery toward …

Status Of Cardiac Transplantation With A Report Of The First Year's Experience At Henry Ford Hospital, Fraser M. Keith, Donald J. Magilligan Jr., Jeffrey B. Lakier, Conrad Drost

Henry Ford Hospital Medical Journal

Cardiac transplantation is now widely accepted as effective treatment for selected patients with end-stage heart disease. Improvements in immunosuppressive treatment and monitoring in the past 15 years have resulted in impressive one-year and five-year survival rates of 80% and 60%. In general, survivors have enjoyed a considerably improved quality of life. A cardiac transplantation program was initiated at Henry Ford Hospital in 1985, and a total of 15 patients received heart transplants in the first 12 months. Fourteen patients are currently alive and well at various stages posttransplant. This early clinical success has prompted the consideration of both combined heart-lung …

A Tribute To Dr. Szilagyi, Roger F. Smith

Henry Ford Hospital Medical Journal

No abstract provided.

Gravid Uterine Rupture Following Cesarean Section And Intervening Vaginal Delivery, Anthony Udo-Inyang, Chang Lee, Elizabeth Evans

Henry Ford Hospital Medical Journal

No abstract provided.

The Effects Of Certain Oral Bacteria On The In Vitro Growth Of Bacteroides Gingivalis, Steven G. Morrow

Loma Linda University Electronic Theses, Dissertations & Projects

The effect of nine gram positive and grain negative cocci and bacilli, which are indigenous to the oral cavity, on the in vitro growth of Bacteroides gingivalis was examined in this study. A pure culture of B. gingivalis is was obtained from the American Type Culture Collection. The nine oral test organisms were Streptococcus mitis, Streptococcus mutans, Streptococcus faecalis, Staphylococcus epidermidis, Staphylococcus aureus, Corynebacteriurn hofmanii, Lactobacillus acidophilus, Branhamella catarrhalis, and Escherichia coli. The effect on the growth of B. gingivalis of the nine test organisms was evaluated on a solid medium by use of …

The Effect Of Dietary Fat Level On Tumor Development And Immunity In Balb/C Mice Fed Casein Of Wheat Gluten As Protein And Challenged With Herpes Type 2-Transformed Cells, Helen Drakou

Loma Linda University Electronic Theses, Dissertations & Projects

A high percentage of fat in the diet has been implicated through epidemiological studies in several human cancers. Studies in experimental animals have produced evidence that increasing the fat in the diet decreases the animal’s ability to restrict tumor development and growth. In previous work done in this laboratory with BALB/c mice injected with herpes simplex Type 2-transformed mouse cells (H238), the effects of a diet which greatly enhanced tumor growth was compared with one which restricted tumor growth. The latter, a low (5%) fat, low protein diet, in which the protein was casein, was also found to produce a …