Medicine and Health Sciences Commons^™

Campus As A Living Lab At Ur: What’S Working & What’S Next, Jack Dupuy

Osmosis Magazine

Living labs—real-world experimental environments where diverse stakeholders ranging from local communities and businesses to universities and governments can collaboratively develop, test, and refine solutions—have become an increasingly popular method for tackling complex societal challenges in areas such as energy, urban planning, and environmental sustainability. Unlike controlled laboratory settings, living labs leverage real-world conditions to test innovations in authentic contexts, fostering systemic change by aligning research with local needs.

Droughts, Destruction, And Displacement: How Climate Change Exacerbates Violence In The Sahel, Stevi Dugas

Osmosis Magazine

February 2023 through January 2024 marked the first 12- month period that global average temperatures exceeded the 1.5°C benchmark proposed in the Paris Climate Agreement, indicating early signs of coming dangerously close to exceeding a permanent 1.5°C increase in global average temperatures. Permanently exceeding the 1.5°C benchmark is expected to lead to increasingly frequent and dangerous extreme weather events such as droughts and wildfires, while also increasing the risk of climate tipping points such as collapse of coral reef systems (UN, n.d.). Though no place is safe from the effects of climate change, few places on Earth will be hit …

Monty Hall Problem: Will You Win A Car?, Tien Nguyen Chu

Osmosis Magazine

Suppose you’re on a game show. There are three closed doors. Behind one is a brand-new car; behind the other two, goats. You pick a door. The host, who knows what’s behind all the doors, opens one of the remaining doors to reveal a goat. Now you’re offered a choice: stick with your original door or switch to the other unopened one. What should you do? Will changing your choice increase your chances of winning the car - or or does it make no difference at all?

Myth Or Fact: Does Teethwhitening Really Work?, Garrett Mayover

Osmosis Magazine

Teeth whitening has rapidly gained popularity as one of the most sought-after dental cosmetic procedures today. Once an exclusive treatment performed primarily by dental professionals, it has now expanded into the mainstream market, with store shelves stocked full of “natural” alternatives and “affordable” whitening strips. But the pressing question remains: do these strips actually work, or are they just a marketing gimmick? This article aims to uncover the truth. We will first explorethe science behind teeth whitening and then delve into the effectiveness andpotential drawbacks of these popular over-the-counter products.

The Science Behind Covid Testing, Zion Kim

Osmosis Magazine

On March 11, 2020, the World Health Organization (WHO) officially declared a COVID-19 pandemic (“CDC…”, 2024). We all remember the days we had to wear masks, shove cotton swabs into our noses and mouths, and quarantine ourselves from others after being infected by the COVID-19 virus. We take this test all the time and trust their accuracy, but we never stop to ask how they work. We all know that a double line indicates an infection of COVID-19, but why?

Arsenic & The Princess Bride: How Your Body Handles Poison, Martin Jara

Osmosis Magazine

It’s a simply iconic scene from a simply iconic movie; in the cult classic film The Princess Bride, the protagonist Westley faces off against the scoundrel Vizzini in a battle of wits to rescue his true love. The challenge is simple: each man is given a chalice, one of them containing poisonous iocane powder. Colorless, odorless, tasteless, and soluble in water, Vizzini must choose the unpoisoned chalice off wits alone. However, he chooses wrong, dying instantly.

Not Human Enough: The Origins Of The Uncanny Valley, Franklin Young

Osmosis Magazine

Why do we feel creeped out when we see something almost human—like a lifelike robot or a bad CGI character? This phenomenon, known as the uncanny valley, describes the uncomfortable emotional response humans experience when encountering entities that appear nearly, but not quite, human. First introduced by Japanese robotics professor Masahiro Mori in 1970, the concept suggests that as objects become more humanlike in appearance, our emotional response to them becomes increasingly positive —until reaching a point where subtle imperfections trigger strong feelings of revulsion.

The Neurobiology Of Schizophrenia: Reduced Brain Volume And Its Implications, Erlinda Sali

Osmosis Magazine

Schizophrenia is a neurological disorder that is highly complex and often misunderstood. Characterized by hallucinations and delusions, disorders of thought and speech, behavior, and emotions, schizophrenia is more complex than how the media portrays it.

Falling Out Of Balance: How Chemical Disequilibrium In Thebrain Leads To Alcohol Addiction, Zack Ruighaver

Osmosis Magazine

This article will explain how imbalances in two neurotransmitter systems in the brain –namely, glutamate and GABA – account for alcoholism at the molecular level.

Does Adhd Make You Smoke? Exploring Emerging Theories, Sam Chanenson

Osmosis Magazine

Here’s a troubling statistic: children with attention deficit hyperactivity disorder (ADHD) are 2.5 times more likely than their non-ADHD peers to develop substance use disorder (SUD) and nicotine dependency. What’s more, people with ADHD are generally more likely to start smoking earlier in life, smoke more per day, and experience more significant withdrawal symptoms.

Letter From The Editor, Sam Chanenson

Osmosis Magazine

Letter from Sam Chanenson, Editor in Chief, Osmosis Science Magazine.

Osmosis Magazine - Science Magazine

Osmosis Magazine

• Explore the latest stories in STEM.
• Discover cutting-edge innovations shaping today & tomorrow
• Faculty Interview & UR Research Highlights

Ensemble Learning With Explainable Ai For Improved Heart Disease Prediction Based On Multiple Datasets, Shahid Mohammad Ganie, Pijush Kanti Dutta Pramanik, Zhongming Zhao

Faculty, Staff and Student Publications

Heart disease is one of the leading causes of death worldwide. Predicting and detecting heart disease early is crucial, as it allows medical professionals to take appropriate and necessary actions at earlier stages. Healthcare professionals can diagnose cardiac conditions more accurately by applying machine learning technology. This study aimed to enhance heart disease prediction using stacking and voting ensemble methods. Fifteen base models were trained on two different heart disease datasets. After evaluating various combinations, six base models were pipelined to develop ensemble models employing a meta-model (stacking) and a majority vote (voting). The performance of the stacking and voting …

Phytochemistry, Antioxidant And Cytotoxic Activities Of Hibiscus (Hibiscus Rosa-Sinensis) Extract On Mcf-7 Breast Cancer Cells, Ade Arsianti, Isma Zahira Suhaima, Steven Gill, Ajeng Megawati Fajrin, Lince Dameria Nadapdap, Norma Nur Azizah, Hiroki Tanimoto, Shun Hirota

Indonesian Journal of Medical Chemistry and Bioinformatics

Background: Breast cancer is the most common type of cancer in women with a very high mortality rate. This cancer is caused by uncontrolled growth of breast cells. Treatments for this malignancy are surgery, chemotherapy, and radiotherapy, however those methods can cause adverse effects and quite expensive. Complementary and alternative medicines (CAMs) are also used to support those main treatments, one of them is herbal medicine. Hibiscus rosa-sinensis is known to have various phytochemical components with antioxidant, antibacterial, anticancer, and analgesic activities. This study is aimed to determine the phytochemical composition, antioxidant activity and cytotoxicity of Hibiscus rosa-sinensis extract towards …

Vaccination Schedules Recommended By The Centers For Disease Control And Prevention: From Human-Readable To Machine-Processable, Xia Jing, Hua Min, Yang Gong, Mytchell A Ernst, Aneesa Weaver, Chloe Crozier, David Robinson, Dean F Sittig, Paul G Biondich, Samuil Orlioglu, Akash Shanmugan Boobalan, Kojo Abanyie, Richard D Boyce, Adam Wright, Christian Nøhr, Timothy D Law, Arild Faxvaag, Lior Rennert, Ronald W Gimbel

Faculty, Staff and Student Publications

Background: Reusable, machine-processable clinical decision support system (CDSS) rules have not been widely achieved in the medical informatics field. This study introduces the process, results, challenges faced, and lessons learned while converting the United States of America Centers for Disease Control and Prevention (CDC)-recommended immunization schedules (2022) to machine-processable CDSS rules.

Methods: We converted the vaccination schedules into tabular, charts, MS Excel, and clinical quality language (CQL) formats. The CQL format can be automatically converted to a machine-processable format using existing tools. Therefore, it was regarded as a machine-processable format. The results were reviewed, verified, and tested.

Results: We have …

Can The Discovery Of High-Impact Diagnostics Be Improved By Matching The Sampling Rate Of Clinical Diagnostics To The Frequency Domain Of Diagnostic Information?, Steven W Millward, Peng Wei, David Piwnica-Worms, Seth T Gammon

Faculty, Staff and Student Publications

Over the past 30 years, academic and industrial research investigators have developed molecular reporters to visualize cell death in complex biological systems. In parallel, clinical researchers, chemists, biochemists, and molecular biologists have endeavored to translate these molecular tools into clinical imaging agents. Despite these efforts, there are no clinically approved imaging methodologies with which to image cell death consistently and quantitatively. One reason may reside in the intrinsic mismatch between the sampling frequency of translational molecular imaging and the biochemical kinetics that define cell death. Beyond cell death imaging, many active research programs are now attempting to create translational diagnostic …

Swi/Snf Complex-Mediated Znf410 Cooperative Binding Maintains Chromatin Accessibility And Enhancer Activity, Siyuan Xu, Chuxuan Peng, Ren Ren, Haowen Lu, Han Zhao, Sijian Xia, Yijie Shen, Bin Xu, Haoyue Zhang, Xiaodong Cheng, Gerd A Blobel, Xianjiang Lan

Faculty, Staff and Student Publications

The clustering of multiple transcription factor binding sites (TFBSs) for the same TF has proved to be a pervasive feature of cis-regulatory elements in the eukaryotic genome. However, the contribution of binding sites within the homotypic clusters of TFBSs (HCTs) to TF binding and target gene expression remains to be understood. Here, we characterize the CHD4 enhancers that harbor unique functional ZNF410 HCTs genome wide. We uncover that ZNF410 controls chromatin accessibility and activity of the CHD4 enhancer regions. We demonstrate that ZNF410 binds to the HCTs in a collaborative fashion, further conferring transcriptional activation. In particular, three ZNF410 motifs …

Evidence-Based Alternative Pain Management Techniques For Chronic Pain, Alise Williams Condie, Ashley Yaugher, Kira Swensen, Maren Wright Voss

All Current Publications

Chronic pain and opioid use have become topics of importance as opioid overdose deaths have risen to epidemic proportions throughout the nation. Chronic pain lasts for long periods of time and can be caused by a past injury or have no known cause. Opioids have been utilized to treat pain in the past, but it has been discovered that opioids are better used to treat acute pain and not chronic pain. Opioids can have negative consequences including changes to the brain, depression, increased pain, constipation, sedation, and even death. This fact sheet reviews and explains some of the most successful …

Biallelic Fgf4 Variants Linked To Thoracic Dystrophy And Respiratory Insufficiency, Laura M. Watts, Esther Kinning, Donald R. Latner, Marla Johnston, Jessica Patrick-Esteve, Gregory M. Cooper, Stephen R.F. Twigg, Alistair T. Pagnamenta, Jenny C. Taylor

School of Medicine Faculty Publications

The thoracic dystrophies are inherited skeletal conditions where abnormal embryonic development of the thoracic skeleton results in a narrow chest, pulmonary hypoplasia, and respiratory insufficiency, which can be severe or lethal. The majority of thoracic dystrophies are due to biallelic alterations in genes needed for normal ciliary function. However, despite the identification of over 20 genes as causal for the thoracic dystrophy phenotype, around 20% of patients remain without a molecular diagnosis. We present two unrelated families with a clinical diagnosis of thoracic dystrophy with associated respiratory insufficiency without a molecular diagnosis on previous genetic testing. Both harbor rare biallelic …

04.21.2025 Ored Connect, Liz Williamson

ORED Newsletter

ORED Stakeholder Meetings

SEC Travel Grants

Lack Of Patient-Centered Care Relative To Evidence-Based Practice In Clinical Diagnosis And Treatment Of Endometriosis In The U.S.: A Review, Piper E. Scoskie

Honors Theses

This scoping review examines the impact of combining Patient-Centered Care (PCC) and Evidence-Based Care (EBC) on clinical outcomes and patient satisfaction in the diagnosis and treatment of endometriosis in the United States. In particular, the review aims to (1) examine the body of research from the United States to learn more about the connection between PCC and EBC and their collective impact on patient satisfaction and clinical outcomes in the treatment of endometriosis; (2) identify the gaps in existing research and practice, specifically regarding PCC procedures, varying patient populations, and longitudinal investigations; and (3) provide recommendation for future research and …

2025 Academic Conference Program

Holy Cross Undergraduate Academic Conference

No abstract provided.

Sex Differences In Exercise And Sleep Among University Faculty And Staff Members, Jorge O. Vazquez, David A. Tobar, Faith Yingling, K Todd Keylock

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 6: Issue 1, Article 4, 2025. There has been minimal research examining the exercise and sleeping patterns of university faculty and staff members and what role these factors play in overall health. The information gathered in this study was used to analyze how faculty and staff can adapt their behaviors to improve health and well-being. To explore sex differences in exercise and sleep in faculty and staff at a university in the Midwest, the study performed secondary analyses on data collected from the 2022 American College Health Association’s National Faculty and Staff Health …

Rnase1-Driven Alk-Activation Is An Oncogenic Driver And Therapeutic Target In Non-Small Cell Lung Cancer, Zhengyu Zha, Chunxiao Liu, Meisi Yan, Cong Chen, Cheng Yu, Yaohui Chen, Chenhao Zhou, Lu Li, Yi-Chuan Li, Hiro Yamaguchi, Leiguang Ye, Tong Liu, Ying-Nai Wang, Heng-Huan Lee, Wen-Hao Yang, Li-Chuan Chan, Baozhen Ke, Jennifer L Hsu, Lieming Ding, Dong Ji, Peng Pan, Yiran Meng, Yue Pu, Lunxu Liu, Mien-Chie Hung

Faculty, Staff and Student Publications

Targeted therapy has achieved significant success in the treatment of non-small cell lung cancer (NSCLC), particularly in patients harboring common oncogenic driver mutations such as EGFR, KRAS, and ALK rearrangement. However, ~35-50% of NSCLC patients without tyrosine kinase mutation or rearrangement (non-mutated) cannot benefit from these targeted treatments, highlighting the urgent need for novel therapeutic strategies for this patient population. In this study, we report a non-canonical role of human secretory ribonuclease 1 (RNase1), which binds to and activates wild-type ALK in lung cancer cells, thereby triggering its downstream signaling pathway. RNase1-driven ALK-activation (RDAA) cells exhibit enhanced cell proliferation, migration, …

Association Between B-Cell Marker Expression And Runx1 Lesions In Acute Myeloid Leukemia, Beyond Runx1::Runx1t1 Fusion: Diagnostic Pitfalls With Mixed-Phenotype Acute Leukemia—B/Myeloid, Giby V George, Malgorzata Kajstura, Audrey N Jajosky, Hong Fang, Fatima Zahra Jelloul, Andrew G Evans, W Richard Burack, John M Bennett, L Jeffrey Medeiros, Wei Wang, Siba El Hussein

Faculty, Staff and Student Publications

Acute myeloid leukemia (AML) with RUNX1::RUNX1T1 fusion is well known to often demonstrate aberrant upregulation of CD19 expression. We studied the clinicopathologic and genetic features of 16 cases of AML with various RUNX1 lesions, including mutations, copy number gains, and translocations other than fusions with RUNX1T1. Most of these cases were classified as AML-myelodysplasia-related or AML-post-cytotoxic therapy based on the cytogenetic and molecular work-up. These neoplasms showed partial expression of one or more B-cell antigens by flow cytometry and/or immunohistochemistry, fulfilling the criteria for mixed-phenotype acute leukemia (MPAL)-B/myeloid (i.e., ≥20% blasts expressing B and myeloid lineage antigens) …

Progesterone Signaling In Oviductal Epithelial Cells Modulates The Immune Response To Support Preimplantation Embryonic Development, Emily A Mcglade, Jiude Mao, Kalli K Stephens, Ryan M Marquardt, Feyza Nur Arguc, Peter F Lais, San-Pin Wu, Sarayut Winuthayanon, Haval Shirwan, Esma S Yolcu, Mark I Hunter, James K Pru, John P Lydon, Francesco J Demayo, Wipawee Winuthayanon

Faculty, Staff and Students Publications

More than 60% of pregnancy losses occur during the first trimester, highlighting the need to understand the role of the oviduct in early pregnancy. In this study, we conditionally ablated the classical progesterone receptor (Pgr) in oviductal epithelial cells, called the Pgrd/d mouse model. We found that 40% of embryos collected from Pgrd/d females were nonviable or developmentally delayed, indicating that epithelial PGR expression is crucial for embryonic development. Single-cell RNA sequencing revealed up-regulation of proinflammatory genes, including interleukin-22 (IL-22), in the epithelial cells of Pgrd/d females. Pharmacological inhibition of inflammation using nonsteroidal anti-inflammatory drugs …

Enriched Pathways In Gut Microbiome Predict Response To Immune Checkpoint Inhibitor Treatment Across Demographic Regions And Various Cancer Types, Xunhui Cai, Jennifer Y Cho, Lijun Chen, Yufeng Liu, Fenghu Ji, Katia Salgado, Siyi Ge, Dehua Yang, Hui Yu, Jianbo Shao, P Andrew Futreal, Boris Sepesi, Don Gibbons, Yaobing Chen, Guoping Wang, Chao Cheng, Meng Wu, Jianjun Zhang, Ansel Hsiao, Tian Xia

Faculty, Staff and Student Publications

Understanding the effect of gut microbiota function on immune checkpoint inhibitor (ICI) responses is urgently needed. Here, we integrated 821 fecal metagenomes from 12 datasets to identify differentially abundant genes and construct random forest models to predict ICI response. Gene markers demonstrated excellent predictive performance, with an average area under the curve (AUC) of 0.810. Pathway analyses revealed that quorum sensing (QS), ABC transporters, flagellar assembly, and amino acid biosynthesis pathways were enriched between responders (R) and non-responders (NRs) across 12 datasets. Furthermore,

Robust Sex Determination In The Caenorhabditis Nigoni Germ Line, Jonathan P Harbin, Yongquan Shen, Shin-Yi Lin, Kevin Kemper, Eric S Haag, Erich M Schwarz, Ronald E Ellis

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Sexual characteristics and reproductive systems are dynamic traits in many taxa, but the developmental modifications that allow change and innovation are largely unknown. A leading model for this process is the evolution of self-fertile hermaphrodites from male/female ancestors. However, these studies require direct analysis of sex-determination in male/female species, as well as in the hermaphroditic species that are related to them. In Caenorhabditis nematodes this has only become possible recently, with the discovery of new species. Here, we use gene editing to characterize major sex-determination genes in C. nigoni, a sister to the widely studied hermaphroditic species C. briggsae. These …

The Impact Of Diet On Preeclampsia: An Observational Study Of Nutritional Influence, Trinity G. Moye, Alyssa Cunningham

Department of Nutrition Student Projects

Preeclampsia is a pregnancy-specific condition typically diagnosed after 20 weeks of gestation in women with no prior history of hypertension. Characterized by high blood pressure, proteinuria, thrombocytopenia, increased liver enzymes, and affecting the arteries carrying blood to the placenta, preeclampsia affects the health of both the mother and the fetus. Preeclampsia is disproportionately prevalent in certain populations, specifically among Black women, with various factors contributing to the higher susceptibility including socioeconomic status, education, and health distrust. These factors have been historically structured against Black women in American society. This study aims to reveal how dietary habits can play a role …

Reduced Venetoclax Exposure To 7 Days Vs Standard Exposure With Hypomethylating Agents In Newly Diagnosed Aml Patients, Christophe Willekens, Alexandre Bazinet, Samy Chraibi, Alex Bataller, Justine Decroocq, Naszrin Arani, Benjamin Carpentier, Caitlin Rausch, Delphine Lebon, Abhishek Maiti, Nicolas Gauthier, Nicholas Short, Sarah Bonnet, Koji Sasaki, Sabine Khalife-Hachem, Mahesh Swaminathan, Jean-Baptiste Micol, Florence Pasquier, Christophe Marzac, Damien Roos-Weil, Laurent Pascal, Naval Daver, Tapan Kadia, Didier Bouscary, Farhad Ravandi, Arnaud Pages, Hagop Kantarjian, Stéphane De Botton, Courtney Dinardo

Faculty, Staff and Student Publications

Hypomethylating agent (HMA) plus venetoclax (VEN) regimens are standard of care in patients with acute myeloid leukemia (AML) ineligible for intensive chemotherapy. While the VEN label recommends continuous 28-day cycles, shortened VEN durations may induce similar response rates and improve tolerability. It is unknown how a VEN exposure reduced to 7 days during cycles compares to standard HMA + VEN. We retrospectively compared newly diagnosed AML patients treated with azacitidine (AZA) x 7 days plus VEN x 7 days ("7 + 7" regimen) from the first cycle (n = 82) vs patients treated with standard dose HMA + VEN (std-HMA/VEN) …