Medicine and Health Sciences Commons^™

Mites [Of Dogs And Cats], Susan E. Little, Roberto Cortinas

School of Veterinary and Biomedical Sciences: Faculty Publications

Veterinary parasitology: 20,000-word article details recognition and treatments for mite infestations of dogs and cats. Mite species reviewed include:

Cheyletiella spp. (“Walking Dandruff”)

Demodex spp. (Hair Follicle Mites, Red Mange, Demodicosis, Demodectic Mange)

Sarcoptes scabiei (Itch Mite, Scabies, Sarcoptic Mange)

Notoedres cati (Feline Head and Neck Mange)

Otodectes cynotis (Ear Mites)

Pneumonyssoides caninum (Nasal Mite)

Lynxacarus radovskyi (Fur Mite, Hair Clasping Mite)

Trombiculid Mites (Chiggers, Red Bugs, Berry Bugs, Harvest Mites, Scrub Itch or Grass Itch Mites)

Discussions include Etiology and epidemiology, Pathogenesis, Clinical features, Diagnosis, Treatment and prognosis, Immunity, Prevention, and Public health aspects.

Complete with 209 references.

Manydogs Project: A Big Team Science Approach To Investigating Canine Behavior And Cognition, Daniela Alberghina, Emily E. Bray, Daphna Buchsbaum, Sarah- Elizabeth Byosiere, Julia Espinosa, Gitanjali E. Gnanadesikan, C.-N. Alexandrina Guran, Elizabeth Hare, Daniel J. Horschler, Ludwig Huber, Valerie A. Kuhlmeier, Evan L. Maclean, Madeline H. Pelgrim, Bryan Perez, Dana Ravid-Schurr, Liza Rothkoff, Courtney L. Sexton, Zachary A. Silver, Jeffrey R. Stevens

Center for Brain, Biology, and Behavior: Faculty and Staff Publications

Dogs have a special place in human history as the first domesticated species and play important roles in many cultures around the world. However, their role in scientific studies has been relatively recent. With a few notable exceptions (e.g., Darwin, Pavlov, Scott, and Fuller), domestic dogs were not commonly the subject of rigorous scientific investigation of behavior until the late 1990s. Although the number of canine science studies has increased dramatically over the last 20 years, most research groups are limited in the inferences they can draw because of the relatively small sample sizes used, along with the exceptional diversity …

A Standardized Nomenclature For Mammalian Histone Genes., Ruth L Seal, Paul Denny, Elspeth A Bruford, Anna K Gribkova, David Landsman, William F Marzluff, Monica Mcandrews, Anna R Panchenko, Alexey K Shaytan, Paul B Talbert

Faculty Research 2022

Histones have a long history of research in a wide range of species, leaving a legacy of complex nomenclature in the literature. Community-led discussions at the EMBO Workshop on Histone Variants in 2011 resulted in agreement amongst experts on a revised systematic protein nomenclature for histones, which is based on a combination of phylogenetic classification and historical symbol usage. Human and mouse histone gene symbols previously followed a genome-centric system that was not applicable across all vertebrate species and did not reflect the systematic histone protein nomenclature. This prompted a collaboration between histone experts, the Human Genome Organization (HUGO) Gene …

Using A One Health Approach For The Assessment Of Rabies Control In Rural Victoria Falls, Zimbabwe, Ryan Lapenna

Electronic Thesis and Dissertation Repository

Rabies, a viral zoonotic disease, is widespread in Zimbabwe, with human fatalities reported annually in the country. To supplement the Government’s effort on rabies control, the Victoria Falls Wildlife Trust and Veterinarians for Animal Welfare Zimbabwe have joined forces to carry out dog rabies vaccinations in rural communities adjacent to the major tourist attraction of The Victoria Falls. A One Health approach was used to 1) determine the level of protective rabies antibodies among a sample of rural dogs and 2) collect information and describe the knowledge, attitudes, and practices related to rabies among dog owners. In 2020, blood was …

Effect Of Calcium Chloride And Isoflurane On Force Frequency Relationship In Canines, Harrison Patrizio, Lawrence Mulligan

Rowan-Virtua Research Day

Proper calcium cycling is critical for a optimally functioning heart.

Improper calcium cycling in humans can contribute to heart failure.

Human calcium cycling is difficult to study due to the risks of damaging the patient’s cardiac tissue.

Risk of further damaging cardiac tissue is substantially increased in a heart failure patient.

Past studies focus on studying the effects of changing calcium cycling in lab rats.

Current research shows limited alternative methods in studying relationships between calcium cycling and FFR in larger mammals.

This project analyzes data to determine the response of the canine force frequency relationship to calcium chloride and …

The Effects Of Biological And Health Characteristics Of Dogs On Intraindividual Variabilityof Blood Parameters, Sandra Nikolic, Branislava Belic, Marko Cincovic, Nikolina Novakov, Nada Plavsa, Sara Savic

Turkish Journal of Veterinary & Animal Sciences

Considering the great diversity among dogs and their different biological and health characteristics, as well as different treatment protocols, it has become important to assess the effects of these factors on intraindividual variability of blood parameters in dogs, which is the aim of this study. Blood samples were collected from one hundred client-owned dogs. The dogs were of different age, breed, sex, body condition, reproductive, and health status and were presented to the veterinary clinic for preventive or diagnostic procedures. The effect of age on intraindividual variation was significant for various blood parameters and it was essential to establish new …

Pulmonary Capillary Recruitment And Distention In Mammalian Lungs: Species Similarities, David Langleben, Benjamin D. Fox, Stylianos E. Orfanos, Michele Giovinazzo, John D. Catravas

Bioelectrics Publications

Pulmonary arterial pressure rises minimally during exercise. The pulmonary microcirculation accommodates increasing blood flow via recruitment of pulmonary capillaries and, at higher flows, by distention of already perfused capillaries. The flow transition range between recruitment and distention has not been studied or compared across mammalian species, including humans. We hypothesised that the range would be similar. Functional pulmonary capillary surface area (FCSA) can be estimated using validated metabolic techniques. We reviewed data from previous studies in three mammalian species (perfused rabbit lungs and dog lung lobes, and exercising humans) and generated blood flow-FCSA curves over a range of flows. We …

Canine Hypoadrenocorticism: A Retrospective Study Of 32 Cases From 2011 To 2018., Cinthia Peres Camilo, Mauro Jose Lahm Cardoso, Paula Nassar De Marchi, Rafael Fagnani

Turkish Journal of Veterinary & Animal Sciences

Primary hypoadrenocorticism is characterized by insufficient adrenocortical hormonal secretion of glucocorticoids and mineralocorticoids, which causes unspecific signs and laboratory alterations such as hyponatremia and hyperkalemia, resulting in a low relation between these two electrolytes. The aim of this work was to carry out a retrospective study with data obtained from the medical records of 32 dogs with a proven diagnosis of hypoadrenocorticism between the years 2011 and 2018. The parameters weight, sex, reproductive condition, breed, and age were analyzed, as well as the results of laboratory tests of dogs with confirmed hypoadrenocorticism. There was no breed or sex predisposition. There …

Clinical And Hemostasis Predictors Of Mammary Gland Tumors In Bitches, Dmytro Bilyi, Mykhailo Rublenko, Liudmyla Kovalova, Dmytro Sliusarenko, Liudmyla Haluzina, Oleksandr Stotskyi, Sergey Maslikov

Turkish Journal of Veterinary & Animal Sciences

This study presents the results of the study of clinical and hemostasis predictors of mammary gland tumors in bitches, which allow to determine the risk groups for this disease. The highest incidence rates were found in German and Eastern European Shepherds (22.1%), Dachshunds (12.8%) and Yorkshire terriers (9.5%) when kept in private households: 97.1%, 96.3% and 97.3%, respectively. Significantly increases the likelihood of mammary gland cancer in excess body weight - by 30%-100%, in the case of mixed feeding - up to 39.3%, the use of hormonal contraceptives - by 50%-60%. Adverse prognosis correlates with an increase in the size, …

Behavioural Risks In Female Dogs With Minimal Lifetime Exposure To Gonadal Hormones, Melissa J. Starling, Anne Fawcett, Bethany Wilson, James Serpell, Paul Mcgreevy

Physiology Collection

Spaying of female dogs is a widespread practice, performed primarily for population control. While the consequences of early spaying for health are still being debated, the consequences for behaviour are believed to be negligible. The current study focused on the reported behaviour of 8981 female dogs spayed before 520 weeks (ten years) of life for reasons other than behavioural management, and calculated their percentage lifetime exposure to gonadal hormones (PLGH) as a proportion of their age at the time of being reported to the online Canine Behavioral Assessment and Research Questionnaire (C-BARQ). We found that 23 behaviours differed between entire …

Risk And Protective Factors Associated With Gastrointestinal Parasites Of Dogs From An Urban Area Of Córdoba, Argentina, Carlos Eugenio Motta, Maria Romina Rivero, Carlos Daniel De Angelo, Ana María Sbaffo, Karina Ivana Tiranti

Turkish Journal of Veterinary & Animal Sciences

Prevalence of gastrointestinal (GI) parasites and the effect of associated factors were evaluated in household dogs from an urban area of Córdoba, Argentina. A total of 493 fecal samples were collected during 2010 and 2013 and processed with Willis` salt, Sheathers sugar flotation, and formol-ether concentration techniques. Overall prevalence of GI parasites was 45.23% (95% CI 40.83-49.62), and Ancylostoma caninum (30.83%) was the most frequent parasite, followed by Trichuris vulpis (9.94%), Cystoisospora spp. (7.71%), Toxocara canis (6.90%), and Giardia spp. (5.88%). Independent variables were presence of at least one parasite element, named "all parasites", and each GI parasite more frequently …

The New World Of Pet Prosthetics, Anna Brooks

Capstones

When an abandoned dog was found in Brooklyn with his paw gnawed off, the animal shelter had two options: amputate the leg, or put the dog down. But neither seemed like a solution. So they decided to do something different, and fit the dog for a prosthetic leg. Prosthetics for people have been around for millennia, and now these devices are moving into the animal kingdom. This story explores the new world of animal prosthetics, and how these devices have changed the lives of animals like Mr. Stubbs — the first alligator with a prosthetic tail — and saved the …

Proteomics Of Human Liver Membrane Transporters: A Focus On Fetuses And Newborn Infants., Bianca D. Van Groen, Evita Van De Steeg, Miriam G. Mooij, Marola M H Van Lipzig, Barbara A E De Koning, Robert M. Verdijk, Heleen M. Wortelboer, R Gaedigk, Chengpeng Bi, J Steven Leeder, Ron H N Van Schaik, Joost Van Rosmalen, Dick Tibboel, Wouter H. Vaes, Saskia N. De Wildt

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Hepatic membrane transporters are involved in the transport of many endogenous and exogenous compounds, including drugs. We aimed to study the relation of age with absolute transporter protein expression in a cohort of 62 mainly fetus and newborn samples.

METHODS: Protein expressions of BCRP, BSEP, GLUT1, MCT1, MDR1, MRP1, MRP2, MRP3, NTCP, OCT1, OATP1B1, OATP1B3, OATP2B1 and ATP1A1 were quantified with LC-MS/MS in isolated crude membrane fractions of snap-frozen post-mortem fetal and pediatric, and surgical adult liver samples. mRNA expression was quantified using RNA sequencing, and genetic variants with TaqMan assays. We explored relationships between protein expression and age …

Clinical Evaluation Of Topical Tacrolimus Ointment Usagein Different Stages Of Keratoconjunctivitis Sicca In Dogs, Christina John, Aswathy Gopinathan, Kiranjeet Singh, Pallvi Sharma, Chelladurai Sowbharenya, Sherin B. Sarangom

Turkish Journal of Veterinary & Animal Sciences

This study was conducted to investigate the effect of topical tacrolimus (0.1%) ointment in stimulating tear production in dogs with keratoconjunctivitis sicca (KCS). Thirty-six dogs (58 eyes) diagnosed with KCS were included in this study. KCS was grouped as early (E, n = 21 eyes), late (L, n = 21 eyes), and reflex tear due to corneal ulceration (R, n = 16 eyes) based on Schirmer tear test (STT) readings. The dogs in each group were randomly allotted treatment with either tacrolimus 0.1% ointment applied once daily (ET, n = 11 eyes; LT, n = 10 eyes; RT, n = …

Survey Of Dirofilaria Immitis In Dogs From Sivas Province In Thecentral Anatolia Region Of Turkey, Ahmet Duran Ataş, Kürşat Altay, Ahmet Ali̇m, Erkan Özkan

Turkish Journal of Veterinary & Animal Sciences

In this research, we investigate the prevalence of Dirofilaria immitis infection in dogs using microscopical, serological, and molecular methods from the Central Anatolia Region (Sivas) of Turkey and reveal the associated risk factors. Whole blood and serum samples were obtained from 306 dogs older than 7 months. Polymerase chain reaction (PCR) and the modified Knott's method (Knott) were used for detecting the microfilaria and enzyme-linked immunosorbent assay (ELISA) was applied for the presence of D. immitis antigens. The prevalence of D. immitis in dogs was detected as 2.9% (9/306) by PCR and ELISA and as 1.3% (4/306) by Knott. All …

Effect Of Epidural Dexmedetomidine With Or Without Local Anesthetics On Painscore And Serum Il-6 Levels In Dogs Undergoing Elective Ovariohysterectomy, Mudasir Ahmad Shah, Prakash Kinjavdekar, Amarpal -, Deepti Sharma, Abhijit Motiram Pawde, Abu Rafee Malik, Abas Rashid Bhat

Turkish Journal of Veterinary & Animal Sciences

To evaluate the postoperative analgesic effects of epidural dexmedetomidine with or without local anesthetics, prospective randomized double-blinded clinical trials were performed with 24 healthy client-owned mixed-breed adult dogs with an average weight of 18.1 ± 2.4 kg allotted equally (n = 6) to four groups: A, B, C, and D. All animals were premedicated intramuscularly with atropine (0.04 mg/kg) and after 5 min by intravenous midazolam (0.7 mg/kg). After 10 min of premedication, in group A dexmedetomidine (7 µg/kg) and in groups B, C, and D, in addition to dexmedetomidine (7 µg/kg), lidocaine (4.4 mg/kg), bupivacaine (2 mg/kg), and ropivacaine …

Investigation Of The Safety Of Focused Ultrasound-Induced Blood-Brain Barrier Opening In A Natural Canine Model Of Aging, Meaghan Anne O'Reilly, Ryan Matthew Jones, Edward Barrett, Anthony P. Schwab, Elizabeth Head, Kullervo Hynynen

Sanders-Brown Center on Aging Faculty Publications

Rationale: Ultrasound-mediated opening of the Blood-Brain Barrier(BBB) has shown exciting potential for the treatment of Alzheimer's disease(AD). Studies in transgenic mouse models have shown that this approach can reduce plaque pathology and improve spatial memory. Before clinical translation can occur the safety of the method needs to be tested in a larger brain that allows lower frequencies be used to treat larger tissue volumes, simulating clinical situations. Here we investigate the safety of opening the BBB in half of the brain in a large aged animal model with naturally occurring amyloid deposits.

Methods: Aged dogs naturally accumulate plaques and show …

Advances In Neuroscience Imply That Harmful Experiments In Dogs Are Unethical, Jarrod Bailey, Shiranee Pereira

Professional Science Research Ethics Collection

Functional MRI (fMRI) of fully awake and unrestrained dog 'volunteers' has been proven an effective tool to understand the neural circuitry and functioning of the canine brain. Although every dog owner would vouch that dogs are perceptive, cognitive, intuitive and capable of positive emotions/empathy, as indeed substantiated by ethological studies for some time, neurological investigations now corroborate this. These studies show that there exists a striking similarity between dogs and humans in the functioning of the caudate nucleus (associated with pleasure and emotion), and dogs experience positive emotions, empathic-like responses and demonstrate human bonding which, some scientists claim, may be …

Therapy Dogs And The Impact On Employees In The Pediatric Medical Setting, Laine Foith

Electronic Theses and Dissertations

More than 40% of nurses reported experiencing significant burnout. Burnout is characterized by disengagement, cynicism, negative views of personal accomplishment and ability, and emotional exhaustion. The healthcare providers that experience burnout can possibly expect a decrease in ability to recognize/report errors, increase of negative feelings toward the patient, and decrease levels of patient satisfaction (Ernest, 2014). One of the ways Schub (2015) suggested to regulate burnout for employees was to provide psychosocial support to colleagues to reduce stress. This study is one of the first attempts to bridge the gap between the unknown correlation between qualitative and quantitative benefits of …

Aβ Vaccination In Combination With Behavioral Enrichment In Aged Beagles: Effects On Cognition, Aβ, And Microhemorrhages, Paulina R. Davis, Ginevra Giannini, Karin Rudolph, Nathaniel Calloway, Christopher M. Royer, Tina L. Beckett, M. Paul Murphy, Frederick Bresch, Dieter Pagani, Thomas Platt, Xiaohong Wang, Amy Skinner Donovan, Tiffany L. Sudduth, Wenjie Lou, Erin L. Abner, Richard J. Kryscio, Donna M. Wilcock, Edward G. Barrett, Elizabeth Head

Sanders-Brown Center on Aging Faculty Publications

Beta-amyloid (Aβ) immunotherapy is a promising intervention to slow Alzheimer’s disease (AD). Aging dogs naturally accumulate Aβ and show cognitive decline. An active vaccine against fibrillar Aβ 1–42 (VAC) in aged beagles resulted in maintenance but not improvement of cognition along with reduced brain Aβ. Behavioral enrichment (ENR) led to cognitive benefits but no reduction in Aβ. We hypothesized cognitive outcomes could be improved by combining VAC with ENR in aged dogs. Aged dogs (11–12 years) were placed into 4 groups: (1) control/control (C/C); (2) control/VAC (C/V); (3) ENR/control (E/C); (4) ENR and VAC (E/V) and treated for 20 months. …

Extraskeletal Chondroblastic Osteosarcoma Of The Subcutaneous Tissue In A Maltese Dog, Byungjoon Seung, Junghyung Ju, Seunghee Cho, Soohyeon Kim, Hwan Choi, Junghyang Sur

Turkish Journal of Veterinary & Animal Sciences

A 10-year-old spayed female Maltese dog presented to a local animal hospital with a subcutaneous mass (4 x 3 x 3 cm) in the right shoulder region. The mass was well circumscribed, with soft tissue opacity and variable levels of mineralization, but with no bony involvement in radiography. The mass was surgically removed. Upon histological examination, the mass consisted of malignant mesenchymal cells that had produced a chondroid matrix and osteoid. Round to polygonal neoplastic cells with large nuclei showed moderate anisokaryosis and variable numbers of mitotic figures. The tumor cells were positive for vimentin and osteocalcin and negative for …

Naturalizing Anthropomorphism: Behavioral Prompts To Our Humanizing Of Animals, Alexandra C. Horowitz, Marc Bekoff

Marc Bekoff, PhD

Anthropomorphism is the use of human characteristics to describe or explain nonhuman animals. In the present paper, we propose a model for a unified study of such anthropomorphizing. We bring together previously disparate accounts of why and how we anthropomorphize and suggest a means to analyze anthropomorphizing behavior itself. We introduce an analysis of bouts of dyadic play between humans and a heavily anthropomorphized animal, the domestic dog. Four distinct patterns of social interaction recur in successful dog–human play: directed responses by one player to the other, indications of intent, mutual behaviors, and contingent activity. These findings serve as a …

Comparison Of Protein Phosphatase Inhibition Assay With Lc-Ms/Ms For Diagnosis Of Microcystin Toxicosis In Veterinary Cases, Caroline E. Moore, Jeanette Juan, Yanping Lin, Cynthia L. Gaskill, Birgit Puschner

Veterinary Diagnostic Laboratory Faculty Publications

Microcystins are acute hepatotoxins of increasing global concern in drinking and recreational waters and are a major health risk to humans and animals. Produced by cyanobacteria, microcystins inhibit serine/threonine protein phosphatase 1 (PP1). A cost-effective PP1 assay using p-nitrophenyl phosphate was developed to quickly assess water and rumen content samples. Significant inhibition was determined via a linear model, which compared increasing volumes of sample to the log-transformed ratio of the exposed rate over the control rate of PP1 activity. To test the usefulness of this model in diagnostic case investigations, samples from two veterinary cases were tested. In August …

Occurrence Of Arcobacter In Dogs And Cats In Selangor,Malaysia, And Associated Risk Factors, Dauda Mohammed Goni, Saleha Abdulaziz, Gurmeet Kaur Dhaliwa, Zunita Zakaria, Ibrahim Jalo Muhammad, Mohamed Abdelrahman Mohamed, Abdulrasheed Aliyu Bello, Asinamai Athliamai Bitrus

Turkish Journal of Veterinary & Animal Sciences

Arcobacter is widely regarded as an emerging foodborne pathogen because of its increasing occurrence in food production causing gastroenteritis in humans. In addition, it is also reported as a potential zoonosis. The objectives of this study were to determine the occurrence of Arcobacter in dogs and cats and the associated risk factors. Rectal and buccal cavity swab samples were taken from dogs (n = 40) and cats (n = 40) owned by individuals who brought the animals to a university teaching hospital and stray dogs (n = 61) and cats (n = 46). Suspected colonies of Arcobacter were subjected to …

Protective Effects Of S-Adenosylmethionine (Same) And Silybin On Hepatorenal And Hemostatic Functions In Dogs With Endotoxemia, Meri̇ç Kocatürk, Oya Eralp İnan, Pinar Levent, Zeki̇ Yilmaz

Turkish Journal of Veterinary & Animal Sciences

We aimed to investigate the protective effects of S-adenosylmethionine (SAMe) and silybin treatment on hepatorenal and hemostatic functions in dogs with endotoxemia. Healthy dogs (n = 20) were divided equally into 4 groups as control, SAMe + silybin (SS), lipopolysaccharide (LPS), and LPS + SS. Controls received 0.9% NaCl intravenously. Animals were treated daily with 20 mg of SAMe and 1 mg of silybin per kilogram of body weight in SS and LPS + SS. LPS was injected (2 μg/kg, once intravenously) to dogs in LPS and LPS + SS. Hemostatic functions were assessed by thromboelastography (TEG). LPS-induced clinical and …

Ultrasonographic Features Of Medial Iliac And Jejunal Lymph Nodesin Apparently Healthy Dogs, Shriram Ganesan, Jitender Mohindroo, Pallavi Verma, Narinder Singh Saini

Turkish Journal of Veterinary & Animal Sciences

Ultrasonographic examination of medial iliac and jejunal lymph nodes were performed in 36 dogs presented to the Department of Surgery and Radiology for spaying and castration. Ultrasonographic features such as length, height in longitudinal plane, shape, ease of scanning, echotexture, and echogenicity were recorded. The medial iliac and jejunal lymph nodes were scanned consistently in all 36 dogs. However, the presence of gas in the intestines affected the ease of scanning of the lymph nodes. The majority of these lymph nodes were easy to scan, and had homogeneous and hypoechoic echogenicity. The dogs were grouped based on body weight and …

Free-Roaming Dogs In Developing Countries: The Benefits Of Capture, Neuter, And Return Programs, Jennifer Jackman, Andrew N. Rowan

Jennifer Jackman, Ph.D.

This chapter provides an overview of animal welfare and public health problems associated with free-roaming dog populations and strategies to resolve these problems. Placing CNR programs in the context of earlier dog and rabies control methods, the chapter explores CNR’s potential to overcome some of the shortcomings of earlier approaches and to improve animal welfare, reduce dog population growth, and prevent the spread of rabies and other canine-transmitted diseases. Constraints and current debates on current implementation of CNR programs are also examined.

The Accuracy Of The Patellar Reflex For Localization Of The Site Of A Single Level Thoracolumbar Disc Herniation In Dogs, Mohammed Abdelhakiem, Yuuhi Asai, Hiroaki Kamishina, Masaaki Katayama, Yuji Uzuka

Turkish Journal of Veterinary & Animal Sciences

The patellar reflex was used in this study to determine the site of thoracolumbar spinal cord dysfunction (T3-L3 or L4-L6) as a result of disc herniation. The results of neurological examinations were compared with the findings of CT myelography. This study was conducted on 21 dogs, selected from a total of 26 dogs confirmed to have a single thoracolumbar lesion. Results revealed that the accuracy of the patellar reflex for lesion localization was 71.4%. The accuracy of the patellar reflex (normal or hyperreflexic) for lesion localization in the T3-L3 segment in 15 dogs was 100%, while the accuracy of the …

A Single Base Pair Mutation Encoding A Premature Stop Codon In The Mis Type Ii Receptor Is Responsible For Canine Persistent Mullerian Duct Syndrome, Wenfang Wu, Shengqin Wan, Pujar Shashikant, Mark Haskins, Donald Schlafer, Mary Lee, Vicki Meyers-Wallen

Mary M. Lee

Mullerian inhibiting substance (MIS), a secreted glycoprotein in the transforming growth factor-beta family of growth factors, mediates regression of the Mullerian ducts during embryonic sex differentiation in males. In persistent Mullerian duct syndrome (PMDS), rather than undergoing involution, the Mullerian ducts persist in males, giving rise to the uterus, fallopian tubes, and upper vagina. Genetic defects in MIS or its receptor (MISRII) have been identified in patients with PMDS. The phenotype in the canine model of PMDS derived from the miniature schnauzer breed is strikingly similar to that of human patients. In this model, PMDS is inherited as a sex-limited …

Evaluation Of Signalment, Clinical, And Laboratory Variables As Prognostic Indicators In Dogs With Acute Abdominal Syndrome, Galina Simeonova, Dinko Dinev, Tzvetan Chaprazov, Rumen Roydev

Turkish Journal of Veterinary & Animal Sciences

The aim of the study was to identify predictors of mortality and to propose a new severity scoring system in dogs with acute abdominal syndrome. A retrospective study was carried out on 58 dogs presented with acute abdominal syndrome with American Society of Anesthesiologists grades III-IV and treated surgically by exploratory laparotomy. Medical records were reviewed and information regarding dog signalment, history, clinical, and laboratory data; surgical findings; and outcome was collected. Multiple easily measurable variables were found to be mortality predictors in dogs with acute abdominal syndrome, but the most relevant were the presence of neoplastic process, organ rupture, …